NO20005454L - Nye hydroksyindoler, deres anvendelse som fosfodiesterase 4 inhibitorer og fremgangsmåte for fremstilling derav - Google Patents

Nye hydroksyindoler, deres anvendelse som fosfodiesterase 4 inhibitorer og fremgangsmåte for fremstilling derav

Info

Publication number: NO20005454L
Authority: NO; Norway
Prior art keywords: phosphodiesterase; inhibitors; preparation; novel hydroxy; hydroxy indoles
Prior art date: 1998-04-28

Application number

NO20005454A

Other languages

English (en)

Other versions

NO321867B1 (no

NO20005454D0 (no

Inventor

Norbert Hoefgen

Ute Egerland

Hildegard Poppe

Degenhard Marx

Stefan Szelenyi

Thomas Kronbach

Emmanuel Polymeropoulos

Sabine Heer

Original Assignee

Dresden Arzneimittel

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-28

Filing date

2000-10-27

Publication date

2000-12-07

1998-04-28 Priority claimed from DE19818964A external-priority patent/DE19818964A1/de

1999-04-17 Priority claimed from DE1999117504 external-priority patent/DE19917504A1/de

2000-10-27 Application filed by Dresden Arzneimittel filed Critical Dresden Arzneimittel

2000-10-27 Publication of NO20005454D0 publication Critical patent/NO20005454D0/no

2000-12-07 Publication of NO20005454L publication Critical patent/NO20005454L/no

2006-07-17 Publication of NO321867B1 publication Critical patent/NO321867B1/no

Links

NLMQHXUGJIAKTH-UHFFFAOYSA-N 4-hydroxyindole Chemical class OC1=CC=CC2=C1C=CN2 NLMQHXUGJIAKTH-UHFFFAOYSA-N 0.000 title 1
239000002587 phosphodiesterase IV inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
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- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Diabetes (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Tropical Medicine & Parasitology (AREA)
Pain & Pain Management (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Hematology (AREA)
Addiction (AREA)
Otolaryngology (AREA)
Ophthalmology & Optometry (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)

NO20005454A 1998-04-28 2000-10-27 Nye hydroksyindoler, disse for bruk som medikament, fremgangsmate for fremstilling derav, anvendelse av disse for fremstilling av legemidler, legemiddel inneholdende disse samt en fremgangsmate for fremstilling av legemidlene NO321867B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE19818964A DE19818964A1 (de)	1998-04-28	1998-04-28	Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phospodiesterase 4 und Verfahren zu deren Herstellung
DE1999117504 DE19917504A1 (de)	1999-04-17	1999-04-17	Verwendung von Hydroxyindolen, die Inhibitoren der Phosphodiesterase 4 sind, zur Therapie chronisch obstruktiver Lungenerkrankungen
PCT/EP1999/002792 WO1999055696A1 (de)	1998-04-28	1999-04-24	Neue hydroxyindole, deren verwendung als inhibitoren der phosphodiesterase 4 und verfahren zu deren herstellung

Publications (3)

Publication Number	Publication Date
NO20005454D0 NO20005454D0 (no)	2000-10-27
NO20005454L true NO20005454L (no)	2000-12-07
NO321867B1 NO321867B1 (no)	2006-07-17

Family

ID=26045814

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20005454A NO321867B1 (no)	1998-04-28	2000-10-27	Nye hydroksyindoler, disse for bruk som medikament, fremgangsmate for fremstilling derav, anvendelse av disse for fremstilling av legemidler, legemiddel inneholdende disse samt en fremgangsmate for fremstilling av legemidlene

Country Status (27)

