NO20005293L - Certain thiolin inhibitors of endothelin converting enzyme - Google Patents

Certain thiolin inhibitors of endothelin converting enzyme

Info

Publication number
NO20005293L
NO20005293L NO20005293A NO20005293A NO20005293L NO 20005293 L NO20005293 L NO 20005293L NO 20005293 A NO20005293 A NO 20005293A NO 20005293 A NO20005293 A NO 20005293A NO 20005293 L NO20005293 L NO 20005293L
Authority
NO
Norway
Prior art keywords
thiolin
inhibitors
certain
converting enzyme
endothelin converting
Prior art date
Application number
NO20005293A
Other languages
Norwegian (no)
Other versions
NO20005293D0 (en
Inventor
Stephane De Lombaert
Cynthia Anne Fink
Fariborz Firoozina
Denton Wade Hoyer
Acro Yingcheu Jeng
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO20005293D0 publication Critical patent/NO20005293D0/en
Publication of NO20005293L publication Critical patent/NO20005293L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hospice & Palliative Care (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
NO20005293A 1998-04-23 2000-10-20 Certain thiolin inhibitors of endothelin converting enzyme NO20005293L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6526598A 1998-04-23 1998-04-23
PCT/EP1999/002690 WO1999055726A1 (en) 1998-04-23 1999-04-21 Certain thiol inhibitors of endothelin-converting enzyme

Publications (2)

Publication Number Publication Date
NO20005293D0 NO20005293D0 (en) 2000-10-20
NO20005293L true NO20005293L (en) 2000-12-18

Family

ID=22061502

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20005293A NO20005293L (en) 1998-04-23 2000-10-20 Certain thiolin inhibitors of endothelin converting enzyme

Country Status (16)

Country Link
EP (1) EP1073674A1 (en)
JP (1) JP4350306B2 (en)
KR (1) KR20010034816A (en)
CN (1) CN1297453A (en)
AU (1) AU3819999A (en)
BR (1) BR9909805A (en)
CA (1) CA2323691A1 (en)
HU (1) HUP0101640A3 (en)
ID (1) ID26822A (en)
IL (1) IL138246A0 (en)
NO (1) NO20005293L (en)
PL (1) PL343594A1 (en)
RU (1) RU2000129510A (en)
SK (1) SK15812000A3 (en)
WO (1) WO1999055726A1 (en)
ZA (1) ZA200004680B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6426354B1 (en) 1998-04-23 2002-07-30 Novartis Ag Certain heteroaryl substituted thiol inhibitors of endothelin-converting enzyme
US6423727B1 (en) 1998-04-23 2002-07-23 Novartis Ag Certain thiol inhibitors of endothelin-converting enzyme
AU2001254776A1 (en) * 2000-04-06 2001-10-23 Novartis Ag Organic compounds
US6777443B2 (en) * 2001-05-15 2004-08-17 Novartis Ag Dipeptide derivatives
PT1430045E (en) * 2001-09-21 2007-01-31 Novartis Ag Pyrane derivatives as both ace- and nep-inhibitors
WO2003065789A2 (en) 2002-02-08 2003-08-14 Merck & Co., Inc. N-biphenylmethyl aminocycloalkanecarboxamide derivatives
US6919343B2 (en) 2002-02-08 2005-07-19 Merck & Co., Inc. N-biphenyl(substituted methyl) aminocycloalkane-carboxamide derivatives
EP1481967B1 (en) 2002-03-05 2011-05-04 Sumitomo Chemical Company, Limited Process for the preparation of biaryl compounds
EP1578418A2 (en) * 2002-12-20 2005-09-28 Bayer HealthCare AG Use of substituted 2,5-diamidoindoles for the treatment of urological diseases
US7427611B2 (en) 2003-09-26 2008-09-23 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl)-cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
US7452875B2 (en) 2003-09-26 2008-11-18 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
US7262184B2 (en) 2003-09-26 2007-08-28 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
PL1706121T3 (en) * 2004-01-12 2009-02-27 Turski Lechoslaw Neutral endopeptidase (nep) and human soluble endopeptidase (hsep) inhibitors for prophylaxis and treatment of neurodegenerative disorders
JP3975226B2 (en) 2006-01-11 2007-09-12 生化学工業株式会社 Cycloalkylcarbonylamino acid derivative and process for producing the same
JP4047365B2 (en) 2006-01-11 2008-02-13 生化学工業株式会社 Cycloalkanecarboxamide derivative and method for producing the same
EP2036920B1 (en) * 2006-01-11 2011-05-18 Seikagaku Corporation Cycloalkylcarbonylamino acid ester derivative and process for producing the same
CA2708281A1 (en) 2007-12-11 2009-08-27 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitors using metal binding moieties in combination with targeting moieties
CN104725279B (en) * 2015-02-12 2018-03-02 威海迪素制药有限公司 A kind of preparation method of N Boc biphenylalanine derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995012611A1 (en) * 1993-11-01 1995-05-11 Japat Ltd. Endothelin receptor antagonists
ES2148305T3 (en) * 1993-11-16 2000-10-16 Novartis Ag DERIVATIVES OF CYCLE AMINO ACIDS THAT HAVE ACE AND NEP INHIBITING ACTIVITY.
FR2745571B1 (en) * 1996-03-04 1998-06-19 Inst Nat Sante Rech Med NOVEL SULFUR DERIVATIVES COMPRISING AN AMIDE BINDING, THEIR PREPARATION PROCESS, THEIR USE AS MEDICAMENTS, AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Also Published As

Publication number Publication date
SK15812000A3 (en) 2001-03-12
JP4350306B2 (en) 2009-10-21
NO20005293D0 (en) 2000-10-20
HUP0101640A3 (en) 2002-10-28
KR20010034816A (en) 2001-04-25
BR9909805A (en) 2000-12-26
HUP0101640A2 (en) 2001-09-28
CA2323691A1 (en) 1999-11-04
JP2002513032A (en) 2002-05-08
PL343594A1 (en) 2001-08-27
ID26822A (en) 2001-02-15
EP1073674A1 (en) 2001-02-07
CN1297453A (en) 2001-05-30
AU3819999A (en) 1999-11-16
IL138246A0 (en) 2001-10-31
RU2000129510A (en) 2002-11-10
ZA200004680B (en) 2001-04-25
WO1999055726A1 (en) 1999-11-04

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application