NO20033672D0 - Anvendelse av fusjonsproteiner der den N-terminale delen er et hirudinderivat for fremstilling av rekombinante proteiner via sekresjon fragj¶r - Google Patents

Anvendelse av fusjonsproteiner der den N-terminale delen er et hirudinderivat for fremstilling av rekombinante proteiner via sekresjon fragj¶r

Info

Publication number
NO20033672D0
NO20033672D0 NO20033672A NO20033672A NO20033672D0 NO 20033672 D0 NO20033672 D0 NO 20033672D0 NO 20033672 A NO20033672 A NO 20033672A NO 20033672 A NO20033672 A NO 20033672A NO 20033672 D0 NO20033672 D0 NO 20033672D0
Authority
NO
Norway
Prior art keywords
nucleic acid
acid sequence
hirudin
production
protein
Prior art date
Application number
NO20033672A
Other languages
English (en)
Other versions
NO20033672L (no
NO331376B1 (no
Inventor
Paul Habermann
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of NO20033672D0 publication Critical patent/NO20033672D0/no
Publication of NO20033672L publication Critical patent/NO20033672L/no
Publication of NO331376B1 publication Critical patent/NO331376B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO20033672A 2001-02-20 2003-08-19 DNA-molekyl kodende for fusjonsproteiner der den N-terminale delen er et hirudinderivat for fremstilling av rekombinante proteiner via sekresjon fra gjaer, samt multikopivektor, plasmid, vertscelle og fremgangsmater for fermentering og fremstilling NO331376B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10108211A DE10108211A1 (de) 2001-02-20 2001-02-20 Verwendung von Fusionsproteinen, deren N-terminaler Anteil aus einem Hirudinderivat besteht, zur Herstellung rekombinanter Proteine über Sekretion durch Hefen
PCT/EP2002/001308 WO2002070722A1 (en) 2001-02-20 2002-02-08 Use of fusion proteins whose n-terminal part is a hirudin derivative for the production of recombinant proteins via secretion by yeasts

Publications (3)

Publication Number Publication Date
NO20033672D0 true NO20033672D0 (no) 2003-08-19
NO20033672L NO20033672L (no) 2003-10-17
NO331376B1 NO331376B1 (no) 2011-12-12

Family

ID=7674912

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20033672A NO331376B1 (no) 2001-02-20 2003-08-19 DNA-molekyl kodende for fusjonsproteiner der den N-terminale delen er et hirudinderivat for fremstilling av rekombinante proteiner via sekresjon fra gjaer, samt multikopivektor, plasmid, vertscelle og fremgangsmater for fermentering og fremstilling

Country Status (21)

Country Link
US (1) US20030176673A1 (no)
EP (1) EP1364032B1 (no)
JP (1) JP4199543B2 (no)
KR (1) KR100858833B1 (no)
CN (1) CN1279171C (no)
AT (1) ATE342367T1 (no)
AU (1) AU2002250903B2 (no)
BR (1) BR0207379A (no)
CA (1) CA2439042C (no)
CY (1) CY1106274T1 (no)
DE (2) DE10108211A1 (no)
DK (1) DK1364032T3 (no)
ES (1) ES2272696T3 (no)
IL (2) IL157416A0 (no)
MX (1) MXPA03007116A (no)
NO (1) NO331376B1 (no)
NZ (1) NZ527642A (no)
PE (1) PE20020857A1 (no)
PT (1) PT1364032E (no)
WO (1) WO2002070722A1 (no)
ZA (1) ZA200305868B (no)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7638618B2 (en) * 2001-02-20 2009-12-29 Sanofi-Aventis Deutschland Gmbh Nucleic acids encoding a hirudin and pro-insulin as superscretable peptides and for parallel improvement of the exported forms of one or more polypeptides of interest
DE102006031962A1 (de) 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Amidiertes Insulin Glargin
DE102006031955A1 (de) 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende
DE102008003566A1 (de) 2008-01-09 2009-07-16 Sanofi-Aventis Deutschland Gmbh Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
CN102007143B (zh) 2008-01-09 2015-08-26 塞诺菲-安万特德国有限公司 具有超延迟时效特征的新型胰岛素衍生物
DE102008025007A1 (de) 2008-05-24 2009-11-26 Sanofi-Aventis Deutschland Gmbh Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
EP2229406B1 (de) 2008-01-09 2015-04-22 Sanofi-Aventis Deutschland GmbH Neue insulinderivate mit extrem verzögertem zeit- / wirkungsprofil
CN102256618A (zh) 2008-10-17 2011-11-23 赛诺菲-安万特德国有限公司 胰岛素和glp-1激动剂的组合
PL2451437T3 (pl) 2009-07-06 2017-05-31 Sanofi-Aventis Deutschland Gmbh Wodne preparaty insuliny zawierające metioninę
TR201809460T4 (tr) 2009-11-13 2018-07-23 Sanofi Aventis Deutschland Bir GLP- 1-agonisti, bir insülin ve metiyonin içeren farmasötik bileşim.
NZ599847A (en) 2009-11-13 2013-09-27 Sanofi Aventis Deutschland Pharmaceutical composition comprising a glp-1 agonist and methionine
WO2012028172A1 (en) 2010-08-30 2012-03-08 Sanofi-Aventis Deutschland Gmbh Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
AR087693A1 (es) 2011-08-29 2014-04-09 Sanofi Aventis Deutschland Combinacion farmaceutica para uso en el control glucemico en pacientes con diabetes de tipo 2
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
PE20171622A1 (es) 2014-12-12 2017-11-02 Sanofi Aventis Deutschland Formulacion de relacion fija de insulina glargina/lixisenatida
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985004418A1 (fr) * 1984-03-27 1985-10-10 Transgene S.A. Vecteurs d'expression de l'hirudine, cellules transformees et procede de preparation de l'hirudine
US5705355A (en) * 1984-03-27 1998-01-06 Transgene, S.A. Hirudin, pharmaceutical compositions comprising it and their use
DE3738541A1 (de) * 1987-11-13 1989-05-24 Hoechst Ag Verfahren zur isolierung und reinigung von hirudin
US6875589B1 (en) * 1988-06-23 2005-04-05 Hoechst Aktiengesellschaft Mini-proinsulin, its preparation and use
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids
DE4009268A1 (de) * 1990-03-22 1991-09-26 Consortium Elektrochem Ind Sekretion von hirudinderivaten
DK0687731T3 (da) * 1990-11-08 1999-09-20 Japan Energy Corp Sekretionsvektor, transformerede mikroorganismer indeholdende vektoren og fremstilling af produkter fra denne mikroorganism
FI92601C (fi) * 1992-03-11 1994-12-12 Marja Makarow Menetelmä hyötyproteiinien erittämiseksi hiivoista
DE19543737A1 (de) * 1995-11-24 1997-05-28 Hoechst Ag Verfahren zur Ultrafiltration von Peptide oder Proteine enthaltender biologischer Matrices
DE19544233A1 (de) * 1995-11-28 1997-06-05 Hoechst Ag Verfahren zur Nutzung des Hefe-ADH II-Promotorsystems zur biotechnologischen Produktion heterologer Proteine in hohen Ausbeuten
US6150133A (en) * 1996-03-13 2000-11-21 Delta Biotechnology Limited Fermentation control
DE10033195A1 (de) * 2000-07-07 2002-03-21 Aventis Pharma Gmbh Bifunktionale Fusionsproteine aus Hirudin und TAP
US7202059B2 (en) * 2001-02-20 2007-04-10 Sanofi-Aventis Deutschland Gmbh Fusion proteins capable of being secreted into a fermentation medium

