NO20004357L - FremgangsmÕte ved fremstilling av simvastatin samt derivater derav - Google Patents

FremgangsmÕte ved fremstilling av simvastatin samt derivater derav

Info

Publication number: NO20004357L
Authority: NO; Norway
Prior art keywords: compound; formula; iii; general formula; agent
Prior art date: 1998-03-05

Application number

NO20004357A

Other languages

English (en)

Other versions

NO321444B1 (no

NO20004357D0 (no

Inventor

Frans Van Dalen

Jacobus Maria Lemmens

Gertruda Antonetta Ph Helvoirt

Theodorus Hendricus Ant Peters

Frantisek Picha

Original Assignee

Synthon Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-03-05

Filing date

2000-09-01

Publication date

2000-11-06

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26150393&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20004357(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1998-05-27 Priority claimed from EP98201762A external-priority patent/EP0940395A1/en

2000-09-01 Application filed by Synthon Bv filed Critical Synthon Bv

2000-09-01 Publication of NO20004357D0 publication Critical patent/NO20004357D0/no

2000-11-06 Publication of NO20004357L publication Critical patent/NO20004357L/no

2006-05-08 Publication of NO321444B1 publication Critical patent/NO321444B1/no

Links

238000000034 method Methods 0.000 title abstract 2
RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 title 1
RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 title 1
229960002855 simvastatin Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 13
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
239000003223 protective agent Substances 0.000 abstract 2
230000009257 reactivity Effects 0.000 abstract 2
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
229940100198 alkylating agent Drugs 0.000 abstract 1
239000002168 alkylating agent Substances 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000003301 hydrolyzing effect Effects 0.000 abstract 1
239000011630 iodine Substances 0.000 abstract 1
229910052740 iodine Inorganic materials 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1
238000007142 ring opening reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being unsaturated and containing rings other than six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
- C07C2602/28—Hydrogenated naphthalenes
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pyrane Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Steroid Compounds (AREA)

NO20004357A 1998-03-05 2000-09-01 Fremgangsmate ved fremstilling av simvastatin-derivater samt intermediater egnet for fremstillingen. NO321444B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
NL1008502		1998-03-05
EP98201762A EP0940395A1 (en)	1998-03-05	1998-05-27	Process for producing simvastatin and/or its derivatives
PCT/NL1999/000119 WO1999045003A1 (en)	1998-03-05	1999-03-05	Process for producing simvastatin and/or its derivatives

Publications (3)

Publication Number	Publication Date
NO20004357D0 NO20004357D0 (no)	2000-09-01
NO20004357L true NO20004357L (no)	2000-11-06
NO321444B1 NO321444B1 (no)	2006-05-08

Family

ID=26150393

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO991045A NO991045L (no)	1998-03-05	1999-03-03	FremgangsmÕte ved fremstilling av simvastatin og/eller dets derivater
NO20004357A NO321444B1 (no)	1998-03-05	2000-09-01	Fremgangsmate ved fremstilling av simvastatin-derivater samt intermediater egnet for fremstillingen.

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
NO991045A NO991045L (no)	1998-03-05	1999-03-03	FremgangsmÕte ved fremstilling av simvastatin og/eller dets derivater

Country Status (14)

