NO20004121L - New compounds and their use as positive AMPA receptor modulators - Google Patents

New compounds and their use as positive AMPA receptor modulators

Info

Publication number
NO20004121L
NO20004121L NO20004121A NO20004121A NO20004121L NO 20004121 L NO20004121 L NO 20004121L NO 20004121 A NO20004121 A NO 20004121A NO 20004121 A NO20004121 A NO 20004121A NO 20004121 L NO20004121 L NO 20004121L
Authority
NO
Norway
Prior art keywords
new compounds
ampa receptor
receptor modulators
positive ampa
bond
Prior art date
Application number
NO20004121A
Other languages
Norwegian (no)
Other versions
NO20004121D0 (en
Inventor
Alex Haahr Gouliaev
Mogens Larsen
Thomas Varming
Claus Mathiesen
Tina Holm Johansen
Joergen Scheel-Krueger
Gunnar M Olsen
Elsebet Istergaard Nielsen
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Publication of NO20004121D0 publication Critical patent/NO20004121D0/en
Publication of NO20004121L publication Critical patent/NO20004121L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/15—Six-membered rings
    • C07D285/16—Thiadiazines; Hydrogenated thiadiazines
    • C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
    • C07D285/20—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems
    • C07D285/22—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D285/24—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/15—Six-membered rings
    • C07D285/16—Thiadiazines; Hydrogenated thiadiazines
    • C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
    • C07D285/20—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems
    • C07D285/22—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D285/24—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom
    • C07D285/26—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom substituted in position 6 or 7 by sulfamoyl or substituted sulfamoyl radicals
    • C07D285/28—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom substituted in position 6 or 7 by sulfamoyl or substituted sulfamoyl radicals with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Oppfinnelsen tilveiebringer nye forbindelser representert ved den generelle formel (I). hvor bindingen representert ved den brutte linje kan være en enkelt- eller dobbeltbinding, eller fraværende; og dersom bindingen er fraværende, så er nitrogenatomet substituert med et hydrogenatom og R; X er SO, C=0 eller CH; Y er -CH(R)-, -N(R)-, -N(R)-CHeller 0; og betydningen av,, R,,,og Rer som definert i søknaden. Forbindelsene kan anvendes som positive modulatorer for AMPA-reseptoren.The invention provides new compounds represented by the general formula (I). where the bond represented by the broken line may be a single or double bond, or absent; and if the bond is absent, then the nitrogen atom is substituted by a hydrogen atom and R; X is SO, C=O or CH; Y is -CH(R)-, -N(R)-, -N(R)-CH or 0; and the meaning of,, R,,, and Rer as defined in the application. The compounds can be used as positive modulators for the AMPA receptor.

NO20004121A 1998-02-18 2000-08-17 New compounds and their use as positive AMPA receptor modulators NO20004121L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK22698 1998-02-18
PCT/DK1999/000070 WO1999042456A2 (en) 1998-02-18 1999-02-18 Novel compounds and their use as positive ampa receptor modulators

Publications (2)

Publication Number Publication Date
NO20004121D0 NO20004121D0 (en) 2000-08-17
NO20004121L true NO20004121L (en) 2000-10-17

Family

ID=8091151

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20004121A NO20004121L (en) 1998-02-18 2000-08-17 New compounds and their use as positive AMPA receptor modulators

Country Status (17)

Country Link
EP (1) EP1071426A2 (en)
JP (1) JP2002504481A (en)
CN (1) CN1293665A (en)
AU (1) AU751384B2 (en)
CA (1) CA2320354A1 (en)
EE (1) EE200000468A (en)
HU (1) HUP0101280A3 (en)
IL (1) IL137720A0 (en)
IS (1) IS5581A (en)
NO (1) NO20004121L (en)
NZ (1) NZ506251A (en)
PL (1) PL342843A1 (en)
RU (1) RU2214405C2 (en)
SK (1) SK11892000A3 (en)
TR (1) TR200002427T2 (en)
WO (1) WO1999042456A2 (en)
ZA (1) ZA991301B (en)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7671200B2 (en) 1999-10-27 2010-03-02 Cytokinetics, Inc. Quinazolinone KSP inhibitors
DE10004572A1 (en) 2000-02-02 2001-08-09 Boehringer Ingelheim Pharma New positive allosteric AMPA receptor modulators (PAARM), processes for their production and their use as medicines
FR2812291B1 (en) * 2000-07-28 2002-12-13 Adir NOVEL BENZOTHIADIAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
CN1314351A (en) * 2001-03-22 2001-09-26 刘志红 Process for synthesizing quinazolone and quinazolone compound with anti-cancer function
TWI232863B (en) 2001-06-11 2005-05-21 Akzo Nobel Nv Benzoxazepine derivatives
HUP0400196A3 (en) * 2001-06-14 2007-05-02 Organon Nv (pyrido/thieno)[f]oxazepin-5-one derivatives, their use and pharmaceutical compositions containing them
EP1436270A1 (en) * 2001-10-10 2004-07-14 Neurosearch A/S Novel benzothiazine derivatives, their preparation and use
PL371722A1 (en) 2001-11-26 2005-06-27 Cortex Pharmaceuticals, Inc. Carbonylbenzoxazine compounds for enhancing glutamatergic synaptic responses
FR2833955B1 (en) * 2001-12-21 2004-01-30 Servier Lab NOVEL BENZOTHIAZINE AND BENZOTHIADIAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2833950B1 (en) * 2001-12-21 2005-12-16 Servier Lab NOVEL BENZOTHIAZINE AND BENZOTHIADIAZINE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
FR2833956B1 (en) * 2001-12-21 2004-01-30 Servier Lab NOVEL BENZOTHIAZINE AND BENZOTHIADIAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2854634B1 (en) * 2003-05-05 2005-07-08 Servier Lab NOVEL THIADIAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2856064B1 (en) * 2003-06-13 2005-08-19 Servier Lab NOVEL BENZOTHIAZINE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
FR2856065B1 (en) * 2003-06-13 2005-08-19 Servier Lab NOVEL BENZOTHIAZINE AND BENZOTHIADIAZINE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
WO2005005395A2 (en) 2003-07-02 2005-01-20 F. Hoffmann-La Roche Ag Arylamine-substituted quinazolinone compounds
JP2007504136A (en) 2003-08-28 2007-03-01 ニトロメッド インコーポレーティッド Nitrosated and nitrosylated diuretic compounds, compositions and methods of use
US7244843B2 (en) 2003-10-07 2007-07-17 Bristol-Myers Squibb Company Modulators of serotonin receptors
FR2865474B1 (en) * 2004-01-26 2008-06-13 Servier Lab NOVEL FLUORINATED BENZOTHIAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
FR2877338B1 (en) 2004-11-03 2007-01-26 Servier Lab NOVEL BENZOTHIADIAZINE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
FR2877342B1 (en) * 2004-11-03 2007-01-26 Servier Lab NOVEL BENZOTHIADIAZINE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
FR2879201B1 (en) * 2004-12-10 2007-02-16 Servier Lab NOVEL BENZOTHIAZINE AND BENZOTHIADIAZINE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
EP1846410B1 (en) 2005-02-10 2009-01-21 Bristol-Myers Squibb Company Dihydroquinazolinones as 5ht modulators
WO2006091716A2 (en) 2005-02-24 2006-08-31 Nitromed, Inc. Nitric oxide enhancing diuretic compounds, compositions and methods of use
GB0507298D0 (en) * 2005-04-11 2005-05-18 Novartis Ag Organic compounds
TW200800959A (en) 2005-06-10 2008-01-01 Wyeth Corp Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor
RU2333211C1 (en) * 2006-11-01 2008-09-10 Институт физиологически активных веществ Российской Академии наук N,n'-substituted 3,7-diazabicyclo[3,3,1]nonanes with pharmacological effect, pharmacological compositions on their base, and application method
MY154877A (en) 2007-01-03 2015-08-14 Servier Lab 3-substituted-[1,2,3]-benzotriazinone compound for enhancing glutamateric synaptic responses
TW200901974A (en) 2007-01-16 2009-01-16 Wyeth Corp Compounds, compositions, and methods of making and using them
EA200901546A1 (en) 2007-05-17 2010-04-30 Кортекс Фармасеутикалс, Инк. DESIGNED AMIDES FOR ENHANCING GLUTAMATERGIC SYNAPTIC RESPONSES
BRPI0814149A2 (en) 2007-08-10 2011-09-13 Cortex Pharma Inc compound, pharmaceutical composition, methods of treatment and use of the compound
