NO20005452L - Matriser tildannet fra polymer- og hydrofobforbindelser for bruk i medikamentavlevering - Google Patents

Matriser tildannet fra polymer- og hydrofobforbindelser for bruk i medikamentavlevering

Info

Publication number
NO20005452L
NO20005452L NO20005452A NO20005452A NO20005452L NO 20005452 L NO20005452 L NO 20005452L NO 20005452 A NO20005452 A NO 20005452A NO 20005452 A NO20005452 A NO 20005452A NO 20005452 L NO20005452 L NO 20005452L
Authority
NO
Norway
Prior art keywords
drug
hydrophobic
matrix
integrated
drug delivery
Prior art date
Application number
NO20005452A
Other languages
English (en)
Other versions
NO324895B1 (no
NO20005452D0 (no
Inventor
Howard Bernstein
Donald Chickering
Sarwat Khattak
Julie Ann Straub
Original Assignee
Acusphere Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acusphere Inc filed Critical Acusphere Inc
Publication of NO20005452D0 publication Critical patent/NO20005452D0/no
Publication of NO20005452L publication Critical patent/NO20005452L/no
Publication of NO324895B1 publication Critical patent/NO324895B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Cephalosporin Compounds (AREA)
  • Steroid Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO20005452A 1998-04-30 2000-10-27 Poros polymermatriks tildannet fra polymer- og hydrofobforbindelser for bruk i medikamentavlevering, fremgangsmate for fremstilling av disse. NO324895B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8363698P 1998-04-30 1998-04-30
US09/255,179 US6423345B2 (en) 1998-04-30 1999-02-22 Matrices formed of polymer and hydrophobic compounds for use in drug delivery
PCT/US1999/005187 WO1999056731A1 (en) 1998-04-30 1999-03-08 Matrices formed of polymer and hydrophobic compounds for use in drug delivery

Publications (3)

Publication Number Publication Date
NO20005452D0 NO20005452D0 (no) 2000-10-27
NO20005452L true NO20005452L (no) 2000-12-29
NO324895B1 NO324895B1 (no) 2007-12-27

Family

ID=26769533

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20005452A NO324895B1 (no) 1998-04-30 2000-10-27 Poros polymermatriks tildannet fra polymer- og hydrofobforbindelser for bruk i medikamentavlevering, fremgangsmate for fremstilling av disse.

Country Status (19)

Country Link
US (5) US6423345B2 (no)
EP (1) EP1073422B1 (no)
JP (1) JP5153032B2 (no)
KR (1) KR100703051B1 (no)
CN (1) CN1201729C (no)
AT (1) ATE319433T1 (no)
AU (1) AU746696B2 (no)
BR (1) BR9910340A (no)
CA (1) CA2329875C (no)
DE (1) DE69930240T2 (no)
DK (1) DK1073422T3 (no)
ES (1) ES2259472T3 (no)
IL (2) IL139252A0 (no)
MX (1) MXPA00010566A (no)
NO (1) NO324895B1 (no)
NZ (1) NZ508470A (no)
PL (1) PL196159B1 (no)
PT (1) PT1073422E (no)
WO (1) WO1999056731A1 (no)

Families Citing this family (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743777B1 (en) * 1992-03-19 2004-06-01 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
US7208011B2 (en) * 2001-08-20 2007-04-24 Conor Medsystems, Inc. Implantable medical device with drug filled holes
US6241762B1 (en) 1998-03-30 2001-06-05 Conor Medsystems, Inc. Expandable medical device with ductile hinges
US7208010B2 (en) 2000-10-16 2007-04-24 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US6423345B2 (en) * 1998-04-30 2002-07-23 Acusphere, Inc. Matrices formed of polymer and hydrophobic compounds for use in drug delivery
US7022683B1 (en) 1998-05-13 2006-04-04 Carrington Laboratories, Inc. Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation
ES2325141T3 (es) * 1998-07-17 2009-08-26 Pacira Pharmaceuticals, Inc. Composiciones biodegradables para la liberacion controlada de sustancias encapsuladas.
CA2362016A1 (en) * 1999-03-03 2000-09-08 Kenneth Philip Moder Echinocandin/carbohydrate complexes
RU2250763C2 (ru) * 1999-03-03 2005-04-27 Эли Лилли Энд Компани Фармацевтические препараты эхинокандина, содержащие мицелообразующие поверхностно-активные вещества
EP1642572A1 (en) * 1999-05-27 2006-04-05 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
CN100376291C (zh) * 1999-05-27 2008-03-26 阿库斯菲尔公司 多孔药物基质及其制造方法
US7919119B2 (en) 1999-05-27 2011-04-05 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
CA2371836C (en) * 1999-05-27 2006-01-31 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
US6395300B1 (en) * 1999-05-27 2002-05-28 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
US6610317B2 (en) 1999-05-27 2003-08-26 Acusphere, Inc. Porous paclitaxel matrices and methods of manufacture thereof
WO2001049268A1 (en) * 2000-01-05 2001-07-12 Imarx Therapeutics, Inc. Pharmaceutical formulations for the delivery of drugs having low aqueous solubility
US20040009229A1 (en) * 2000-01-05 2004-01-15 Unger Evan Charles Stabilized nanoparticle formulations of camptotheca derivatives
US6589557B2 (en) * 2000-06-15 2003-07-08 Acusphere, Inc. Porous celecoxib matrices and methods of manufacture thereof
WO2002032398A2 (en) * 2000-10-16 2002-04-25 Massachusetts Institute Of Technology Lipid-protein-sugar particles for drug delivery
ATE300255T1 (de) 2000-10-16 2005-08-15 Conor Medsystems Inc Expandierbare medizinische vorrichtung zum zuführen eines heilmittels
US7494669B2 (en) * 2001-02-28 2009-02-24 Carrington Laboratories, Inc. Delivery of physiological agents with in-situ gels comprising anionic polysaccharides
US6777000B2 (en) * 2001-02-28 2004-08-17 Carrington Laboratories, Inc. In-situ gel formation of pectin
MXPA03011784A (es) * 2001-06-22 2004-04-02 Pfizer Prod Inc Composiciones farmaceuticas de dispersiones de farmacos y polimeros neutros.
US7842083B2 (en) 2001-08-20 2010-11-30 Innovational Holdings, Llc. Expandable medical device with improved spatial distribution
US7056338B2 (en) * 2003-03-28 2006-06-06 Conor Medsystems, Inc. Therapeutic agent delivery device with controlled therapeutic agent release rates
WO2003035051A2 (en) * 2001-10-19 2003-05-01 Inhale Therapeutic Systems, Inc. The use of proton sequestering agents in drug formulations
US9308220B2 (en) 2001-12-11 2016-04-12 Cosmo Technologies Limited Pharmaceutical compositions for the oral administration of heparin or derivatives thereof
ITMI20012599A1 (it) * 2001-12-11 2003-06-11 Cosmo Spa Composizioni farmaceutiche per la somministrazione orale di eparina osuoi derivati, utili per la terapia di malattie infiammatorie dell'int
JP4679822B2 (ja) * 2002-03-13 2011-05-11 ノバルティス アーゲー 医薬微粒子
AU2003218306B2 (en) * 2002-03-20 2006-09-14 Advanced Inhalation Research, Inc. Method for administration of growth hormone via pulmonary delivery
