NO20006542L - N-fenyl-N'-fenylpropylpiperazinderivater og fremgangsmåte for fremstilling derav - Google Patents

N-fenyl-N'-fenylpropylpiperazinderivater og fremgangsmåte for fremstilling derav

Info

Publication number
NO20006542L
NO20006542L NO20006542A NO20006542A NO20006542L NO 20006542 L NO20006542 L NO 20006542L NO 20006542 A NO20006542 A NO 20006542A NO 20006542 A NO20006542 A NO 20006542A NO 20006542 L NO20006542 L NO 20006542L
Authority
NO
Norway
Prior art keywords
group
phenylpropylpiperazine
phenyl
derivative
derivatives
Prior art date
Application number
NO20006542A
Other languages
English (en)
Other versions
NO20006542D0 (no
Inventor
Hiroki Sato
Eiichi Nagano
Jun Chikazawa
Mineo Takei
Raita Higashino
Original Assignee
Zeria Pharmaceutical Company L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeria Pharmaceutical Company L filed Critical Zeria Pharmaceutical Company L
Publication of NO20006542D0 publication Critical patent/NO20006542D0/no
Publication of NO20006542L publication Critical patent/NO20006542L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Det beskrives et N-fenyl-N'-fenylpropylpiperazin-derivat med formel (1): (1) (hvor R1 utgjør en lavere alkylgruppe; R2 utgjør en lavere alkoksygruppe; og R3 utgjør en cyanogruppe, en karboksylgruppe eller en indolkarbonylgruppe); et medikament; og en fremgangsmåte for fremstilling av derivatet. Forbindelsen har potent a,- adrenoreseptor-blokkerende virkning, og er således egnet for forhindring eller behandling av hypertensjon, kongestiv hjertesvikt, myokardiskemi, arytmi, angina pectoris, og urinobstruksjon og pollakisuri forårsaket av benign prostatahyperplasi.
NO20006542A 1998-06-30 2000-12-21 N-fenyl-N'-fenylpropylpiperazinderivater og fremgangsmåte for fremstilling derav NO20006542L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP19814898 1998-06-30
PCT/JP1999/003448 WO2000000471A1 (en) 1998-06-30 1999-06-28 N-phenyl-n'-phenylpropylpiperazine derivatives and process for the preparation thereof

Publications (2)

Publication Number Publication Date
NO20006542D0 NO20006542D0 (no) 2000-12-21
NO20006542L true NO20006542L (no) 2001-02-28

Family

ID=16386265

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20006542A NO20006542L (no) 1998-06-30 2000-12-21 N-fenyl-N'-fenylpropylpiperazinderivater og fremgangsmåte for fremstilling derav

Country Status (14)

Country Link
US (1) US6395739B1 (no)
EP (1) EP1090913A4 (no)
KR (1) KR20010053010A (no)
CN (1) CN1307563A (no)
AU (1) AU742720B2 (no)
BR (1) BR9911992A (no)
CA (1) CA2336083A1 (no)
HU (1) HUP0102609A3 (no)
NO (1) NO20006542L (no)
PE (1) PE20001332A1 (no)
PL (1) PL345166A1 (no)
TR (1) TR200003884T2 (no)
WO (1) WO2000000471A1 (no)
ZA (1) ZA200007636B (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4117417A1 (de) * 1991-05-28 1992-12-03 Herberts Gmbh Waessrige dispersion eines kathodisch abscheidbaren bindemittels, verfahren zu deren herstellung und deren verwendung
CN1172919C (zh) * 2002-06-03 2004-10-27 上海医药工业研究院 芳烷醇哌嗪衍生物及其在制备抗抑郁症药物中的应用
HUP0700353A2 (en) * 2007-05-18 2008-12-29 Richter Gedeon Nyrt Metabolites of (thio)carbamoyl-cyclohexane derivatives
US20090076043A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched alfuzosin
CA2715760C (en) * 2008-02-21 2017-06-13 Mitsubishi Tanabe Pharma Corporation Solid preparation for oral administration of cariprazine hydrochloride
RS53866B1 (sr) 2008-07-16 2015-08-31 Richter Gedeon Nyrt. Farmaceutske formulacije koje sadrže ligande dopaminskih receptora
JP2017214342A (ja) * 2016-06-02 2017-12-07 日清オイリオグループ株式会社 排尿障害の予防用又は改善用組成物
US11274087B2 (en) 2016-07-08 2022-03-15 Richter Gedeon Nyrt. Industrial process for the preparation of cariprazine
US11547707B2 (en) 2019-04-10 2023-01-10 Richter Gedeon Nyrt. Carbamoyl cyclohexane derivatives for treating autism spectrum disorder

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH446345A (de) 1963-01-23 1967-11-15 Ciba Geigy Verfahren zur Herstellung von Piperazinverbindungen
GB9021535D0 (en) * 1990-10-03 1990-11-14 Wyeth John & Brother Ltd Piperazine derivatives
EP0576766A1 (en) * 1992-06-29 1994-01-05 Novo Nordisk A/S Propanolamine derivatives, their preparation and use
DE69521687T2 (de) * 1994-03-30 2001-10-25 Zeria Pharmaceutical Co., Ltd. 4-indol-1-yl-buttersäure derivate, deren herstellung und deren verwendung als inhibitoren für alpha1-adrenerge rezeptoren und testosteron 5alpha-reduktasen

Also Published As

Publication number Publication date
CA2336083A1 (en) 2000-01-06
AU742720B2 (en) 2002-01-10
AU4290399A (en) 2000-01-17
NO20006542D0 (no) 2000-12-21
PE20001332A1 (es) 2000-12-19
ZA200007636B (en) 2001-07-09
HUP0102609A3 (en) 2002-12-28
EP1090913A1 (en) 2001-04-11
WO2000000471A1 (en) 2000-01-06
US6395739B1 (en) 2002-05-28
HUP0102609A2 (hu) 2001-12-28
EP1090913A4 (en) 2001-11-07
BR9911992A (pt) 2001-03-27
PL345166A1 (en) 2001-12-03
KR20010053010A (ko) 2001-06-25
TR200003884T2 (tr) 2001-05-21
CN1307563A (zh) 2001-08-08

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