Country	Link
EP (1)	EP1064275B2 (no)
JP (1)	JP2002505327A (no)
CN (2)	CN1232030A (no)
AT (1)	ATE227280T1 (no)
AU (1)	AU759878B2 (no)
CA (1)	CA2321676A1 (no)
DE (1)	DE69903799T3 (no)
DK (1)	DK1064275T4 (no)
ES (1)	ES2182493T5 (no)
IL (1)	IL138119A (no)
NO (2)	NO991045L (no)
PT (1)	PT1064275E (no)
SI (1)	SI1064275T2 (no)
WO (1)	WO1999045003A1 (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CZ2003554A3 (cs) *	2000-07-27	2003-08-13	Plus Chemicals, B. V.	Vysoce přečištěný simvastatin
CN1277826C (zh) *	2003-12-01	2006-10-04	叶红平	辉伐他汀及其合成方法和以辉伐他汀为原料药的制剂
EP2024341B1 (en)	2006-05-03	2015-12-02	MSN Laboratories Private Limited	Novel process for statins and its pharmaceutically acceptable salts thereof
US8404841B2 (en)	2006-10-09	2013-03-26	Msn Laboratories Limited	Process for the preparation of statins and their pharmaceutically acceptable salts thereof
CN101289440B (zh) *	2007-06-29	2010-08-25	中国热带农业科学院热带生物技术研究所	一种多烯大环类化合物及其制备方法与应用
WO2010089770A2 (en)	2009-01-19	2010-08-12	Msn Laboratories Limited	Improved process for the preparation of highly pure (3r,5s)-7-[2-cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl]-3,5-dihydroxy-6(e)-heptenoic acid and pharmaceutically acceptable salts thereof
CN102574896B (zh)	2009-09-30	2015-04-08	科德克希思公司	变异LovD多肽及其用途
CN102695792B (zh)	2009-10-08	2015-02-18	加利福尼亚大学董事会	对辛伐他汀合成表现出改善性质的LovD突变体
US8987444B2 (en)	2010-01-18	2015-03-24	Msn Laboratories Private Limited	Process for the preparation of amide intermediates and their use thereof
HU229260B1 (en) *	2010-11-29	2013-10-28	Egis Gyogyszergyar Nyrt	Process for preparation of rosuvastatin salts
CN105147659A (zh) *	2013-12-24	2015-12-16	深圳华润九新药业有限公司	一种洛伐他汀羟基酸化物的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4820850A (en) *	1987-07-10	1989-04-11	Merck & Co., Inc.	Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
US5393893A (en) †	1993-11-08	1995-02-28	Apotex, Inc.	Process for producing simvastatin and analogs thereof
US5763646A (en) †	1997-03-13	1998-06-09	Ranbaxy Laboratories, Ltd.	Process for manufacturing simvastatin from lovastatin or mevinolinic acid
ES2266671T3 (es) *	1997-01-28	2007-03-01	Plus Chemicals B.V.	Proceso para la produccion de estatinas semisinteticas a traves de nuevos intermediarios.

1999
- 1999-03-03 NO NO991045A patent/NO991045L/no not_active Application Discontinuation
- 1999-03-05 CA CA002321676A patent/CA2321676A1/en not_active Abandoned
- 1999-03-05 ES ES99909407T patent/ES2182493T5/es not_active Expired - Lifetime
- 1999-03-05 DE DE69903799T patent/DE69903799T3/de not_active Expired - Fee Related
- 1999-03-05 WO PCT/NL1999/000119 patent/WO1999045003A1/en not_active Ceased
- 1999-03-05 CN CN99103408A patent/CN1232030A/zh active Pending
- 1999-03-05 DK DK99909407T patent/DK1064275T4/da active
- 1999-03-05 JP JP2000534546A patent/JP2002505327A/ja active Pending
- 1999-03-05 SI SI9930186T patent/SI1064275T2/sl unknown
- 1999-03-05 PT PT99909407T patent/PT1064275E/pt unknown
- 1999-03-05 AT AT99909407T patent/ATE227280T1/de not_active IP Right Cessation
- 1999-03-05 EP EP99909407A patent/EP1064275B2/en not_active Expired - Lifetime
- 1999-03-05 AU AU28612/99A patent/AU759878B2/en not_active Ceased
- 1999-03-05 IL IL13811999A patent/IL138119A/en not_active IP Right Cessation
- 1999-03-05 CN CN998036927A patent/CN1292786A/zh active Pending
2000
- 2000-09-01 NO NO20004357A patent/NO321444B1/no unknown

