NO20005588L - Inhibisjon av Helicobacter Pylori proliferasjon - Google Patents
Inhibisjon av Helicobacter Pylori proliferasjonInfo
- Publication number
- NO20005588L NO20005588L NO20005588A NO20005588A NO20005588L NO 20005588 L NO20005588 L NO 20005588L NO 20005588 A NO20005588 A NO 20005588A NO 20005588 A NO20005588 A NO 20005588A NO 20005588 L NO20005588 L NO 20005588L
- Authority
- NO
- Norway
- Prior art keywords
- somatostatin
- inhibition
- proliferation
- helicobacter pylori
- pylori
- Prior art date
Links
- 230000035755 proliferation Effects 0.000 title abstract 3
- 241000590002 Helicobacter pylori Species 0.000 title abstract 2
- 229940037467 helicobacter pylori Drugs 0.000 title abstract 2
- 230000005764 inhibitory process Effects 0.000 title abstract 2
- 102000005157 Somatostatin Human genes 0.000 abstract 5
- 108010056088 Somatostatin Proteins 0.000 abstract 5
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 abstract 5
- 229960000553 somatostatin Drugs 0.000 abstract 5
- 239000000556 agonist Substances 0.000 abstract 3
- 206010025323 Lymphomas Diseases 0.000 abstract 1
- 208000008469 Peptic Ulcer Diseases 0.000 abstract 1
- 208000005718 Stomach Neoplasms Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 206010017758 gastric cancer Diseases 0.000 abstract 1
- 201000011587 gastric lymphoma Diseases 0.000 abstract 1
- 208000011906 peptic ulcer disease Diseases 0.000 abstract 1
- 201000011549 stomach cancer Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/31—Somatostatins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Det er beskrevet en fremgangsmåte for anvendelse av somatostatin eller en somatostatin agonist for å inhibere proliferasjon av Helicobacter pylori (H. pylori), som omfatter administrering til en pasient som trenger det en effektiv mengde av nevnte somastotatin eller somatostatin agonist. Det er foretrukket at en somatostatin sub-type resepter 2 (SSTR-2) selektiv somatostatin agonist blir administrert i en fremgangsmåte som beskrevet heri. Inhibisjon av H. pylori proliferasjon er nyttig ved behandling av forskjellige gastroduodenal sykdommer så som peptisk sår, mage cancer og gastrisk lymfom.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/074,117 US5968903A (en) | 1998-05-07 | 1998-05-07 | Inhibition of H. pylori proliferation |
| PCT/US1999/010058 WO1999056769A2 (en) | 1998-05-07 | 1999-05-06 | Inhibition of helicobacter pylori proliferation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20005588D0 NO20005588D0 (no) | 2000-11-06 |
| NO20005588L true NO20005588L (no) | 2001-01-05 |
Family
ID=22117835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20005588A NO20005588L (no) | 1998-05-07 | 2000-11-06 | Inhibisjon av Helicobacter Pylori proliferasjon |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5968903A (no) |
| EP (1) | EP1075273A2 (no) |
| JP (1) | JP2002513769A (no) |
| AU (1) | AU3975499A (no) |
| NO (1) | NO20005588L (no) |
| WO (1) | WO1999056769A2 (no) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002243552C1 (en) * | 2001-01-12 | 2006-08-31 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Pharmaceutical compositions which inhibit vascular proliferation and method of use thereof |
| DE60220157T2 (de) * | 2001-03-06 | 2008-01-17 | Il Consorzio Ferrara Richerche | Verfahren zur modulierung der proliferation von medullären schilddrüsen-karzinomzellen |
| AU2002362030A1 (en) * | 2001-11-27 | 2003-06-10 | Fred Hutchinson Cancer Research Center | Methods for inhibiting deacetylase activity |
| US7122622B2 (en) * | 2002-04-16 | 2006-10-17 | Biosynthema Inc. | Peptide compounds having improved binding affinity to somatostatin receptors |
| JP2007518702A (ja) * | 2003-11-25 | 2007-07-12 | ノバルティス アクチエンゲゼルシャフト | ソマトスタチン類似体処置の効力についてのバイオマーカー |
| CA2727082C (en) | 2008-06-12 | 2019-02-26 | Syntaxin Limited | Fusion proteins for use in suppression of acromegaly |
| CN102083451A (zh) | 2008-06-12 | 2011-06-01 | 赛恩泰新公司 | 癌症的抑制 |
| GB0820970D0 (en) | 2008-11-17 | 2008-12-24 | Syntaxin Ltd | Suppression of cancer |
| ES2351569B8 (es) * | 2009-05-07 | 2012-06-20 | Bcn Peptides S.A. | Ligandos peptídicos de receptores de somatostatina. |
| EP2399931A1 (fr) * | 2010-06-22 | 2011-12-28 | Ipsen Pharma S.A.S. | Nouveaux composés octapeptidiques et leur utilisation thérapeutique |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4291022A (en) * | 1975-03-11 | 1981-09-22 | Sandoz Ltd. | Organic compounds |
| US4133782A (en) * | 1976-06-07 | 1979-01-09 | The Salk Institute For Biological Studies | Somatostatin analogs with dissociated biological activities |
| US4190575A (en) * | 1977-12-27 | 1980-02-26 | American Home Products Corporation | Polypeptides related to somatostatin |
| DE2860734D1 (en) * | 1977-06-08 | 1981-09-03 | Merck & Co Inc | Somatostatin analogs, process for their preparation and pharmaceutical compositions containing them |
| DK153293C (da) * | 1977-07-22 | 1988-11-14 | Stamicarbon | Katalysator til dehydrogenering af organiske forbindelser, isaer aminer, thioler og alkoholer, og fremgangsmaade til fremstilling deraf |
| US4211693A (en) * | 1977-09-20 | 1980-07-08 | The Salk Institute For Biological Studies | Peptides with para-substituted phenylalanine |
| LU78191A1 (de) * | 1977-09-28 | 1979-05-25 | Ciba Geigy Ag | Verfahren zur herstellung von neuen cyclopeptiden |
| CA1107273A (en) * | 1978-05-19 | 1981-08-18 | Chester A. Meyers | Somatostatin analogs having a substituted tryptophyl residue in position eight |
| JPS5819669B2 (ja) * | 1978-10-28 | 1983-04-19 | 白井松新薬株式会社 | 新規生理活性ペプチド化合物及びその製造法 |
| US4215039A (en) * | 1979-02-15 | 1980-07-29 | American Home Products Corporation | Somatostatin analogues |
| US4190648A (en) * | 1979-03-13 | 1980-02-26 | Merck & Co., Inc. | Peptides having somatostatin activity |
| US4316890A (en) * | 1979-03-16 | 1982-02-23 | Ciba-Geigy Corporation | Peptides and processes for the manufacture thereof |
| US4209426A (en) * | 1979-05-29 | 1980-06-24 | American Home Products Corporation | Polypeptides related to somatostatin |
| US4328214A (en) * | 1979-07-04 | 1982-05-04 | Ciba-Geigy Corporation | Cyclopeptides and pharmaceutical preparations thereof and also processes for their manufacture |
| US4310518A (en) * | 1979-10-31 | 1982-01-12 | Merck & Co., Inc. | Cyclic hexapeptide somatostatin analogs |
| US4235886A (en) * | 1979-10-31 | 1980-11-25 | Merck & Co., Inc. | Cyclic hexapeptide somatostatin analogs |
| DE3062075D1 (en) * | 1979-11-27 | 1983-03-24 | Sandoz Ag | Polypeptides, processes for their production, pharmaceutical compositions comprising said polypeptides and their use |
| US4369179A (en) * | 1979-12-14 | 1983-01-18 | Ciba-Geigy Corporation | Acylpeptides |
| US4358439A (en) * | 1979-12-21 | 1982-11-09 | Ciba-Geigy Corporation | Cyclooctapeptides |
| US4282143A (en) * | 1980-06-13 | 1981-08-04 | American Home Products Corporation | Octapeptides lowering growth hormone |
| DK81082A (da) * | 1981-03-06 | 1982-09-07 | Sandoz Ag | Fremgangsmaade til fremstilling af polypeptider |
| US4360516A (en) * | 1981-04-13 | 1982-11-23 | Merck & Co., Inc. | Modified D-retro cyclic hexapeptide somatostatin analogs |
| EP0083305B1 (de) * | 1981-12-24 | 1985-07-10 | Ciba-Geigy Ag | Cyclische Octapeptide und pharmazeutische Präparate davon, sowie Verfahren zur Herstellung derselben und ihre Anwendung |
| FR2522655B1 (fr) * | 1982-03-05 | 1987-03-06 | Sanofi Sa | Analogues de la somatostatine possedant une liaison du type hydrazide et medicaments en contenant |
| US4486415A (en) * | 1983-08-15 | 1984-12-04 | Merck & Co., Inc. | Cyclic hexapeptide somatostatin analogs |
| US4485101A (en) * | 1983-10-11 | 1984-11-27 | Administrators Of The Tulane Educational Fund | Peptides |
| US4522813A (en) * | 1983-10-27 | 1985-06-11 | Merck & Co., Inc. | Cyclic hexapeptide somatostatin analogs |
| US4684620A (en) * | 1984-09-04 | 1987-08-04 | Gibson-Stephens Neuropharmaceuticals, Inc. | Cyclic polypeptides having mu-receptor specificity |
| HUT42101A (en) * | 1985-01-07 | 1987-06-29 | Sandoz Ag | Process for preparing stomatostatine derivatives and pharmaceutical compositions containing such compounds |
| US4650787A (en) * | 1985-04-25 | 1987-03-17 | Schally Andrew Victor | Biologically active octapeptides |
| US4725577A (en) * | 1985-04-25 | 1988-02-16 | Administrators Of The Tulane Educational Fund | Biologically active lysine containing octapeptides |
| US4585755A (en) * | 1985-04-29 | 1986-04-29 | Merck & Co., Inc. | Cyclic and bridged cyclic somatostatin analogs useful as local anti-inflammatory agents |
| US4904642A (en) * | 1985-09-12 | 1990-02-27 | The Administrators Of The Tulane Educational Fund | Therapeutic somatostatin analogs |
| US4853371A (en) * | 1986-06-17 | 1989-08-01 | The Administrators Of The Tulane Educational Fund | Therapeutic somatostatin analogs |
| NL194729C (nl) * | 1986-10-13 | 2003-01-07 | Novartis Ag | Werkwijze voor de bereiding van peptidealcoholen via vaste fase. |
| US4871717A (en) * | 1987-01-07 | 1989-10-03 | Administrators Of The Tulane Educational Fund | Peptides |
| EP0329295A1 (en) * | 1988-02-01 | 1989-08-23 | The Upjohn Company | Renin inhibiting peptides with polar end groups |
| ZA895838B (en) * | 1988-08-18 | 1991-03-27 | Syntex Inc | Pharmaceutical compounds |
| CA2012115C (en) * | 1989-03-15 | 2001-07-03 | Biomeasure, Inc. | Iodinated somatostatins |
| CA2053250A1 (en) * | 1989-04-26 | 1990-10-27 | David H. Coy | Linear somatostatin analogs |
| IT1240643B (it) * | 1990-05-11 | 1993-12-17 | Mediolanum Farmaceutici Spa | Peptidi biologicamente attivi contenenti in catena 2-alchiltriptofano |
| HU207104B (en) * | 1991-01-25 | 1993-03-01 | Biosignal Kutato Fejlesztoe Kf | Process for producing new somatostatin analogs inhibiting tumour growth and pharmaceutical compositions comprising such compounds |
| RO117259B1 (ro) * | 1993-08-09 | 2001-12-28 | Biomeasure Inc. | Derivaţi peptidici, terapeutici |
| MY147327A (en) * | 1995-06-29 | 2012-11-30 | Novartis Ag | Somatostatin peptides |
| WO1998008528A1 (en) * | 1996-08-30 | 1998-03-05 | Biomeasure Incorporated | Method of inhibiting fibrosis with a somatostatin agonist |
| AU4133997A (en) * | 1996-09-12 | 1998-04-02 | Yarom Cohen | Pharmaceutical composition for the treatment of syndrome x of reaven |
-
1998
- 1998-05-07 US US09/074,117 patent/US5968903A/en not_active Expired - Fee Related
-
1999
- 1999-05-06 AU AU39754/99A patent/AU3975499A/en not_active Abandoned
- 1999-05-06 EP EP99922851A patent/EP1075273A2/en not_active Withdrawn
- 1999-05-06 JP JP2000546793A patent/JP2002513769A/ja active Pending
- 1999-05-06 WO PCT/US1999/010058 patent/WO1999056769A2/en not_active Ceased
-
2000
- 2000-11-06 NO NO20005588A patent/NO20005588L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999056769A3 (en) | 2000-11-09 |
| US5968903A (en) | 1999-10-19 |
| AU3975499A (en) | 1999-11-23 |
| EP1075273A2 (en) | 2001-02-14 |
| WO1999056769A2 (en) | 1999-11-11 |
| JP2002513769A (ja) | 2002-05-14 |
| NO20005588D0 (no) | 2000-11-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |