NO20004601L - A system for confocal microscopy imaging - Google Patents

A system for confocal microscopy imaging

Info

Publication number
NO20004601L
NO20004601L NO20004601A NO20004601A NO20004601L NO 20004601 L NO20004601 L NO 20004601L NO 20004601 A NO20004601 A NO 20004601A NO 20004601 A NO20004601 A NO 20004601A NO 20004601 L NO20004601 L NO 20004601L
Authority
NO
Norway
Prior art keywords
confocal microscopy
microscopy imaging
ccd
designed
imaging system
Prior art date
Application number
NO20004601A
Other languages
Norwegian (no)
Other versions
NO20004601D0 (en
Inventor
Jay K Trautman
Timothy D Harris
Richard L Hansen
William Karsh
Neal A Nicklaus
Original Assignee
Praelux Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Praelux Inc filed Critical Praelux Inc
Publication of NO20004601D0 publication Critical patent/NO20004601D0/en
Publication of NO20004601L publication Critical patent/NO20004601L/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5002—Partitioning blood components
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0028—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders specially adapted for specific applications, e.g. for endoscopes, ophthalmoscopes, attachments to conventional microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/006—Optical details of the image generation focusing arrangements; selection of the plane to be imaged
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0064—Optical details of the image generation multi-spectral or wavelength-selective arrangements, e.g. wavelength fan-out, chromatic profiling
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0072—Optical details of the image generation details concerning resolution or correction, including general design of CSOM objectives
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/008—Details of detection or image processing, including general computer control
    • G02B21/0084—Details of detection or image processing, including general computer control time-scale detection, e.g. strobed, ultra-fast, heterodyne detection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy

Landscapes

  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Microscoopes, Condenser (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Et konfokalt avbildningssystem som bruker en linjeformet strålebunt. Spesifikke realiseringer er innrettet for apparatur med lysfølsomme kretser (CCD, charge coupled devices) og slike hvor apparaturen brukes til observasjon av fluorescerende gjenstander.A confocal imaging system that uses a linear beam. Specific realizations are designed for apparatus with light-sensitive circuits (CCD, charge coupled devices) and such where the apparatus is used for observing fluorescent objects.

NO20004601A 1998-03-16 2000-09-15 A system for confocal microscopy imaging NO20004601L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4252798A 1998-03-16 1998-03-16
PCT/US1999/005589 WO1999047963A1 (en) 1998-03-16 1999-03-16 Confocal microscopy imaging system

Publications (2)

Publication Number Publication Date
NO20004601D0 NO20004601D0 (en) 2000-09-15
NO20004601L true NO20004601L (en) 2000-11-10

Family

ID=21922413

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20004601A NO20004601L (en) 1998-03-16 2000-09-15 A system for confocal microscopy imaging

Country Status (10)