Country	Link
US (8)	US6251923B1 (no)
EP (2)	EP1076657B1 (no)
JP (2)	JP3842043B2 (no)
KR (1)	KR100448748B1 (no)
CN (1)	CN1234705C (no)
AR (1)	AR016236A1 (no)
AT (2)	ATE330955T1 (no)
AU (1)	AU748403B2 (no)
BG (1)	BG65023B1 (no)
BR (1)	BR9910029A (no)
CY (1)	CY1105075T1 (no)
CZ (1)	CZ20003985A3 (no)
DE (2)	DE59913617D1 (no)
DK (2)	DK1076657T3 (no)
ES (2)	ES2262072T3 (no)
HU (1)	HUP0101625A3 (no)
IL (2)	IL138847A0 (no)
NO (1)	NO321867B1 (no)
NZ (1)	NZ507406A (no)
PL (1)	PL198983B1 (no)
PT (2)	PT1475377E (no)
SI (2)	SI1475377T1 (no)
SK (1)	SK286192B6 (no)
TR (1)	TR200003130T2 (no)
TW (1)	TW530048B (no)
UA (1)	UA59443C2 (no)
WO (1)	WO1999055696A1 (no)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19946301A1 (de)	1998-04-02	2001-04-19	Asta Medica Ag	Indolyl-3-glyoxylsäure-Derivate mit therapeutisch wertvollen Eigenschaften
DE19814838C2 (de) *	1998-04-02	2001-01-18	Asta Medica Ag	Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
DK1076657T3 (da) *	1998-04-28	2004-11-08	Elbion Ag	Hidtil ukendte hydroxyindoler, deres anvendelse som inhibitorer for phosphodiesterase 4 og fremgangsmåde til deres fremstilling
AU4834200A (en) *	1999-05-10	2000-11-21	Protarga, Inc.	Fatty acid-n-substituted indol-3-glyoxyl-amide compositions and uses thereof
DE19924138A1 (de)	1999-05-26	2000-11-30	Henkel Kgaa	Lösbare Klebeverbindungen
US6469006B1 (en) *	1999-06-15	2002-10-22	Bristol-Myers Squibb Company	Antiviral indoleoxoacetyl piperazine derivatives
TWI269654B (en) *	1999-09-28	2007-01-01	Baxter Healthcare Sa	N-substituted indole-3-glyoxylamide compounds having anti-tumor action
DE19951599A1 (de) *	1999-10-27	2001-05-23	Henkel Kgaa	Verfahren zur adhesiven Trennung von Klebeverbunden
DE19962300A1 (de) *	1999-12-23	2001-06-28	Asta Medica Ag	Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung
IT1315267B1 (it) *	1999-12-23	2003-02-03	Novuspharma Spa	Derivati di 2-(1h-indol-3-il)-2-oxo-acetammidi ad attivita'antitumorale
US6436965B1 (en)	2000-03-02	2002-08-20	Merck Frosst Canada & Co.	PDE IV inhibiting amides, compositions and methods of treatment
US6573262B2 (en)	2000-07-10	2003-06-03	Bristol-Myers Sqibb Company	Composition and antiviral activity of substituted indoleoxoacetic piperazine derivatives
IT1318641B1 (it)	2000-07-25	2003-08-27	Novuspharma Spa	Ammidi di acidi 2-(1h-indol-3-il)-2-oxo-acetici ad attivita'antitumorale.
DE10037310A1 (de)	2000-07-28	2002-02-07	Asta Medica Ag	Neue Indolderivate und deren Verwendung als Arzneimittel
DE10037884A1 (de) *	2000-08-03	2002-02-21	Henkel Kgaa	Verfahren zur beschleunigten Klebstoffaushärtung
US6903104B2 (en) *	2001-12-06	2005-06-07	National Health Research Institutes	Indol-3-YL-2-oxoacetamide compounds and methods of use thereof
WO2003099559A1 (en)	2002-05-24	2003-12-04	Michel Joyce	Article of clothing with moisture absorbent portion
TW200400177A (en)	2002-06-04	2004-01-01	Wyeth Corp	1-(Aminoalkyl)-3-sulfonylindole and-indazole derivatives as 5-hydroxytryptamine-6 ligands
UA78999C2 (en) *	2002-06-04	2007-05-10	Wyeth Corp	1-(aminoalkyl)-3-sulfonylazaindoles as ligands of 5-hydroxytryptamine-6
US20040038958A1 (en) *	2002-07-11	2004-02-26	Chris Rundfeldt	Topical treatment of skin diseases
CA2493982A1 (en)	2002-08-01	2004-02-12	Elbion Ag	Method for producing highly pure hydroxy indolyl glyoxylic acid amides
UA82323C2 (uk) *	2002-08-09	2008-04-10	Меда Фарма Гмбх & Ко. Кг	Нова комбінація глюкокортикоїду та pde-інгібітору для лікування респіраторних захворювань, алергічних захворювань, астми та хронічних обструктивних легеневих захворювань
DE10253426B4 (de) *	2002-11-15	2005-09-22	Elbion Ag	Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung
DE10318610A1 (de)	2003-04-24	2004-11-11	Elbion Ag	7-Azaindole und deren Verwendung als Therapeutika
DE10318611A1 (de) *	2003-04-24	2004-11-11	Elbion Ag	4-, 6- oder 7-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika
DE10318609A1 (de) *	2003-04-24	2004-11-11	Elbion Ag	5-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika
WO2004098578A2 (en) *	2003-05-12	2004-11-18	Altana Pharma Ag	Composition comprising a pde4 inhibitor and a tnf-alfa antagonist selected from infliximab, adalimumab, cdp870 and cdp517
WO2004098606A1 (en) *	2003-05-12	2004-11-18	Altana Pharma Ag	Composition comprising a pde4 inhibitor and shuil-1r ii
US7205299B2 (en) *	2003-06-05	2007-04-17	Zentaris Gmbh	Indole derivatives having an apoptosis-inducing effect
US7211588B2 (en) *	2003-07-25	2007-05-01	Zentaris Gmbh	N-substituted indolyl-3-glyoxylamides, their use as medicaments and process for their preparation
US20050187278A1 (en) *	2003-08-28	2005-08-25	Pharmacia Corporation	Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors
EP1670787B1 (en)	2003-09-11	2012-05-30	iTherX Pharma, Inc.	Cytokine inhibitors
US20070105937A1 (en) *	2003-12-22	2007-05-10	Miguel Pappolla	Indole-3-propionamide and derivatives thereof
DE102004031538A1 (de) *	2004-06-29	2006-02-09	Baxter International Inc., Deerfield	Pharmazeutische Darreichungsform zur oralen Verabreichung eines schwerlöslichen Wirkstoffs, Verfahren zu deren Herstellung und Kit
JPWO2006041120A1 (ja) *	2004-10-13	2008-05-15	協和醗酵工業株式会社	医薬組成物
CA2584169A1 (en) *	2004-10-13	2006-04-20	Kyowa Hakko Kogyo Co., Ltd.	Remedies/preventives for chronic skin disease
BRPI0517652A (pt) *	2004-11-08	2008-10-14	Baxter Healthcare Sa	composições farmacêuticas nanoparticuladas de inibidores de tubulina, métodos para as suas preparações e respectivos usos
TW200738677A (en) *	2005-06-27	2007-10-16	Elbion Ag	Nitro-substituted hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them
EP2258359A3 (en)	2005-08-26	2011-04-06	Braincells, Inc.	Neurogenesis by muscarinic receptor modulation with sabcomelin
JP2009506069A (ja)	2005-08-26	2009-02-12	ブレインセルス，インコーポレイティド	ムスカリン性受容体調節による神経発生
RU2008119323A (ru)	2005-10-19	2009-11-27	Рэнбакси Лабораториз Лимитед (In)	Фармацевтические композиции мускаринового рецептора
JP2009512711A (ja)	2005-10-21	2009-03-26	ブレインセルス，インコーポレイティド	Ｐｄｅ阻害による神経新生の調節
EP2314289A1 (en)	2005-10-31	2011-04-27	Braincells, Inc.	Gaba receptor mediated modulation of neurogenesis
AU2006311577B2 (en)	2005-11-09	2013-02-07	Zalicus Inc.	Methods, compositions, and kits for the treatment of medical conditions
CN101370775A (zh)	2006-01-13	2009-02-18	惠氏公司	作为5-羟基色胺受体配体的经磺酰基取代1h-吲哚
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
CA2651862A1 (en)	2006-05-09	2007-11-22	Braincells, Inc.	5 ht receptor mediated neurogenesis
AU2007249399A1 (en)	2006-05-09	2007-11-22	Braincells, Inc.	Neurogenesis by modulating angiotensin
RS53084B (sr)	2006-07-05	2014-06-30	Takeda Gmbh	Kombinacija inhibitora hmg-coa reduktaze rosuvastatina sa inhibitorom fosfodiesteraze 4, kao što je roflumilast, roflumilast-n-oksid za lečenje inflamatornih plućnih obolenja
EP2049520A4 (en)	2006-08-07	2011-01-05	Ironwood Pharmaceuticals Inc	indole compounds
WO2008030651A1 (en)	2006-09-08	2008-03-13	Braincells, Inc.	Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
WO2008066807A1 (en) *	2006-11-28	2008-06-05	Ziopharm Oncology, Inc.	Use of indolyl-3-glyoxylic acid derivatives including indibulin, alone or in combination with further agents for treating cancer
US20100098641A1 (en) *	2006-12-13	2010-04-22	William Baker	Monophosphates as Mutual Prodrugs of Anti-Inflammatory Signal Transduction Modulators (AISTM's) and Beta-Agonists for the Treatment of Pulmonary Inflammation and Bronchoconstriction
US20090182035A1 (en) *	2007-04-11	2009-07-16	Alcon Research, Ltd.	Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
MX2009010946A (es) *	2007-04-11	2009-10-29	Alcon Res Ltd	Uso de un inhibidor del factor de necrosis tumoral alfa mas una antihistamina para tratar rinitis alergica y conjuntivitis alergica.
US7750027B2 (en)	2008-01-18	2010-07-06	Oxagen Limited	Compounds having CRTH2 antagonist activity
US20100216805A1 (en)	2009-02-25	2010-08-26	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
KR20120091037A (ko) *	2009-10-01	2012-08-17	알콘 리서치, 리미티드	올로파타딘 조성물 및 그의 용도
AR084433A1 (es)	2010-12-22	2013-05-15	Ironwood Pharmaceuticals Inc	Inhibidores de la faah y composiciones farmaceuticas que los contienen
WO2013106547A1 (en)	2012-01-10	2013-07-18	President And Fellows Of Harvard College	Beta-cell replication promoting compounds and methods of their use
GB201407820D0 (en)	2014-05-02	2014-06-18	Atopix Therapeutics Ltd	Polymorphic form
GB201407807D0 (en)	2014-05-02	2014-06-18	Atopix Therapeutics Ltd	Polymorphic form
US20190016680A1 (en)	2016-01-14	2019-01-17	Beth Israel Deaconess Medical Center, Inc.	Mast-cell modulators and uses thereof
CN113423435A (zh)	2018-12-28	2021-09-21	雷杰纳荣制药公司	使用花生四烯酸15-脂氧合酶(alox15)抑制剂治疗呼吸系统病症
US11674450B1 (en)	2021-12-13	2023-06-13	Pratt & Whitney Canada Corp.	System and method for synthesizing engine thrust

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL100127C (no)	1954-04-28
US2870162A (en)	1954-04-28	1959-01-20	Upjohn Co	Production of certain tryptamines and compounds produced in the process
US2825734A (en)	1955-04-11	1958-03-04	Upjohn Co	Reduction of carbonylic radicals in indolyl-3 compounds
US2930797A (en)	1957-11-22	1960-03-29	Upjohn Co	2-alkyl-3-indoleglyoxylamides
GB944443A (no)	1959-09-25	1900-01-01
US3028393A (en)	1960-05-11	1962-04-03	Upjohn Co	Novel 1-(3-indoyl)-1, 2-alkanediols and substituted hydroxymethyl 3-in-dolyl ketones
US3196162A (en)	1961-03-13	1965-07-20	Merck & Co Inc	Indolyl aliphatic acids
US3271416A (en)	1961-10-24	1966-09-06	Merck & Co Inc	Indolyl aliphatic acids
US3259622A (en)	1962-09-07	1966-07-05	Merck & Co Inc	1-benzyl-3-indolyl-alpha-haloalkyl and alkylidenyl acetic acids
US3238215A (en)	1963-10-17	1966-03-01	Sterling Drug Inc	1-[(3-, 2-, and 1-indolyl)-lower-alkyl-, lower-alkenyl-, and lower-alkynyl]piperidines
US3342834A (en)	1964-03-02	1967-09-19	Merck & Co Inc	Indolyl alkenoic acids
US3821387A (en)	1965-10-23	1974-06-28	Robins Co Inc A H	The treatment of parkinsonism with 3-(omega-substituted alkyl)-indoles
US3459770A (en)	1966-12-07	1969-08-05	American Home Prod	Indoleglyoxyloylpyrroles
US3527261A (en)	1968-11-12	1970-09-08	Babcock & Wilcox Co	Tube guide apparatus
US3578669A (en)	1969-09-16	1971-05-11	Sterling Drug Inc	1-((2 - substituted - 3 - indolyl) - lower-alkanoyl) - cycloalkyl - lower-alkylpiperidines and 1 - ((2 - hydroxymethyl-3 - indolyl)-lower-alkayl)-cycloalkyl-lower-alkylpiperidines
US5192770A (en) *	1990-12-07	1993-03-09	Syntex (U.S.A.) Inc.	Serotonergic alpha-oxoacetamides
SK283413B6 (sk) *	1992-08-06	2003-07-01	Warner-Lambert Company	2-Tioindoly, 2-indolíntióny a polysulfidy, ich selénové analógy a farmaceutické prostriedky na ich báze
WO1994012461A1 (en)	1992-12-02	1994-06-09	Pfizer Inc.	Catechol diethers as selective pdeiv inhibitors
DE69329894T2 (de) *	1992-12-08	2001-05-03	Ss Pharmaceutical Co., Ltd.	Arylamidderivate
US5424329A (en)	1993-08-18	1995-06-13	Warner-Lambert Company	Indole-2-carboxamides as inhibitors of cell adhesion
US5502072A (en)	1993-11-26	1996-03-26	Pfizer Inc.	Substituted oxindoles
US5489586A (en)	1994-03-07	1996-02-06	Warner-Lambert Company	Method for treating inflammatory disease in humans
DE19511916A1 (de)	1994-08-03	1996-02-08	Asta Medica Ag	Neue N-Benzylindol- und Benzopyrazol-Derivate mit antiasthmatischer, antiallergischer, entzündungshemmender und immunmodulierender Wirkung
WO1996004266A2 (de)	1994-08-03	1996-02-15	Asta Medica Aktiengesellschaft	Indol-, indazol-, pyridopyrrol- und pyridopyrazol-derivate mit antiasthmatischer, antiallergischer, entzündungshemmender und immunmodulierender wirkung
US5728844A (en) *	1995-08-29	1998-03-17	Celgene Corporation	Immunotherapeutic agents
TW429148B (en)	1995-10-27	2001-04-11	Pfizer	Pharmaceutical agents for the treatment of acute and chronic inflammatory diseases
WO1997048697A1 (en)	1996-06-19	1997-12-24	Rhone-Poulenc Rorer Limited	Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase
EP0920306A2 (en)	1996-07-12	1999-06-09	Leukosite, Inc.	Chemokine receptor antagonists and methods of use therefor
CA2264020A1 (en)	1996-08-26	1998-03-05	Jean Bemis	Inhibitors of phospholipase enzymes
DE19636150A1 (de)	1996-09-06	1998-03-12	Asta Medica Ag	N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung
DK1076657T3 (da) *	1998-04-28	2004-11-08	Elbion Ag	Hidtil ukendte hydroxyindoler, deres anvendelse som inhibitorer for phosphodiesterase 4 og fremgangsmåde til deres fremstilling
IT1315267B1 (it)	1999-12-23	2003-02-03	Novuspharma Spa	Derivati di 2-(1h-indol-3-il)-2-oxo-acetammidi ad attivita'antitumorale

1999
- 1999-04-24 DK DK99920779T patent/DK1076657T3/da active
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Publication number	Publication date
BG65023B1 (bg)	2006-12-29
US6545025B2 (en)	2003-04-08
IL138847A0 (en)	2001-10-31
ES2222706T3 (es)	2005-02-01
KR100448748B1 (ko)	2004-09-18
HK1035183A1 (en)	2001-11-16
EP1076657A1 (de)	2001-02-21
US20040220183A1 (en)	2004-11-04
SK15752000A3 (sk)	2001-08-06
CY1105075T1 (el)	2010-03-03
EP1475377B1 (de)	2006-06-21
PL343569A1 (en)	2001-08-27
NO321867B1 (no)	2006-07-17
US20020111351A1 (en)	2002-08-15
AR016236A1 (es)	2001-06-20
US20020119971A1 (en)	2002-08-29
TR200003130T2 (tr)	2001-01-22
DE59910142D1 (de)	2004-09-09
USRE38624E1 (en)	2004-10-12
DK1076657T3 (da)	2004-11-08
ES2262072T3 (es)	2006-11-16
CN1234705C (zh)	2006-01-04
EP1475377A1 (de)	2004-11-10
NZ507406A (en)	2002-11-26
WO1999055696A1 (de)	1999-11-04
AU748403B2 (en)	2002-06-06
AU3822999A (en)	1999-11-16
PL198983B1 (pl)	2008-08-29
KR20010043106A (ko)	2001-05-25
BG104842A (en)	2001-10-31
TW530048B (en)	2003-05-01
JP2002513017A (ja)	2002-05-08
NO20005454D0 (no)	2000-10-27
CN1307575A (zh)	2001-08-08
ATE330955T1 (de)	2006-07-15
CZ20003985A3 (cs)	2001-09-12
US20030134876A1 (en)	2003-07-17
PT1475377E (pt)	2006-11-30
ATE272631T1 (de)	2004-08-15
US6613794B2 (en)	2003-09-02
DE59913617D1 (de)	2006-08-03
JP3842043B2 (ja)	2006-11-08
SI1076657T1 (en)	2004-12-31
HUP0101625A2 (hu)	2001-11-28
US6602890B2 (en)	2003-08-05
US20020115651A1 (en)	2002-08-22
SK286192B6 (sk)	2008-05-06
EP1475377A8 (de)	2005-01-19
UA59443C2 (uk)	2003-09-15
US6251923B1 (en)	2001-06-26
US7161009B2 (en)	2007-01-09
BR9910029A (pt)	2000-12-26
US6545158B2 (en)	2003-04-08
PT1076657E (pt)	2004-11-30
EP1076657B1 (de)	2004-08-04
DK1475377T3 (da)	2006-10-23
US20020137745A1 (en)	2002-09-26
JP2006249091A (ja)	2006-09-21
IL138847A (en)	2006-08-20
SI1475377T1 (sl)	2006-12-31
HUP0101625A3 (en)	2002-12-28

Publication	Publication Date	Title
NO20005454D0 (no)	2000-10-27	Nye hydroksyindoler, deres anvendelse som fosfodiesterase 4 inhibitorer og fremgangsmÕte for fremstilling derav
DK1202733T3 (da)	2005-10-31	3(5)-amino-pyrazolderivater, fremgangsmåde til deres fremstilling og deres anvendelse som antitumormidler
NO20012058D0 (no)	2001-04-26	2-ureido-tiazolderivater, fremgangsmåte for deres fremstilling og anvendelse som antitumormidler
NO20003972D0 (no)	2000-08-04	Borefluid og vedlikeholdsfluid, fremgangsmÕte for deres fremstilling samt anvendelse derav
NO20020687D0 (no)	2002-02-11	3(5)-ureidopyrazolderivater, fremgangsmåte for fremstilling av disse og deres anvendelse som antitumormidler
NO20012158D0 (no)	2001-05-02	Substituerte 2-fenylbenzimidazoler, fremgangsmåte til fremstilling og anvendelse derav
DK0950657T3 (da)	2004-11-22	Substituerede carbazoler, fremgangsmåde til deres fremstilling og deres anvendelse som sPLA2-inhibitorer
NO20012057L (no)	2001-06-28	2-amino-tiazolderivater, fremgangsmåte for deres fremstilling og anvendelse som antitumormidler
NO963506D0 (no)	1996-08-22	4-Heterocyklyl-substituerte kinazolin-derivater, fremgangsmåte for fremstilling derav og deres anvendelse som anti-kreftmidler
DK1180518T3 (da)	2007-05-21	5-pyridyl-1,3-azolforbindelser, fremgangsmåde til fremstilling deraf og anvendelse deraf
NO20006029L (no)	2001-01-26	Pyrazolinderivater, deres fremstilling og anvendelse som legemidler
DK1244647T3 (da)	2006-09-25	Quinzolinderivater som VIGF-inhibitorer
NO986103D0 (no)	1998-12-23	Substituerte indazol-derivater og deres anvendelse som fosfodiesterase (PDE
DK0885234T3 (da)	2002-08-26	Nye erythromycinderivater, fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler
DK1330455T3 (da)	2005-12-05	Hidtil ukendte 7-azaindoler, deres anvendelse som inhibitorer for phosphodiesterase 4 og fremgangsmåde til deres fremstilling
NO20015062L (no)	2001-10-18	Substituerte 3-cyano-[1.7],[1.5]og[1.8]-naftyridin- inhibitorer for tyrosin-kinaser
NO20022834D0 (no)	2002-06-14	Zeolitt SSZ-50, fremgangsmåte for fremstilling og anvendelse av denne
NO20010331D0 (no)	2001-01-19	Ftalazinderivater som fosfodiesterase 4-inhibitorer
NO985307L (no)	1999-01-12	Distamycinderivater, fremgangsmÕte for deres fremstilling, og deres anvende
DK0795547T3 (da)	2000-09-18	(Aminoalkyl- og acylaminoalkyl-oxy)benzyloxyquinoliner, fremgangsmåde til deres fremstilling og deres anvendelse som bradyk
DK1098891T3 (da)	2005-12-12	Polycycliske thiazolidin-2-yliden-aminer, fremgangsmåde til fremstilling deraf og deres anvendelse som lægemidler
DK1214302T3 (da)	2004-02-16	Substituerede 3-phenyl-5-alkoxy-1,3,4-oxadiazol-2-oner og deres anvendelse som lipasehæmmere
DK0782575T3 (da)	2003-05-12	Substituerede pyrazol-pyrazol-derivater, fremgangsmåde til deres fremsstilling samt deres anvendelse som midler med herbicid virkning
NO20013878D0 (no)	2001-08-08	(1-fenacy-3-fenyl-3-piperidylety1)piperidin-derivater, fremgangsmate for fremstilling derav og farmasoytiske preparaterinneholdende de samme
DK1265856T3 (da)	2004-07-05	Hidtil ukendt fremgangsmåde til fremstillingen af alpha-(2,4-disulfophenyl)-N-tert-butylnitron og farmaceutisk acceptable salte deraf