US7008644B2 (en) * 2002-03-20 2006-03-07 Advanced Inhalation Research, Inc. Method and apparatus for producing dry particles
US6991800B2 (en) * 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products
GB0222522D0 (en) 2002-09-27 2002-11-06 Controlled Therapeutics Sct Water-swellable polymers
WO2004030659A1 (en) * 2002-09-30 2004-04-15 Acusphere, Inc. Sustained release porous microparticles for inhalation
AU2003291470A1 (en) * 2002-11-08 2004-06-03 Innovational Holdings, Llc Expandable medical device and method for treating chronic total occlusions with local delivery of an angiogenic factor
GB0228571D0 (en) * 2002-12-06 2003-01-15 Novartis Ag Organic compounds
US6962006B2 (en) * 2002-12-19 2005-11-08 Acusphere, Inc. Methods and apparatus for making particles using spray dryer and in-line jet mill
US20040121003A1 (en) * 2002-12-19 2004-06-24 Acusphere, Inc. Methods for making pharmaceutical formulations comprising deagglomerated microparticles
US20040202692A1 (en) * 2003-03-28 2004-10-14 Conor Medsystems, Inc. Implantable medical device and method for in situ selective modulation of agent delivery
JP5596896B2 (ja) 2003-03-28 2014-09-24 イノヴェイショナル・ホールディングズ・エルエルシー 有益な薬剤の濃度勾配を有する、移植可能な医療装置の形成方法
ES2359977T3 (es) 2003-03-31 2011-05-30 Titan Pharmaceuticals, Inc. Dispositivo polimérico implantable para liberación sostenida de agonista de dopamina.
US20040247624A1 (en) * 2003-06-05 2004-12-09 Unger Evan Charles Methods of making pharmaceutical formulations for the delivery of drugs having low aqueous solubility
US7645474B1 (en) * 2003-07-31 2010-01-12 Advanced Cardiovascular Systems, Inc. Method and system of purifying polymers for use with implantable medical devices
US7785512B1 (en) 2003-07-31 2010-08-31 Advanced Cardiovascular Systems, Inc. Method and system of controlled temperature mixing and molding of polymers with active agents for implantable medical devices
US20050118262A1 (en) * 2003-09-17 2005-06-02 Jack Aurora Controlled release formulation
JP2007533634A (ja) * 2003-09-30 2007-11-22 アキュスフィア， インコーポレイテッド 注射、経口、または局所用の徐放性医薬製剤
KR100703872B1 (ko) * 2003-10-10 2007-04-09 주식회사 삼양사 양친성 블록 공중합체 및 이를 포함하는 약물 전달용고분자 조성물
US20050084455A1 (en) * 2003-10-16 2005-04-21 Council Of Scientific & Industrial Research Inhalable biodegradable microparticles for target-specific drug delivery in tuberculosis and a process thereof
US8157788B2 (en) * 2003-11-06 2012-04-17 Paolo L. Manfredi Multi-site drug delivery platform
US20050100577A1 (en) * 2003-11-10 2005-05-12 Parker Theodore L. Expandable medical device with beneficial agent matrix formed by a multi solvent system
MXPA06005913A (es) * 2003-12-04 2006-06-27 Pfizer Prod Inc Formas de dosificacion de multiparticulas de azitromicina por procedimientos basados en liquidos.
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
BRPI0417348A (pt) * 2003-12-04 2007-03-13 Pfizer Prod Inc processo de gelatinização por spray com utilização de uma extrusora para preparação de composições de droga cristalina multiparticulada contendo preferencialmente um poloxámero e um glicerìdeo
RU2331410C2 (ru) * 2003-12-04 2008-08-20 Пфайзер Продактс Инк. Способ получения фармацевтических мультичастиц
CA2547597A1 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate compositions with improved stability
WO2005053639A2 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Controlled release multiparticulates formed with dissolution enhancers
KR20050104152A (ko) 2004-04-28 2005-11-02 최승호 경구용 약물의 흡수를 증진하는 약제학적 조성물
US7446131B1 (en) 2004-06-10 2008-11-04 The United States Of America As Represented By The Secretary Of Agriculture Porous polymeric matrices made of natural polymers and synthetic polymers and optionally at least one cation and methods of making
WO2006012502A2 (en) * 2004-07-23 2006-02-02 Rigel Pharmaceuticals, Inc. Formulation of insoluble small molecule therapeutics in lipid-based carriers
GB0417401D0 (en) 2004-08-05 2004-09-08 Controlled Therapeutics Sct Stabilised prostaglandin composition
US7862835B2 (en) * 2004-10-27 2011-01-04 Boston Scientific Scimed, Inc. Method of manufacturing a medical device having a porous coating thereon
US8128952B2 (en) * 2005-01-12 2012-03-06 Clemson University Research Foundation Ligand-mediated controlled drug delivery
DE102005002703C5 (de) 2005-01-19 2013-07-04 Heraeus Kulzer Gmbh Antibiotische Beschichtung von Implantaten sowie Verfahren zur antibiotischen Beschichtung
EP1879552B1 (en) * 2005-03-14 2016-02-17 Biotegra, Inc. Drug delivery compositions comprising a polyelectrolyte complex within a polymeric matrix
US8246984B2 (en) * 2005-12-06 2012-08-21 Rigel Pharmaceuticals, Inc. Formulation of insoluble small molecule therapeutics in lipid-based carriers
EP1978933A2 (en) * 2005-12-15 2008-10-15 Acusphere, Inc. Processes for making particle-based pharmaceutical formulations for oral administration
US20070142287A1 (en) * 2005-12-20 2007-06-21 Biomed Solutions, Llc Compositions And Methods For Treatment Of Cancer
JP5214464B2 (ja) 2005-12-28 2013-06-19 アドバンスド バイオニュートリション コーポレーション 多糖類、糖類およびポリオール類の乾燥マトリックスを含む、ガラス形態の、プロバイオティクス細菌用送達媒体およびその製造方法
US8968721B2 (en) 2005-12-28 2015-03-03 Advanced Bionutrition Corporation Delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same
GB0613333D0 (en) 2006-07-05 2006-08-16 Controlled Therapeutics Sct Hydrophilic polyurethane compositions
US20100004124A1 (en) * 2006-12-05 2010-01-07 David Taft Systems and methods for delivery of materials for agriculture and aquaculture
US8956602B2 (en) * 2006-12-05 2015-02-17 Landec, Inc. Delivery of drugs
US8399007B2 (en) * 2006-12-05 2013-03-19 Landec Corporation Method for formulating a controlled-release pharmaceutical formulation
US20090263346A1 (en) * 2006-12-05 2009-10-22 David Taft Systems and methods for delivery of drugs
US20090246155A1 (en) * 2006-12-05 2009-10-01 Landec Corporation Compositions and methods for personal care
CA2673120C (en) 2006-12-18 2012-08-07 Advanced Bionutrition Corporation A dry food product containing live probiotic
US10258571B2 (en) * 2007-02-12 2019-04-16 Particle Sciences, Inc. Delivery devices containing encapsulated and/or practice-bound active pharmaceutical ingredients
US20090148498A1 (en) * 2007-05-14 2009-06-11 Sustained Nano Systems Llc Controlled release implantable dispensing device and method
EP2160184B1 (en) * 2007-05-14 2018-03-07 Sustained Nano Systems Llc Hypercompressed particles for controlled release of ophthalmic medications
US8071119B2 (en) * 2007-05-14 2011-12-06 Sustained Nano Systems Llc Controlled release implantable dispensing device and method
US8101274B2 (en) * 2007-06-11 2012-01-24 Spedden Richard H Solid state membranes with surface-embedded glycosylated amphiphilic molecules and micelles formed therefrom
FR2919188B1 (fr) * 2007-07-27 2010-02-26 Proteins & Peptides Man Complexes entre un polymere amphiphile et une proteine osteogenique appartenant a la famille des bmps
US8067028B2 (en) * 2007-08-13 2011-11-29 Confluent Surgical Inc. Drug delivery device
US8114883B2 (en) * 2007-12-04 2012-02-14 Landec Corporation Polymer formulations for delivery of bioactive materials
JP5502751B2 (ja) 2007-12-20 2014-05-28 エボニック コーポレイション 低残留溶媒濃度を有する微粒子を調製するためのプロセス
DK2299953T3 (en) * 2008-07-14 2017-06-19 Polypid Ltd CARBON COMPOSITION FOR MEDICINAL PRODUCTS WITH CONTINUOUS EXPOSURE
KR20170029019A (ko) 2008-07-18 2017-03-14 바이오모드 컨셉츠 인코포레이티드 활성 성분을 방출하는 제품
CA2769878A1 (en) 2008-08-07 2010-02-11 Bioactive Surgical, Inc. Stem cell capture and immobilization coatings for medical devices and implants
EA201100533A1 (ru) * 2008-09-24 2011-10-31 Резилюкс Способ получения материала, содержащего жизнеспособные микроорганизмы, и полученный этим способом материал
ES2908047T3 (es) 2009-03-27 2022-04-27 Intervet Int Bv Vacunas en micropartículas para la vacunación oral o nasal y el refuerzo de animales incluidos los peces
AU2010254235B2 (en) 2009-05-26 2015-04-02 Advanced Bionutrition Corporation Stable dry powder composition comprising biologically active microorganisms and/or bioactive materials and methods of making
CA2767973C (en) 2009-07-14 2019-06-18 Polypid Ltd. Lipid-based sustained-release drug carrier matrix
US8795726B2 (en) 2010-01-19 2014-08-05 Polypid Ltd. Sustained-release nucleic acid matrix compositions
US8834951B2 (en) 2010-01-28 2014-09-16 Advanced Bionutrition Corporation Dry glassy composition comprising a bioactive material
US9504750B2 (en) 2010-01-28 2016-11-29 Advanced Bionutrition Corporation Stabilizing composition for biological materials
EP2571526B1 (en) 2010-05-17 2019-03-13 Novaer Holdings, Inc. Drug delivery devices for delivery of ocular therapeutic agents
CN103140145B (zh) 2010-08-13 2014-08-20 高级生物营养公司 用于生物材料的干的贮存稳定用组合物
US8927007B2 (en) 2010-09-17 2015-01-06 Paul Talalay Formulations for treatment with glucosinolates
ITMI20111050A1 (it) 2011-06-10 2012-12-11 Sevecom Spa Uso di emulsionanti in associazione con oleine vegetali in un alimento per animali.
EP2736492A4 (en) * 2011-07-27 2015-06-17 Polypid Ltd MATRIX COMPOSITIONS FOR THE CONTROLLED RELEASE OF PEPTIDES AND POLYPEPTIDE MOLECULES
CN105287431A (zh) * 2014-05-30 2016-02-03 中国科学院过程工程研究所 一种载活性药物的聚合物脂质球及其制备方法
BR112017000878B1 (pt) 2014-07-21 2022-05-10 Sevecom S.P.A. Mistura sólida, seu uso, e alimento para animal
EP3179985A1 (en) 2014-08-14 2017-06-21 Brown University Compositions for stabilizing and delivering proteins
KR102685914B1 (ko) 2015-07-29 2024-07-16 어드밴스드 바이오뉴트리션 코프. 특수 식이 용도를 위한 안정한 프로바이오틱 건조 조성물
US12558395B2 (en) 2015-07-29 2026-02-24 Advanced Bionutrition Corp. Stable dry probiotic compositions for special dietary uses
US10327935B2 (en) * 2016-07-21 2019-06-25 Cook Medical Technologies Llc Stent graft with internal constraining mechanism
JP2021501753A (ja) 2017-11-03 2021-01-21 ザ・トラスティーズ・オブ・プリンストン・ユニバーシティＴｈｅ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｐｒｉｎｃｅｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ 徐放性ナノキャリア製剤を形成するための疎水性イオン対化およびフラッシュナノ沈殿
CN119236191A (zh) 2018-05-24 2025-01-03 塞拉尼斯伊娃高性能聚合物公司 用于持续释放大分子药物化合物的可植入器件
US11689849B2 (en) 2018-05-24 2023-06-27 Nureva, Inc. Method, apparatus and computer-readable media to manage semi-constant (persistent) sound sources in microphone pickup/focus zones
MX2020012458A (es) 2018-05-24 2021-04-28 Celanese Eva Performance Polymers Llc Dispositivo implantable para liberacion sostenida de un compuesto de farmaco macromolecular.
WO2020018890A1 (en) 2018-07-19 2020-01-23 Prudhomme Robert K Triblock copolymer stabilizers for the formation of nanoparticles encapsulating soluble biologics, therapeutics, and imaging agents
US20200147032A1 (en) 2018-11-14 2020-05-14 Robert K. Prud'homme Dihydromyricetin hot melt extrusion formulations and methods for forming them
CN112094580A (zh) * 2020-09-01 2020-12-18 杭州曦茂新材料科技有限公司 一种树脂防腐涂料及其生产方法
JP2024515220A (ja) 2021-04-26 2024-04-05 セラニーズ・イーブイエイ・パフォーマンス・ポリマーズ・エルエルシー 高分子薬剤化合物の持続放出用の埋め込み型デバイス
EP4594520A2 (en) 2022-09-30 2025-08-06 Sixfold Bioscience Ltd. Compositions containing oligonucleotides with theranostic applications

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2409283A (en) 1943-04-21 1946-10-15 James L Hudson Coupling for plastic tubes
US3022209A (en) 1956-11-23 1962-02-20 Phillips Petroleum Co Method of welding butted pipe sections of polyethylene to form a reinforced joint
US3643805A (en) 1970-01-20 1972-02-22 Abcor Water Management Co Inc A membrane system which includes a tube sheet for securing supported membrane tubes therein
US3683960A (en) 1970-11-19 1972-08-15 Jerry Kirsch Block manifold for fluid control systems and method of making the same
GB1390379A (en) 1972-06-28 1975-04-09 Serck Industries Ltd Method of manufacturing hollow articles eg heat exchangers
US3776001A (en) 1973-01-16 1973-12-04 Kimberly Clark Co Self-lubricating compound for use in hygienic and medical applications, and suppositories made therefrom
US4070044A (en) 1976-01-22 1978-01-24 Phillips Petroleum Company Polymer pipe connection and method to make it
US4312687A (en) 1980-12-15 1982-01-26 Chevron Research Company Solar collector headers
US4818542A (en) 1983-11-14 1989-04-04 The University Of Kentucky Research Foundation Porous microspheres for drug delivery and methods for making same
US4615114A (en) 1984-03-12 1986-10-07 Asea Electric, Incorporated Method of manufacturing molded buswork for power distribution systems
US4730458A (en) * 1986-09-26 1988-03-15 The United States Of America As Represented By The United States Department Of Energy Thermal electric vapor trap arrangement and method
US5012052A (en) * 1988-03-22 1991-04-30 Indiana University Foundation Isotope-ratio-monitoring gas chromatography-mass spectrometry apparatus and method
US5447341A (en) 1988-06-13 1995-09-05 Metzeler Automotive Profiles Gmbh Molder rubber hose branch
CA1328550C (en) 1988-09-19 1994-04-19 Yoshinori Umezawa Method of fabricating pipe units
AU645003B2 (en) 1988-11-08 1994-01-06 Takeda Chemical Industries Ltd. Sustained release preparations
US5342628A (en) 1990-10-11 1994-08-30 Applied Medical Research, Inc. Drug diffusion polymer system and method
US5287758A (en) * 1991-01-26 1994-02-22 Behringwerke Ag Temperature controlled pipette tube
US5335944A (en) 1991-03-25 1994-08-09 Toyoda Gosei Co., Ltd. Hose coupling structure
JPH0538769A (ja) 1991-07-19 1993-02-19 Mitsutoyo Jushi Kk ブロー成形管の端部に厚肉フランジを射出成形する方法
JPH0570793A (ja) * 1991-09-10 1993-03-23 Nissei Baadeishie Kk 脂質の粒状組成物
FR2693249B1 (fr) 1992-07-03 1994-09-16 Hutchinson Procédé de raccordement de tubes ou tuyaux, raccords et dispositifs analogues obtenus par sa mise en Óoeuvre.
JP3266656B2 (ja) * 1992-08-18 2002-03-18 日清ファルマ株式会社 ビタミン含浸粒状物およびその製造方法
WO1994005265A1 (en) 1992-09-10 1994-03-17 Children's Medical Center Corporation Biodegradable polymer matrices for sustained delivery of local anesthetic agents
US5411300A (en) 1993-03-16 1995-05-02 Toyoda Gosei Co., Ltd. Hose connecting assembly
FR2710265B1 (fr) 1993-09-22 1995-10-20 Adir Composition pharmaceutique bioadhésive pour la libération contrôlée de principes actifs.
DE4337492C2 (de) 1993-11-03 1999-06-02 Joerg Michael Dr Re Schierholz Verfahren zur Inkorporierung lipophiler pharmazeutisch wirksamer Substanzen in weiche Kontaktlinsen zur Erstellung ophthalmologischer kontrollierter Freisetzungssysteme mittels diffusionskontrollierter Sorption
US5626862A (en) 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
US6333021B1 (en) 1994-11-22 2001-12-25 Bracco Research S.A. Microcapsules, method of making and their use
US5942253A (en) 1995-10-12 1999-08-24 Immunex Corporation Prolonged release of GM-CSF
CA2244742C (en) 1996-02-07 2005-08-23 Anthony Joseph Cesaroni Bonding of tubes of thermoplastic polymers
US5762961A (en) * 1996-02-09 1998-06-09 Quadrant Holdings Cambridge Ltd. Rapidly soluble oral solid dosage forms, methods of making same, and compositions thereof
JP3544604B2 (ja) * 1996-12-16 2004-07-21 株式会社荏原製作所 切替式トラップ装置
US5855913A (en) 1997-01-16 1999-01-05 Massachusetts Instite Of Technology Particles incorporating surfactants for pulmonary drug delivery
US5874064A (en) * 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US5837221A (en) 1996-07-29 1998-11-17 Acusphere, Inc. Polymer-lipid microencapsulated gases for use as imaging agents
DE19631001C1 (de) * 1996-08-01 1997-12-18 Testo Gmbh & Co Kondensatabscheider
KR0181252B1 (ko) * 1996-12-31 1999-03-20 박원훈 에멀젼 방법에 의한 다공성 매트릭스형 서방성 제제의 제조방법
US5895695A (en) 1997-03-28 1999-04-20 Rowley; William W. Crosslinked overmolded plumbing tubes
JP3347977B2 (ja) * 1997-07-02 2002-11-20 フリヂスター株式会社 液体循環型熱電冷却・加熱装置
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US6540926B2 (en) * 1997-10-02 2003-04-01 David Paul Goodrich Filter assembly
US6423345B2 (en) * 1998-04-30 2002-07-23 Acusphere, Inc. Matrices formed of polymer and hydrophobic compounds for use in drug delivery
US6096178A (en) * 1998-08-24 2000-08-01 Aviv Amirav Electrolyzer device for the operation of flame ionization detectors
US6101815A (en) * 1998-11-09 2000-08-15 General Electric Company Thermo-electrical dehumidifier
US6490879B1 (en) * 2000-09-27 2002-12-10 Assist International Marketing, Inc. Water generating machine
US6427449B1 (en) * 2000-12-15 2002-08-06 Solid State Cooling Systems Compact volatile organic compound removal system
US6370884B1 (en) * 2001-03-30 2002-04-16 Maher I. Kelada Thermoelectric fluid cooling cartridge

Also Published As

Publication number Publication date
NO324895B1 (no) 2007-12-27
AU2995499A (en) 1999-11-23
IL139252A0 (en) 2001-11-25
US7052719B2 (en) 2006-05-30
EP1073422B1 (en) 2006-03-08
CN1301150A (zh) 2001-06-27
KR20010043136A (ko) 2001-05-25
KR100703051B1 (ko) 2007-04-05
JP2002513752A (ja) 2002-05-14
CA2329875C (en) 2003-09-16
PL343691A1 (en) 2001-08-27
IL139252A (en) 2006-10-31
DE69930240D1 (de) 2006-05-04
US6689390B2 (en) 2004-02-10
DK1073422T3 (da) 2006-07-03
NO20005452D0 (no) 2000-10-27
ES2259472T3 (es) 2006-10-01
US20010043948A1 (en) 2001-11-22
US7160557B2 (en) 2007-01-09
US6423345B2 (en) 2002-07-23
US20010000470A1 (en) 2001-04-26
DE69930240T2 (de) 2006-11-23
MXPA00010566A (es) 2002-04-24
US20010000230A1 (en) 2001-04-12
WO1999056731A1 (en) 1999-11-11
ATE319433T1 (de) 2006-03-15
PT1073422E (pt) 2006-05-31
US20030147962A1 (en) 2003-08-07
PL196159B1 (pl) 2007-12-31
CN1201729C (zh) 2005-05-18
EP1073422A1 (en) 2001-02-07
CA2329875A1 (en) 1999-11-11
AU746696B2 (en) 2002-05-02
JP5153032B2 (ja) 2013-02-27
BR9910340A (pt) 2001-01-09
US20070104656A1 (en) 2007-05-10
NZ508470A (en) 2003-02-28

Similar Documents

Publication Publication Date Title
NO20005452L (no) Matriser tildannet fra polymer- og hydrofobforbindelser for bruk i medikamentavlevering
Ogawa et al. Controlled-release of leuprolide acetate from polylactic acid or copoly (lactic/glycolic) acid microcapsules: influence of molecular weight and copolymer ratio of polymer
CY1117889T1 (el) Πολυμερες γαλακτικου οξεος και διεργασια για την παραγωγη αυτου
CA2455680A1 (en) Ophthalmic depot formulations for periocular or subconjunctival administration
WO2002015877A3 (en) Methods and compositions for targeted delivery
EP2033648A3 (en) Sustained release drug delivery system containing prodrugs
TR200102801T2 (tr) Solid tümörlerin tedavisine yönelik yöntem ve bileşimler
IT1243390B (it) Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione.
PT1028707E (pt) Formulacoes oftalmicas de libertacao controlada contendo medicamentos soluveis em agua
PT839525E (pt) Preparacao de libertacao prolongada
PT1028753E (pt) Libertacao de moleculas de poli(etilenoglicol)-conjugado a partir de hidrogeles degradaveis
TR200002685T2 (tr) Biyoaktif maddelerin kontrollü salınımı için sıvı polimerik bileşimler
WO1999036099A8 (fr) Compositions a liberation controlee, leur procede de fabrication et leur utilisation
WO1996040073A3 (en) Composition for sustained release of non-aggregated erythropoietin
BR9916881A (pt) Métodos para tratamento do câncer ovariano, composições de poli(fosfoéster) e artigos biodegradáveis das mesmas
MXPA03011440A (es) Composicion de liberacion sostenida y proceso para producirla.
NO970990D0 (no) Implanterbare formlegemer for administrering av virkestoffer til planter
WO2001091553A1 (en) Composite wafer for controlled drug delivery
ATE364403T1 (de) Retardtablette hergestellt aus linearen wasserunlöslichen polysacchariden
ATE273684T1 (de) Eingekapselte wasserdispergierbare perfluoroetherpolymere

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees