NO20022457L - Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines and their use as drugs - Google Patents

Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines and their use as drugs

Info

Publication number
NO20022457L
NO20022457L NO20022457A NO20022457A NO20022457L NO 20022457 L NO20022457 L NO 20022457L NO 20022457 A NO20022457 A NO 20022457A NO 20022457 A NO20022457 A NO 20022457A NO 20022457 L NO20022457 L NO 20022457L
Authority
NO
Norway
Prior art keywords
benzazocines
methano
hexahydro
drugs
substituted
Prior art date
Application number
NO20022457A
Other languages
Norwegian (no)
Other versions
NO20022457D0 (en
Inventor
Matthias Grauert
Adrian Carter
Thomas Weiser
Helmut Ensinger
Wolfram Gaida
Joachim Mierau
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of NO20022457D0 publication Critical patent/NO20022457D0/en
Publication of NO20022457L publication Critical patent/NO20022457L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/06—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO20022457A 1999-11-27 2002-05-24 Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines and their use as drugs NO20022457L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19957156A DE19957156A1 (en) 1999-11-27 1999-11-27 New amino and fluoro substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine derivatives useful in treatment of e.g. arrythmias, spasms, ischaemia, pain and neurodegenerative disorders
PCT/EP2000/011585 WO2001051471A1 (en) 1999-11-27 2000-11-21 Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines and the use thereof as medicaments

Publications (2)

Publication Number Publication Date
NO20022457D0 NO20022457D0 (en) 2002-05-24
NO20022457L true NO20022457L (en) 2002-05-24

Family

ID=7930562

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20022457A NO20022457L (en) 1999-11-27 2002-05-24 Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines and their use as drugs

Country Status (32)

Country Link
EP (1) EP1235809B1 (en)
JP (1) JP2003519687A (en)
KR (1) KR20020058042A (en)
CN (1) CN1177825C (en)
AR (1) AR026586A1 (en)
AT (1) ATE254108T1 (en)
AU (1) AU5789701A (en)
BG (1) BG106682A (en)
BR (1) BR0015786A (en)
CA (1) CA2383114C (en)
CO (1) CO5251469A1 (en)
CZ (1) CZ20022120A3 (en)
DE (2) DE19957156A1 (en)
DK (1) DK1235809T3 (en)
EA (1) EA005681B1 (en)
EE (1) EE200200267A (en)
ES (1) ES2210036T3 (en)
HR (1) HRP20020460A2 (en)
HU (1) HUP0204169A3 (en)
IL (1) IL149607A0 (en)
MX (1) MXPA02003822A (en)
NO (1) NO20022457L (en)
NZ (1) NZ519758A (en)
PL (1) PL355493A1 (en)
PT (1) PT1235809E (en)
SK (1) SK9302002A3 (en)
TR (1) TR200302031T4 (en)
UA (1) UA72566C2 (en)
UY (1) UY26448A1 (en)
WO (1) WO2001051471A1 (en)
YU (1) YU37902A (en)
ZA (1) ZA200204056B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6683089B2 (en) 2002-02-02 2004-01-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg N-allyoxyethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine-10-ols
DE10204276A1 (en) * 2002-02-02 2003-08-07 Boehringer Ingelheim Pharma N-Allyloxyethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines and their use as pharmaceuticals
CA2890655A1 (en) * 2012-11-09 2014-05-15 Purdue Pharma L.P. Benzomorphan analogs and the use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4121821A1 (en) * 1991-07-02 1993-01-14 Boehringer Ingelheim Kg NEW BENZOMORPHANE AND ITS USE AS A MEDICAMENT
US5354758A (en) * 1992-12-16 1994-10-11 Japan Tobacco Inc. Benzomorphans useful as NMDA receptor antagonists
DE19740110A1 (en) * 1997-09-12 1999-03-18 Boehringer Ingelheim Pharma Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-ols, process for their preparation and their use as medicaments
DE19907874A1 (en) * 1999-02-23 2000-08-24 Boehringer Ingelheim Pharma New N-substituted hexahydro-2,6-methano-3-benzazocin-10-ol derivatives, as tension-dependent sodium channel blockers useful for treating e.g. arrhythmia, spasms, pain or neurodegenerative diseases

Also Published As

Publication number Publication date
EP1235809A1 (en) 2002-09-04
CZ20022120A3 (en) 2002-09-11
CA2383114A1 (en) 2001-07-19
ZA200204056B (en) 2003-07-30
CA2383114C (en) 2008-06-17
WO2001051471A1 (en) 2001-07-19
HRP20020460A2 (en) 2003-10-31
HUP0204169A3 (en) 2005-03-29
IL149607A0 (en) 2002-11-10
EP1235809B1 (en) 2003-11-12
ES2210036T3 (en) 2004-07-01
DE19957156A1 (en) 2001-05-31
PL355493A1 (en) 2004-05-04
UY26448A1 (en) 2001-06-29
JP2003519687A (en) 2003-06-24
EE200200267A (en) 2003-06-16
EA200200491A1 (en) 2002-12-26
MXPA02003822A (en) 2002-12-13
AU5789701A (en) 2001-07-24
CO5251469A1 (en) 2003-02-28
UA72566C2 (en) 2005-03-15
DK1235809T3 (en) 2004-03-15
NZ519758A (en) 2004-05-28
TR200302031T4 (en) 2004-01-21
DE50004455D1 (en) 2003-12-18
CN1177825C (en) 2004-12-01
PT1235809E (en) 2004-04-30
NO20022457D0 (en) 2002-05-24
AR026586A1 (en) 2003-02-19
HK1052176A1 (en) 2003-09-05
CN1399630A (en) 2003-02-26
YU37902A (en) 2005-07-19
BG106682A (en) 2003-01-31
BR0015786A (en) 2002-08-13
SK9302002A3 (en) 2002-11-06
HUP0204169A2 (en) 2003-03-28
KR20020058042A (en) 2002-07-12
ATE254108T1 (en) 2003-11-15
EA005681B1 (en) 2005-04-28

Similar Documents

Publication Publication Date Title
NO20021449L (en) Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use
NO20015156L (en) 5-pyridyl-1,3-azole compounds, their preparation and use
NO20014603L (en) Tienopyrimidine Compounds, Their Preparation and Use
NO20021719D0 (en) 6-position substituted indolines, preparation and use thereof as a drug
NO20015113L (en) New compounds, their preparation and use
DK1095025T3 (en) Benzimidazoles, their preparation and their use as drugs
NO20012567D0 (en) Azepinoindole derivatives, preparation and use thereof
NO20011503D0 (en) Indeno-, naphtho- and benzocyclohepta-dihydrotiazole derivatives, their preparation and use as anorectic drugs
NO20024175D0 (en) Acetidine derivatives, their preparation and pharmaceutical compounds containing the same
NO20011216L (en) Acetidine derivatives, their preparation and medicaments containing the compounds
DK1083171T3 (en) Pyrazoline derivatives, their preparation and use as drugs
DK1198454T3 (en) Multiline derivatives and their use as antibacterial agents
DK1538160T3 (en) Substituted isoquinoline-3-carboxylic acid amides, their preparation and their use as a drug
NO20005146D0 (en) Thienylazolylalkoxyethanamines, their preparation and their use as drugs
NO20014702D0 (en) Diaryl derivatives and their use as drugs
NO20006138D0 (en) Substituted indolinones, preparation and use thereof as drugs
DK1073672T3 (en) Antipicornaviral compounds, their preparation and use
NO20023146L (en) Substituted phenyl-piperazine derivatives, their preparation and use
DK1043307T3 (en) 3-Amino-3-arylpropan-1-ol derivatives, their preparation and use
NO20020156D0 (en) Titanium derived compounds, their preparation and their use
DK1157020T3 (en) Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-2-benzazocin-10-ols, processes for their preparation and their use as a drug
NO20000066D0 (en) 6-Pyrrolidin-2-ylpyrindine Derivatives, their Preparation and their Pharmaceutical Use
NO20006479D0 (en) Tienopyridine compounds, their preparation and use
DK1235809T3 (en) Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines and their use as drugs
NO20001782L (en) 3-Amino-3-arylpropan-1-ol derivatives, their preparation and use

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application