NO20006177L - Nye insulinanaloga med ökt sinkbinding - Google Patents

Nye insulinanaloga med ökt sinkbinding

Info

Publication number
NO20006177L
NO20006177L NO20006177A NO20006177A NO20006177L NO 20006177 L NO20006177 L NO 20006177L NO 20006177 A NO20006177 A NO 20006177A NO 20006177 A NO20006177 A NO 20006177A NO 20006177 L NO20006177 L NO 20006177L
Authority
NO
Norway
Prior art keywords
insulin analog
zinc binding
new insulin
increased zinc
increased
Prior art date
Application number
NO20006177A
Other languages
English (en)
Other versions
NO329956B1 (no
NO20006177D0 (no
Inventor
Johann Ertl
Paul Habermann
Karl Geisen
Gerhard Seipke
Axel Wollmer
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of NO20006177D0 publication Critical patent/NO20006177D0/no
Publication of NO20006177L publication Critical patent/NO20006177L/no
Publication of NO329956B1 publication Critical patent/NO329956B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
NO20006177A 1998-06-06 2000-12-05 Nye insulinanaloger med okt sinkbinding og forloper til denne, fremgangsmate for fremstilling, DNA sekvens, ekspresjonsvektor og isolert vertscelle, insulin-sink-kompleks, farmasoytisk preparat, injiserbar opplosning og anvendelse av insulinanalogene. NO329956B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19825447A DE19825447A1 (de) 1998-06-06 1998-06-06 Neue Insulinanaloga mit erhöhter Zinkbildung
PCT/EP1999/003490 WO1999064598A2 (de) 1998-06-06 1999-05-21 Neue insulinanaloga mit erhöhter zinkbindung

Publications (3)

Publication Number Publication Date
NO20006177D0 NO20006177D0 (no) 2000-12-05
NO20006177L true NO20006177L (no) 2000-12-05
NO329956B1 NO329956B1 (no) 2011-01-31

Family

ID=7870213

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20006177A NO329956B1 (no) 1998-06-06 2000-12-05 Nye insulinanaloger med okt sinkbinding og forloper til denne, fremgangsmate for fremstilling, DNA sekvens, ekspresjonsvektor og isolert vertscelle, insulin-sink-kompleks, farmasoytisk preparat, injiserbar opplosning og anvendelse av insulinanalogene.

Country Status (23)

Country Link
US (1) US6686177B1 (no)
EP (1) EP1084248B1 (no)
JP (1) JP4402296B2 (no)
KR (1) KR100649339B1 (no)
CN (1) CN1304450B (no)
AR (1) AR019852A1 (no)
AT (1) ATE334201T1 (no)
AU (1) AU757275B2 (no)
BR (1) BR9910978A (no)
CA (1) CA2330183C (no)
CZ (1) CZ301377B6 (no)
DE (2) DE19825447A1 (no)
DK (1) DK1084248T3 (no)
ES (1) ES2268871T3 (no)
HU (1) HU228908B1 (no)
MX (1) MXPA00011456A (no)
NO (1) NO329956B1 (no)
PL (1) PL198190B1 (no)
PT (1) PT1084248E (no)
RU (1) RU2225723C2 (no)
TR (1) TR200003606T2 (no)
WO (1) WO1999064598A2 (no)
ZA (1) ZA200006835B (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19825447A1 (de) * 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
AU2002248464A1 (en) 2001-02-21 2002-09-12 Medtronic Minimed, Inc. Stabilized insulin formulations
US20040038864A1 (en) * 2002-06-27 2004-02-26 Per Balschmidt Use of dimethyl sulfone as isotonicity agent
CN103223160B (zh) 2004-07-19 2015-02-18 比奥孔有限公司 胰岛素-低聚物共轭物,制剂及其用途
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
US9241908B2 (en) * 2007-10-16 2016-01-26 Biocon Limited Orally administrable solid pharmaceutical composition and a process thereof
WO2009063072A2 (en) * 2007-11-16 2009-05-22 Novo Nordisk A/S Pharmaceutical compositions containing insulin and an insulinotropic peptide
PL219335B1 (pl) 2008-07-04 2015-04-30 Inst Biotechnologii I Antybiotyków Pochodna insuliny lub jej farmaceutycznie dopuszczalna sól, jej zastosowanie oraz zawierająca ją kompozycja farmaceutyczna
ES2552636T3 (es) * 2008-07-31 2015-12-01 Case Western Reserve University Insulina estabilizada por halógenos
WO2011103575A1 (en) * 2010-02-22 2011-08-25 Case Western Reserve University Long-acting insulin analogue preparations in soluble and crystalline forms
PL222975B1 (pl) 2012-05-23 2016-09-30 Inst Biotechnologii I Antybiotyków Analog insuliny lub jego farmaceutycznie dopuszczalna sól, kompozycja farmaceutyczna o przedłużonym działaniu terapeutycznym oraz zastosowanie analogu insuliny
FR3013049B1 (fr) 2013-11-14 2015-11-13 You-Ping Chan Analogue de l'insuline glargine
WO2016144658A1 (en) * 2015-03-10 2016-09-15 Merck Sharp & Dohme Corp. Process for preparing recombinant insulin using microfiltration
UY36870A (es) * 2015-08-28 2017-03-31 Hanmi Pharm Ind Co Ltd Análogos de insulina novedosos

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI78616C (fi) 1982-02-05 1989-09-11 Novo Industri As Foerfarande foer framstaellning av en foer infusionsaendamaol avsedd stabiliserad insulinloesning, som har en foerhoejd zinkhalt.
DE3326472A1 (de) 1983-07-22 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE3327709A1 (de) * 1983-07-29 1985-02-07 Hoechst Ag, 6230 Frankfurt Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung
SU1250303A1 (ru) * 1983-12-30 1986-08-15 Филиал По Разработке Готовых Лекарственных Средств Научно-Исследовательского Института По Биологическим Испытаниям Химических Соединений Способ стабилизации суспензии цинк-инсулина кристаллического
DE3440988A1 (de) 1984-11-09 1986-07-10 Hoechst Ag, 6230 Frankfurt Verfahren zur spaltung von peptiden und proteinen an der methionyl-bindung
US4569794A (en) 1984-12-05 1986-02-11 Eli Lilly And Company Process for purifying proteins and compounds useful in such process
US5008241A (en) 1985-03-12 1991-04-16 Novo Nordisk A/S Novel insulin peptides
DE3526995A1 (de) 1985-07-27 1987-02-05 Hoechst Ag Fusionsproteine, verfahren zu ihrer herstellung und ihre verwendung
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
DE3636903A1 (de) 1985-12-21 1987-07-02 Hoechst Ag Fusionsproteine mit eukaryotischem ballastanteil
DE3541856A1 (de) 1985-11-27 1987-06-04 Hoechst Ag Eukaryotische fusionsproteine, ihre herstellung und verwendung sowie mittel zur durchfuehrung des verfahrens
RU2104305C1 (ru) * 1986-08-29 1998-02-10 Ново Нордиск А.С. Аналоги инсулина человека, способ их получения, раствор для инъекций
CA1340522C (en) 1987-03-10 1999-05-04 Heinz Dobeli Fusion proteins containing neighbouring histidines for improved purification
DE3805150A1 (de) 1987-04-11 1988-10-20 Hoechst Ag Gentechnologisches verfahren zur herstellung von polypeptiden
DE4012818A1 (de) 1990-04-21 1991-10-24 Hoechst Ag Verfahren zur herstellung von fremdproteinen in streptomyceten
DE3726655A1 (de) 1987-08-11 1989-02-23 Hoechst Ag Verfahren zur isolierung basischer proteine aus proteingemischen, welche solche basischen proteine enthalten
DE3739347A1 (de) 1987-11-20 1989-06-01 Hoechst Ag Verfahren zur selektiven spaltung von fusionsproteinen
DK257988D0 (da) * 1988-05-11 1988-05-11 Novo Industri As Nye peptider
DE58906966D1 (de) 1988-06-23 1994-03-24 Hoechst Ag Mini-Proinsulin, seine Herstellung und Verwendung.
DE3827533A1 (de) 1988-08-13 1990-02-15 Hoechst Ag Pharmazeutische zubereitung zur behandlung des diabetes mellitus
DE3837825A1 (de) 1988-11-08 1990-05-10 Hoechst Ag Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
US5358857A (en) 1989-08-29 1994-10-25 The General Hospital Corp. Method of preparing fusion proteins
IL95495A (en) 1989-08-29 1996-10-16 Hoechst Ag Fusion proteins their preparation and use
US5227293A (en) 1989-08-29 1993-07-13 The General Hospital Corporation Fusion proteins, their preparation and use
SG46612A1 (en) 1992-12-02 1998-02-20 Hoechst Ag Process for obtaining proinsulin in processing correctly linked cystine bridges
DE122006000015I1 (de) * 1993-06-21 2006-06-29 Novo Nordisk As Asp-B28-Insulinkristalle
SI0792290T1 (en) * 1993-09-17 2001-12-31 Novo Nordisk As Acylated insulin
DE4405179A1 (de) 1994-02-18 1995-08-24 Hoechst Ag Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken
DE59711533D1 (de) * 1996-07-26 2004-05-27 Aventis Pharma Gmbh Insulinderivate mit erhöhter Zinkbindung
DE19825447A1 (de) * 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung

Also Published As

Publication number Publication date
PT1084248E (pt) 2006-11-30
JP2002517247A (ja) 2002-06-18
ZA200006835B (en) 2001-07-09
PL198190B1 (pl) 2008-06-30
AU4145499A (en) 1999-12-30
HUP0102217A2 (hu) 2001-10-28
MXPA00011456A (es) 2002-10-17
AU757275B2 (en) 2003-02-13
CZ20004525A3 (cs) 2001-04-11
WO1999064598A2 (de) 1999-12-16
RU2225723C2 (ru) 2004-03-20
NO329956B1 (no) 2011-01-31
HK1036808A1 (en) 2002-01-18
HUP0102217A3 (en) 2004-04-28
PL345898A1 (en) 2002-01-14
JP4402296B2 (ja) 2010-01-20
TR200003606T2 (tr) 2001-06-21
AR019852A1 (es) 2002-03-20
DE59913711D1 (de) 2006-09-07
DK1084248T3 (da) 2006-11-20
BR9910978A (pt) 2001-02-13
ATE334201T1 (de) 2006-08-15
WO1999064598A3 (de) 2000-03-16
KR20010052635A (ko) 2001-06-25
NO20006177D0 (no) 2000-12-05
DE19825447A1 (de) 1999-12-09
CN1304450A (zh) 2001-07-18
EP1084248B1 (de) 2006-07-26
EP1084248A2 (de) 2001-03-21
CZ301377B6 (cs) 2010-02-03
KR100649339B1 (ko) 2006-11-24
US6686177B1 (en) 2004-02-03
ES2268871T3 (es) 2007-03-16
CA2330183C (en) 2009-10-20
HU228908B1 (hu) 2013-06-28
CA2330183A1 (en) 1999-12-16
CN1304450B (zh) 2012-10-10

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