NO20003945L - N-acyl cyclic amine derivatives - Google Patents

N-acyl cyclic amine derivatives

Info

Publication number
NO20003945L
NO20003945L NO20003945A NO20003945A NO20003945L NO 20003945 L NO20003945 L NO 20003945L NO 20003945 A NO20003945 A NO 20003945A NO 20003945 A NO20003945 A NO 20003945A NO 20003945 L NO20003945 L NO 20003945L
Authority
NO
Norway
Prior art keywords
group
atom
hydrogen atoms
cyclic amine
amine derivatives
Prior art date
Application number
NO20003945A
Other languages
Norwegian (no)
Other versions
NO20003945D0 (en
Inventor
Yoshimi Tsuchiya
Hirokazu Ohsawa
Kumiko Kawakami
Kenji Ohwaki
Masaru Nishikibe
Takashi Nomoto
Original Assignee
Banyu Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP10038036A external-priority patent/JPH11224848A/en
Priority claimed from PCT/JP1999/000462 external-priority patent/WO1999040070A1/en
Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd
Publication of NO20003945D0 publication Critical patent/NO20003945D0/en
Publication of NO20003945L publication Critical patent/NO20003945L/en

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Oppfinnelsen omhandler forbindelser representert ved den generelle formelen [X] [I] [hvor Ar betyr en arylgruppe eller en heteroarylgruppe som kan ha en substituentgruppe valgt fra en gruppe bestående av et halogenatom, en lavere alkylgruppe og en lavere alkoksygruppe; R1 betyr en C3-C, sykloalkylgruppe som er substituerbar med et fluoratom; RJ og R4 betyr hydrogen- atomer, grupper representert ved -(A^.-NH-B eller lignende; R3 og R5 betyr hydrogenatomer, Cj-C, alifatiske hydrokarbon- grupper eller lignende som er substituerbare med en lavere alkylgruppe(r); n betyr O eller 1; og X betyr et oksygen- atom eller et svovelatom]. Forbindelser i henhold til oppfinnelsen, siden de ikke bare har svært selektiv antagonistisk aktivitet mot muskarine M3 reseptorer men også viser utmerket oral aktivitet, virk- ningsvarighet og farmakokinetikk, er svært anvendbare som sikre og effektive legemidler mot luftveis-, urinveis- og fordøyelsessykdommer med få ugunstige bivirkninger.The invention relates to compounds represented by the general formula [X] [I] [wherein Ar represents an aryl group or a heteroaryl group which may have a substituent group selected from a group consisting of a halogen atom, a lower alkyl group and a lower alkoxy group; R1 represents a C3-C, cycloalkyl group which is substitutable with a fluorine atom; R 1 and R 4 are hydrogen atoms, groups represented by - (A 1 -NH-B or the like; R 3 and R 5 are hydrogen atoms, C n represents O or 1; and X represents an oxygen atom or a sulfur atom.] Compounds of the invention, since they not only exhibit highly selective antagonistic activity against muscarinic M3 receptors but also exhibit excellent oral activity, duration of action and pharmacokinetics. are very useful as safe and effective medicines for respiratory, urinary and digestive diseases with few adverse side effects.

NO20003945A 1998-02-04 2000-08-04 N-acyl cyclic amine derivatives NO20003945L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP10038036A JPH11224848A (en) 1998-02-04 1998-02-04 Exposure apparatus and device manufacturing method
JP22872698 1998-07-29
PCT/JP1999/000462 WO1999040070A1 (en) 1998-02-04 1999-02-03 N-acyl cyclic amine derivatives

Publications (2)

Publication Number Publication Date
NO20003945D0 NO20003945D0 (en) 2000-08-04
NO20003945L true NO20003945L (en) 2000-10-03

Family

ID=26377219

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20003945A NO20003945L (en) 1998-02-04 2000-08-04 N-acyl cyclic amine derivatives

Country Status (1)

Country Link
NO (1) NO20003945L (en)

Also Published As

Publication number Publication date
NO20003945D0 (en) 2000-08-04

Similar Documents

Publication Publication Date Title
ATE164575T1 (en) SUBSTITUTED AROMATIC COMPOUNDS AS CAMP PHOSPHODIESTERASE AND TNF INHIBITORS
MY142807A (en) Benzimidazole derivative and use thereof.
HUP0402310A2 (en) 1,6-naphthyridine derivatives as antidiabetics and pharmaceutical compositions containing them
NO20065830L (en) Substituted 2-quinolyloxazoles useful as PDE4 inhibitors.
DE60017115D1 (en) AMID DERIVATIVES AND THEIR MEDICAL USE
DK1260512T3 (en) Hitherto unknown cyclic amide derivatives
TW200605883A (en) Condensed heterocycle derivative having HCV inhibitory activity
TW200519088A (en) Aryl or heteroaryl amide compounds
MY153045A (en) Oxopyrazine derivative and herbicide
CA2324418A1 (en) Novel opiate compounds, methods of making and methods of use
MXPA02011417A (en) Substituted 1 aminoalkyl lactams and their use as muscarinic receptor antagonists.
WO2005092858A3 (en) Alpha aryl or heteroaryl methyl beta piperidino propanamide compounds as orl1-receptor antagonist
HUP0002353A2 (en) 1-cycloalkyl-1,8-naphthyridin-4-one derivatives with phoshodiesterase iv inhibitory activity and pharmaceutical compositions containing them
MXPA04002886A (en) Nicotinic acid-heterocyclyl-amides and analogous pyrimidine derivatives serving as pesticides.
DE602004031722D1 (en) CONDENSED BICYCLIC SUBSTITUTED AMINE AS HISTAMIN 3 RECEPTOR LIGANDS
NO20004485L (en) Cycloalken derivatives, their preparation and use
ATE83773T1 (en) 3(2H)PYRIDAZINONE, PROCESS FOR ITS PREPARATION AND ANTI-SRS-A AGENT CONTAINING IT.
MXPA02011418A (en) Substituted 1 aminoalkyl lactams and their use as muscarinic receptor antagonists.
TR200103349T2 (en) Purin derivatives, preparation method and pharmaceutical compositions containing them.
EP1775289A4 (en) NEW IMIDAZOLIDINE DERIVATIVES
DE69022744D1 (en) PIPERIDINE AND PYRROLIDINE DERIVATIVES.
BR0308759A (en) Siliconated phenyl amide derivatives usable as a microbiocide
NO20032291L (en) pyrimidine
MEP12108A (en) Novel branched substituted amino derivatives of 3-amino-1-phenyl-1h[1,2,4]triazol, methods for producing them and pharmaceutical compositions containing them
NO20023251D0 (en) New tetrahydropyridines, processes for their preparation and pharmaceutical compositions containing the same

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application