Also Published As

Publication number Publication date
CN1526021A (zh) 2004-09-01
ES2272696T3 (es) 2007-05-01
DE10108211A1 (de) 2002-08-22
DE60215315T2 (de) 2007-05-24
WO2002070722A1 (en) 2002-09-12
KR100858833B1 (ko) 2008-09-17
IL157416A0 (en) 2004-03-28
AU2002250903B2 (en) 2006-12-07
ATE342367T1 (de) 2006-11-15
DE60215315D1 (de) 2006-11-23
NZ527642A (en) 2005-03-24
JP2004518446A (ja) 2004-06-24
IL157416A (en) 2009-08-03
NO20033672L (no) 2003-10-17
KR20030074841A (ko) 2003-09-19
ZA200305868B (en) 2005-02-23
CA2439042A1 (en) 2002-09-12
PE20020857A1 (es) 2002-11-04
NO331376B1 (no) 2011-12-12
JP4199543B2 (ja) 2008-12-17
DK1364032T3 (da) 2007-02-19
CY1106274T1 (el) 2011-10-12
BR0207379A (pt) 2004-06-15
CA2439042C (en) 2013-06-18
CN1279171C (zh) 2006-10-11
EP1364032A1 (en) 2003-11-26
HK1065068A1 (en) 2005-02-08
PT1364032E (pt) 2007-01-31
MXPA03007116A (es) 2003-11-18
US20030176673A1 (en) 2003-09-18
EP1364032B1 (en) 2006-10-11

Similar Documents

Publication Publication Date Title
NO20033672L (no) Anvendelse av fusjonsproteiner der den N-terminale delen er et hirudinderivat for fremstilling av rekombinante proteiner via sekresjon fragj¶r
Vedvick et al. High-level secretion of biologically active aprotinin from the yeast Pichia pastoris
KR950000300B1 (ko) 융합 단백질의 제조방법
AU2002231784B2 (en) Fusion protein for the secretion of a protein of interest into the supernatant of the bacterial culture
JP2024081707A (ja) 延長組換えポリペプチドおよび延長組換えポリペプチドを含む組成物
JP5697831B2 (ja) 単鎖インシュリン
Hebert et al. Endothelial and leukocyte forms of IL-8. Conversion by thrombin and interactions with neutrophils.
EP0399666A1 (en) Fusion proteins containing N-terminal fragments of human serum albumin
DK168823B1 (da) Fusionsproteiner, hvor ballastandelen består af peptider af interleukin 2, fremgangsmåde til deres fremstilling, deres anvendelse, genstruktur, der koder for et sådant fusionsprotein, vektor indeholdende en sådan genstruktur, og E. coli-celle indeholdende en sådan vektor.
CN103328649A (zh) 用于改善重组酶及其它蛋白的蛋白表达和分泌的新的信号序列
Arlaud et al. Complete amino acid sequence of the catalytic chain of human complement subcomponent C. hivin. 1r
DK1364030T3 (da) Supersecernerbare peptider, processer til frembringelse herf og parallel forbedring af den secernerede form at et eller flere andre polypeptider
Pohlig et al. Purification, Characterization and Biological Evaluation of Recombinant Leech‐Derived Tryptase Inhibitor (rLDTI) Expressed at High Level in the Yeast Saccharomyces Cerevisiae
IE911578A1 (en) Method for the recombinant production of hirudins and novel¹hirudins
US7344856B1 (en) Method of controlling cleavage by OmpT protease
Olins et al. Phosphorylation of high‐and low‐molecular‐mass atrial natriuretic peptide analogs by cyclic AMP‐dependent protein kinase
Przysiecki et al. Characterization of recombinant antistasin secreted by Saccharomyces cerevisiae
Chaudhuri et al. A mutant Kex2 enzyme with a C‐terminal HDEL sequence releases correctly folded human insulin‐like growth factor‐1 from a precursor accumulated in the yeast endoplasmic reticulum
WO1995035376A2 (en) Polypeptides with interleukin 8 receptor 1 (il8r1) binding domains
Yang et al. Expression and localization of recombinant human EDG-1 receptors in Pichia pastoris

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees