NO20031914L - Inhalable solution formulation containing a tiotropium salt - Google Patents

Inhalable solution formulation containing a tiotropium salt

Info

Publication number: NO20031914L
Authority: NO; Norway
Prior art keywords: formulation containing; solution formulation; tiotropium salt; inhalable solution; inhalable
Prior art date: 2000-10-31

Application number

NO20031914A

Other languages

Norwegian (no)

Other versions

NO20031914D0 (en

NO332524B1 (en

Inventor

Karin Drechsel

Barbara Niklaus-Humke

Christel Schmelzer

Original Assignee

Boehringer Ingelheim Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-31

Filing date

2003-04-29

Publication date

2003-06-23

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7661727&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20031914(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-04-29 Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma

2003-04-29 Publication of NO20031914D0 publication Critical patent/NO20031914D0/en

2003-06-23 Publication of NO20031914L publication Critical patent/NO20031914L/en

2012-10-08 Publication of NO332524B1 publication Critical patent/NO332524B1/en

Links

238000009472 formulation Methods 0.000 title 1
239000000203 mixture Substances 0.000 title 1
LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical class O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Pulmonology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Dispersion Chemistry (AREA)
Otolaryngology (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

NO20031914A 2000-10-31 2003-04-29 Inhalable solution formulation containing a tiotropium salt, such preparations for use as a medicament and the use thereof for the manufacture of medicaments for the treatment of disease NO332524B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10054042		2000-10-31
PCT/EP2001/012296 WO2002036591A2 (en)	2000-10-31	2001-10-24	Inhalative solution formulation containing a tiotropium salt

Publications (3)

Publication Number	Publication Date
NO20031914D0 NO20031914D0 (en)	2003-04-29
NO20031914L true NO20031914L (en)	2003-06-23
NO332524B1 NO332524B1 (en)	2012-10-08

Family

ID=7661727

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20031914A NO332524B1 (en)	2000-10-31	2003-04-29	Inhalable solution formulation containing a tiotropium salt, such preparations for use as a medicament and the use thereof for the manufacture of medicaments for the treatment of disease

Country Status (32)

Country	Link
EP (1)	EP1335729A2 (en)
JP (1)	JP4559703B2 (en)
KR (1)	KR100983208B1 (en)
CN (1)	CN1237970C (en)
AR (1)	AR038765A1 (en)
AU (2)	AU2002221741B2 (en)
BG (1)	BG66425B1 (en)
BR (1)	BR0115016A (en)
CA (1)	CA2427583C (en)
CZ (1)	CZ305033B6 (en)
DE (1)	DE10152369A1 (en)
EA (1)	EA009068B1 (en)
EC (1)	ECSP034570A (en)
EE (1)	EE05343B1 (en)
HR (1)	HRP20030337A2 (en)
HU (1)	HUP0301377A3 (en)
IL (2)	IL155676A0 (en)
ME (1)	ME00242B (en)
MX (1)	MXPA03003750A (en)
MY (1)	MY132777A (en)
NO (1)	NO332524B1 (en)
NZ (1)	NZ526024A (en)
PE (1)	PE20020518A1 (en)
PL (1)	PL361001A1 (en)
SA (1)	SA01220503B1 (en)
SK (1)	SK288031B6 (en)
TW (1)	TWI296934B (en)
UA (1)	UA76435C2 (en)
UY (1)	UY26991A1 (en)
WO (1)	WO2002036591A2 (en)
YU (1)	YU33103A (en)
ZA (1)	ZA200303045B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK1652926T3 (en)	2000-04-28	2010-02-15	Kosan Biosciences Inc	Crystalline epothilone D
US20030235538A1 (en)	2002-04-09	2003-12-25	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Method for the administration of an anticholinergic by inhalation
GB2389530B (en)	2002-06-14	2007-01-10	Cipla Ltd	Pharmaceutical compositions
EP1677778A2 (en) *	2003-10-09	2006-07-12	Inverseon, Inc.	Method of treating airway diseases with beta-adrenergic inverse agonists
SE0303269L (en) *	2003-12-03	2005-06-04	Microdrug Ag	Medical product
EP1863476B1 (en) *	2005-03-16	2016-02-03	MEDA Pharma GmbH & Co. KG	The combination of anticholinergics and leukotriene receptor antagonists for the treatment of respiratory diseases
JP2009538361A (en) *	2006-05-26	2009-11-05	デイ・リミテッド・パートナーシップ	Sprayable composition of quaternary ammonium muscarinic receptor antagonist
CN100446770C (en) *	2007-01-10	2008-12-31	上海现代药物制剂工程研究中心有限公司	Peclomethasone Propionate Water Spray
TR200907237A2 (en) *	2009-09-23	2011-04-21	B�Lg�� Mahmut	Tiotropium dry powder combination
CN116196298A (en) *	2018-07-26	2023-06-02	四川海思科制药有限公司	Aerosol pharmaceutical composition containing glycopyrronium salt and preparation method and application thereof
CN111936124A (en) *	2018-07-26	2020-11-13	四川海思科制药有限公司	Aerosol pharmaceutical composition containing glycopyrronium salt and indacaterol salt, and preparation method and application thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0504112A3 (en) *	1991-03-14	1993-04-21	Ciba-Geigy Ag	Pharmaceutical aerosol formulations
DE4203306A1 (en) *	1992-02-06	1993-08-12	Ig Spruehtechnik Gmbh	ASTHMA OR PULMONAL AEROSOL PREPARATIONS WITH LECITHIN
UA62917C2 (en) *	1995-06-27	2004-01-15	Berinher Inhelheim Kg	Medicinal composition for generating propellant-free aerosols
US5824669A (en) *	1996-03-22	1998-10-20	Nitromed, Inc.	Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
AU3153797A (en) *	1996-06-04	1998-01-05	Procter & Gamble Company, The	A nasal spray containing an intranasal steroid and an antihistamine
DE19653969A1 (en) *	1996-12-20	1998-06-25	Boehringer Ingelheim Kg	New aqueous pharmaceutical preparation for the production of propellant-free aerosols
JPH10298107A (en) *	1997-04-25	1998-11-10	Taisho Pharmaceut Co Ltd	Pharmaceutical composition
JP4672143B2 (en) *	1998-08-04	2011-04-20	ヤゴテックアーゲー	Pharmaceutical aerosol formulation
DE19847968A1 (en) *	1998-10-17	2000-04-20	Boehringer Ingelheim Pharma	Separate storage of an active material and a solvent comprises a closure cap and a container, with a chamber attached to the unit.

2001
- 2001-10-24 SK SK526-2003A patent/SK288031B6/en not_active IP Right Cessation
- 2001-10-24 YU YU33103A patent/YU33103A/en unknown
- 2001-10-24 JP JP2002539350A patent/JP4559703B2/en not_active Expired - Lifetime
- 2001-10-24 ME MEP-2008-407A patent/ME00242B/en unknown
- 2001-10-24 EE EEP200300202A patent/EE05343B1/en unknown
- 2001-10-24 NZ NZ526024A patent/NZ526024A/en not_active IP Right Cessation
- 2001-10-24 EA EA200300483A patent/EA009068B1/en not_active IP Right Cessation
- 2001-10-24 PL PL01361001A patent/PL361001A1/en not_active Application Discontinuation
- 2001-10-24 CN CNB018183271A patent/CN1237970C/en not_active Expired - Lifetime
- 2001-10-24 UA UA2003054960A patent/UA76435C2/en unknown
- 2001-10-24 CZ CZ2003-1487A patent/CZ305033B6/en not_active IP Right Cessation
- 2001-10-24 KR KR1020037006001A patent/KR100983208B1/en not_active Expired - Lifetime
- 2001-10-24 DE DE10152369A patent/DE10152369A1/en not_active Withdrawn
- 2001-10-24 HR HR20030337A patent/HRP20030337A2/en not_active Application Discontinuation
- 2001-10-24 CA CA002427583A patent/CA2427583C/en not_active Expired - Fee Related
- 2001-10-24 AU AU2002221741A patent/AU2002221741B2/en not_active Expired
- 2001-10-24 IL IL15567601A patent/IL155676A0/en unknown
- 2001-10-24 WO PCT/EP2001/012296 patent/WO2002036591A2/en not_active Ceased
- 2001-10-24 HU HU0301377A patent/HUP0301377A3/en unknown
- 2001-10-24 EP EP01992710A patent/EP1335729A2/en not_active Ceased
- 2001-10-24 AU AU2174102A patent/AU2174102A/en active Pending
- 2001-10-24 MX MXPA03003750A patent/MXPA03003750A/en active IP Right Grant
- 2001-10-24 BR BR0115016-2A patent/BR0115016A/en active Search and Examination
- 2001-10-29 MY MYPI20014987A patent/MY132777A/en unknown
- 2001-10-29 UY UY26991A patent/UY26991A1/en not_active Application Discontinuation
- 2001-10-29 TW TW090126752A patent/TWI296934B/en not_active IP Right Cessation
- 2001-10-29 PE PE2001001072A patent/PE20020518A1/en active IP Right Grant
- 2001-10-31 AR ARP010105088A patent/AR038765A1/en not_active Application Discontinuation
- 2001-11-03 SA SA01220503A patent/SA01220503B1/en unknown
2003
- 2003-04-16 BG BG107726A patent/BG66425B1/en unknown
- 2003-04-17 ZA ZA200303045A patent/ZA200303045B/en unknown
- 2003-04-28 EC EC2003004570A patent/ECSP034570A/en unknown
- 2003-04-29 NO NO20031914A patent/NO332524B1/en not_active IP Right Cessation
- 2003-04-30 IL IL155676A patent/IL155676A/en active IP Right Grant

Also Published As

Publication number	Publication date
EE200300202A (en)	2003-10-15
CZ305033B6 (en)	2015-04-08
NZ526024A (en)	2005-10-28
UA76435C2 (en)	2006-08-15
MXPA03003750A (en)	2004-10-15
HK1060569A1 (en)	2004-08-13
EE05343B1 (en)	2010-10-15
JP4559703B2 (en)	2010-10-13
ECSP034570A (en)	2003-06-25
ZA200303045B (en)	2004-04-22
JP2004523482A (en)	2004-08-05
AU2002221741B2 (en)	2007-04-05
MEP40708A (en)	2011-02-10
YU33103A (en)	2006-05-25
PE20020518A1 (en)	2002-07-12
EP1335729A2 (en)	2003-08-20
ME00242B (en)	2011-05-10
CN1237970C (en)	2006-01-25
HUP0301377A2 (en)	2003-10-28
IL155676A (en)	2012-05-31
SK288031B6 (en)	2012-12-03
KR20040010552A (en)	2004-01-31
NO20031914D0 (en)	2003-04-29
IL155676A0 (en)	2003-11-23
NO332524B1 (en)	2012-10-08
BG66425B1 (en)	2014-04-30
TWI296934B (en)	2008-05-21
CZ20031487A3 (en)	2003-09-17
PL361001A1 (en)	2004-09-20
MY132777A (en)	2007-10-31
WO2002036591A3 (en)	2002-07-25
SK5262003A3 (en)	2003-10-07
AR038765A1 (en)	2005-01-26
HUP0301377A3 (en)	2005-12-28
HRP20030337A2 (en)	2005-04-30
BG107726A (en)	2004-11-30
SA01220503B1 (en)	2007-03-10
EA200300483A1 (en)	2003-12-25
BR0115016A (en)	2005-05-03
EA009068B1 (en)	2007-10-26
CA2427583C (en)	2008-02-12
WO2002036591A2 (en)	2002-05-10
KR100983208B1 (en)	2010-09-20
DE10152369A1 (en)	2002-05-08
CN1473044A (en)	2004-02-04
UY26991A1 (en)	2002-06-20
CA2427583A1 (en)	2002-05-10
AU2174102A (en)	2002-05-15

Legal Events

Date	Code	Title	Description
2021-11-08	MK1K	Patent expired

Publication	Publication Date	Title
EE200200428A (en)	2003-02-17	Innovative inhalation powder containing tiotropium
EE200200656A (en)	2004-06-15	Tropane derivatives for therapeutic use
DE50014244D1 (en)	2007-05-24	PHARMACEUTICAL TRAMADOL SALTS
EE200200097A (en)	2003-04-15	A pharmaceutical preparation containing a benzamide derivative
CY2009009I1 (en)	2014-04-09	STABLE PHARMACEUTICAL PHARMACEUTICAL SOLUTION FORMS FOR PRESSURE METERED DOSE INHALATION DEVICES
ATE395053T1 (en)	2008-05-15	PHARMACEUTICAL SALTS OF 1-PHENYL-3-DIMETHYLAMINO-PROPANE COMPOUNDS
ATE307571T1 (en)	2005-11-15	PHARMACEUTICAL FORMULATION CONTAINING BICALUTAMID
NO20023367L (en)	2002-09-04	Glyburide preparation
ATE320244T1 (en)	2006-04-15	PHARMACEUTICAL COMPOSITIONS CONTAINING AMLODIPINMALEATE
DK1299095T3 (en)	2004-10-11	Clear aqueous anesthetic preparation
EE200200568A (en)	2004-06-15	Therapeutic diphenylether compounds
NO20031914L (en)	2003-06-23	Inhalable solution formulation containing a tiotropium salt
EE200200073A (en)	2003-04-15	A pharmaceutical preparation containing a benzamide derivative
NO20031911D0 (en)	2003-04-29	Inhalation solution formulation with a tiotropium salt
AU2002221741A1 (en)	2002-07-18	Inhalative solution formulation containing a tiotropium salt
AU2002221738A1 (en)	2002-07-18	Inhalative solution formulation containing a tiotropium salt
EE200300045A (en)	2004-12-15	Crystalline drug substance
DE60001768D1 (en)	2003-04-30	Aqueous pharmaceutical preparation containing tezosentan