NO20006153L - Poly(ADP-ribose)polymerase gen - Google Patents

Poly(ADP-ribose)polymerase gen

Info

Publication number
NO20006153L
NO20006153L NO20006153A NO20006153A NO20006153L NO 20006153 L NO20006153 L NO 20006153L NO 20006153 A NO20006153 A NO 20006153A NO 20006153 A NO20006153 A NO 20006153A NO 20006153 L NO20006153 L NO 20006153L
Authority
NO
Norway
Prior art keywords
methods
effectors
adp
ribose
poly
Prior art date
Application number
NO20006153A
Other languages
English (en)
Other versions
NO20006153D0 (no
Inventor
Michael Kock
Thomas Hoeger
Burkhard Kroeger
Bernd Otterbach
Wilfried Lubisch
Hans-Georg Lemaire
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of NO20006153D0 publication Critical patent/NO20006153D0/no
Publication of NO20006153L publication Critical patent/NO20006153L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1077—Pentosyltransferases (2.4.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/02—Pentosyltransferases (2.4.2)
    • C12Y204/0203—NAD+ ADP-ribosyltransferase (2.4.2.30), i.e. tankyrase or poly(ADP-ribose) polymerase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/91091—Glycosyltransferases (2.4)
    • G01N2333/91142—Pentosyltransferases (2.4.2)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Det er beskrevet poly(ADP-ribose)polymerase (PARP) homologer som har en aminosyresekvens som har a) en funksjonell NAD+ bindingsdomene og b) ingen zinkfingersekvensmotiv med generell formel CX2CDmHX2C hvori m er en tallverdi fra 28 eller 30, og X-radikalene er, uavhengig av hverandre en hvilken som helst aminosyre; og funksjonelle ekvivalenter derav; nukleinsyrer kodende for disse; antistoffer med spesifisitet for det nye proteinet; farmasøytiske og genterapisammensetninger som omfatter produktene; fremgangsmåter for analytisk bestemmelse av proteiner og nukleinsyrer ifølge oppfinnelsen; fremgangsmåter for identifisering av effektorer eller bindingspartnere av proteiner ifølge oppfinnelsen; nye PARP effektorer; og fremgangsmåter for å bestemme aktiviteten til slike effektorer.
NO20006153A 1998-06-05 2000-12-04 Poly(ADP-ribose)polymerase gen NO20006153L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19825213 1998-06-05
DE19908837 1999-03-01
PCT/EP1999/003889 WO1999064572A2 (de) 1998-06-05 1999-06-04 Poly(adp-ribose) polymerase-gene

Publications (2)

Publication Number Publication Date
NO20006153D0 NO20006153D0 (no) 2000-12-04
NO20006153L true NO20006153L (no) 2001-02-02

Family

ID=26046644

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20006153A NO20006153L (no) 1998-06-05 2000-12-04 Poly(ADP-ribose)polymerase gen

Country Status (24)

Country Link
US (3) US7754459B1 (no)
EP (1) EP1082416B1 (no)
JP (1) JP2002517231A (no)
KR (1) KR20010052582A (no)
CN (1) CN1304446A (no)
AR (1) AR020326A1 (no)
AT (1) ATE358175T1 (no)
AU (1) AU4605999A (no)
BG (1) BG105018A (no)
BR (1) BR9910967A (no)
CA (1) CA2330206C (no)
CO (1) CO5070700A1 (no)
DE (1) DE59914280D1 (no)
ES (1) ES2285842T3 (no)
HK (1) HK1038591A1 (no)
HR (1) HRP20010013A2 (no)
HU (1) HUP0103190A2 (no)
ID (1) ID27819A (no)
IL (1) IL139750A0 (no)
NO (1) NO20006153L (no)
PL (1) PL345334A1 (no)
SK (1) SK17892000A3 (no)
TR (1) TR200003624T2 (no)
WO (1) WO1999064572A2 (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19921567A1 (de) 1999-05-11 2000-11-16 Basf Ag Verwendung von Phthalazine-Derivaten
AU779689B2 (en) 1999-06-16 2005-02-03 Icos Corporation Human poly(ADP-ribose) polymerase 2 materials and methods
US7041675B2 (en) 2000-02-01 2006-05-09 Abbott Gmbh & Co. Kg Heterocyclic compounds and their use as PARP inhibitors
RU2447889C2 (ru) 2005-07-18 2012-04-20 Бипар Сайенсиз, Инк. Способ лечения рака (варианты)
CA2662337A1 (en) 2006-09-05 2008-03-13 Bipar Sciences, Inc. Inhibition of fatty acid synthesis by parp inhibitors and methods of treatment thereof
CN101522609A (zh) 2006-09-05 2009-09-02 彼帕科学公司 癌症的治疗
JP2011503111A (ja) 2007-11-12 2011-01-27 バイパー サイエンシズ，インコーポレイティド Ｐａｒｐ阻害剤単独又は抗腫瘍剤との組み合わせによる乳がんの治療
AR084894A1 (es) 2011-02-18 2013-07-10 Danisco Composicion de aditivo para pienso
GB201102865D0 (en) 2011-02-18 2011-04-06 Danisco Feed additive composition
GB201102857D0 (en) 2011-02-18 2011-04-06 Danisco Feed additive composition
GB201213801D0 (en) 2012-08-03 2012-09-12 Dupont Nutrition Biosci Aps Feed additive composition
DK2890780T3 (da) 2012-08-29 2020-09-21 Sangamo Therapeutics Inc Fremgangsmåder og sammensætninger til behandling af en genetisk tilstand

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5162508A (en) 1987-12-18 1992-11-10 Compagnie Oris Industrie Rare earth cryptates, processes for their preparation, synthesis intermediates and application as fluorescent tracers
US5272057A (en) * 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
FR2707011A1 (en) 1993-06-25 1994-12-30 Pasteur Sanofi Diagnostics Immunological process for the detection and assay of antibodies directed against poly(ADP-ribose) polymerase, application to diagnosis, kit for its implementation
DE4444949C1 (de) 1994-12-16 1996-11-21 Deutsches Krebsforsch Vektoren und Viren zur Gentherapie

Also Published As

Publication number Publication date
IL139750A0 (en) 2002-02-10
US7754459B1 (en) 2010-07-13
SK17892000A3 (sk) 2001-09-11
KR20010052582A (ko) 2001-06-25
EP1082416A2 (de) 2001-03-14
DE59914280D1 (en) 2007-05-10
AR020326A1 (es) 2002-05-08
BR9910967A (pt) 2001-02-13
ATE358175T1 (de) 2007-04-15
JP2002517231A (ja) 2002-06-18
BG105018A (en) 2001-12-31
CA2330206A1 (en) 1999-12-16
CN1304446A (zh) 2001-07-18
HUP0103190A2 (hu) 2001-12-28
TR200003624T2 (tr) 2001-06-21
WO1999064572A3 (de) 2000-06-08
US20160010067A1 (en) 2016-01-14
HK1038591A1 (zh) 2002-03-22
NO20006153D0 (no) 2000-12-04
CO5070700A1 (es) 2001-08-28
CA2330206C (en) 2010-04-13
PL345334A1 (en) 2001-12-17
EP1082416B1 (de) 2007-03-28
ID27819A (id) 2001-04-26
US9051553B2 (en) 2015-06-09
HRP20010013A2 (en) 2001-12-31
US20110107444A1 (en) 2011-05-05
AU4605999A (en) 1999-12-30
ES2285842T3 (es) 2007-11-16
WO1999064572A2 (de) 1999-12-16

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