US8119632B2 (en) 2007-08-10 2012-02-21 Cortex Pharmaceuticals, Inc. Bicyclic amide derivatives for enhancing glutamatergic synaptic responses
FR2933698A1 (en) 2008-07-09 2010-01-15 Servier Lab NOVEL CYCLOALKYLATED BENZOTHIADIAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
FR2943342B1 (en) * 2009-03-20 2011-03-04 Servier Lab NOVEL BENZOTHIADIAZEPINES DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
PT2464645T (en) 2009-07-27 2017-10-11 Gilead Sciences Inc HETEROCYCLIC COMPOUNDS FUSIONED AS ION CHANNEL MODULATORS
FR2955106B1 (en) 2010-01-08 2011-12-23 Servier Lab NOVEL CYCLOPROPYLATED BENZOTHIADIAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2955107B1 (en) * 2010-01-08 2012-03-02 Servier Lab NOVEL THIOCHROMAN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
CN102958919A (en) * 2010-07-02 2013-03-06 霍夫曼-拉罗奇有限公司 Novel tetrahydroquinoline derivatives
WO2012003392A1 (en) 2010-07-02 2012-01-05 Gilead Sciences, Inc. Fused heterocyclic compounds as ion channel modulators
FR2964969B1 (en) 2010-09-16 2012-08-24 Servier Lab NOVEL DIHYDROBENZOXATHIAZEPINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
IT1402905B1 (en) * 2010-11-29 2013-09-27 Univ Degli Studi Modena E Reggio Emilia DERIVATIVES OF 1,2,4-BENZOTIADIAZIN 1,1-DIOXIDE, THEIR PREPARATION AND THEIR USE AS ALLOSTERIC MODULATORS OF THE AMPA RECEPTOR.
AU2012253653A1 (en) 2011-05-10 2013-05-02 Gilead Sciences, Inc. Fused heterocyclic compounds as sodium channel modulators
TWI622583B (en) 2011-07-01 2018-05-01 基利科學股份有限公司 Fused heterocyclic compound as ion channel regulator
NO3175985T3 (en) 2011-07-01 2018-04-28
CN102977054A (en) * 2012-12-12 2013-03-20 中国药科大学 Use of a class of selective α2A receptor agonists for treating Alzheimer's disease
CA2912133C (en) 2013-05-30 2021-06-22 Actelion Pharmaceuticals Ltd Cxcr7 receptor modulators
JO3316B1 (en) 2013-05-30 2019-03-13 Lilly Co Eli 3,4-dihydroisoquinolin-2(1h)-yl compounds
CN103275016B (en) * 2013-06-04 2015-03-11 温州医科大学附属第二医院 Synthetic method of 2-subsituted quinazoline compounds
BR112015031249A2 (en) 2013-06-13 2017-07-25 Veroscience Llc treatment method, method for treating a metabolic disorder or a key element thereof, method for normalizing a daily dopamine release rate in the sumn, method for stimulating dopamine release from dopaminergic neurons in an individual's sumn and pharmaceutical composition
CN103319381B (en) * 2013-06-14 2014-08-27 湖州康企药业有限公司 Preparation method of high-purity fine sulfanilamide
CN103772296B (en) * 2013-12-19 2015-06-17 安徽师范大学 Synthesis method for quinazoline derivative
EP3227263B1 (en) 2014-12-01 2019-04-10 Idorsia Pharmaceuticals Ltd Cxcr7 receptor modulators
CN105294599B (en) * 2015-09-17 2017-09-22 三峡大学 A kind of diazthines compound and its asymmetric synthetic method
US20190112300A1 (en) 2016-03-29 2019-04-18 Arnold Stan Lippa Compositions And Methods For Treating Attention Deficit Disorders
CN106946920A (en) * 2017-04-05 2017-07-14 泰力特医药（湖北）有限公司 A kind of preparation method of 4 amino phenyl boronic acid derivative
EP3962901A1 (en) 2019-04-29 2022-03-09 Solent Therapeutics, LLC 3-amino-4h-benzo[e][1,2,4]thiadiazine 1,1-dioxide derivatives as inhibitors of mrgx2
TW202115042A (en) * 2019-06-21 2021-04-16 大陸商江蘇豪森藥業集團有限公司 Aryl phosphorus oxide derivative inhibitors, preparation methods and applications thereof
PL4031552T3 (en) 2019-09-16 2025-03-17 Takeda Pharmaceutical Company Limited Azole-fused pyridazin-3(2h)-one derivatives
RU2726456C1 (en) * 2019-10-02 2020-07-14 Общество с ограниченной ответственностью "Научно-исследовательский институт ХимРар" (ООО "НИИ ХимРар") Hepatitis b virus (hbv) inhibitor
CN111100042B (en) * 2019-11-18 2022-05-31 苏州诚和医药化学有限公司 Preparation method of 2-methoxy-5-sulfonamide benzoic acid
CN111018750B (en) * 2019-12-19 2022-05-27 苏州诚和医药化学有限公司 Novel preparation method of 2, 3-dimethoxy-5-sulfamide benzoic acid
EP4291195A4 (en) * 2021-02-11 2025-07-09 Medical College Wisconsin Inc Small molecule inhibitors of PBRM1-BD2
CN113121470A (en) * 2021-03-05 2021-07-16 天津理工大学 Preparation method of benzothiadiazine-1, 1-dioxide compound
WO2024141660A2 (en) * 2022-12-30 2024-07-04 Aexon Labs. Inc. Dihydro-quinazoline, -benzothiazine and -benzoxazine derivatives and use thereof as orexin receptors agonists for treating or preventing neurological diseases

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3275625A (en) * 1966-09-27 Derivatives of
NL296964A (en) *
FR1217929A (en) * 1958-03-03 1960-05-06 Ciba Geigy Process for the preparation of 6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide and its salts
GB863474A (en) * 1958-08-13 1961-03-22 Knud Abildgaard Benzothiadiazine derivatives and their preparation
DE1125938B (en) * 1960-02-12 1962-03-22 Thomae Gmbh Dr K Process for the preparation of 7-sulfamyl-3, 4-dihydro-1, 2, 4-benzothiadiazine-1, 1-dioxydes
GB946864A (en) * 1960-05-06 1964-01-15 Knud Abildgaard Method for the production of 3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxides
US3419552A (en) * 1961-04-12 1968-12-31 Lilly Co Eli Preparation of substituted dihydrobenzothiadiazine-1,1-dioxides
CH475269A (en) * 1962-04-19 1969-07-15 Hans Voigt Chem Pharm Fabrik D Process for the preparation of 7-sulfonamido-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxydes
US3351595A (en) * 1962-12-07 1967-11-07 Ciba Geigy Corp Derivatives of 3, 4-dihydro-2h-1, 2, 4-benzothiadiazine-1, 1-dioxide
US3311620A (en) * 1963-05-31 1967-03-28 Stanley C Bell Fused ring benzothiadiazines
US3277086A (en) * 1964-07-07 1966-10-04 American Home Prod 1, 2, 4-benzothiadiazine 1, 1-dioxides having a heterocyclic ring fused to the "b" face thereof
US4184039A (en) * 1977-12-01 1980-01-15 Paul Finkelstein Benzothiadiazine 1, 1-dioxides
EP0636124A1 (en) * 1992-04-15 1995-02-01 Aventis Pharma S.A. 3,4-dihydro-2h-1,2,4-benzothiadiazine-1,1-dioxide-3-carboxylic acid derivatives, preparation thereof and drugs containing same
US5488049A (en) * 1993-12-10 1996-01-30 Fidia - Georgetown Institute For The Neuro-Sciences Method of treating learning and memory disorders using benzothiadiazide derivatives as nootropic agents
FR2722502B1 (en) * 1994-07-12 1996-08-23 Adir NOVEL BENZOTHIADIAZINE DERIVATIVE, ITS PREPARATION METHOD AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
WO1997026884A1 (en) * 1996-01-29 1997-07-31 The Regents Of The University Of California Method for treating sexual dysfunctions
AU4345297A (en) * 1996-09-17 1998-04-14 Regents Of The University Of California, The Benzothiadiazide derivatives and their use as allosteric up-modulators of the ampa receptor

Also Published As

Publication number Publication date
EP1071426A2 (en) 2001-01-31
CN1293665A (en) 2001-05-02
IL137720A0 (en) 2001-10-31
NZ506251A (en) 2003-01-31
TR200002427T2 (en) 2001-01-22
AU751384B2 (en) 2002-08-15
SK11892000A3 (en) 2001-02-12
PL342843A1 (en) 2001-07-16
IS5581A (en) 2000-08-04
JP2002504481A (en) 2002-02-12
WO1999042456A3 (en) 1999-10-07
ZA991301B (en) 1999-09-13
RU2214405C2 (en) 2003-10-20
HUP0101280A2 (en) 2001-10-28
WO1999042456A2 (en) 1999-08-26
AU2512399A (en) 1999-09-06
EE200000468A (en) 2002-04-15
HUP0101280A3 (en) 2003-02-28
NO20004121D0 (en) 2000-08-17
CA2320354A1 (en) 1999-08-26

Similar Documents

Publication Publication Date Title
NO20025821L (en) 2-aminocarbonyl-9H-purine
NO20005714L (en) Novel substituted cyclic compounds, process for their preparation and pharmaceutical compositions containing them
MY119150A (en) Azetidine derivatives, their preparation and medicaments containing them
WO1999042456A3 (en) Novel compounds and their use as positive ampa receptor modulators
WO1999033858A3 (en) Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use
IS6257A (en) Cell adhesion blocks
PL325425A1 (en) Novel 4-(oxyalkoxyphenyl)-3-oxy piperisiden for treating cardiac and recal insufficiency
PT923554E (en) N-BENZYLPIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES
NO994671L (en) Aryl or heteroarylsulfonamide-substituted hydroxamic acid derivatives, process for their preparation and their use as pharmaceuticals
AU2605784A (en) N-aromatic-n:-cycloalkylalkanoyl-piperazines
NO883487D0 (en) PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE HETEROCYCLIC COMPOUNDS.
DK0567271T3 (en) Steroid derivatives for the treatment of prostate hypertrophy, method of preparation thereof and applications thereof
NO20000722L (en) 2- (4-aryl or heteroaryl-piperazin-1-ylmethyl) -1H-indole derivatives
NO953763L (en) Heterocycle-containing amidine derivatives, their preparation and use
YU49486B (en) Processes and intermediates for preparing 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl) methylpiperidine
NO983178L (en) Use of 3,4-diphenylchromanes in the preparation of a pharmaceutical composition for the treatment or prophylaxis of menopausal symptoms
NO304885B1 (en) Nipectoin acid derivatives as antithrombotic compounds
NO970123L (en) New chemical compound, its preparation and use as a drug
ES2152563T3 (en) PROCEDURE TO PREPARE DERIVATIVES OF DIHYDROXIPIRIMIDINE.
NO981393L (en) Guanidinoproteasehemmere
NO971142L (en) Bis- (2-haloethyl) aminophenyl-substituted distamycin derivatives as antitumor and antiviral agents
NO932431L (en) PROCEDURE AND INTERMEDIATES FOR THE MANUFACTURE OF AZABICYCLO (2,2,2) OCTAN-3-IMINES
NO20023251L (en) New tetrahydropyridines, processes for their preparation and pharmaceutical compositions containing the same
NO990914L (en) Amorphous benzothiophenes, methods of preparation and methods of use
NO933837L (en) 4-aryl-3- (heteroarylureido) quinoline derivatives