Also Published As

Publication number	Publication date
PT1064275E (pt)	2003-03-31
DE69903799T3 (de)	2006-11-16
DK1064275T3 (da)	2003-01-27
SI1064275T2 (sl)	2006-08-31
NO991045D0 (no)	1999-03-03
ATE227280T1 (de)	2002-11-15
CN1292786A (zh)	2001-04-25
NO991045L (no)	1999-09-06
SI1064275T1 (en)	2003-04-30
DK1064275T4 (da)	2006-05-29
NO321444B1 (no)	2006-05-08
CA2321676A1 (en)	1999-09-10
WO1999045003A1 (en)	1999-09-10
AU759878B2 (en)	2003-05-01
DE69903799T2 (de)	2003-09-04
AU2861299A (en)	1999-09-20
IL138119A (en)	2004-05-12
EP1064275B1 (en)	2002-11-06
EP1064275B2 (en)	2006-04-19
ES2182493T5 (es)	2006-11-16
CN1232030A (zh)	1999-10-20
EP1064275A1 (en)	2001-01-03
ES2182493T3 (es)	2003-03-01
IL138119A0 (en)	2001-10-31
NO20004357D0 (no)	2000-09-01
JP2002505327A (ja)	2002-02-19
DE69903799D1 (de)	2002-12-12

Publication	Publication Date	Title
FI940788A0 (fi)	1994-02-18	Alkoholi- tai aldehydijohdannaiset ja niiden käyttö
CA2264824A1 (en)	1999-01-14	A process for preparing 2-amino malonic acid derivatives and 2-amino-1,3-propanediol derivatives, and intermediates for preparing the same
NZ513164A (en)	2006-03-31	Substituted porphyrins
NO20004357L (no)	2000-11-06	FremgangsmÕte ved fremstilling av simvastatin samt derivater derav
KR950702206A (ko)	1995-06-19	감미제로 유용한 신규 화합물과 그 제조방법(compounds useful as sweetening agents and process for their preparation)
BR9808330A (pt)	2000-05-16	Sìntese de 2-alcoxiestradióis e composto de estradiol
FI864527L (fi)	1986-11-07	Tricyklofoereningar, foerfarande foer deras framstaellning och dessa innehaollande farmaceutiska blandning.
ES2112870T3 (es)	1998-04-16	Derivados de acido glicirretico.
IE821872L (en)	1983-02-05	Amine derivatives.
TW358806B (en)	1999-05-21	Process for the preparation of an alkylimidazolidone (meth)acrylate
ES2001094A6 (es)	1988-04-16	Un procedimiento para la preparacion de un derivado de guanina
KR840004746A (ko)	1984-10-24	2-옥소-1-아제티딘술폰산 유도체의 제조방법
ES2001953A6 (es)	1988-07-01	Procedimiento para la obtencion de compuestos de b -lactama.
CA2291133A1 (en)	2001-04-25	Method for the preparation of citalopram
GB1495305A (en)	1977-12-14	3-phenyl-4-oxo-4h-benzopyran derivatives
AU1399092A (en)	1992-10-08	Benzothiazole derivative
CA2377233A1 (en)	2001-01-04	Intermediates for the synthesis of benzimidazole compounds and process for the preparation thereof
JPS55147257A (en)	1980-11-17	Pyroglutamic acid derivative, its preparation and pharmaceutical composition containing it as effective component
JPS5484591A (en)	1979-07-05	Preparation of cephalosporin compound
MX9704258A (es)	1998-07-31	Procedimiento para la preparacion de derivados del cefemo e isooxacefemo.
JPS5481292A (en)	1979-06-28	Preparation of cephalosporin compound
ES8604396A1 (es)	1986-02-01	Procedimiento para la preparacion de esteres del acido-14,15-dihidro-14 b-hidroxi-(3x,16x)-eburnamenina-14-carboxilico
ES468924A2 (es)	1978-12-16	Procedimiento de obtencion de un nuevo compuesto fenoxilado.
JPS5742664A (en)	1982-03-10	Alpha-substituted ureidophenylacetic acid derivative
JPS5620583A (en)	1981-02-26	Synthesis of 3-alkyl-2-methyldihydro-4h-1,3-thiazinium salt