NO20032482L - Compounds specific for adenosine A1, A2A and A <N> 3 receptor, and use thereof - Google Patents

Compounds specific for adenosine A1, A2A and A <N> 3 receptor, and use thereof

Info

Publication number: NO20032482L
Authority: NO; Norway
Prior art keywords: adenosine; receptor; compounds specific; compounds; specific
Prior art date: 2000-12-01

Application number

NO20032482A

Other languages

Norwegian (no)

Other versions

NO20032482D0 (en

NO327207B1 (en

Inventor

Arlindo Lucas Castelhano

Bryan Mckibben

David J Witter

Original Assignee

Osi Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-01

Filing date

2003-06-02

Publication date

2003-07-28

2000-12-01 Priority claimed from US09/728,316 external-priority patent/US6680322B2/en

2000-12-01 Priority claimed from US09/728,616 external-priority patent/US7160890B2/en

2000-12-01 Priority claimed from US09/728,607 external-priority patent/US6664252B2/en

2003-06-02 Application filed by Osi Pharm Inc filed Critical Osi Pharm Inc

2003-06-02 Publication of NO20032482D0 publication Critical patent/NO20032482D0/en

2003-07-28 Publication of NO20032482L publication Critical patent/NO20032482L/en

2009-05-11 Publication of NO327207B1 publication Critical patent/NO327207B1/en

Links

OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 title 2
239000002126 C01EB10 - Adenosine Substances 0.000 title 1
229960005305 adenosine Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Diabetes (AREA)
Hospice & Palliative Care (AREA)
Toxicology (AREA)
Psychology (AREA)
Rheumatology (AREA)
Immunology (AREA)
Hematology (AREA)
Biochemistry (AREA)
Endocrinology (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO20032482A 2000-12-01 2003-06-02 Compounds specific for adenosine A1, A2A and A3 receptor as well as their use in the preparation of drugs and methods for the preparation of the compounds NO327207B1 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US09/728,316 US6680322B2 (en)	1999-12-02	2000-12-01	Compounds specific to adenosine A1 receptors and uses thereof
US09/728,616 US7160890B2 (en)	1999-12-02	2000-12-01	Compounds specific to adenosine A3 receptor and uses thereof
US09/728,607 US6664252B2 (en)	1999-12-02	2000-12-01	4-aminopyrrolo[2,3-d]pyrimidine compounds specific to adenosine A2a receptor and uses thereof
PCT/US2001/045280 WO2002057267A1 (en)	2000-12-01	2001-11-30	Compounds specific to adenosine a1, a2a, and a3 receptor and uses thereof

Publications (3)

Publication Number	Publication Date
NO20032482D0 NO20032482D0 (en)	2003-06-02
NO20032482L true NO20032482L (en)	2003-07-28
NO327207B1 NO327207B1 (en)	2009-05-11

Family

ID=27419112

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20032482A NO327207B1 (en)	2000-12-01	2003-06-02	Compounds specific for adenosine A1, A2A and A3 receptor as well as their use in the preparation of drugs and methods for the preparation of the compounds

Country Status (20)

Country	Link
EP (1)	EP1347980A4 (en)
JP (1)	JP4579497B2 (en)
CN (1)	CN1263757C (en)
AP (1)	AP1893A (en)
AU (1)	AU2002248151B2 (en)
BR (1)	BR0115847A (en)
CA (1)	CA2430577A1 (en)
CZ (1)	CZ20031831A3 (en)
EA (1)	EA007254B1 (en)
HU (1)	HUP0400692A3 (en)
IL (1)	IL155962A0 (en)
ME (1)	MEP35308A (en)
MX (1)	MXPA03004717A (en)
NO (1)	NO327207B1 (en)
NZ (1)	NZ525885A (en)
OA (1)	OA13295A (en)
PL (1)	PL363245A1 (en)
WO (1)	WO2002057267A1 (en)
YU (1)	YU42703A (en)
ZA (1)	ZA200303729B (en)

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DE10148883A1 (en) *	2001-10-04	2003-04-10	Merck Patent Gmbh	New fused bi- or tricyclic pyrimidine derivatives, are phosphodiesterase V inhibitors useful e.g. for treating impotence, cardiovascular disorders, inflammation or tumors
DK1450811T3 (en)	2001-11-30	2010-02-15	Osi Pharm Inc	Compounds specific for adenosine A1 and A3 receptors and uses thereof
ATE466581T1 (en) *	2001-12-07	2010-05-15	Vertex Pharma	PYRIMIDINE-BASED COMPOUNDS AS GSK-3 INHIBITORS
US20030229067A1 (en)	2001-12-20	2003-12-11	Arlindo Castelhano	Pyrrolopyrimidine A2b selective antagonist compounds, their synthesis and use
CN1620294A (en)	2001-12-20	2005-05-25	Osi药物公司	Pyrimidine A2B selective antagonist compounds, their synthesis and application
WO2004041285A1 (en) *	2002-10-31	2004-05-21	Amgen Inc.	Antiinflammation agents
HUP0203976A3 (en) *	2002-11-15	2004-08-30	Sanofi Aventis	Adenozine a3 receptors, process for their preparation and pharmaceutical compositions containing them
MY179032A (en)	2004-10-25	2020-10-26	Cancer Research Tech Ltd	Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
UY29177A1 (en)	2004-10-25	2006-05-31	Astex Therapeutics Ltd	SUBSTITUTED DERIVATIVES OF PURINA, PURINONA AND DEAZAPURINA, COMPOSITIONS THAT CONTAIN METHODS FOR THEIR PREPARATION AND ITS USES
ES2344800T3 (en) *	2005-02-18	2010-09-07	Solvay Pharmaceuticals Gmbh	PHARMACEUTICAL COMPOSITIONS THAT INCLUDE NEP INHIBITORS, INHIBITORS OF THE ENDOGELINE AND DIURETIC ENDOTELINE PRODUCTION SYSTEM.
DK3421471T3 (en)	2006-04-25	2021-06-14	Astex Therapeutics Ltd	PURIN AND DEAZAPURIN DERIVATIVES AS PHARMACEUTICAL COMPOUNDS
US20070260203A1 (en) *	2006-05-04	2007-11-08	Allergan, Inc.	Vasoactive agent intraocular implant
TW200808819A (en) *	2006-06-19	2008-02-16	Solvay Pharm Gmbh	Use of adenosine A1 antagonists in radiocontrast media induced nephrophaty
PL2201012T3 (en)	2007-10-11	2014-11-28	Astrazeneca Ab	Pyrrolo[2,3-d]pyrimidin derivatives as protein kinase b inhibitors
EP2247596A2 (en)	2008-01-11	2010-11-10	Natco Pharma Limited	Novel pyrazolo [3, 4 -d] pyrimidine derivatives as anti -cancer agents
AR070127A1 (en)	2008-01-11	2010-03-17	Novartis Ag	PIRROLO - PIRIMIDINAS AND PIRROLO -PIRIDINAS
EA027506B1 (en)	2011-04-01	2017-08-31	Астразенека Аб	Method of treating breast cancer
HRP20191982T4 (en)	2011-11-30	2023-01-06	Astrazeneca Ab	Combination treatment of cancer
AU2013204533B2 (en)	2012-04-17	2017-02-02	Astrazeneca Ab	Crystalline forms
CN104350056A (en) *	2012-06-07	2015-02-11	霍夫曼-拉罗奇有限公司	Pyrrolopyrimidone and pyrrolopyridone inhibitors of tankyrase
SI3010503T1 (en)	2013-06-21	2020-07-31	Zenith Epigenetics Ltd.	Novel bicyclic bromodomain inhibitors
JP6461118B2 (en) *	2013-06-21	2019-01-30	ゼニス・エピジェネティクス・リミテッドＺｅｎｉｔｈＥｐｉｇｅｎｅｔｉｃｓＬｔｄ．	Novel substituted bicyclic compounds as bromodomain inhibitors
JP6542212B2 (en)	2013-07-31	2019-07-10	ゼニス・エピジェネティクス・リミテッドＺｅｎｉｔｈＥｐｉｇｅｎｅｔｉｃｓＬｔｄ．	Novel quinazolinones as bromodomain inhibitors
US10710992B2 (en)	2014-12-01	2020-07-14	Zenith Epigenetics Ltd.	Substituted pyridinones as bromodomain inhibitors
US10179125B2 (en)	2014-12-01	2019-01-15	Zenith Epigenetics Ltd.	Substituted pyridines as bromodomain inhibitors
WO2016092375A1 (en)	2014-12-11	2016-06-16	Zenith Epigenetics Corp.	Substituted heterocycles as bromodomain inhibitors
CA2966450A1 (en)	2014-12-17	2016-06-23	Olesya KHARENKO	Inhibitors of bromodomains
EA036122B1 (en) *	2015-01-20	2020-09-30	Уси Форчун Фармасьютикал Ко., Лтд	Jak inhibitor
AU2016254385B2 (en)	2015-04-29	2018-05-10	Wuxi Fortune Pharmaceutical Co., Ltd	JAK inhibitors
KR102081272B1 (en)	2015-05-29	2020-02-25	우시 포춘 파마슈티컬 컴퍼니 리미티드	Janus kinase inhibitor
CN105771672B (en) *	2016-04-18	2018-03-02	天津工业大学	A kind of antipollution antibiotic aromatic polyamide reverse osmosis composite film and preparation method
EP3594216B1 (en) *	2017-03-07	2022-04-06	Guangzhou Maxinovel Pharmaceuticals Co., Ltd.	Aminopyrimidine five-membered heterocyclic compound, and intermediate, preparation method, pharmaceutical composition and application thereof
CN108017584B (en) *	2017-06-20	2021-03-23	南开大学	A3Small molecule antagonists of adenosine receptors
CA3100923A1 (en) *	2018-06-04	2019-12-12	Exscientia Ltd	Pyrazolopyrimidine compounds as adenosine receptor antagonists
CN110128316B (en) *	2019-05-22	2021-08-31	北京大学深圳研究生院	The preparation method of 5-substituted β-proline and its derivatives
CN110272373B (en) *	2019-07-02	2022-07-29	天津国际生物医药联合研究院	Selective adenosine A 1 Receptor antagonists and uses thereof
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KR19990067704A (en) *	1992-12-17	1999-08-25	디. 제이. 우드, 스피겔 알렌 제이	Pharmaceutical composition containing pyrrolopyrimidine as an adrenal cortical stimulating hormone free factor antagonist
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JP4611524B2 (en) *	1998-06-02	2011-01-12	オーエスアイ・ファーマスーティカルズ・インコーポレーテッド	Pyrrolo [2,3d] pyrimidine compositions and uses thereof
HK1050319B (en) *	1999-12-02	2007-04-04	Osi Pharmaceuticals, Inc.	Compounds specific to adenosine a1, a2a, and a3 receptor and uses thereof
DK1450811T3 (en) *	2001-11-30	2010-02-15	Osi Pharm Inc	Compounds specific for adenosine A1 and A3 receptors and uses thereof

2001
- 2001-11-30 CA CA002430577A patent/CA2430577A1/en not_active Abandoned
- 2001-11-30 NZ NZ525885A patent/NZ525885A/en active IP Right Revival
- 2001-11-30 WO PCT/US2001/045280 patent/WO2002057267A1/en not_active Ceased
- 2001-11-30 EA EA200300628A patent/EA007254B1/en not_active IP Right Cessation
- 2001-11-30 CZ CZ20031831A patent/CZ20031831A3/en unknown
- 2001-11-30 IL IL15596201A patent/IL155962A0/en unknown
- 2001-11-30 PL PL01363245A patent/PL363245A1/en not_active Application Discontinuation
- 2001-11-30 YU YU42703A patent/YU42703A/en unknown
- 2001-11-30 AP APAP/P/2003/002807A patent/AP1893A/en active
- 2001-11-30 EP EP01997029A patent/EP1347980A4/en not_active Ceased
- 2001-11-30 OA OA1200300148A patent/OA13295A/en unknown
- 2001-11-30 AU AU2002248151A patent/AU2002248151B2/en not_active Ceased
- 2001-11-30 MX MXPA03004717A patent/MXPA03004717A/en active IP Right Grant
- 2001-11-30 HU HU0400692A patent/HUP0400692A3/en unknown
- 2001-11-30 JP JP2002557944A patent/JP4579497B2/en not_active Expired - Fee Related
- 2001-11-30 CN CNB018224601A patent/CN1263757C/en not_active Expired - Fee Related
- 2001-11-30 ME MEP-353/08A patent/MEP35308A/en unknown
- 2001-11-30 BR BR0115847-3A patent/BR0115847A/en not_active Application Discontinuation
2003
- 2003-05-14 ZA ZA200303729A patent/ZA200303729B/en unknown
- 2003-06-02 NO NO20032482A patent/NO327207B1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
MEP35308A (en)	2011-02-10
CN1263757C (en)	2006-07-12
OA13295A (en)	2007-04-13
EA200300628A1 (en)	2003-12-25
AP1893A (en)	2008-09-23
JP4579497B2 (en)	2010-11-10
WO2002057267A1 (en)	2002-07-25
EA007254B1 (en)	2006-08-25
MXPA03004717A (en)	2004-06-30
AP2003002807A0 (en)	2003-06-30
HUP0400692A3 (en)	2007-09-28
EP1347980A4 (en)	2005-02-09
EP1347980A1 (en)	2003-10-01
JP2004517896A (en)	2004-06-17
CA2430577A1 (en)	2002-07-25
AU2002248151B2 (en)	2008-02-21
PL363245A1 (en)	2004-11-15
CN1489590A (en)	2004-04-14
NO20032482D0 (en)	2003-06-02
ZA200303729B (en)	2004-05-14
NO327207B1 (en)	2009-05-11
CZ20031831A3 (en)	2004-05-12
BR0115847A (en)	2004-02-25
YU42703A (en)	2006-03-03
IL155962A0 (en)	2003-12-23
HUP0400692A2 (en)	2004-07-28
NZ525885A (en)	2005-01-28

Legal Events

Date	Code	Title	Description
2011-06-27	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO20032482L (en)	2003-07-28	Compounds specific for adenosine A1, A2A and A <N> 3 receptor, and use thereof
PT1056759E (en)	2003-01-31	2- (PURIN-9-YL) -TETRAHYDROFURANE-3,4-DIOLE DERIVATIVES
ATE256141T1 (en)	2003-12-15	N-PYRAZOLE A2A RECEPTOR AGONISTS
ATE240341T1 (en)	2003-05-15	C-PYRAZOLE A2A RECEPTOR AGONISTS
MA26878A1 (en)	2004-12-20	ADENOSINE RECEPTOR REGULATORS
NO20032735L (en)	2003-08-06	Diphenyllazetidinone derivatives, process for their preparation, drugs containing these compounds and their use
DK1283839T3 (en)	2005-07-25	Adenosine A2a receptor antagonists
NO20022573D0 (en)	2002-05-30	N6 heterocyclic, 8-modified adenosine derivatives
MXPA03002269A (en)	2003-06-06	Purine derivatives.
DE60209251D1 (en)	2006-04-20	ADENOSINE A2A RECEPTOR ANTAGONISTS
PT1192170E (en)	2003-09-30	PROPARGILFENILETER A2A RECEPTOR AGONISTS
DE69934814D1 (en)	2007-02-22	NON-CIRCULAR MICRO-DRILLING
NO20032483L (en)	2003-07-30	Condensed purine derivatives as A <N> 1 <N /> - adenosine receptor antagonists
DE69821009D1 (en)	2004-02-12	6,9-BRIDGED ERYTHROMYCIN DERIVATIVES
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