NO20031448L - Fremgangsmåte for fremstilling av nanopartikler av paclitaxel og albumin - Google Patents

Fremgangsmåte for fremstilling av nanopartikler av paclitaxel og albumin

Info

Publication number
NO20031448L
NO20031448L NO20031448A NO20031448A NO20031448L NO 20031448 L NO20031448 L NO 20031448L NO 20031448 A NO20031448 A NO 20031448A NO 20031448 A NO20031448 A NO 20031448A NO 20031448 L NO20031448 L NO 20031448L
Authority
NO
Norway
Prior art keywords
paclitaxel
nanoparticles
albumin
preparation
Prior art date
Application number
NO20031448A
Other languages
English (en)
Other versions
NO20031448D0 (no
NO334407B1 (no
Inventor
Maurizio Zenoni
Simone Maschio
Original Assignee
Acs Dobfar Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acs Dobfar Spa filed Critical Acs Dobfar Spa
Publication of NO20031448D0 publication Critical patent/NO20031448D0/no
Publication of NO20031448L publication Critical patent/NO20031448L/no
Publication of NO334407B1 publication Critical patent/NO334407B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5052—Proteins, e.g. albumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
NO20031448A 2002-03-29 2003-03-28 Fremgangsmåte for fremstilling av et sterilt, lyofilisert pulver bestående av nanopartikler av paclitaxel og humant serumalbumin NO334407B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2002MI000681A ITMI20020681A1 (it) 2002-03-29 2002-03-29 Procedimento per la produzione di nanoparticelle di paclitaxel ed albumina

Publications (3)

Publication Number Publication Date
NO20031448D0 NO20031448D0 (no) 2003-03-28
NO20031448L true NO20031448L (no) 2003-09-30
NO334407B1 NO334407B1 (no) 2014-02-24

Family

ID=11449619

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20031448A NO334407B1 (no) 2002-03-29 2003-03-28 Fremgangsmåte for fremstilling av et sterilt, lyofilisert pulver bestående av nanopartikler av paclitaxel og humant serumalbumin

Country Status (15)

