NO20006456L - En mutant human hepatitt B viral stamme og anvendelser derav - Google Patents
En mutant human hepatitt B viral stamme og anvendelser deravInfo
- Publication number
- NO20006456L NO20006456L NO20006456A NO20006456A NO20006456L NO 20006456 L NO20006456 L NO 20006456L NO 20006456 A NO20006456 A NO 20006456A NO 20006456 A NO20006456 A NO 20006456A NO 20006456 L NO20006456 L NO 20006456L
- Authority
- NO
- Norway
- Prior art keywords
- virus
- hepatitis
- nucleic acid
- isolated nucleic
- polypeptide
- Prior art date
Links
- 208000002672 hepatitis B Diseases 0.000 title 1
- 230000003612 virological effect Effects 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 9
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 6
- 102000039446 nucleic acids Human genes 0.000 abstract 5
- 108020004707 nucleic acids Proteins 0.000 abstract 5
- 150000007523 nucleic acids Chemical class 0.000 abstract 5
- 241000700721 Hepatitis B virus Species 0.000 abstract 4
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 150000001413 amino acids Chemical group 0.000 abstract 3
- 239000000427 antigen Substances 0.000 abstract 3
- 102000036639 antigens Human genes 0.000 abstract 3
- 108091007433 antigens Proteins 0.000 abstract 3
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 2
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 2
- 239000004473 Threonine Substances 0.000 abstract 2
- 229930182817 methionine Natural products 0.000 abstract 2
- 241000700605 Viruses Species 0.000 abstract 1
- 238000004113 cell culture Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Denne oppfinnelse frembringer en isolert stamme med hepatitt B virus som er benevnt human hepatitt B virus overflateantigen -"S" - 133 Oon stamme (metionin til treonin), hvis inneholdende virusgenom er arkivert under tilgangsnummerene P97121501, P97121502 og P97121503 i den europeiske cellekultur samling den 15. desember 1997. Denne oppfinnelse frembringer også en isolert nukleinsyre som koder for et polypeptid som er et mutant stort overflate antigen på en stamme med hepatitt B virus, der nevnte polypeptid har en aminosyresekvens som skiller seg fra aminosyresekvensen til et stort overflateantigen fra et villtype hepatitt B virus i at aminosyren i posisjon 133 i et slikt polypeptid er treonin istedenfor metionin. Denne oppfinnelse frembringer også en isolert nukleinsyre som koder for et peptid, der peptidet blir kodet for av et nukleinsyremolekyl som omfatter nukleotidet 527 til og med 595 i SEQ.ID.No. 1 og det rensete peptid. Denne oppfinnelse frembringer også ulike fremgangsmåter for å bruke de beskrevne isolerte nukleinsyrer og peptider. Denne oppfinnelse frembringer videre ulike anvendelser av den beskrevne isolerte nukleinsyre, de beskrevne polypeptider og peptider, og antistoff.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/SG1998/000046 WO1999066048A1 (en) | 1998-06-19 | 1998-06-19 | A mutant human hepatitis b viral strain and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20006456D0 NO20006456D0 (no) | 2000-12-18 |
| NO20006456L true NO20006456L (no) | 2001-02-16 |
Family
ID=20429862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20006456A NO20006456L (no) | 1998-06-19 | 2000-12-18 | En mutant human hepatitt B viral stamme og anvendelser derav |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6558675B1 (no) |
| EP (1) | EP1098981A1 (no) |
| JP (1) | JP2002518014A (no) |
| KR (1) | KR100498118B1 (no) |
| CN (1) | CN1322251A (no) |
| AR (1) | AR020093A1 (no) |
| AU (1) | AU756866B2 (no) |
| BG (1) | BG105066A (no) |
| BR (1) | BR9815913A (no) |
| CA (1) | CA2330935C (no) |
| HU (1) | HUP0103409A3 (no) |
| IL (1) | IL140364A0 (no) |
| IS (1) | IS5778A (no) |
| MX (1) | MXPA00012720A (no) |
| MY (1) | MY118955A (no) |
| NO (1) | NO20006456L (no) |
| NZ (1) | NZ508890A (no) |
| PL (1) | PL192129B1 (no) |
| TR (1) | TR200003777T2 (no) |
| UA (1) | UA73476C2 (no) |
| WO (1) | WO1999066048A1 (no) |
| YU (1) | YU80600A (no) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006132598A1 (en) | 2005-06-07 | 2006-12-14 | Temasek Life Sciences Laboratory Limited | Porcine circovirus type 2 vaccines |
| EP3708176A1 (en) * | 2019-03-15 | 2020-09-16 | Centre National De La Recherche Scientifique -Cnrs- | Mutant vsv ectodomain polypeptide and uses thereof |
| KR20220074917A (ko) | 2019-09-30 | 2022-06-03 | 길리애드 사이언시즈, 인코포레이티드 | Hbv 백신 및 hbv를 치료하는 방법 |
| CN113201051B (zh) * | 2021-04-27 | 2022-08-02 | 复旦大学 | 一种乙肝病毒表面蛋白突变体及其在抗乙肝病毒中的应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9401987D0 (en) | 1994-02-02 | 1994-03-30 | Imperial College | Modified nucleic acid |
| EP0969863A4 (en) | 1996-09-18 | 2001-11-07 | Univ Texas | DEFECTIVE VIRAL INTERFERENCE PARTICLES AND THEIR USE. |
-
1998
- 1998-06-19 CA CA002330935A patent/CA2330935C/en not_active Expired - Fee Related
- 1998-06-19 YU YU80600A patent/YU80600A/sh unknown
- 1998-06-19 PL PL345573A patent/PL192129B1/pl not_active IP Right Cessation
- 1998-06-19 KR KR10-2000-7014456A patent/KR100498118B1/ko not_active Expired - Fee Related
- 1998-06-19 US US09/719,528 patent/US6558675B1/en not_active Expired - Fee Related
- 1998-06-19 UA UA2000127297A patent/UA73476C2/uk unknown
- 1998-06-19 WO PCT/SG1998/000046 patent/WO1999066048A1/en not_active Ceased
- 1998-06-19 TR TR2000/03777T patent/TR200003777T2/xx unknown
- 1998-06-19 IL IL14036498A patent/IL140364A0/xx unknown
- 1998-06-19 MX MXPA00012720A patent/MXPA00012720A/es not_active Application Discontinuation
- 1998-06-19 BR BR9815913-5A patent/BR9815913A/pt not_active Application Discontinuation
- 1998-06-19 AU AU77951/98A patent/AU756866B2/en not_active Ceased
- 1998-06-19 JP JP2000554857A patent/JP2002518014A/ja active Pending
- 1998-06-19 EP EP98926023A patent/EP1098981A1/en not_active Withdrawn
- 1998-06-19 NZ NZ508890A patent/NZ508890A/en unknown
- 1998-06-19 CN CN98814201A patent/CN1322251A/zh active Pending
- 1998-06-19 HU HU0103409A patent/HUP0103409A3/hu unknown
-
1999
- 1999-06-18 AR ARP990102962A patent/AR020093A1/es unknown
- 1999-06-18 MY MYPI99002517A patent/MY118955A/en unknown
-
2000
- 2000-12-18 BG BG105066A patent/BG105066A/xx unknown
- 2000-12-18 NO NO20006456A patent/NO20006456L/no not_active Application Discontinuation
- 2000-12-19 IS IS5778A patent/IS5778A/is unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2330935C (en) | 2005-05-10 |
| NZ508890A (en) | 2004-04-30 |
| JP2002518014A (ja) | 2002-06-25 |
| IL140364A0 (en) | 2002-02-10 |
| PL192129B1 (pl) | 2006-09-29 |
| KR20010106129A (ko) | 2001-11-29 |
| AU7795198A (en) | 2000-01-05 |
| EP1098981A1 (en) | 2001-05-16 |
| TR200003777T2 (tr) | 2001-06-21 |
| CN1322251A (zh) | 2001-11-14 |
| NO20006456D0 (no) | 2000-12-18 |
| PL345573A1 (en) | 2001-12-17 |
| MY118955A (en) | 2005-02-28 |
| CA2330935A1 (en) | 1999-12-23 |
| HUP0103409A2 (hu) | 2001-12-28 |
| MXPA00012720A (es) | 2002-05-08 |
| BG105066A (en) | 2001-09-28 |
| KR100498118B1 (ko) | 2005-07-01 |
| YU80600A (sh) | 2005-06-10 |
| HUP0103409A3 (en) | 2003-10-28 |
| US6558675B1 (en) | 2003-05-06 |
| UA73476C2 (en) | 2005-08-15 |
| AR020093A1 (es) | 2002-04-10 |
| IS5778A (is) | 2000-12-19 |
| BR9815913A (pt) | 2001-12-26 |
| AU756866B2 (en) | 2003-01-23 |
| WO1999066048A1 (en) | 1999-12-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |