NO20012833L - <Alfa>-metylbenzyl-holdige tiourea-inhibitorer for herpesvirus inneholdende en fenylendiamingruppe - Google Patents
<Alfa>-metylbenzyl-holdige tiourea-inhibitorer for herpesvirus inneholdende en fenylendiamingruppeInfo
- Publication number
- NO20012833L NO20012833L NO20012833A NO20012833A NO20012833L NO 20012833 L NO20012833 L NO 20012833L NO 20012833 A NO20012833 A NO 20012833A NO 20012833 A NO20012833 A NO 20012833A NO 20012833 L NO20012833 L NO 20012833L
- Authority
- NO
- Norway
- Prior art keywords
- methylbenzyl
- alpha
- herpes virus
- phenylenediamine group
- thiourea inhibitors
- Prior art date
Links
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 title 2
- GEYOCULIXLDCMW-UHFFFAOYSA-N 1,2-phenylenediamine Chemical group NC1=CC=CC=C1N GEYOCULIXLDCMW-UHFFFAOYSA-N 0.000 title 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 125000006178 methyl benzyl group Chemical group 0.000 title 1
- 241001529453 unidentified herpesvirus Species 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Hydrogenated Pyridines (AREA)
- Quinoline Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20890298A | 1998-12-09 | 1998-12-09 | |
| PCT/US1999/028839 WO2000034260A2 (en) | 1998-12-09 | 1999-12-06 | Alpha-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a phenylenediamine group |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20012833D0 NO20012833D0 (no) | 2001-06-08 |
| NO20012833L true NO20012833L (no) | 2001-08-02 |
Family
ID=22776519
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20012833A NO20012833L (no) | 1998-12-09 | 2001-06-08 | <Alfa>-metylbenzyl-holdige tiourea-inhibitorer for herpesvirus inneholdende en fenylendiamingruppe |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP1137645B1 (de) |
| JP (1) | JP2002531555A (de) |
| KR (1) | KR20010089551A (de) |
| CN (1) | CN1165531C (de) |
| AR (1) | AR035308A1 (de) |
| AT (1) | ATE267824T1 (de) |
| AU (1) | AU1934600A (de) |
| BR (1) | BR9916084A (de) |
| CA (1) | CA2350833A1 (de) |
| CZ (1) | CZ20012067A3 (de) |
| DE (1) | DE69917673T2 (de) |
| DK (1) | DK1137645T3 (de) |
| EA (1) | EA004205B1 (de) |
| ES (1) | ES2221470T3 (de) |
| HU (1) | HUP0104492A3 (de) |
| IL (1) | IL143183A0 (de) |
| NO (1) | NO20012833L (de) |
| NZ (1) | NZ512135A (de) |
| PT (1) | PT1137645E (de) |
| WO (1) | WO2000034260A2 (de) |
| ZA (1) | ZA200104376B (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6844367B1 (en) | 1999-09-17 | 2005-01-18 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
| WO2001064642A2 (en) | 2000-02-29 | 2001-09-07 | Cor Therapeutics, Inc. | Benzamides and related inhibitors of factor xa |
| NZ523882A (en) * | 2000-08-21 | 2004-11-26 | Pacific Corp | Novel thiourea derivatives and the pharmaceutical compositions containing the same |
| JP4360885B2 (ja) | 2003-11-28 | 2009-11-11 | 富士フイルム株式会社 | アルキルチオ基を有する芳香族アミン化合物の製造方法 |
| EP1928843A1 (de) * | 2005-08-22 | 2008-06-11 | Amgen, Inc | Bis-arylharnstoffverbindungen zur behandlung von durch proteinkinase vemittelten krankheiten |
| EP2077995B1 (de) | 2006-11-02 | 2012-02-08 | Millennium Pharmaceuticals, Inc. | Verfahren zur synthetisierung pharmazeutischer salze aus einem faktor-xa-hemmer |
