NO20021611L - Dyremodell for mesangial proliferativ nefritt - Google Patents

Dyremodell for mesangial proliferativ nefritt

Info

Publication number
NO20021611L
NO20021611L NO20021611A NO20021611A NO20021611L NO 20021611 L NO20021611 L NO 20021611L NO 20021611 A NO20021611 A NO 20021611A NO 20021611 A NO20021611 A NO 20021611A NO 20021611 L NO20021611 L NO 20021611L
Authority
NO
Norway
Prior art keywords
animal model
proliferative nephritis
mesangial
mesangial proliferative
nephritis
Prior art date
Application number
NO20021611A
Other languages
English (en)
Other versions
NO20021611D0 (no
Inventor
Toshio Miyata
Original Assignee
Kurokawa Kiyoshi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kurokawa Kiyoshi filed Critical Kurokawa Kiyoshi
Publication of NO20021611D0 publication Critical patent/NO20021611D0/no
Publication of NO20021611L publication Critical patent/NO20021611L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

En dyremodell for mesangial proliferativ nefritt ble frembrakt ved anvendelse av megsin-transgene dyr. Transgene mus konstruert ved anvendelse av et megsingen viser typiske symptomer på mesangial proliferativ nefritt forbundet med ekspansjon av den mesangiale matriks, deponering av immunkomplekser og økt antall mesangiale celler. Denne dyremodellen for mesangial proliferativ nefritt er anvendbar for analyse av de patologiske tilstander ved kroniske glomerulære sykdommer og for søk etter terapeutiske midler.
NO20021611A 1999-10-06 2002-04-05 Dyremodell for mesangial proliferativ nefritt NO20021611L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP28573699 1999-10-06
PCT/JP2000/006988 WO2001024628A1 (en) 1999-10-06 2000-10-06 Model animal of mesangial cell proliferative nephritis

Publications (2)

Publication Number Publication Date
NO20021611D0 NO20021611D0 (no) 2002-04-05
NO20021611L true NO20021611L (no) 2002-06-05

Family

ID=17695389

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20021611A NO20021611L (no) 1999-10-06 2002-04-05 Dyremodell for mesangial proliferativ nefritt

Country Status (7)

Country Link
EP (1) EP1224862A4 (no)
KR (1) KR20020092917A (no)
CN (1) CN1200735C (no)
AU (1) AU780532B2 (no)
CA (1) CA2385984A1 (no)
NO (1) NO20021611L (no)
WO (1) WO2001024628A1 (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003244385A1 (en) * 2002-02-08 2003-09-02 Kiyoshi Kurokawa Megsin ligands
EP1712125A4 (en) * 2003-12-12 2009-06-10 Japan Science & Tech Agency ANIMAL MODEL Animal expressing MEGSIN / RAGE / iNOS AND METHOD FOR EVALUATING COMPOUNDS WITH THE HELP OF ANIMALS
RU2387019C2 (ru) * 2008-06-23 2010-04-20 Федеральное государственное образовательное учреждение высшего профессионального образования Пермская государственная сельскохозяйственная академия имени академика Д.Н. Прянишникова Способ моделирования острого пиелонефрита на фоне криогенного воздействия
CN111154809B (zh) * 2020-01-09 2020-11-27 电子科技大学附属医院·四川省人民医院 利用基因操作技术构建肾小球疾病模型的方法和应用
CN114698592B (zh) * 2022-04-29 2022-11-04 中国医学科学院北京协和医院 一种干燥综合征肾损害小鼠模型的构建方法及其应用
CN117296788A (zh) * 2023-08-24 2023-12-29 山东省职业卫生与职业病防治研究院 一种苯诱导急性髓性白血病小鼠模型建立及染毒的方法
CN118453854B (zh) * 2024-07-12 2024-10-29 广州粤华制药有限公司 一种用于建立慢性肾小球肾病模型的组合物及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4190893A (en) * 1992-07-17 1994-01-20 Suntory Limited Megakaryocyte differentiation factor
JP3956272B2 (ja) * 1997-09-22 2007-08-08 敏男 宮田 メグシンタンパク質

Also Published As

Publication number Publication date
NO20021611D0 (no) 2002-04-05
WO2001024628A1 (en) 2001-04-12
CN1200735C (zh) 2005-05-11
CN1399514A (zh) 2003-02-26
EP1224862A4 (en) 2003-01-02
AU7558100A (en) 2001-05-10
EP1224862A1 (en) 2002-07-24
CA2385984A1 (en) 2001-04-12
KR20020092917A (ko) 2002-12-12
AU780532B2 (en) 2005-03-24

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