NO20010136L - FremgangsmÕte for screening av potensielle antimetastase og antiinflammatoriske midler ved anvendelse av pattedyr heparanase som en probe - Google Patents

FremgangsmÕte for screening av potensielle antimetastase og antiinflammatoriske midler ved anvendelse av pattedyr heparanase som en probe

Info

Publication number
NO20010136L
NO20010136L NO20010136A NO20010136A NO20010136L NO 20010136 L NO20010136 L NO 20010136L NO 20010136 A NO20010136 A NO 20010136A NO 20010136 A NO20010136 A NO 20010136A NO 20010136 L NO20010136 L NO 20010136L
Authority
NO
Norway
Prior art keywords
antimetastase
screening
probe
potential
inflammatory agents
Prior art date
Application number
NO20010136A
Other languages
English (en)
Norwegian (no)
Other versions
NO20010136D0 (no
Inventor
Hanna Ben-Artzi
Maty Ayal-Hershkovitz
Israel Vlodavsky
Iris Pecker
Yoav Peleg
Daphna Miron
Original Assignee
Insight Strategy & Marketing
Hadasit Med Res Service
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Insight Strategy & Marketing, Hadasit Med Res Service filed Critical Insight Strategy & Marketing
Publication of NO20010136D0 publication Critical patent/NO20010136D0/no
Publication of NO20010136L publication Critical patent/NO20010136L/no

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01166Heparanase (3.2.1.166)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28Materials for coating prostheses
    • A61L27/34Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/527Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/924Hydrolases (3) acting on glycosyl compounds (3.2)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/988Lyases (4.), e.g. aldolases, heparinase, enolases, fumarase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/38Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence, e.g. gluco- or galactomannans, Konjac gum, Locust bean gum or Guar gum
    • G01N2400/40Glycosaminoglycans, i.e. GAG or mucopolysaccharides, e.g. chondroitin sulfate, dermatan sulfate, hyaluronic acid, heparin, heparan sulfate, and related sulfated polysaccharides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/20Screening for compounds of potential therapeutic value cell-free systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
NO20010136A 1998-07-10 2001-01-09 FremgangsmÕte for screening av potensielle antimetastase og antiinflammatoriske midler ved anvendelse av pattedyr heparanase som en probe NO20010136L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/113,168 US6190875B1 (en) 1997-09-02 1998-07-10 Method of screening for potential anti-metastatic and anti-inflammatory agents using mammalian heparanase as a probe
PCT/US1999/015643 WO2000003036A1 (fr) 1998-07-10 1999-07-12 Procede de recherche par criblage d'agents potentiels anti-metastatiques et anti-inflammatoires au moyen d'une sonde d'heparanase mammifere

Publications (2)

Publication Number Publication Date
NO20010136D0 NO20010136D0 (no) 2001-01-09
NO20010136L true NO20010136L (no) 2001-03-09

Family

ID=22347939

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20010136A NO20010136L (no) 1998-07-10 2001-01-09 FremgangsmÕte for screening av potensielle antimetastase og antiinflammatoriske midler ved anvendelse av pattedyr heparanase som en probe

Country Status (7)

Country Link
US (1) US6190875B1 (fr)
EP (1) EP1097241A1 (fr)
JP (1) JP2002520029A (fr)
AU (1) AU758485B2 (fr)
CA (1) CA2335382A1 (fr)
NO (1) NO20010136L (fr)
WO (1) WO2000003036A1 (fr)

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US20010006630A1 (en) * 1997-09-02 2001-07-05 Oron Yacoby-Zeevi Introducing a biological material into a patient
US20020088019A1 (en) * 1997-09-02 2002-07-04 Oron Yacoby-Zeevi Methods of and pharmaceutical compositions for improving implantation of embryos
US20040213789A1 (en) * 1997-09-02 2004-10-28 Oron Yacoby-Zeevi Heparanase activity neutralizing anti-heparanase monoclonal antibody and other anti-heparanase antibodies
US6699672B1 (en) * 1997-09-02 2004-03-02 Insight Biopharmaceuticals Ltd. Heparanase specific molecular probes and their use research and medical applications
US6177545B1 (en) * 1997-09-02 2001-01-23 Insight Strategy & Marketing Ltd. Heparanase specific molecular probes and their use in research and medical applications
US7056504B1 (en) 1998-08-27 2006-06-06 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase I and II
EP1109919A2 (fr) * 1998-08-27 2001-06-27 Massachusetts Institute Of Technology Heparinases a conception rationnelle derivees de l'heparinase i et ii
US20030217375A1 (en) * 1998-08-31 2003-11-20 Eyal Zcharia Transgenic animals expressing heparanase and uses thereof
AU2878600A (en) * 1999-03-01 2000-09-21 Hadasit Medical Research Services & Development Company Ltd Polynucleotide encoding a polypeptide having heparanase activity and expression of same in genetically modified cells
US7412332B1 (en) 1999-04-23 2008-08-12 Massachusetts Institute Of Technology Method for analyzing polysaccharides
GB9913415D0 (en) * 1999-06-10 1999-08-11 Central Manchester Healthcare Heparanase assay
WO2001066772A2 (fr) * 2000-03-08 2001-09-13 Massachusetts Institute Of Technology Heparinase iii et ses utilisations
WO2002004645A2 (fr) * 2000-07-12 2002-01-17 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Deuxieme heparanase humaine et ses variantes epissees a expression predominante dans les muscles du squelette, du coeur et du pancreas
ATE426805T1 (de) * 2000-09-12 2009-04-15 Massachusetts Inst Technology Verfahren und produkte, die mit niedermolekularem heparin assoziiert sind
EP1356083A2 (fr) 2000-09-15 2003-10-29 Reddy US Therapeutics, Inc. Procedes et compositions utilises pour des dosages de glycosidase
AU2440802A (en) * 2000-10-18 2002-04-29 Massachusetts Inst Technology Methods and products related to pulmonary delivery of polysaccharides
US7407773B2 (en) * 2000-11-03 2008-08-05 Procognia, Ltd. Method for characterizing a carbohydrate polymer
FR2816213B1 (fr) * 2000-11-03 2005-04-22 Goemar Lab Sa Medicament anti-inflammatoire et cicatrisant
CA2432157A1 (fr) * 2000-12-19 2002-06-27 Insight Strategy And Marketing Ltd. Utilisation d'enzymes de degradation de l'ecm en vue de l'amelioration de greffes de cellules
US6630295B2 (en) * 2001-01-04 2003-10-07 Insight Strategy & Marketing Ltd. High throughput assay for monitoring polycation or polyanion molecular weight, degradation or synthesis
AU2002243630A1 (en) * 2001-01-23 2002-08-06 Massachusetts Institute Of Technology Solid- and solution -phase synthesis of heparin and other glycosaminoglycans
US20040132123A1 (en) * 2001-05-09 2004-07-08 Oron Yacoby-Zeevi Methods and kits utilizing heparanase as a diagnostic marker for haemostatic disorders
WO2003033512A2 (fr) * 2001-10-16 2003-04-24 Procognia, Ltd. Procede de preparation de banques d'oligosaccharides biologiquement actifs purifies
DE10258770B4 (de) * 2001-12-18 2005-02-10 F. Hoffmann-La Roche Ag Verfahren zum Testen eines Mittels auf dessen Fähigkeit, die Heparanaseaktivität zu hemmen
CH696701A5 (de) * 2001-12-18 2007-10-15 Hoffmann La Roche Verfahren zum Testen eines Mittels auf dessen Fähigkeit, die Heparanaseaktivität zu hemmen.
CA2493509C (fr) * 2002-06-03 2010-03-09 Massachusetts Institute Of Technology Lyases de polysaccharide derivees de chondroitinase b, concues de facon rationnelle
US7482116B2 (en) 2002-06-07 2009-01-27 Dna Genotek Inc. Compositions and methods for obtaining nucleic acids from sputum
FR2843126B1 (fr) * 2002-08-01 2006-01-27 Cis Bio Int "methode de determination d'une activite enzymatique endoglycosidase"
CN101747385B (zh) * 2002-09-23 2013-03-06 安万特医药股份有限公司 测定构成肝素的特殊基团的方法
FR2844808B1 (fr) * 2002-09-23 2005-02-25 Aventis Pharma Sa Methode de determination de groupements specifiques constituant les heparines ou les heparines de bas poids moleculaire
WO2004043989A2 (fr) * 2002-11-07 2004-05-27 Medarex, Inc. Anticorps monoclonaux humains diriges contre l'heparanase
US20070231856A1 (en) * 2003-05-30 2007-10-04 Pei Ye Recombinant Protein and Polypeptide Production Using Methylotropic or Ethylotropic Microorganisms with a Dilute Methanol or Ethanol Feeding
US20060269552A1 (en) * 2003-06-09 2006-11-30 Oron Yacoby-Zeevi Heparanase activity neutralizing anti-heparanase monclonal antibody and other anti-heparanase antibodies
US20070009989A1 (en) * 2003-09-26 2007-01-11 Christian Steinkuhler Synthetic heparanase molecules and uses thereof
FR2873377B1 (fr) * 2004-07-23 2006-10-13 Sanofi Synthelabo Derives d'azasucre, inhibiteurs d'heparanases, leur procede de preparation, les compositions en contenant et leur utilisation
US7455862B2 (en) * 2005-03-23 2008-11-25 Lee's Pharmaceutical (Hong Kong) Limited Herbal compositions useful in cancer treatment
ES2444705T3 (es) 2007-07-24 2014-02-26 Active Biomaterials Llc Método para medir la concentración de un anticoagulante de glicosaminoglicano
US20100266558A1 (en) * 2007-12-18 2010-10-21 Dov Zipori Method and assay for glycosylation pattern detection related to cell state of stem cells
WO2012177656A2 (fr) 2011-06-19 2012-12-27 Abogen, Inc. Dispositifs, solutions et procédés de recueillement d'échantillons
CN103288981A (zh) * 2013-06-20 2013-09-11 深圳市海普瑞药业股份有限公司 一种抑制细胞增殖的硫酸酯化的硫酸乙酰肝素
JP2017510284A (ja) * 2014-04-10 2017-04-13 ディーエヌエー ジェノテック インク 過ヨウ素酸塩を用いる微生物溶解のための方法およびシステム
EP3362093A4 (fr) 2015-10-13 2019-05-08 Technion Research & Development Foundation Limited Anticorps monoclonaux neutralisant l'héparanase
EP3398971A4 (fr) * 2015-12-30 2019-09-25 Shenzhen Hepalink Pharmaceutical Group Co., Ltd. Oligosaccharide d'héparine sulfaté et procédé de préparation et application de celui-ci
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Also Published As

Publication number Publication date
US6190875B1 (en) 2001-02-20
NO20010136D0 (no) 2001-01-09
AU4869799A (en) 2000-02-01
EP1097241A1 (fr) 2001-05-09
AU758485B2 (en) 2003-03-20
JP2002520029A (ja) 2002-07-09
WO2000003036A1 (fr) 2000-01-20
CA2335382A1 (fr) 2000-01-20

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