NO20010136L - FremgangsmÕte for screening av potensielle antimetastase og antiinflammatoriske midler ved anvendelse av pattedyr heparanase som en probe - Google Patents
FremgangsmÕte for screening av potensielle antimetastase og antiinflammatoriske midler ved anvendelse av pattedyr heparanase som en probeInfo
- Publication number
- NO20010136L NO20010136L NO20010136A NO20010136A NO20010136L NO 20010136 L NO20010136 L NO 20010136L NO 20010136 A NO20010136 A NO 20010136A NO 20010136 A NO20010136 A NO 20010136A NO 20010136 L NO20010136 L NO 20010136L
- Authority
- NO
- Norway
- Prior art keywords
- antimetastase
- screening
- probe
- potential
- inflammatory agents
- Prior art date
Links
- 102100024025 Heparanase Human genes 0.000 title 1
- 229940121363 anti-inflammatory agent Drugs 0.000 title 1
- 239000002260 anti-inflammatory agent Substances 0.000 title 1
- 108010037536 heparanase Proteins 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000523 sample Substances 0.000 title 1
- 238000012216 screening Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01166—Heparanase (3.2.1.166)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/924—Hydrolases (3) acting on glycosyl compounds (3.2)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/988—Lyases (4.), e.g. aldolases, heparinase, enolases, fumarase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
- G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- G01N2400/38—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence, e.g. gluco- or galactomannans, Konjac gum, Locust bean gum or Guar gum
- G01N2400/40—Glycosaminoglycans, i.e. GAG or mucopolysaccharides, e.g. chondroitin sulfate, dermatan sulfate, hyaluronic acid, heparin, heparan sulfate, and related sulfated polysaccharides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/20—Screening for compounds of potential therapeutic value cell-free systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/113,168 US6190875B1 (en) | 1997-09-02 | 1998-07-10 | Method of screening for potential anti-metastatic and anti-inflammatory agents using mammalian heparanase as a probe |
| PCT/US1999/015643 WO2000003036A1 (fr) | 1998-07-10 | 1999-07-12 | Procede de recherche par criblage d'agents potentiels anti-metastatiques et anti-inflammatoires au moyen d'une sonde d'heparanase mammifere |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20010136D0 NO20010136D0 (no) | 2001-01-09 |
| NO20010136L true NO20010136L (no) | 2001-03-09 |
Family
ID=22347939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20010136A NO20010136L (no) | 1998-07-10 | 2001-01-09 | FremgangsmÕte for screening av potensielle antimetastase og antiinflammatoriske midler ved anvendelse av pattedyr heparanase som en probe |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6190875B1 (fr) |
| EP (1) | EP1097241A1 (fr) |
| JP (1) | JP2002520029A (fr) |
| AU (1) | AU758485B2 (fr) |
| CA (1) | CA2335382A1 (fr) |
| NO (1) | NO20010136L (fr) |
| WO (1) | WO2000003036A1 (fr) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010006630A1 (en) * | 1997-09-02 | 2001-07-05 | Oron Yacoby-Zeevi | Introducing a biological material into a patient |
| US20020088019A1 (en) * | 1997-09-02 | 2002-07-04 | Oron Yacoby-Zeevi | Methods of and pharmaceutical compositions for improving implantation of embryos |
| US20040213789A1 (en) * | 1997-09-02 | 2004-10-28 | Oron Yacoby-Zeevi | Heparanase activity neutralizing anti-heparanase monoclonal antibody and other anti-heparanase antibodies |
| US6699672B1 (en) * | 1997-09-02 | 2004-03-02 | Insight Biopharmaceuticals Ltd. | Heparanase specific molecular probes and their use research and medical applications |
| US6177545B1 (en) * | 1997-09-02 | 2001-01-23 | Insight Strategy & Marketing Ltd. | Heparanase specific molecular probes and their use in research and medical applications |
| US7056504B1 (en) | 1998-08-27 | 2006-06-06 | Massachusetts Institute Of Technology | Rationally designed heparinases derived from heparinase I and II |
