NO20006380L - Amidino- og guanidino-azetidinon-tryptaseinhibitorer - Google Patents

Amidino- og guanidino-azetidinon-tryptaseinhibitorer

Info

Publication number
NO20006380L
NO20006380L NO20006380A NO20006380A NO20006380L NO 20006380 L NO20006380 L NO 20006380L NO 20006380 A NO20006380 A NO 20006380A NO 20006380 A NO20006380 A NO 20006380A NO 20006380 L NO20006380 L NO 20006380L
Authority
NO
Norway
Prior art keywords
azetidinone
guanidino
amidino
tryptase inhibitors
tryptase
Prior art date
Application number
NO20006380A
Other languages
English (en)
Other versions
NO20006380D0 (no
Inventor
Gregory S Bisacchi
William A Slusarchyk
Uwe Treuner
James C Sutton
Robert Zahler
Steven Seiler
David R Kronenthal
Michael E Randazzo
Zhongmin Xu
Zhongping Shi
Mark D Schwinden
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO20006380D0 publication Critical patent/NO20006380D0/no
Publication of NO20006380L publication Critical patent/NO20006380L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO20006380A 1998-06-25 2000-12-14 Amidino- og guanidino-azetidinon-tryptaseinhibitorer NO20006380L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9063698P 1998-06-25 1998-06-25
PCT/US1999/013811 WO1999067215A1 (en) 1998-06-25 1999-06-18 Amidino and guanidino azetidinone tryptase inhibitors

Publications (2)

Publication Number Publication Date
NO20006380D0 NO20006380D0 (no) 2000-12-14
NO20006380L true NO20006380L (no) 2000-12-14

Family

ID=22223632

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20006380A NO20006380L (no) 1998-06-25 2000-12-14 Amidino- og guanidino-azetidinon-tryptaseinhibitorer

Country Status (24)

Country Link
EP (1) EP1089973B1 (no)
JP (1) JP2002518478A (no)
KR (1) KR20010053173A (no)
CN (1) CN1202081C (no)
AR (1) AR018945A1 (no)
AT (1) ATE309211T1 (no)
AU (1) AU752320B2 (no)
BR (1) BR9911373A (no)
CA (1) CA2336003A1 (no)
DE (1) DE69928257T2 (no)
ES (1) ES2249017T3 (no)
HU (1) HUP0104308A3 (no)
ID (1) ID27137A (no)
IL (1) IL140414A0 (no)
NO (1) NO20006380L (no)
NZ (1) NZ507627A (no)
PE (1) PE20000729A1 (no)
PL (1) PL345067A1 (no)
RU (1) RU2211832C2 (no)
TR (1) TR200003859T2 (no)
TW (1) TW548270B (no)
UY (1) UY25580A1 (no)
WO (1) WO1999067215A1 (no)
ZA (1) ZA200006028B (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005063704A1 (ja) 2003-12-25 2005-07-14 Ono Pharmaceutical Co., Ltd. アゼチジン環化合物およびその医薬
WO2006062110A1 (ja) * 2004-12-06 2006-06-15 Banyu Pharmaceutical Co., Ltd. ピペラジン誘導体
WO2011102436A1 (ja) * 2010-02-17 2011-08-25 国立大学法人京都大学 ＴＧＦ－βシグナル伝達阻害剤
AR095569A1 (es) * 2013-03-20 2015-10-28 Hoffmann La Roche Derivados de urea
US20160068486A1 (en) 2013-04-22 2016-03-10 Reuter Chemische Apparatebau Kg Process for preparing enantiomerically enriched 3-hydroxymethylpiperidine
EP3036219A4 (en) 2013-06-04 2017-08-23 Temple University Of The Commonwealth System Of Higher Education Novel beta lactams as modulators of glutamate uptake and methods for use thereof
US9499532B2 (en) * 2014-02-07 2016-11-22 eXIthera Pharmaceuticals Inc. Therapeutic compounds and compositions
WO2019156929A1 (en) 2018-02-07 2019-08-15 eXIthera Pharmaceuticals Inc. Therapeutic compounds and compositions
EP3778588A4 (en) * 2018-03-30 2021-04-28 Shanghai Meiyue Biotech Development Co., Ltd. QUATERNARY LACTAM COMPOUND AND ITS PHARMACEUTICAL USES THEREOF
CN109988098A (zh) * 2019-05-23 2019-07-09 常州工程职业技术学院 一种(r)-n-叔丁氧羰基-3-羟甲基哌啶的合成方法
CN114040908A (zh) * 2019-06-25 2022-02-11 广东东阳光药业有限公司 一种凝血因子XIa抑制剂的晶型及其制备方法
CA3160619A1 (en) 2019-11-08 2021-05-14 Coave Therapeutics Modified adeno-associated virus vectors and delivery thereof into the central nervous system
CN116802279A (zh) 2020-11-06 2023-09-22 科亚韦治疗公司 内酰胺修饰的腺相关病毒载体
ES3063368T3 (en) * 2020-11-06 2026-04-16 Coave Therapeutics Lactam-modified adeno-associated virus vectors
CN118754827B (zh) * 2024-06-27 2025-03-25 成都普康唯新生物科技有限公司 含保护基的α-甲基鸟氨酸的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5110812A (en) * 1990-06-04 1992-05-05 Bristol-Myers Squibb Co. Azetidin-2-one derivatives as serine protease inhibitors
US5250677A (en) * 1990-06-04 1993-10-05 Bristol-Myers Squibb Company Azetidin-2-one derivatives as serine protease inhibitors
US5037819A (en) * 1990-06-04 1991-08-06 Bristol-Myers Squibb Company Azetidin-2-one derivatives as serine protease inhibitors
US5175283A (en) * 1990-06-04 1992-12-29 Bristol-Myers Squibb Company Azetidin-2-one derivatives as serine protease inhibitors
CA2108584C (en) * 1992-10-27 1998-11-24 James B. Doherty Substituted azetidinones as anti-inflammatory and antidegenerative agents
US5633246A (en) * 1994-11-18 1997-05-27 Schering Corporation Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
US5747485A (en) * 1995-04-13 1998-05-05 Merck & Co., Inc. Substituted azetidiones as anti-inflammatory and antidegenerative agents
JP2001503738A (ja) * 1996-09-23 2001-03-21 シンファー ラボラトリーズ，インコーポレーティッド システイン・プロテイナーゼ調節剤として有用な３，４―ジ置換アゼチジン―２―オン誘導体

Also Published As

Publication number Publication date
WO1999067215A1 (en) 1999-12-29
TW548270B (en) 2003-08-21
ZA200006028B (en) 2002-09-25
DE69928257D1 (de) 2005-12-15
PL345067A1 (en) 2001-12-03
IL140414A0 (en) 2002-02-10
CA2336003A1 (en) 1999-12-29
EP1089973A4 (en) 2001-12-12
ID27137A (id) 2001-03-01
AU752320B2 (en) 2002-09-12
ATE309211T1 (de) 2005-11-15
DE69928257T2 (de) 2006-08-03
CN1202081C (zh) 2005-05-18
UY25580A1 (es) 2001-08-27
RU2211832C2 (ru) 2003-09-10
NZ507627A (en) 2003-12-19
JP2002518478A (ja) 2002-06-25
BR9911373A (pt) 2001-09-18
CN1307560A (zh) 2001-08-08
NO20006380D0 (no) 2000-12-14
PE20000729A1 (es) 2000-10-28
TR200003859T2 (tr) 2001-07-23
ES2249017T3 (es) 2006-03-16
HUP0104308A2 (hu) 2002-04-29
KR20010053173A (ko) 2001-06-25
AR018945A1 (es) 2001-12-12
AU4695099A (en) 2000-01-10
HUP0104308A3 (en) 2002-06-28
EP1089973A1 (en) 2001-04-11
EP1089973B1 (en) 2005-11-09

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