Country Link
EP (1) EP1064579A4 (en)
JP (1) JP4812937B2 (en)
KR (2) KR100618502B1 (en)
CN (1) CN100380160C (en)
AU (1) AU758571B2 (en)
BR (1) BR9908767B1 (en)
CA (1) CA2324262C (en)
IL (2) IL138496A0 (en)
NO (1) NO20004601L (en)
WO (1) WO1999047963A1 (en)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5876946A (en) * 1997-06-03 1999-03-02 Pharmacopeia, Inc. High-throughput assay
US20030036855A1 (en) 1998-03-16 2003-02-20 Praelux Incorporated, A Corporation Of New Jersey Method and apparatus for screening chemical compounds
GB2338568B (en) * 1998-06-19 2000-12-20 Optiscan Pty Ltd Two photon endoscope or microscope method and apparatus
US6690463B2 (en) * 2000-02-10 2004-02-10 Evotec Biosystems Ag Fluorescence intensity and lifetime distribution analysis
CA2426798C (en) * 2000-10-27 2012-02-21 Praelux Incorporated Method and apparatus for screening chemical compounds
FR2820828B1 (en) * 2001-02-09 2003-05-02 Commissariat Energie Atomique SAMPLE OBSERVATION DEVICE BY FLUORESCENCE, IN PARTICULAR SEQUENTIALLY
DE10117723A1 (en) * 2001-04-09 2002-10-17 Evotec Ag Carrier for biological or synthetic samples has a sample holding plate with reservoirs and a dosing plate with projections, fitted with membranes, of an optically transparent material with trouble-free light beam transparency
US7219016B2 (en) 2001-04-20 2007-05-15 Yale University Systems and methods for automated analysis of cells and tissues
DE10122607B4 (en) * 2001-05-10 2006-11-30 Leica Microsystems Cms Gmbh Method and arrangement for direct Fourier imaging of samples
DE10157511A1 (en) * 2001-11-23 2003-06-12 Evotec Ag Method and device for correcting the size and / or shape of a measurement volume in a chemical and / or biological sample
JP2003177131A (en) * 2001-12-11 2003-06-27 Olympus Optical Co Ltd Method for detecting biological bonding affinity
GB0211068D0 (en) * 2002-05-14 2002-06-26 Amersham Biosciences Uk Ltd Method for assessing biofilms
GB0211072D0 (en) * 2002-05-15 2002-06-26 Amersham Biosciences Uk Ltd Reagent and method for the determination of changes in a cellular morphological parameter
US9157860B2 (en) 2002-05-16 2015-10-13 Applied Biosystems, Llc Achromatic lens array
US6982166B2 (en) 2002-05-16 2006-01-03 Applera Corporation Lens assembly for biological testing
DE102004014048B4 (en) * 2004-03-19 2008-10-30 Sirona Dental Systems Gmbh Measuring device and method according to the basic principle of confocal microscopy
US7170675B2 (en) 2004-05-19 2007-01-30 Celloptic, Inc. Method and system for wide-field multi-photon microscopy having a confocal excitation plane
DE102004034970A1 (en) * 2004-07-16 2006-02-02 Carl Zeiss Jena Gmbh Scanning microscope and use
CN101031837B (en) * 2004-07-23 2011-06-15 通用电气医疗集团尼亚加拉有限公司 Method and apparatus for fluorescent confocal microscopy
CN1310023C (en) * 2004-11-10 2007-04-11 哈尔滨工业大学 Three-differential focasing micro-three-dimensional super-resolution imaging method
GB0427050D0 (en) * 2004-12-10 2005-01-12 Amersham Biosciences Uk Ltd Method of,and apparatus and computer software for,imaging biological objects
DE202005010588U1 (en) * 2005-07-04 2005-10-13 Weiss Umwelttechnik Gmbh Simulationsanlagen-Messtechnik Testing chamber for photostability of pharmaceuticals and cosmetics in storage, includes mechanical filter promoting uniform illumination of samples
US7329860B2 (en) 2005-11-23 2008-02-12 Illumina, Inc. Confocal imaging methods and apparatus
KR100737170B1 (en) * 2006-01-20 2007-07-10 경북대학교 산학협력단 Mobile fluorescence measuring device using quantum dot phosphor
US7567346B2 (en) * 2006-03-01 2009-07-28 General Electric Company System and method for multimode imaging
WO2007130677A2 (en) 2006-05-05 2007-11-15 Yale University Use of subcellular localization profiles as prognostic or predictive indicators
CA2657324A1 (en) 2006-07-13 2008-01-17 Yale University Methods for making cancer prognoses based on subcellular localization of biomarkers
US7838302B2 (en) 2006-08-07 2010-11-23 President And Fellows Of Harvard College Sub-diffraction limit image resolution and other imaging techniques
GB0625775D0 (en) * 2006-12-22 2007-02-07 Isis Innovation Focusing apparatus and method
JP4957458B2 (en) * 2007-08-27 2012-06-20 株式会社Ｊｖｃケンウッド Voice coil and speaker
WO2009048142A1 (en) * 2007-10-11 2009-04-16 Nikon Corporation Observing device
WO2009085218A1 (en) * 2007-12-21 2009-07-09 President And Fellows Of Harvard College Sub-diffraction limit image resolution in three dimensions
WO2009115108A1 (en) * 2008-03-19 2009-09-24 Ruprecht-Karls-Universität Heidelberg A method and an apparatus for localization of single dye molecules in the fluorescent microscopy
KR101532611B1 (en) * 2009-04-28 2015-07-01 삼성전자주식회사 Digital image processing apparatus and method showing zooming shot effect
EP2543989A4 (en) * 2010-03-01 2017-11-01 Olympus Corporation Optical analysis device, optical analysis method, and computer program for optical analysis
US8692708B2 (en) * 2010-03-30 2014-04-08 Sony Corporation Radiometric imaging device and corresponding method
US8767069B2 (en) * 2010-06-30 2014-07-01 Luminex Corporation Apparatus, system, and method for increasing measurement accuracy in a particle imaging device using light distribution
WO2012014778A1 (en) 2010-07-26 2012-02-02 オリンパス株式会社 Method for detecting dilute particles in solution using luminescent probe
WO2012032955A1 (en) 2010-09-10 2012-03-15 オリンパス株式会社 Optical analysis method using optical measurement in multiple wavelength bands
EP2602613B1 (en) 2010-09-10 2017-02-22 Olympus Corporation Optical analysis method using optical intensity of single light-emitting particle
JP5914341B2 (en) * 2010-09-21 2016-05-11 オリンパス株式会社 Optical analysis method using single luminescent particle detection
JP5737704B2 (en) * 2010-09-27 2015-06-17 株式会社ライフテック Fluorescent single particle detection method and detection system
JP5904947B2 (en) * 2010-10-13 2016-04-20 オリンパス株式会社 Method for measuring particle diffusion characteristics using single luminescent particle detection
EP2620763A4 (en) 2010-10-19 2015-05-27 Olympus Corp Optical analysis device for observing polarisation characteristics of single light-emitting particle, optical analysis method and optical analysis computer program therefor
EP2631631B1 (en) 2010-11-25 2016-01-20 Olympus Corporation Photometric analysis device and photometric analysis method using wavelength characteristic of light emitted from single illuminant particle
EP2667183A4 (en) 2011-01-20 2017-05-10 Olympus Corporation Photoanalysis method and photoanalysis device using detection of light from single light-emitting particle
WO2012102260A1 (en) 2011-01-26 2012-08-02 オリンパス株式会社 Method for identifying polymorphism of nucleic acid molecule
EP2669376B1 (en) 2011-01-26 2017-08-16 Olympus Corporation Method for identifying polymorphism of nucleic acid molecules
JP6033798B2 (en) * 2011-03-01 2016-11-30 ジーイー・ヘルスケア・バイオサイエンス・コーポレイション System and method for illumination phase control in fluorescence microscopy
CN103460026B (en) 2011-03-29 2015-06-10 奥林巴斯株式会社 Photometric analysis device, photometric analysis method, and computer program for photometric analysis, using single light-emitting particle detection
JP5885738B2 (en) 2011-04-13 2016-03-15 オリンパス株式会社 Optical analysis apparatus using single luminescent particle detection, optical analysis method, and computer program for optical analysis
JP6013328B2 (en) 2011-04-18 2016-10-25 オリンパス株式会社 Target particle quantification method
JP6013335B2 (en) 2011-08-11 2016-10-25 オリンパス株式会社 Target particle counting method
JP6013337B2 (en) 2011-08-15 2016-10-25 オリンパス株式会社 Optical analysis apparatus using single luminescent particle detection, optical analysis method, and computer program for optical analysis
CN103765196B (en) 2011-08-26 2016-03-02 奥林巴斯株式会社 The light analytical equipment utilizing single incandescnet particle to detect and light analytical approach
CN103765195B (en) 2011-08-26 2018-06-01 奥林巴斯株式会社 Single particle detection device using optical analysis, single particle detection method, and computer program for single particle detection
EP2752654A4 (en) 2011-08-30 2015-04-15 Olympus Corp Optical analyzer using single light-emitting particle detection, optical analysis method, and computer program for optical analysis
CN103765194B (en) 2011-08-30 2016-02-17 奥林巴斯株式会社 Detection methods of target particles
WO2013035009A1 (en) * 2011-09-06 2013-03-14 Koninklijke Philips Electronics N.V. Optical biosensor with a plurality of sensors regions
JP5941923B2 (en) 2011-11-10 2016-06-29 オリンパス株式会社 Optical analysis apparatus using single luminescent particle detection, optical analysis method, and computer program for optical analysis
DE102011087196A1 (en) * 2011-11-28 2013-05-29 Leica Microsystems Cms Gmbh Microscope illumination system and method
WO2013121905A1 (en) 2012-02-17 2013-08-22 オリンパス株式会社 Optical analysis device using single particle detection technique, optical analysis method and computer program for optical analysis
CN104115003B (en) 2012-02-22 2016-03-23 奥林巴斯株式会社 The detection method of intended particle
CH706326A2 (en) * 2012-03-14 2013-09-30 Tecan Trading Ag Procedures and microplate readers for study of biological cells or cell cultures.
WO2013140890A1 (en) 2012-03-21 2013-09-26 オリンパス株式会社 Method for detecting target nucleic acid molecule
JP5940651B2 (en) 2012-04-18 2016-06-29 オリンパス株式会社 Target particle detection method
CN104246479B (en) 2012-04-18 2016-10-19 奥林巴斯株式会社 Single particle detection device using optical analysis, single particle detection method, and computer program for single particle detection
CN102841083B (en) * 2012-06-11 2014-08-20 北京大学 Method and system of laser scanning phase-microscope imaging
US8654352B1 (en) * 2012-08-08 2014-02-18 Asm Technology Singapore Pte Ltd Chromatic confocal scanning apparatus
CN104155279B (en) * 2013-05-13 2017-04-26 中国科学院大连化学物理研究所 Linear confocal ultraviolet Raman spectrometer
WO2015015951A1 (en) 2013-07-31 2015-02-05 オリンパス株式会社 Optical microscope device, microscopy method, and computer program for microscopy using single-light-emitting-particle detection technology
WO2015052965A1 (en) 2013-10-07 2015-04-16 オリンパス株式会社 Photometric analysis device employing single light-emitting particle detection, photometric analysis method, and computer program for photometric analysis
CN106662530A (en) * 2014-09-05 2017-05-10 特莫费希尔科学公司 Method and apparatus for optical measurement of liquid sample
CN104296684B (en) * 2014-11-05 2016-11-30 哈尔滨工业大学 Film thickness error bearing calibration based on surface coating confocal microscopy topography measurement device
GB2534402A (en) * 2015-01-22 2016-07-27 Idea Biomedical Ltd Auto-focussing method and device
CN104677884B (en) * 2015-03-17 2017-07-11 北京理工大学 High-space resolution laser light splitting pupil differential confocal mass spectrum micro imaging method and device
CN104697452A (en) * 2015-03-24 2015-06-10 宁波高新区零零七工业设计有限公司 Laser imaging system
US9599807B2 (en) * 2015-06-30 2017-03-21 General Electric Company Optical microscope and method for detecting lens immersion
WO2017098597A1 (en) 2015-12-09 2017-06-15 オリンパス株式会社 Optical analysis method and optical analysis device employing single light-emitting particle detection
LU93022B1 (en) * 2016-04-08 2017-11-08 Leica Microsystems Method and microscope for examining a sample
CN108061964B (en) * 2017-10-25 2020-03-27 中国科学技术大学 High-speed three-dimensional microscopic imaging device and method for large sample
CN108319008B (en) * 2018-02-02 2019-11-12 华中科技大学 An optical microscopic imaging method and device
CN108680542B (en) * 2018-03-26 2020-01-10 华中科技大学 Array type line scanning fluorescence microscopic imaging device
CN108445619A (en) * 2018-05-11 2018-08-24 中国工程物理研究院流体物理研究所 Optical scanning system and method
CN210155405U (en) * 2019-03-18 2020-03-17 苏州溢博伦光电仪器有限公司 A microscope objective containing a photodetector
EP4097634A1 (en) * 2020-01-31 2022-12-07 Stellenbosch University Method for determining mitochondrial events
CN111239047B (en) * 2020-03-09 2023-10-27 深圳中科飞测科技股份有限公司 Optical device and method for realizing automatic focusing
GB2593194B (en) * 2020-03-18 2022-09-07 Refeyn Ltd Methods and apparatus for optimised interferometric scattering microscopy
WO2022056385A1 (en) 2020-09-14 2022-03-17 Singular Genomics Systems, Inc. Methods and systems for multidimensional imaging
KR102447224B1 (en) * 2020-10-26 2022-09-27 한국생산기술연구원 Device for qualitative and quantitative analysis of fine particles
KR102766494B1 (en) * 2021-12-30 2025-02-12 한국광기술원 Holographic Microscope Including Holographic Image Sensor
CN114813706B (en) * 2022-06-29 2022-12-13 国科大杭州高等研究院 Blood cell hyperspectral optical tweezers capture energy resonance transfer analyzer

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63306413A (en) * 1987-06-09 1988-12-14 Olympus Optical Co Ltd Scanning type optical microscope
US4844617A (en) * 1988-01-20 1989-07-04 Tencor Instruments Confocal measuring microscope with automatic focusing
US5020891A (en) * 1988-09-14 1991-06-04 Washington University Single aperture confocal scanning biomicroscope and kit for converting single lamp biomicroscope thereto
US5034613A (en) * 1989-11-14 1991-07-23 Cornell Research Foundation, Inc. Two-photon laser microscopy
US5274240A (en) * 1990-01-12 1993-12-28 The Regents Of The University Of California Capillary array confocal fluorescence scanner and method
GB9015793D0 (en) * 1990-07-18 1990-09-05 Medical Res Council Confocal scanning optical microscope
JPH04221917A (en) * 1990-12-25 1992-08-12 Tamron Co Ltd Automatically focusing method and device for microscope
US5162641A (en) * 1991-02-19 1992-11-10 Phoenix Laser Systems, Inc. System and method for detecting, correcting and measuring depth movement of target tissue in a laser surgical system
US5784162A (en) * 1993-08-18 1998-07-21 Applied Spectral Imaging Ltd. Spectral bio-imaging methods for biological research, medical diagnostics and therapy
US5465147A (en) * 1991-04-29 1995-11-07 Massachusetts Institute Of Technology Method and apparatus for acquiring images using a ccd detector array and no transverse scanner
JPH05188301A (en) * 1991-09-09 1993-07-30 Sumitomo Electric Ind Ltd Laser microscope
JPH05332733A (en) * 1992-05-27 1993-12-14 Hitachi Ltd Detection optical system and three-dimensional shape detection method
JPH07128596A (en) * 1993-09-08 1995-05-19 Nikon Corp Confocal microscope
US5587832A (en) * 1993-10-20 1996-12-24 Biophysica Technologies, Inc. Spatially light modulated confocal microscope and method
JP3450406B2 (en) * 1994-03-10 2003-09-22 オリンパス光学工業株式会社 Position adjustment device for observation image and scanning optical microscope
JPH07281100A (en) * 1994-04-05 1995-10-27 Nikon Corp Clamp specimen for autofocus microscope
US5515864A (en) * 1994-04-21 1996-05-14 Zuckerman; Ralph Method and apparatus for the in vivo measurement of oxygen concentration levels by the indirect determination of fluoescence lifetime
US5981956A (en) * 1996-05-16 1999-11-09 Affymetrix, Inc. Systems and methods for detection of labeled materials
US5900949A (en) * 1996-05-23 1999-05-04 Hewlett-Packard Company CCD imager for confocal scanning microscopy
US5880465A (en) * 1996-05-31 1999-03-09 Kovex Corporation Scanning confocal microscope with oscillating objective lens
US5915048A (en) * 1996-06-05 1999-06-22 Zetetic Institute Method and apparatus for discriminating in-focus images from out-of-focus light signals from background and foreground light sources
JPH09329749A (en) * 1996-06-11 1997-12-22 Nikon Corp Optical scanning microscope
DE19627568A1 (en) * 1996-07-09 1998-01-15 Zeiss Carl Jena Gmbh Arrangement for confocal microscopy with top and lower carrier discs
DE19632594A1 (en) * 1996-08-13 1998-02-19 Johannes Prof Dr Schwider Confocal microscopy method using refractive microlens fields
US5760901A (en) * 1997-01-28 1998-06-02 Zetetic Institute Method and apparatus for confocal interference microscopy with background amplitude reduction and compensation
JP3816632B2 (en) * 1997-05-14 2006-08-30 オリンパス株式会社 Scanning microscope

Also Published As

Publication number Publication date
IL138496A0 (en) 2001-10-31
CA2324262A1 (en) 1999-09-23
BR9908767A (en) 2001-10-16
KR20010041945A (en) 2001-05-25
CN1301357A (en) 2001-06-27
KR100618502B1 (en) 2006-09-01
NO20004601D0 (en) 2000-09-15
KR100560588B1 (en) 2006-03-16
WO1999047963A9 (en) 1999-12-23
EP1064579A1 (en) 2001-01-03
JP2002507762A (en) 2002-03-12
JP4812937B2 (en) 2011-11-09
EP1064579A4 (en) 2007-11-07
AU3354799A (en) 1999-10-11
AU758571B2 (en) 2003-03-27
BR9908767B1 (en) 2011-09-06
CN100380160C (en) 2008-04-09
KR20050088500A (en) 2005-09-06
IL164319A0 (en) 2005-12-18
CA2324262C (en) 2010-05-25
WO1999047963A8 (en) 1999-11-18
WO1999047963A1 (en) 1999-09-23

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