| EP1109919A2 (fr) * | 1998-08-27 | 2001-06-27 | Massachusetts Institute Of Technology | Heparinases a conception rationnelle derivees de l'heparinase i et ii |
| US20030217375A1 (en) * | 1998-08-31 | 2003-11-20 | Eyal Zcharia | Transgenic animals expressing heparanase and uses thereof |
| AU2878600A (en) * | 1999-03-01 | 2000-09-21 | Hadasit Medical Research Services & Development Company Ltd | Polynucleotide encoding a polypeptide having heparanase activity and expression of same in genetically modified cells |
| US7412332B1 (en) | 1999-04-23 | 2008-08-12 | Massachusetts Institute Of Technology | Method for analyzing polysaccharides |
| GB9913415D0 (en) * | 1999-06-10 | 1999-08-11 | Central Manchester Healthcare | Heparanase assay |
| WO2001066772A2 (fr) * | 2000-03-08 | 2001-09-13 | Massachusetts Institute Of Technology | Heparinase iii et ses utilisations |
| WO2002004645A2 (fr) * | 2000-07-12 | 2002-01-17 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Deuxieme heparanase humaine et ses variantes epissees a expression predominante dans les muscles du squelette, du coeur et du pancreas |
| ATE426805T1 (de) * | 2000-09-12 | 2009-04-15 | Massachusetts Inst Technology | Verfahren und produkte, die mit niedermolekularem heparin assoziiert sind |
| EP1356083A2 (fr) | 2000-09-15 | 2003-10-29 | Reddy US Therapeutics, Inc. | Procedes et compositions utilises pour des dosages de glycosidase |
| AU2440802A (en) * | 2000-10-18 | 2002-04-29 | Massachusetts Inst Technology | Methods and products related to pulmonary delivery of polysaccharides |
| US7407773B2 (en) * | 2000-11-03 | 2008-08-05 | Procognia, Ltd. | Method for characterizing a carbohydrate polymer |
| FR2816213B1 (fr) * | 2000-11-03 | 2005-04-22 | Goemar Lab Sa | Medicament anti-inflammatoire et cicatrisant |
| CA2432157A1 (fr) * | 2000-12-19 | 2002-06-27 | Insight Strategy And Marketing Ltd. | Utilisation d'enzymes de degradation de l'ecm en vue de l'amelioration de greffes de cellules |
| US6630295B2 (en) * | 2001-01-04 | 2003-10-07 | Insight Strategy & Marketing Ltd. | High throughput assay for monitoring polycation or polyanion molecular weight, degradation or synthesis |
| AU2002243630A1 (en) * | 2001-01-23 | 2002-08-06 | Massachusetts Institute Of Technology | Solid- and solution -phase synthesis of heparin and other glycosaminoglycans |
| US20040132123A1 (en) * | 2001-05-09 | 2004-07-08 | Oron Yacoby-Zeevi | Methods and kits utilizing heparanase as a diagnostic marker for haemostatic disorders |
| WO2003033512A2 (fr) * | 2001-10-16 | 2003-04-24 | Procognia, Ltd. | Procede de preparation de banques d'oligosaccharides biologiquement actifs purifies |
| DE10258770B4 (de) * | 2001-12-18 | 2005-02-10 | F. Hoffmann-La Roche Ag | Verfahren zum Testen eines Mittels auf dessen Fähigkeit, die Heparanaseaktivität zu hemmen |
| CH696701A5 (de) * | 2001-12-18 | 2007-10-15 | Hoffmann La Roche | Verfahren zum Testen eines Mittels auf dessen Fähigkeit, die Heparanaseaktivität zu hemmen. |
| CA2493509C (fr) * | 2002-06-03 | 2010-03-09 | Massachusetts Institute Of Technology | Lyases de polysaccharide derivees de chondroitinase b, concues de facon rationnelle |
| US7482116B2 (en) | 2002-06-07 | 2009-01-27 | Dna Genotek Inc. | Compositions and methods for obtaining nucleic acids from sputum |
| FR2843126B1 (fr) * | 2002-08-01 | 2006-01-27 | Cis Bio Int | "methode de determination d'une activite enzymatique endoglycosidase" |
| CN101747385B (zh) * | 2002-09-23 | 2013-03-06 | 安万特医药股份有限公司 | 测定构成肝素的特殊基团的方法 |
| FR2844808B1 (fr) * | 2002-09-23 | 2005-02-25 | Aventis Pharma Sa | Methode de determination de groupements specifiques constituant les heparines ou les heparines de bas poids moleculaire |
| WO2004043989A2 (fr) * | 2002-11-07 | 2004-05-27 | Medarex, Inc. | Anticorps monoclonaux humains diriges contre l'heparanase |