Country Link
US (2) US20030185894A1 (no)
EP (1) EP1348431A1 (no)
JP (2) JP4794115B2 (no)
KR (1) KR20030078722A (no)
CN (2) CN1259902C (no)
AU (1) AU2003200920A1 (no)
BR (1) BR0300846A (no)
CA (1) CA2423915A1 (no)
IL (1) IL154762A0 (no)
IT (1) ITMI20020681A1 (no)
MX (1) MXPA03002543A (no)
NO (1) NO334407B1 (no)
NZ (1) NZ524605A (no)
RU (1) RU2003108821A (no)
ZA (1) ZA200302040B (no)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030133955A1 (en) * 1993-02-22 2003-07-17 American Bioscience, Inc. Methods and compositions useful for administration of chemotherapeutic agents
US20070117862A1 (en) * 1993-02-22 2007-05-24 Desai Neil P Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
US8137684B2 (en) 1996-10-01 2012-03-20 Abraxis Bioscience, Llc Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
KR100904931B1 (ko) * 1997-06-27 2009-06-29 아브락시스 바이오사이언스, 엘엘씨 나노 입자 및 그의 제조 방법
US8853260B2 (en) * 1997-06-27 2014-10-07 Abraxis Bioscience, Llc Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
US20030199425A1 (en) * 1997-06-27 2003-10-23 Desai Neil P. Compositions and methods for treatment of hyperplasia
LT1585548T (lt) * 2002-12-09 2018-09-25 Abraxis Bioscience, Llc Farmakologinių agentų kompozicijos ir įvedimo būdai
US8735394B2 (en) 2005-02-18 2014-05-27 Abraxis Bioscience, Llc Combinations and modes of administration of therapeutic agents and combination therapy
NZ595313A (en) 2005-02-18 2013-03-28 Abraxis Bioscience Llc The Use Of Nanoparticles Comprising Rapamycin Or Taxane In The Treatment Of Proliferative Diseases
CA2618807C (en) * 2005-08-12 2015-01-06 University Health Network Methods and devices for lymphatic targeting
CA2880727C (en) 2005-08-31 2019-05-07 Neil P. Desai Compositions comprising poorly water soluble pharmaceutical agents and antimicrobial agents
KR101643416B1 (ko) 2005-08-31 2016-07-27 아브락시스 바이오사이언스, 엘엘씨 증가된 안정성을 가진 수 난용성 약물의 조성물 및 제조방법
AR054215A1 (es) * 2006-01-20 2007-06-13 Eriochem Sa Una formulacion farmaceutica de un taxano, una composicion solida de un taxano liofilizado a partir de una solucion de acido acetico, un procedimiento para la preparacion de dicha composicion solida de un taxano, una composicion solubilizante de un taxano liofilizado, y un conjunto de elementos (kit
EP1870649A1 (en) 2006-06-20 2007-12-26 Octapharma AG Lyophilisation targetting defined residual moisture by limited desorption energy levels
US20080280987A1 (en) * 2006-08-31 2008-11-13 Desai Neil P Methods of inhibiting angiogenesis and treating angiogenesis-associated diseases
ES2460576T3 (es) * 2007-12-13 2014-05-13 Novartis Ag Procedimiento para preparar una sustancia farmacológica en partículas y cristalina
WO2009126401A1 (en) * 2008-04-10 2009-10-15 Abraxis Bioscience, Llc Compositions of hydrophobic taxane derivatives and uses thereof
EP2156823A1 (en) * 2008-08-14 2010-02-24 Pharmatex Italia Srl Process for the preparation of sterile powdered pharmeceutical compounds in the form of micro and nanoparticles
CN101658516B (zh) * 2008-08-26 2011-10-05 齐鲁制药有限公司 紫杉醇类药物组合物及其制备方法
PT2419732T (pt) 2009-04-15 2019-12-24 Abraxis Bioscience Llc Composições e métodos de nanopartículas isentas de priões
WO2011017835A1 (en) * 2009-08-11 2011-02-17 Nanjing University Preparation method of protein or peptide nanoparticles for in vivo drug delivery by unfolding and refolding
EP2521539A4 (en) * 2009-12-31 2014-11-26 Mannkind Corp INJECTABLE PREPARATIONS FOR PARENTERAL ADMINISTRATION
PL2552438T3 (pl) 2010-03-26 2016-12-30 Sposoby leczenia raka wątrobowokomórkowego
BR112012024590A2 (pt) 2010-03-29 2016-05-31 Abraxis Bioscience Inc métodos de reforço da liberação de fármaco e da eficácia de agentes terapêuticos
RU2016119999A (ru) 2010-03-29 2018-11-08 АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи Способы лечения онкологических заболеваний
KR100971087B1 (ko) * 2010-05-06 2010-07-16 김현수 불투명부에 암막기능을 갖는 블라인드지의 제직방법
JP6257324B2 (ja) 2010-06-04 2018-01-10 アブラクシス バイオサイエンス， エルエルシー 膵臓がんの処置方法
CN102274190B (zh) * 2010-06-11 2012-12-05 上海现代药物制剂工程研究中心有限公司 一种注射用紫杉醇白蛋白亚微粒及其制备方法
CN102078306A (zh) * 2011-01-11 2011-06-01 无锡圆容生物医药股份有限公司 一种含有重组人血白蛋白的紫杉醇纳米颗粒冷冻干燥制剂
SMT201900502T1 (it) 2011-12-14 2019-11-13 Abraxis Bioscience Llc Uso di eccipienti polimerici per la liofilizzazione o il congelamento di particelle
EP2826482A4 (en) 2012-03-16 2015-09-02 Taiho Pharmaceutical Co Ltd NOVEL ANTITUM-AGENT WITH A COMBINATION OF THREE ACTIVE SUBSTANCES
US9149455B2 (en) 2012-11-09 2015-10-06 Abraxis Bioscience, Llc Methods of treating melanoma
US9511046B2 (en) * 2013-01-11 2016-12-06 Abraxis Bioscience, Llc Methods of treating pancreatic cancer
JP6349381B2 (ja) 2013-03-12 2018-06-27 アブラクシス バイオサイエンス， エルエルシー 肺がんを処置する方法
NZ630213A (en) 2013-03-14 2017-05-26 Abraxis Bioscience Llc Methods of treating bladder cancer
US10705070B1 (en) 2015-03-05 2020-07-07 Abraxis Bioscience, Llc Methods of assessing suitability of use of pharmaceutical compositions of albumin and poorly water soluble drug
US10527604B1 (en) 2015-03-05 2020-01-07 Abraxis Bioscience, Llc Methods of assessing suitability of use of pharmaceutical compositions of albumin and paclitaxel
JP6987644B2 (ja) 2015-06-29 2022-01-05 アブラクシス バイオサイエンス， エルエルシー 類上皮細胞腫瘍を処置する方法
CN105012251A (zh) * 2015-08-24 2015-11-04 吉林大学 注射用紫杉烷类药物白蛋白纳米粒冻干制剂及制备方法
EP3509643A1 (en) * 2016-09-06 2019-07-17 Mayo Foundation for Medical Education and Research Paclitaxel-albumin-binding agent compositions and methods for using and making the same
EP3520824A4 (en) 2016-09-27 2020-04-29 Sogang University Research Foundation COMPOSITION FOR HEPATIC ARTERIAL CHIMIOEMBOLIZATION USING HUMAN SERUM ALBUMIN NANOPARTICLES CARRYING ANTI-CANCER AGENT, AND METHOD FOR PRODUCING THE SAME
CN110062622B (zh) * 2016-10-27 2022-10-14 珠海贝海生物技术有限公司 多西他赛和人血清白蛋白的中性pH组合物
RU2020134124A (ru) 2018-03-20 2022-04-20 АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи СПОСОБЫ ЛЕЧЕНИЯ НАРУШЕНИЙ ЦЕНТРАЛЬНОЙ НЕРВНОЙ СИСТЕМЫ ПУТЕМ ВВЕДЕНИЯ СОДЕРЖАЩИХ ИНГИБИТОР mTOR И АЛЬБУМИН НАНОЧАСТИЦ
CN108524452A (zh) * 2018-05-08 2018-09-14 辽宁大学 一种紫杉醇白蛋白纳米粒的制备方法和应用
CN110496111B (zh) * 2018-05-18 2021-07-23 国家纳米科学中心 一种白蛋白纳米复合结构及其制备方法和应用
WO2021086946A1 (en) 2019-10-28 2021-05-06 Abraxis Bioscience, Llc Pharmaceutical compositions of albumin and rapamycin
CN110585444A (zh) * 2019-10-31 2019-12-20 董军 一种中西医结合药物及其制备方法与应用
CN114681408B (zh) * 2020-12-26 2023-06-23 四川汇宇制药股份有限公司 白蛋白结合型紫杉醇纳米粒的制备方法
KR102526793B1 (ko) * 2021-11-03 2023-04-28 주식회사 에스엔바이오사이언스 입도분포 유지 안정성이 개선된 알부민 결합 탁산 나노입자 제조방법
KR20240164809A (ko) 2022-04-27 2024-11-20 씨에스피씨 종콰이 팔마씨우티컬 테크놀로지 (스자좡) 컴퍼니 리미티드 급속 현탁용 나노입자 조성물 및 이의 제조 방법
WO2024003424A1 (es) * 2022-06-28 2024-01-04 Compliance Consulting And Engineering Services, S.L. Sistema para el control del proceso de liofilización en un liofilizador con sistema de castillo de placas y método para la generación de un espacio de diseño
GB202401848D0 (en) 2024-02-11 2024-03-27 Univ College Dublin Nat Univ Ireland Dublin Albumin nanoparticles

