NO20006195L - Genes for the biosynthesis of epothilones - Google Patents

Genes for the biosynthesis of epothilones

Info

Publication number: NO20006195L
Authority: NO; Norway
Prior art keywords: epothilones; biosynthesis; genes
Prior art date: 1998-06-18

Application number

NO20006195A

Other languages

Norwegian (no)

Other versions

NO20006195D0 (en

Inventor

Thomas Schupp

James Madison Ligon

Istvan Molnar

Ross Zirkle

Joern Goerlach

Devon Cyr

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-18

Filing date

2000-12-06

Publication date

2001-02-16

2000-12-06 Application filed by Novartis Ag filed Critical Novartis Ag

2000-12-06 Publication of NO20006195D0 publication Critical patent/NO20006195D0/en

2001-02-16 Publication of NO20006195L publication Critical patent/NO20006195L/en

Links

230000015572 biosynthetic process Effects 0.000 title 1
229930013356 epothilone Natural products 0.000 title 1
HESCAJZNRMSMJG-KKQRBIROSA-N epothilone A Chemical class C/C([C@@H]1C[C@@H]2O[C@@H]2CCC[C@@H]([C@@H]([C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)O)C)=C\C1=CSC(C)=N1 HESCAJZNRMSMJG-KKQRBIROSA-N 0.000 title 1
108090000623 proteins and genes Proteins 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Biophysics (AREA)
Microbiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Oncology (AREA)
Gastroenterology & Hepatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)

NO20006195A 1998-06-18 2000-12-06 Genes for the biosynthesis of epothilones NO20006195L (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US9950498A	1998-06-18	1998-06-18
US10163198P	1998-09-24	1998-09-24
US11890699P	1999-02-05	1999-02-05
PCT/EP1999/004171 WO1999066028A2 (en)	1998-06-18	1999-06-16	Genes for the biosynthesis of epothilones

Publications (2)

Publication Number	Publication Date
NO20006195D0 NO20006195D0 (en)	2000-12-06
NO20006195L true NO20006195L (en)	2001-02-16

Family

ID=27378840

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO20006195A NO20006195L (en)	1998-06-18	2000-12-06	Genes for the biosynthesis of epothilones
NO20091055A NO20091055L (en)	1998-06-18	2009-03-09	Genes for the biosynthesis of epothilones

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
NO20091055A NO20091055L (en)	1998-06-18	2009-03-09	Genes for the biosynthesis of epothilones

Country Status (16)

Country	Link
EP (1)	EP1088078A2 (en)
JP (3)	JP2002518004A (en)
KR (1)	KR100511233B1 (en)
CN (1)	CN100374565C (en)
AU (1)	AU753567B2 (en)
BR (1)	BR9911349A (en)
CA (1)	CA2329774A1 (en)
HU (1)	HUP0102186A3 (en)
ID (1)	ID29128A (en)
IL (3)	IL139735A0 (en)
NO (2)	NO20006195L (en)
NZ (1)	NZ508326A (en)
PL (1)	PL200157B1 (en)
SK (1)	SK19242000A3 (en)
TR (1)	TR200003759T2 (en)
WO (1)	WO1999066028A2 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2273083C (en)	1996-12-03	2012-09-18	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US6204388B1 (en)	1996-12-03	2001-03-20	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
FR2775187B1 (en)	1998-02-25	2003-02-21	Novartis Ag	USE OF EPOTHILONE B FOR THE MANUFACTURE OF AN ANTIPROLIFERATIVE PHARMACEUTICAL PREPARATION AND A COMPOSITION COMPRISING EPOTHILONE B AS AN IN VIVO ANTIPROLIFERATIVE AGENT
DE19846493A1 (en) *	1998-10-09	2000-04-13	Biotechnolog Forschung Gmbh	DNA sequence coding for products involved in the biosynthesis of polyketide or heteropolyketide compounds, especially epothilone
WO2000031247A2 (en)	1998-11-20	2000-06-02	Kosan Biosciences, Inc.	Recombinant methods and materials for producing epothilone and epothilone derivatives
US6410301B1 (en)	1998-11-20	2002-06-25	Kosan Biosciences, Inc.	Myxococcus host cells for the production of epothilones
AU2001245263A1 (en) *	2000-01-21	2001-07-31	Kosan Biosciences, Inc.	Method for cloning polyketide synthase genes
DK1652926T3 (en) *	2000-04-28	2010-02-15	Kosan Biosciences Inc	Crystalline epothilone D
US6998256B2 (en)	2000-04-28	2006-02-14	Kosan Biosciences, Inc.	Methods of obtaining epothilone D using crystallization and /or by the culture of cells in the presence of methyl oleate
US7257562B2 (en)	2000-10-13	2007-08-14	Thallion Pharmaceuticals Inc.	High throughput method for discovery of gene clusters
IL155306A0 (en)	2000-10-13	2003-11-23	Univ Mississippi	Methods for producing epothilone derivatives and analogs and epothilone derivatives and analogs produced thereby
SI1483251T1 (en)	2002-03-12	2010-03-31	Bristol Myers Squibb Co	C3-cyano epothilone derivatives
AU2006211216B2 (en) *	2005-01-31	2011-02-03	Merck Sharp & Dohme Llc	Purification process for plasmid DNA
DK2668284T3 (en)	2011-01-28	2014-12-15	Amyris Inc	Screening of colony micro encapsulated in gel
CA2834783A1 (en)	2011-05-13	2012-11-22	Amyris, Inc.	Methods and compositions for detecting microbial production of water-immiscible compounds
AU2013299608B2 (en)	2012-08-07	2019-02-21	Amyris, Inc.	Methods for stabilizing production of acetyl-coenzyme a derived compounds
JP6595449B2 (en)	2013-03-15	2019-10-23	アミリス，インコーポレイテッド	Use of phosphoketolase and phosphotransacetylase to produce acetyl coenzyme A derived compounds
BR112016002526B1 (en)	2013-08-07	2021-11-23	Total Marketing Services	METHOD FOR THE PRODUCTION OF A NON-CATABOLIC HETEROLOGOUS COMPOUND, AND, FERMENTATION COMPOSITION
US10808015B2 (en)	2015-06-25	2020-10-20	Amyris, Inc.	Maltose dependent degrons, maltose-responsive promoters, stabilization constructs, and their use in production of non-catabolic compounds
CN106916834B (en) *	2015-12-24	2022-08-05	武汉合生科技有限公司	Biosynthetic gene cluster of compounds and application thereof
CN111138444B (en) *	2020-01-08	2022-05-03	山东大学	Epothilone B glucoside compounds and enzymatic preparation and application thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2312695T3 (en) *	1996-11-18	2009-03-01	Gesellschaft Fur Biotechnologische Forschung Mbh (Gbf)	EPOTILONES E AND F.

1998
- 1998-06-12 NZ NZ508326A patent/NZ508326A/en not_active IP Right Cessation
1999
- 1999-06-16 TR TR2000/03759T patent/TR200003759T2/en unknown
- 1999-06-16 KR KR10-2000-7014348A patent/KR100511233B1/en not_active Expired - Fee Related
- 1999-06-16 CA CA002329774A patent/CA2329774A1/en not_active Abandoned
- 1999-06-16 WO PCT/EP1999/004171 patent/WO1999066028A2/en not_active Ceased
- 1999-06-16 AU AU46116/99A patent/AU753567B2/en not_active Ceased
- 1999-06-16 IL IL13973599A patent/IL139735A0/en unknown
- 1999-06-16 CN CNB998074217A patent/CN100374565C/en not_active Expired - Fee Related
- 1999-06-16 ID IDW20002594A patent/ID29128A/en unknown
- 1999-06-16 EP EP99929243A patent/EP1088078A2/en not_active Withdrawn
- 1999-06-16 SK SK1924-2000A patent/SK19242000A3/en not_active Application Discontinuation
- 1999-06-16 BR BR9911349-0A patent/BR9911349A/en not_active Application Discontinuation
- 1999-06-16 PL PL345579A patent/PL200157B1/en not_active IP Right Cessation
- 1999-06-16 JP JP2000554837A patent/JP2002518004A/en not_active Withdrawn
- 1999-06-16 HU HU0102186A patent/HUP0102186A3/en unknown
2000
- 2000-11-16 IL IL139735A patent/IL139735A/en not_active IP Right Cessation
- 2000-12-06 NO NO20006195A patent/NO20006195L/en unknown
2005
- 2005-10-20 JP JP2005305998A patent/JP2006061166A/en active Pending
2007
- 2007-12-26 JP JP2007334606A patent/JP2008092958A/en active Pending
2008
- 2008-03-24 IL IL190391A patent/IL190391A0/en unknown
2009
- 2009-03-09 NO NO20091055A patent/NO20091055L/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
JP2006061166A (en)	2006-03-09
CA2329774A1 (en)	1999-12-23
WO1999066028A2 (en)	1999-12-23
IL139735A (en)	2009-06-15
HUP0102186A2 (en)	2001-10-28
KR100511233B1 (en)	2005-08-31
EP1088078A2 (en)	2001-04-04
AU753567B2 (en)	2002-10-24
JP2002518004A (en)	2002-06-25
HUP0102186A3 (en)	2005-10-28
SK19242000A3 (en)	2001-07-10
PL200157B1 (en)	2008-12-31
NO20006195D0 (en)	2000-12-06
AU4611699A (en)	2000-01-05
CN100374565C (en)	2008-03-12
ID29128A (en)	2001-08-02
IL190391A0 (en)	2008-11-03
WO1999066028A3 (en)	2000-06-29
BR9911349A (en)	2001-03-13
TR200003759T2 (en)	2001-06-21
KR20010052962A (en)	2001-06-25
JP2008092958A (en)	2008-04-24
NO20091055L (en)	2001-02-16
CN1305530A (en)	2001-07-25
IL139735A0 (en)	2002-02-10
NZ508326A (en)	2003-10-31
PL345579A1 (en)	2001-12-17

Publication	Publication Date	Title
NO20006195D0 (en)	2000-12-06	Genes for the biosynthesis of epothilones
FI980732A0 (en)	1998-03-31	Foerfarande Foer koppling av dataoeverfoeringsstroemmar
FI980343A0 (en)	1998-02-13	Foerfarande Foer kontrollering av effekt
ATE426598T1 (en)	2009-04-15	EPOTHILONE DERIVATIVES
PT1109558E (en)	2002-10-31	RANOLAZINE FORMULATIONS OF CONTROLLED LIBERTACAO
ZA99194B (en)	2000-07-12	Synthesis of ZSM-48.
FI980465A0 (en)	1998-02-27	Foerfarande Foer installering av tjaenster
ATE317007T1 (en)	2006-02-15	GENES OF THE 1-DESOXY-D-XYLULOSE BIOSYNTHESIS PATHWAY
DE69905495D1 (en)	2003-03-27	BISMUTHMANGANIT PIGMENTS
NO20004680D0 (en)	2000-09-19	Limnanthes oil genes
FI980327A0 (en)	1998-02-12	Foerfarande Foer foermedling av telefonsamtal
FI972346A0 (en)	1997-06-02	For the purposes of this Regulation
PT1246817E (en)	2004-11-30	DERIVATIVES OF 4-PHENYL-1-PIPERAZINYL, -PIPERIDINYL E-TETRAHYDROPYRIDYL
AU2001250428A1 (en)	2001-11-20	Genes of the 1-desoxy-d-xylulose biosynthesis path
NO20005285L (en)	2000-12-19	Control of multiple downhole tools
NO20024058D0 (en)	2002-08-26	Process for the preparation of an oxazolylethanol derivative
NO20006262D0 (en)	2000-12-08	Feeding of pipes
FI980044A0 (en)	1998-01-12	Foerfarande Foer behandling av en fiberbana
EP1160325A4 (en)	2004-06-30	GENES OF AVLYCTIN AGLYCONE SYNTHASE
HK1035557A (en)	2001-11-30	Genes for the biosynthesis of epothilones
FI980710A0 (en)	1998-03-27	Foerfarande Foer smaeltning av stenmaterial Foer mineralullsproduktion
NO20005856D0 (en)	2000-11-20	Use of 1,1-dioxo-perhydro-1,2,4-thiadiazines
FI980575A0 (en)	1998-03-16	For the purposes of this Regulation
SE9902239D0 (en)	1999-06-15	Kornisch consisting of several parts
SE9902775D0 (en)	1999-07-23	Genes for the synthesis of an antimicrobial substance