| US20070231856A1 (en) * | 2003-05-30 | 2007-10-04 | Pei Ye | Recombinant Protein and Polypeptide Production Using Methylotropic or Ethylotropic Microorganisms with a Dilute Methanol or Ethanol Feeding |
| US20060269552A1 (en) * | 2003-06-09 | 2006-11-30 | Oron Yacoby-Zeevi | Heparanase activity neutralizing anti-heparanase monclonal antibody and other anti-heparanase antibodies |
| US20070009989A1 (en) * | 2003-09-26 | 2007-01-11 | Christian Steinkuhler | Synthetic heparanase molecules and uses thereof |
| FR2873377B1 (fr) * | 2004-07-23 | 2006-10-13 | Sanofi Synthelabo | Derives d'azasucre, inhibiteurs d'heparanases, leur procede de preparation, les compositions en contenant et leur utilisation |
| US7455862B2 (en) * | 2005-03-23 | 2008-11-25 | Lee's Pharmaceutical (Hong Kong) Limited | Herbal compositions useful in cancer treatment |
| ES2444705T3 (es) | 2007-07-24 | 2014-02-26 | Active Biomaterials Llc | Método para medir la concentración de un anticoagulante de glicosaminoglicano |
| US20100266558A1 (en) * | 2007-12-18 | 2010-10-21 | Dov Zipori | Method and assay for glycosylation pattern detection related to cell state of stem cells |
| WO2012177656A2 (fr) | 2011-06-19 | 2012-12-27 | Abogen, Inc. | Dispositifs, solutions et procédés de recueillement d'échantillons |
| CN103288981A (zh) * | 2013-06-20 | 2013-09-11 | 深圳市海普瑞药业股份有限公司 | 一种抑制细胞增殖的硫酸酯化的硫酸乙酰肝素 |
| JP2017510284A (ja) * | 2014-04-10 | 2017-04-13 | ディーエヌエー ジェノテック インク | 過ヨウ素酸塩を用いる微生物溶解のための方法およびシステム |
| EP3362093A4 (fr) | 2015-10-13 | 2019-05-08 | Technion Research & Development Foundation Limited | Anticorps monoclonaux neutralisant l'héparanase |
| EP3398971A4 (fr) * | 2015-12-30 | 2019-09-25 | Shenzhen Hepalink Pharmaceutical Group Co., Ltd. | Oligosaccharide d'héparine sulfaté et procédé de préparation et application de celui-ci |
| CN116648506A (zh) | 2020-07-06 | 2023-08-25 | 技术研发基金会有限公司 | 乙酰肝素酶中和a54单克隆抗体 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4859581A (en) * | 1986-03-10 | 1989-08-22 | Board Of Regents, The University Of Texas System | Endoglycosidase assay |
| US5206223A (en) * | 1986-06-26 | 1993-04-27 | Yeda Research And Development Co. Ltd. | Method for inhibiting heparanase activity |
| IL79255A0 (en) * | 1986-06-26 | 1986-09-30 | Hadassah Med Org | Composition for metastasis prevention |
| US5129877A (en) * | 1988-04-29 | 1992-07-14 | University Of Georgia Research Foundation, Inc. | Receptor-mediated delivery system |
| US5362641A (en) * | 1989-08-23 | 1994-11-08 | Hadassah Medical Organization Kiryat Hadassah | Heparanase derived from human Sk-Hep-1 cell line |
| US5246698A (en) * | 1990-07-09 | 1993-09-21 | Biomatrix, Inc. | Biocompatible viscoelastic gel slurries, their preparation and use |
| FR2669932B1 (fr) * | 1990-12-03 | 1994-07-01 | Sanofi Sa | Nouvel heparosane-n,o-sulfate, son procede de preparation et les compositions pharmaceutiques qui le contiennent. |
| GB9225581D0 (en) * | 1992-12-08 | 1993-01-27 | Courtaulds Plc | Wound dressings |
| US5739115A (en) * | 1993-10-07 | 1998-04-14 | Glycomed Incorporated | Sulfated maltooligosaccharides with heparin-like properties |
-
1998
- 1998-07-10 US US09/113,168 patent/US6190875B1/en not_active Expired - Lifetime
-
1999
- 1999-07-12 AU AU48697/99A patent/AU758485B2/en not_active Ceased
- 1999-07-12 EP EP99932382A patent/EP1097241A1/fr not_active Withdrawn
- 1999-07-12 WO PCT/US1999/015643 patent/WO2000003036A1/fr not_active Ceased
- 1999-07-12 JP JP2000559256A patent/JP2002520029A/ja active Pending
- 1999-07-12 CA CA002335382A patent/CA2335382A1/fr not_active Abandoned
-
2001
- 2001-01-09 NO NO20010136A patent/NO20010136L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US6190875B1 (en) | 2001-02-20 |
| NO20010136D0 (no) | 2001-01-09 |
| AU4869799A (en) | 2000-02-01 |
| EP1097241A1 (fr) | 2001-05-09 |
| AU758485B2 (en) | 2003-03-20 |
| JP2002520029A (ja) | 2002-07-09 |
| WO2000003036A1 (fr) | 2000-01-20 |
| CA2335382A1 (fr) | 2000-01-20 |
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