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5439686A (en) * 1993-02-22 1995-08-08 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
US6096331A (en) * 1993-02-22 2000-08-01 Vivorx Pharmaceuticals, Inc. Methods and compositions useful for administration of chemotherapeutic agents
US5498421A (en) * 1993-02-22 1996-03-12 Vivorx Pharmaceuticals, Inc. Composition useful for in vivo delivery of biologics and methods employing same
US5362478A (en) * 1993-03-26 1994-11-08 Vivorx Pharmaceuticals, Inc. Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell
US5916596A (en) * 1993-02-22 1999-06-29 Vivorx Pharmaceuticals, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
WO1998056424A1 (en) * 1997-06-12 1998-12-17 Ml Laboratories Plc Biologically active materials
KR100904931B1 (ko) * 1997-06-27 2009-06-29 아브락시스 바이오사이언스, 엘엘씨 나노 입자 및 그의 제조 방법
WO2000006152A1 (en) * 1998-07-30 2000-02-10 Novopharm Biotech, Inc. Pharmaceutically acceptable composition comprising an aqueous solution of paclitaxel and albumin
US20020041898A1 (en) * 2000-01-05 2002-04-11 Unger Evan C. Novel targeted delivery systems for bioactive agents
WO2001076567A1 (en) * 2000-04-10 2001-10-18 Teva Pharmaceutical Industries Ltd. Method and composition for treating cancer by administration of apoptosis-inducing chemotherapeutic agents
ITMI20001107A1 (it) * 2000-05-18 2001-11-18 Acs Dobfar Spa Metodo per il trattamento di tumori solici mediante microparticelle di albumina incorporanti paclitaxel

Also Published As

Publication number Publication date
MXPA03002543A (es) 2005-08-26
RU2003108821A (ru) 2004-11-10
ITMI20020681A1 (it) 2003-09-29
KR20030078722A (ko) 2003-10-08
NO20031448D0 (no) 2003-03-28
BR0300846A (pt) 2004-08-17
AU2003200920A1 (en) 2003-10-16
ITMI20020681A0 (it) 2002-03-29
CA2423915A1 (en) 2003-09-29
CN1448128A (zh) 2003-10-15
EP1348431A1 (en) 2003-10-01
US20060121119A1 (en) 2006-06-08
JP2011132253A (ja) 2011-07-07
NZ524605A (en) 2004-03-26
JP2003300878A (ja) 2003-10-21
IL154762A0 (en) 2003-10-31
CN1911446A (zh) 2007-02-14
NO334407B1 (no) 2014-02-24
JP4794115B2 (ja) 2011-10-19
CN1259902C (zh) 2006-06-21
ZA200302040B (en) 2003-09-17
US20030185894A1 (en) 2003-10-02

Similar Documents

Publication Publication Date Title
NO20031448D0 (no) Fremgangsmåte for fremstilling av nanopartikler av paclitaxel og albumin
DE60310339D1 (de) Querträger und Herstellungsverfahren
DE60319810D1 (de) Anschwemmfiltermedien und herstellungs- und verwendungsverfahren
DE60324888D1 (de) und Herstellungsverfahren
DE60218767D1 (de) Reissverschluss und Herstellungsverfahren
DE60225385D1 (de) Autentisches Document und dessen Herstellungsverfahren
NO20050136D0 (no) Fremgangsmate for fremstilling av mikropartikler
NO20042680L (no) Fremgangsmater for fremstilling av O-demetylvenflaxine
DE60136927D1 (de) Rfelektiver bedruckter gegenstand und sein herstellungsverfahren
DE60235142D1 (de) Kondensator und dessen Herstellungsverfahren
NO20051493D0 (no) Imidazolpyridiner og fremgangsmater for fremstilling og anvendelse av de samme
IL235090A (en) Exposure apparatus, exposure method and method for producing a device
DE60223735D1 (de) Interferometer und zugehöriges Herstellungsverfahren
NO20034523L (no) Pyrazolderivater for behandling av HIV
DE602004021802D1 (de) Heisspressgeformtes produkt und herstellungsverfahren dafür
DE60233444D1 (de) Teileanbringvorrichtung und teileanbringverfahren
ATE509668T1 (de) Zusammensetzung mit kontrollierter freisetzung und herstellungsverfahren dafür
DE60210535D1 (de) Vibrator und Herstellungsverfahren desselben
DE50214244D1 (de) Klauenpolläufer und dessen herstellverfahren
PL1608811T3 (pl) Wyrób wielowarstwowy i sposób jego wytwarzania
DE60334632D1 (de) Mechanolumineszenzstoff und dessen herstellung
NO20044814L (no) Fremgangsmate for fremstilling av combretastaniner
DE60236994D1 (de) Halbleiterbauelement und dessen Herstellungsverfahren
DE60302916D1 (de) Halbleiterlaser und Herstellungsverfahren
DE602004006815D1 (de) Monolithischer Halbleiterlaser und dessen Herstellungsverfahren

Legal Events

Date Code Title Description
MK1K Patent expired