NO20022093L - Fremstilling av polymorfe former I og II av finasterid ved kompleksbinding med gruppe I- eller II metallsalter - Google Patents

Fremstilling av polymorfe former I og II av finasterid ved kompleksbinding med gruppe I- eller II metallsalter

Info

Publication number
NO20022093L
NO20022093L NO20022093A NO20022093A NO20022093L NO 20022093 L NO20022093 L NO 20022093L NO 20022093 A NO20022093 A NO 20022093A NO 20022093 A NO20022093 A NO 20022093A NO 20022093 L NO20022093 L NO 20022093L
Authority
NO
Norway
Prior art keywords
finasteride
group
preparation
metal salts
polymorphic forms
Prior art date
Application number
NO20022093A
Other languages
English (en)
Other versions
NO20022093D0 (no
Inventor
Clarke E Slemon
Original Assignee
Torcan Chemical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Torcan Chemical Ltd filed Critical Torcan Chemical Ltd
Publication of NO20022093D0 publication Critical patent/NO20022093D0/no
Publication of NO20022093L publication Critical patent/NO20022093L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Polymorf form (l) finasterid blir fremstilt ved først å danne et vesentlig uoppløselig kompleks av finasterid og et gruppe (l) eller gruppe (II) -metallsalt, så som litiumbromid, og deretter dissosiering av komplekset ved å løse bort saltkomponenten med vann, for å oppnå vesentlig ren form (l) polymorf, krystallinsk finasterid.
NO20022093A 1999-11-01 2002-05-02 Fremstilling av polymorfe former I og II av finasterid ved kompleksbinding med gruppe I- eller II metallsalter NO20022093L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CA1999/001017 WO2001032683A1 (en) 1999-11-01 1999-11-01 Production of polymorphic forms i and ii of finasteride by complexation with group i or ii metal salts

Publications (2)

Publication Number Publication Date
NO20022093D0 NO20022093D0 (no) 2002-05-02
NO20022093L true NO20022093L (no) 2002-06-03

Family

ID=4173394

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20022093A NO20022093L (no) 1999-11-01 2002-05-02 Fremstilling av polymorfe former I og II av finasterid ved kompleksbinding med gruppe I- eller II metallsalter

Country Status (9)

Country Link
US (1) US6677453B1 (no)
EP (1) EP1228084A1 (no)
JP (1) JP2003513103A (no)
CN (1) CN1379784A (no)
AU (1) AU773067B2 (no)
CA (1) CA2389666A1 (no)
EA (1) EA200200524A1 (no)
NO (1) NO20022093L (no)
WO (1) WO2001032683A1 (no)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1556058T1 (sl) 2002-10-23 2008-02-29 Pantarhei Bioscience Bv Farmacevtski sestavki, ki obsegajo estetrolne derivate, za uporabo pri zdravljenju raka
US7550593B2 (en) 2003-07-03 2009-06-23 Cipla Limited Process for the preparation of finasteride Form I
CN1294913C (zh) * 2004-12-23 2007-01-17 鲁南制药集团股份有限公司 含有非那雄胺与环糊精或其衍生物的药物组合物
US20070167477A1 (en) * 2006-01-13 2007-07-19 Mandava Venkata Naga Brahmeswa Processes to prepare finasteride polymorphs

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2529521C2 (de) 1975-06-30 1984-11-29 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur Gewinnung von 3-Hydroxysteroiden und 3-Oxosteroiden
US4452994A (en) * 1981-03-02 1984-06-05 G. D. Searle & Co. Process for isolating organic compounds and lithium salt complexes useful in said process
US5468860A (en) * 1992-11-19 1995-11-21 Merck & Co., Inc. New finasteride processes
GB2338234B (en) * 1998-06-10 2000-05-03 Torcan Chemical Ltd Preparation of finasteride

Also Published As

Publication number Publication date
EA200200524A1 (ru) 2002-10-31
JP2003513103A (ja) 2003-04-08
CA2389666A1 (en) 2001-05-10
CN1379784A (zh) 2002-11-13
AU1021300A (en) 2001-05-14
AU773067B2 (en) 2004-05-13
NO20022093D0 (no) 2002-05-02
EP1228084A1 (en) 2002-08-07
WO2001032683A1 (en) 2001-05-10
US6677453B1 (en) 2004-01-13

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application