NO20006244L - Corrected combinatorial compound library and high yield analyzes for screening thereof - Google Patents

Corrected combinatorial compound library and high yield analyzes for screening thereof

Info

Publication number
NO20006244L
NO20006244L NO20006244A NO20006244A NO20006244L NO 20006244 L NO20006244 L NO 20006244L NO 20006244 A NO20006244 A NO 20006244A NO 20006244 A NO20006244 A NO 20006244A NO 20006244 L NO20006244 L NO 20006244L
Authority
NO
Norway
Prior art keywords
monomer
nucleoside
spacer
screening
corrected
Prior art date
Application number
NO20006244A
Other languages
Norwegian (no)
Other versions
NO20006244D0 (en
Inventor
Jeremy Carver
James W Dennis
Francois D Tropper
Uttam Saha
Lothar Ziser
Alessandro Datti
Rob Donovan
Original Assignee
Glycodesign Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycodesign Inc filed Critical Glycodesign Inc
Publication of NO20006244D0 publication Critical patent/NO20006244D0/en
Publication of NO20006244L publication Critical patent/NO20006244L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C07K9/003—Peptides being substituted by heterocyclic radicals, e.g. bleomycin, phleomycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Et kombinatorisk bibliotek omfattende en forutbestemt kolleksjon av nukleosid- peptidmolekylerfor inhibering av overføring av et sukker fra en valgt sukkernukleotid- donor til en valgt aksepter av et karbohydratprosesserende enzym. Nukleosidpeptidmolekylet omfatter (a) en nukleosidmonomer; (b) en spacermonomer koblet til nuklosidmonomeren hvori spacermonomeren omfatter en eller flere amidkoblete aminosyreresidier, eller en peptidomimetik og (c) monomerer koblet til spacermonomeren. Nukleosidpeptidmolekylene er forskjellige ved at identiteten til minst et element av nukleosidmonomeren, spacermonomeren eller capmonomeren.A combinatorial library comprising a predetermined collection of nucleoside peptide molecules for inhibiting transfer of a sugar from a selected sugar nucleotide donor to a selected acceptor of a carbohydrate processing enzyme. The nucleoside peptide molecule comprises (a) a nucleoside monomer; (b) a spacer monomer coupled to the nucleoside monomer wherein the spacer monomer comprises one or more amide-linked amino acid residues, or a peptidomimetic and (c) monomers coupled to the spacer monomer. The nucleoside peptide molecules are different in that the identity of at least one element of the nucleoside monomer, spacer monomer or cap monomer.

NO20006244A 1998-06-10 2000-12-08 Corrected combinatorial compound library and high yield analyzes for screening thereof NO20006244L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8882898P 1998-06-10 1998-06-10
US12056299P 1999-02-17 1999-02-17
PCT/CA1999/000550 WO1999064378A2 (en) 1998-06-10 1999-06-10 Directed combinatorial compound library and high throughput assays for screening same

Publications (2)

Publication Number Publication Date
NO20006244D0 NO20006244D0 (en) 2000-12-08
NO20006244L true NO20006244L (en) 2001-02-08

Family

ID=26779099

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20006244A NO20006244L (en) 1998-06-10 2000-12-08 Corrected combinatorial compound library and high yield analyzes for screening thereof

Country Status (8)

Country Link
EP (1) EP1086064A2 (en)
JP (1) JP2002517474A (en)
CN (1) CN1314913A (en)
AU (1) AU4493099A (en)
CA (1) CA2334338A1 (en)
MX (1) MXPA00012237A (en)
NO (1) NO20006244L (en)
WO (1) WO1999064378A2 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001009141A1 (en) * 1999-07-29 2001-02-08 National Institute Of Advanced Industrial Science And Technology Polymerizable biotin derivatives, biotin polymer, and polymer responsive to avidin stimulation
CA2390441A1 (en) 1999-11-08 2001-05-17 Origenix Technologies, Inc. Combinatorial library synthesis and pharmaceutically active compounds produced thereby
US20020127598A1 (en) * 2000-03-27 2002-09-12 Wenqiang Zhou Solution-phase combinatorial library synthesis and pharmaceutically active compounds produced thereby
US7338932B2 (en) 2000-05-11 2008-03-04 Glycozym Aps Methods of modulating functions of polypeptide GalNAc-transferases and of screening test substances to find agents herefor, pharmaceutical compositions comprising such agents and the use of such agents for preparing medicaments
DE60128218D1 (en) * 2000-05-11 2007-06-14 Glycozym Aps METHODS FOR MODELING THE FUNCTION OF POLYPEPTIDE GalNAc TRANSFERASES AND ZURSCREENING SUBSTANCES THEREFOR
WO2002092006A2 (en) 2001-05-16 2002-11-21 Micrologix Biotech, Inc. Nucleic acid-based compounds and methods of use thereof
WO2002102820A1 (en) 2001-06-20 2002-12-27 Nuevolution A/S Nucleoside derivatives for library preparation
WO2003078625A2 (en) 2002-03-15 2003-09-25 Nuevolution A/S An improved method for synthesising templated molecules
EP1539980B1 (en) 2002-08-01 2016-02-17 Nuevolution A/S Library of complexes comprising small non-peptide molecules and double-stranded oligonucleotides identifying the molecules
WO2004028682A2 (en) 2002-09-27 2004-04-08 Carlsberg A/S Spatially encoded polymer matrix
WO2004039825A2 (en) 2002-10-30 2004-05-13 Nuevolution A/S Method for the synthesis of a bifunctional complex
WO2004056994A2 (en) 2002-12-19 2004-07-08 Nuevolution A/S Quasirandom structure and function guided synthesis methods
WO2004074429A2 (en) 2003-02-21 2004-09-02 Nuevolution A/S Method for producing second-generation library
EP1644395B1 (en) * 2003-06-19 2006-11-22 F. Hoffmann-La Roche Ag Processes for preparing 4'azido nucleoside derivatives
ATE447626T1 (en) 2003-09-18 2009-11-15 Nuevolution As METHOD FOR OBTAINING STRUCTURAL INFORMATION FROM ENCODED MOLECULES AND FOR SELECTING COMPOUNDS
WO2007038829A1 (en) * 2005-10-04 2007-04-12 Alchemia Ltd Method of drug design
SI3305900T1 (en) 2005-12-01 2022-02-28 Nuevolution A/S Enzymatic encoding methods for efficient synthesis of large libraries
EP2555801A4 (en) * 2010-04-07 2014-02-26 Momenta Pharmaceuticals Inc Selection and use of host cells for production of glycoproteins
EP3540059A1 (en) 2010-04-16 2019-09-18 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995010296A1 (en) * 1993-10-12 1995-04-20 Glycomed Incorporated A library of glyco-peptides useful for identification of cell adhesion inhibitors
IL110024A (en) * 1994-06-15 1998-04-05 Yissum Res Dev Co Controlled release oral drug delivery system containing hydrogel- forming polymer

Also Published As

Publication number Publication date
CA2334338A1 (en) 1999-12-16
WO1999064378A3 (en) 2000-09-21
WO1999064378A2 (en) 1999-12-16
MXPA00012237A (en) 2002-11-15
JP2002517474A (en) 2002-06-18
NO20006244D0 (en) 2000-12-08
EP1086064A2 (en) 2001-03-28
AU4493099A (en) 1999-12-30
CN1314913A (en) 2001-09-26

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application