| CN112807294B (zh) * | 2019-11-18 | 2023-09-05 | 武汉大学 | 一种酰基硫脲类化合物在制备治疗或预防单纯疱疹病毒i型感染药物中的应用 |
| CN115433093A (zh) * | 2022-09-26 | 2022-12-06 | 无锡双启科技有限公司 | 一种3-氯-4-三氟甲基苯胺的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU210683B (en) * | 1990-06-18 | 1995-06-28 | Sandoz Ag | Process for producing n-benzyl-n1-(phenyl-alkyl)-thiourea derivatives and pharmaceutical compositions containing the same |
| JPH11503110A (ja) * | 1995-02-17 | 1999-03-23 | スミスクライン・ビーチャム・コーポレイション | Ｉｌ−８受容体拮抗剤 |
| GB9519270D0 (en) * | 1995-09-21 | 1995-11-22 | Sandoz Pharma Uk | Organic compounds |
| PL192628B1 (pl) * | 1996-04-23 | 2006-11-30 | Vertex Pharma | Pochodne mocznika, kompozycje farmaceutyczne i zastosowanie związku i kompozycji |
-
1999
- 1999-12-06 AT AT99963022T patent/ATE267824T1/de not_active IP Right Cessation
- 1999-12-06 PT PT99963022T patent/PT1137645E/pt unknown
- 1999-12-06 AU AU19346/00A patent/AU1934600A/en not_active Abandoned
- 1999-12-06 IL IL14318399A patent/IL143183A0/xx unknown
- 1999-12-06 NZ NZ512135A patent/NZ512135A/en unknown
- 1999-12-06 KR KR1020017007053A patent/KR20010089551A/ko not_active Withdrawn
- 1999-12-06 BR BR9916084-6A patent/BR9916084A/pt not_active IP Right Cessation
- 1999-12-06 JP JP2000586707A patent/JP2002531555A/ja active Pending
- 1999-12-06 CN CNB998142778A patent/CN1165531C/zh not_active Expired - Fee Related
- 1999-12-06 EA EA200100638A patent/EA004205B1/ru not_active IP Right Cessation
- 1999-12-06 DK DK99963022T patent/DK1137645T3/da active
- 1999-12-06 EP EP99963022A patent/EP1137645B1/de not_active Expired - Lifetime
- 1999-12-06 ES ES99963022T patent/ES2221470T3/es not_active Expired - Lifetime
- 1999-12-06 DE DE69917673T patent/DE69917673T2/de not_active Expired - Fee Related
- 1999-12-06 CA CA002350833A patent/CA2350833A1/en not_active Abandoned
- 1999-12-06 WO PCT/US1999/028839 patent/WO2000034260A2/en not_active Ceased
- 1999-12-06 CZ CZ20012067A patent/CZ20012067A3/cs unknown
- 1999-12-06 HU HU0104492A patent/HUP0104492A3/hu unknown
- 1999-12-07 AR ARP990106228A patent/AR035308A1/es not_active Application Discontinuation
-
2001
- 2001-05-28 ZA ZA200104376A patent/ZA200104376B/en unknown
- 2001-06-08 NO NO20012833A patent/NO20012833L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69917673D1 (de) | 2004-07-01 |
| PT1137645E (pt) | 2004-09-30 |
| CZ20012067A3 (cs) | 2001-10-17 |
| ATE267824T1 (de) | 2004-06-15 |
| EA200100638A1 (ru) | 2001-12-24 |
| HUP0104492A3 (en) | 2002-12-28 |
| BR9916084A (pt) | 2001-09-04 |
| IL143183A0 (en) | 2002-04-21 |
| WO2000034260A2 (en) | 2000-06-15 |
| WO2000034260A3 (en) | 2000-09-08 |
| EP1137645B1 (de) | 2004-05-26 |
| ZA200104376B (en) | 2002-08-28 |
| AU1934600A (en) | 2000-06-26 |
| DK1137645T3 (da) | 2004-08-09 |
| NZ512135A (en) | 2003-12-19 |
| CA2350833A1 (en) | 2000-06-15 |
| CN1329608A (zh) | 2002-01-02 |
| HUP0104492A2 (hu) | 2002-04-29 |
| KR20010089551A (ko) | 2001-10-06 |
| AR035308A1 (es) | 2004-05-12 |
| CN1165531C (zh) | 2004-09-08 |
| ES2221470T3 (es) | 2004-12-16 |
| DE69917673T2 (de) | 2005-06-09 |
| EA004205B1 (ru) | 2004-02-26 |
| JP2002531555A (ja) | 2002-09-24 |
| NO20012833D0 (no) | 2001-06-08 |
| EP1137645A2 (de) | 2001-10-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |