NO20012832L - Heterocyclic carboxamide-containing thiourea inhibitors of herpesvirus containing phenylenediamine group - Google Patents
Heterocyclic carboxamide-containing thiourea inhibitors of herpesvirus containing phenylenediamine groupInfo
- Publication number
- NO20012832L NO20012832L NO20012832A NO20012832A NO20012832L NO 20012832 L NO20012832 L NO 20012832L NO 20012832 A NO20012832 A NO 20012832A NO 20012832 A NO20012832 A NO 20012832A NO 20012832 L NO20012832 L NO 20012832L
- Authority
- NO
- Norway
- Prior art keywords
- carbon atoms
- alkyl
- hydrogen
- heteroaryl
- perhaloalkyl
- Prior art date
Links
- 241001529453 unidentified herpesvirus Species 0.000 title abstract 3
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 title 2
- GEYOCULIXLDCMW-UHFFFAOYSA-N 1,2-phenylenediamine Chemical group NC1=CC=CC=C1N GEYOCULIXLDCMW-UHFFFAOYSA-N 0.000 title 1
- -1 Heterocyclic carboxamide Chemical class 0.000 title 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 18
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000006584 (C3-C10) heterocycloalkyl group Chemical group 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 101100134925 Gallus gallus COR6 gene Proteins 0.000 abstract 1
- 241000282414 Homo sapiens Species 0.000 abstract 1
- 241000701085 Human alphaherpesvirus 3 Species 0.000 abstract 1
- 241000701024 Human betaherpesvirus 5 Species 0.000 abstract 1
- 241000701044 Human gammaherpesvirus 4 Species 0.000 abstract 1
- 101100477978 Hypocrea jecorina (strain QM6a) sor6 gene Proteins 0.000 abstract 1
- 241000700584 Simplexvirus Species 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004001 thioalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Biotechnology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Det er beskrevet en forbindelse med formel (I) hvor Ri-R5 er uavhengig valgt fra hydrogen, alkyl med 1 til 6 karbonatomer, alkenyl med 2 til 6 karbonatomer, alkynyl med 2 til 6 karbonatomer, perhalogenalkyl med 1 til 6 karnbonatomer, sykloalkyl med 3 til 10 karbonatomer, heterosykloalkyl med 3 til 10 karbonledd, aryl, heteroaryl, halogen, CN, NO2, CO2R6, OR6, SR6, SOR6l SO2R6, CONR7RB, NR6N(R7R8), N(R7R8) eller W-Y-(CH2)n-Z forutsatt at minst en av RrR5 ikke er hydrogen; eller R2 og R3 eller R3 og R4, danner sammen en 3 til 7-leddet heterosykloalkyl eller 3 til 7 leddet heteroaryl; Re og R7 er uavhengig hydrogen, alkyl med 1 til 6 karbonatomer, perhalogenalkyl med 1 til 6 karbonatomer, eller aryl; R8 er hydrogen, alkyl med 1 til 6 karbonatomer, perhalogenalkyl med 1 til 6 karbonatomer, sykloalkyl med 3 tiMO karbonatomer, heterosykloalkyl med 3 til 10 ledd, aryl eller heteroaryl, eller R7 eller RB, kan sammen danne en 3 til 7 leddet heterosykloalkyl; W er O, NR6 eller er fraværende; Y er (CO)- eller (CO2)- eller er fraværende; Z er alkyl med 1 til 4 karbonatomer, CN, CO2R6, COR6, CONR7R8, OCOR6, NR6COR7, OCONR6, OR6l SR6, SOR6, SO2R6, SReNfR.Ra), N(R7R8) eller fenyl; G er monosyklisk heteroaryl; X er en binding; NH, alkyl med 1 til 6 karbonatomer, alkenyl med 1 til 6 karbonatomer, alkoksy med 1 til 6 karbonatomer, eller tioalkyl med 1 til 6 karbonatomer, alkylamino med 1 til 6 karbonatomer, eller (CH)J; J er alkyl med 1 til 6 karbonatomer, sykloalkyl med 3 til 7 karbonatomer, fenyl eller benzyl; og n er et tall fra 1 til 6, nyttig for behandling av sykdommer assosiert med herpesviruser inkludert human cytomegalovirus, herpes simplex viruser, Epstein-Barr virus, varicella-zoster virus, humane herpesviruser-6 og -7 og Kaposi herpesvirus.A compound of formula (I) is disclosed wherein R 1 -R 5 is independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon members, aryl, heteroaryl, halogen, CN, NO2, CO2R6, OR6, SR6, SOR6l SO2R6, CONR7RB, NR6N (R7R8), N (R7R8) or WY- (CH2) nZ provided at least one of RrR5 is not hydrogen; or R2 and R3 or R3 and R4 together form a 3 to 7 membered heterocycloalkyl or 3 to 7 membered heteroaryl; Re and R7 are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; R8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, 3 to 10 membered heterocycloalkyl, aryl or heteroaryl, or R7 or RB may together form a 3 to 7 membered heterocycloalkyl; W is O, NR 6 or is absent; Y is (CO) or (CO2) - or is absent; Z is alkyl of 1 to 4 carbon atoms, CN, CO2R6, COR6, CONR7R8, OCOR6, NR6COR7, OCONR6, OR6l SR6, SOR6, SO2R6, SReNfR.Ra), N (R7R8) or phenyl; G is monocyclic heteroaryl; X is a bond; NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, or thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH) J; J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and n is a number from 1 to 6, useful for treating diseases associated with herpes viruses including human cytomegalovirus, herpes simplex virus, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpes virus.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20855998A | 1998-12-09 | 1998-12-09 | |
| PCT/US1999/028842 WO2000034258A2 (en) | 1998-12-09 | 1999-12-06 | Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing phenylenediamine group |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20012832D0 NO20012832D0 (en) | 2001-06-08 |
| NO20012832L true NO20012832L (en) | 2001-08-07 |
Family
ID=22775044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20012832A NO20012832L (en) | 1998-12-09 | 2001-06-08 | Heterocyclic carboxamide-containing thiourea inhibitors of herpesvirus containing phenylenediamine group |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP1144397A3 (en) |
| JP (1) | JP2002531554A (en) |
| CN (1) | CN1348446A (en) |
| AU (1) | AU1934700A (en) |
| BG (1) | BG105581A (en) |
| BR (1) | BR9916046A (en) |
| CA (1) | CA2350767A1 (en) |
| CZ (1) | CZ20011956A3 (en) |
| EA (1) | EA200100631A1 (en) |
| HU (1) | HUP0200232A2 (en) |
| ID (1) | ID30158A (en) |
| IL (1) | IL143182A0 (en) |
| NO (1) | NO20012832L (en) |
| PL (1) | PL349217A1 (en) |
| SK (1) | SK7682001A3 (en) |
| TR (1) | TR200101664T2 (en) |
| WO (1) | WO2000034258A2 (en) |
| ZA (1) | ZA200104377B (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6166028A (en) * | 1998-12-09 | 2000-12-26 | American Home Products Corporation | Diaminopuridine-containing thiourea inhibitors of herpes viruses |
| US6844367B1 (en) | 1999-09-17 | 2005-01-18 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
| AU2001250783A1 (en) | 2000-02-29 | 2001-09-12 | Cor Therapeutics, Inc. | Benzamides and related inhibitors of factor xa |
| US7220768B2 (en) * | 2003-02-11 | 2007-05-22 | Wyeth Holdings Corp. | Isoxazole-containing thiourea inhibitors useful for treatment of varicella zoster virus |
| ES2550057T3 (en) | 2006-11-02 | 2015-11-04 | Millennium Pharmaceuticals, Inc. | Methods for synthesizing pharmaceutical salts of a Factor Xa inhibitor |
| US9284310B2 (en) | 2012-11-03 | 2016-03-15 | Boehringer Ingelheim International Gmbh | Inhibitors of cytomegalovirus |
| JP6372666B2 (en) * | 2012-11-03 | 2018-08-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Inhibitor of cytomegalovirus |
| CN110565100B (en) * | 2019-07-12 | 2021-05-07 | 西北工业大学 | Cobaltocene cation-based corrosion inhibitor and preparation method and use method thereof |
| JP7700363B2 (en) | 2021-08-05 | 2025-06-30 | 浙江海正薬業股▲ふん▼有限公司 | Aromatic acetylene derivatives, their production method and uses |
| US20250026757A1 (en) | 2021-11-19 | 2025-01-23 | Basf Se | Bicyclic Compounds for the Control of Invertebrate Pests |
| CN115433093A (en) * | 2022-09-26 | 2022-12-06 | 无锡双启科技有限公司 | Preparation method of 3-chloro-4-trifluoromethylaniline |
| CN115710190A (en) * | 2022-11-16 | 2023-02-24 | 常州佳德医药科技有限公司 | 4-methoxy-2-amino-N, N-dimethylaniline, preparation method and application |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2191292T3 (en) * | 1997-04-10 | 2003-09-01 | Upjohn Co | POLYAROMATIC ANTIVIRAL COMPOUNDS. |
-
1999
- 1999-12-06 SK SK768-2001A patent/SK7682001A3/en unknown
- 1999-12-06 CN CN99815997A patent/CN1348446A/en active Pending
- 1999-12-06 CZ CZ20011956A patent/CZ20011956A3/en unknown
- 1999-12-06 TR TR2001/01664T patent/TR200101664T2/en unknown
- 1999-12-06 IL IL14318299A patent/IL143182A0/en unknown
- 1999-12-06 EP EP99963023A patent/EP1144397A3/en not_active Withdrawn
- 1999-12-06 BR BR9916046-3A patent/BR9916046A/en not_active Application Discontinuation
- 1999-12-06 CA CA002350767A patent/CA2350767A1/en not_active Abandoned
- 1999-12-06 JP JP2000586705A patent/JP2002531554A/en active Pending
- 1999-12-06 EA EA200100631A patent/EA200100631A1/en unknown
- 1999-12-06 PL PL99349217A patent/PL349217A1/en not_active Application Discontinuation
- 1999-12-06 ID IDW00200101231A patent/ID30158A/en unknown
- 1999-12-06 HU HU0200232A patent/HUP0200232A2/en unknown
- 1999-12-06 AU AU19347/00A patent/AU1934700A/en not_active Abandoned
- 1999-12-06 WO PCT/US1999/028842 patent/WO2000034258A2/en not_active Ceased
-
2001
- 2001-05-28 ZA ZA200104377A patent/ZA200104377B/en unknown
- 2001-06-08 NO NO20012832A patent/NO20012832L/en not_active Application Discontinuation
- 2001-06-08 BG BG105581A patent/BG105581A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1144397A2 (en) | 2001-10-17 |
| JP2002531554A (en) | 2002-09-24 |
| CN1348446A (en) | 2002-05-08 |
| BG105581A (en) | 2001-12-31 |
| WO2000034258A2 (en) | 2000-06-15 |
| IL143182A0 (en) | 2002-04-21 |
| ZA200104377B (en) | 2002-12-20 |
| TR200101664T2 (en) | 2002-03-21 |
| SK7682001A3 (en) | 2002-07-02 |
| HUP0200232A2 (en) | 2002-05-29 |
| ID30158A (en) | 2001-11-08 |
| NO20012832D0 (en) | 2001-06-08 |
| AU1934700A (en) | 2000-06-26 |
| BR9916046A (en) | 2001-10-02 |
| WO2000034258A3 (en) | 2001-11-29 |
| CZ20011956A3 (en) | 2001-10-17 |
| EP1144397A3 (en) | 2002-09-11 |
| PL349217A1 (en) | 2002-07-01 |
| EA200100631A1 (en) | 2002-02-28 |
| CA2350767A1 (en) | 2000-06-15 |
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| FC2A | Withdrawal, rejection or dismissal of laid open patent application |