NO20030111L - Kjemokinreseptor-modulatorer, deres fremstilling og anvendelse - Google Patents

Kjemokinreseptor-modulatorer, deres fremstilling og anvendelse

Info

Publication number
NO20030111L
NO20030111L NO20030111A NO20030111A NO20030111L NO 20030111 L NO20030111 L NO 20030111L NO 20030111 A NO20030111 A NO 20030111A NO 20030111 A NO20030111 A NO 20030111A NO 20030111 L NO20030111 L NO 20030111L
Authority
NO
Norway
Prior art keywords
terminus
chemokine receptor
treatment
terminal
analogs
Prior art date
Application number
NO20030111A
Other languages
English (en)
Other versions
NO20030111D0 (no
Inventor
Robin E Offord
Olivier Hartley
Hubert Gaertner
Original Assignee
Gryphon Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gryphon Therapeutics Inc filed Critical Gryphon Therapeutics Inc
Publication of NO20030111D0 publication Critical patent/NO20030111D0/no
Publication of NO20030111L publication Critical patent/NO20030111L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

Kjemokinreseptor-modulatorer omfattende en kjemisk modifisert karboksyl-terminus (C-terminus) og/eller amino-terminus (N- terminus) for å modulere potens og farmakokinetikkegenskaper, og fremgangsmåte for fremstilling og anvendelse er omtalt. Forbindelsene og fremgangsmåtene ifølge oppfinnelsen er eksemplifisert ved nye N-terminal, C-terminal og N/C-terminal analoger av CC og CXC kjemokiner. Kjemokinreseptor-modula-toranalogene ifølge oppfinnelsen er anvendbare for behandling av lidelser som involverer det naturlig forekommende kjemokin som analogene ifølge oppfinnelsen antagoniserer, slik som for behandling av HTV og AIDS relaterte lidelser og for behandling av astma, allergisk rhinitt, atopisk dermatitt, aterom/- aterosklerose, organtransplantatavstøtning og revmatoid artritt.
NO20030111A 2000-07-12 2003-01-09 Kjemokinreseptor-modulatorer, deres fremstilling og anvendelse NO20030111L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21768300P 2000-07-12 2000-07-12
PCT/US2001/021934 WO2002004499A1 (en) 2000-07-12 2001-07-12 Chemokine receptor modulators, production and use

Publications (2)

Publication Number Publication Date
NO20030111D0 NO20030111D0 (no) 2003-01-09
NO20030111L true NO20030111L (no) 2003-03-12

Family

ID=22812056

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20030110A NO20030110L (no) 2000-07-12 2003-01-09 Polymer-modifiserte bioaktive syntetiske kjemokiner, fremgangsmåter for deres fremstilling og anvendelse
NO20030111A NO20030111L (no) 2000-07-12 2003-01-09 Kjemokinreseptor-modulatorer, deres fremstilling og anvendelse

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20030110A NO20030110L (no) 2000-07-12 2003-01-09 Polymer-modifiserte bioaktive syntetiske kjemokiner, fremgangsmåter for deres fremstilling og anvendelse

Country Status (14)

Country Link
US (1) US20050089970A1 (no)
EP (2) EP1307216A4 (no)
JP (3) JP2004502783A (no)
KR (2) KR20030032977A (no)
CN (2) CN1460023A (no)
AU (2) AU2002218769A1 (no)
BR (2) BR0112428A (no)
CA (2) CA2412162A1 (no)
IL (2) IL153785A0 (no)
MX (2) MXPA03000310A (no)
NO (2) NO20030110L (no)
RU (1) RU2003104024A (no)
WO (2) WO2002004015A1 (no)
ZA (2) ZA200300312B (no)

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Also Published As

Publication number Publication date
BR0112428A (pt) 2003-11-25
JP2007302667A (ja) 2007-11-22
AU2001273387A1 (en) 2002-01-21
NO20030111D0 (no) 2003-01-09
WO2002004015A1 (en) 2002-01-17
EP1307216A1 (en) 2003-05-07
JP2004502783A (ja) 2004-01-29
ZA200300313B (en) 2004-02-04
EP1299415A4 (en) 2005-01-19
IL153785A0 (en) 2003-07-31
CA2412162A1 (en) 2002-01-17
CN1441808A (zh) 2003-09-10
EP1307216A4 (en) 2005-01-12
KR20030036591A (ko) 2003-05-09
NO20030110D0 (no) 2003-01-09
CN1460023A (zh) 2003-12-03
CA2412150A1 (en) 2002-01-17
WO2002004499A1 (en) 2002-01-17
WO2002004015A9 (en) 2003-08-07
AU2002218769A1 (en) 2002-01-21
ZA200300312B (en) 2004-02-04
IL153789A0 (en) 2003-07-31
KR20030032977A (ko) 2003-04-26
JP2004517040A (ja) 2004-06-10
RU2003104024A (ru) 2004-06-27
NO20030110L (no) 2003-03-12
US20050089970A1 (en) 2005-04-28
MXPA03000311A (es) 2004-12-13
BR0112429A (pt) 2003-12-30
MXPA03000310A (es) 2004-12-13
EP1299415A1 (en) 2003-04-09

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