NO20040421L - Doseringsformer og preparater for osmotisk avlevering av variable doser av oxycodon. - Google Patents
Doseringsformer og preparater for osmotisk avlevering av variable doser av oxycodon.Info
- Publication number
- NO20040421L NO20040421L NO20040421A NO20040421A NO20040421L NO 20040421 L NO20040421 L NO 20040421L NO 20040421 A NO20040421 A NO 20040421A NO 20040421 A NO20040421 A NO 20040421A NO 20040421 L NO20040421 L NO 20040421L
- Authority
- NO
- Norway
- Prior art keywords
- oxycodone
- preparations
- dosage forms
- osmotic delivery
- variable doses
- Prior art date
Links
- BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 title abstract 5
- 229960002085 oxycodone Drugs 0.000 title abstract 5
- 239000002552 dosage form Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 230000003204 osmotic effect Effects 0.000 title 1
- 229940079593 drug Drugs 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 238000013270 controlled release Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000003002 pH adjusting agent Substances 0.000 abstract 1
- 239000008137 solubility enhancer Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Doseringsformer, preparater og metoder for kontrollert frigivning av oksycodon over lengre tidsrom oppnås ved hjelp av nye midler for avlevering av forskjellige doser oksycodon ved bruk av en medikamentblanding med kun oksycodon, en polymer bærer og forskjellige mengder av salt for å gi en spesiell viskositet i den hydratiserte medikamentkjerne for avlevering av medikamentet med ønsket frigivningshastighet.Oppfinnelsens gjenstand er basert på modulering av viskositeten av det hydratiserte medikamentsjikt ved tilsetning eller reduksjon av salter i medikamentblandingen.Systemet er uavhengig av oppløselighetsforbedrere eller ph-modifiserere.Doseringsformene med opprettholdt frigivning gir terapeutisk effektiv, midlere gjennomsnittlig stabiltilstandsplasmaoksycodonkonsentrasjoner ved administrering en gang daglig.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38444202P | 2002-05-31 | 2002-05-31 | |
| PCT/US2003/016747 WO2003101384A2 (en) | 2002-05-31 | 2003-05-28 | Dosage forms and compositions for osmotic delivery of variable dosages of oxycodone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20040421L true NO20040421L (no) | 2004-03-26 |
Family
ID=29712032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20040421A NO20040421L (no) | 2002-05-31 | 2004-01-30 | Doseringsformer og preparater for osmotisk avlevering av variable doser av oxycodon. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20030224051A1 (no) |
| EP (1) | EP1513497A2 (no) |
| JP (1) | JP2005528423A (no) |
| KR (1) | KR20050034645A (no) |
| CN (1) | CN1671358A (no) |
| AR (1) | AR040245A1 (no) |
| AU (1) | AU2003245345A1 (no) |
| BR (1) | BR0304960A (no) |
| CA (1) | CA2487786A1 (no) |
| EC (1) | ECSP045465A (no) |
| IL (1) | IL165361A0 (no) |
| MX (1) | MXPA04012021A (no) |
| MY (1) | MY151013A (no) |
| NO (1) | NO20040421L (no) |
| NZ (1) | NZ536693A (no) |
| PL (1) | PL372797A1 (no) |
| RU (1) | RU2004134728A (no) |
| TW (1) | TW200406206A (no) |
| UY (1) | UY27832A1 (no) |
| WO (1) | WO2003101384A2 (no) |
| ZA (1) | ZA200410398B (no) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110104214A1 (en) | 2004-04-15 | 2011-05-05 | Purdue Pharma L.P. | Once-a-day oxycodone formulations |
| UA81224C2 (uk) | 2001-05-02 | 2007-12-25 | Euro Celtic S A | Дозована форма оксикодону та її застосування |
| WO2003024430A1 (en) | 2001-09-21 | 2003-03-27 | Egalet A/S | Morphine polymer release system |
| EP1429739A1 (en) | 2001-09-21 | 2004-06-23 | Egalet A/S | Polymer release system |
| US8101209B2 (en) | 2001-10-09 | 2012-01-24 | Flamel Technologies | Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles |
| GB0203296D0 (en) | 2002-02-12 | 2002-03-27 | Glaxo Group Ltd | Novel composition |
| MXPA04009968A (es) | 2002-04-09 | 2004-12-13 | Flamel Tech Sa | Formulacion farmaceutica oral bajo forma de suspension acuosa de microcapsulas que permiten la liberacion modificada de principio (s) activo (s). |
| DE60323474D1 (de) | 2002-04-09 | 2008-10-23 | Flamel Tech Sa | Orale pharmazeutische formulierung in form einer wässrigen suspension von mikrokapseln zur modifizierten freisetzung von amoxicillin |
| US20050106249A1 (en) * | 2002-04-29 | 2005-05-19 | Stephen Hwang | Once-a-day, oral, controlled-release, oxycodone dosage forms |
| US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
| US8637512B2 (en) | 2002-07-29 | 2014-01-28 | Glaxo Group Limited | Formulations and method of treatment |
| EP1610767B1 (en) | 2003-03-26 | 2011-01-19 | Egalet A/S | Morphine controlled release system |
| DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
| DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| CA2540056C (en) * | 2003-09-26 | 2015-03-24 | Alza Corporation | Controlled release formulations of opioid and nonopioid analgesics |
| US8246986B2 (en) | 2003-09-26 | 2012-08-21 | Alza Corporation | Drug coating providing high drug loading |
| AU2004285547A1 (en) * | 2003-10-29 | 2005-05-12 | Alza Corporation | Once-a-day, oral, controlled-release, oxycodone dosage forms |
| TWI483944B (zh) | 2004-03-30 | 2015-05-11 | Euro Celtique Sa | 含有小於25ppm14-羥可待因酮之羥可酮鹽酸鹽組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝 |
| DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
| US8541026B2 (en) * | 2004-09-24 | 2013-09-24 | Abbvie Inc. | Sustained release formulations of opioid and nonopioid analgesics |
| ATE413864T1 (de) * | 2005-01-27 | 2008-11-15 | Alza Corp | Orale osmotische darreichungsform mit membran mit hoher flussdichte |
| DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| WO2006103551A1 (en) * | 2005-03-31 | 2006-10-05 | Ranbaxy Laboratories Limited | Controlled release formulations of oxycodone |
| WO2006133733A1 (en) * | 2005-06-13 | 2006-12-21 | Flamel Technologies | Oral dosage form comprising an antimisuse system |
| US8652529B2 (en) | 2005-11-10 | 2014-02-18 | Flamel Technologies | Anti-misuse microparticulate oral pharmaceutical form |
| PT2046300E (pt) * | 2006-08-04 | 2010-07-01 | Ethypharm Sa | Comprimido multicamadas de desintegraão oral |
| SA07280459B1 (ar) | 2006-08-25 | 2011-07-20 | بيورديو فارما إل. بي. | أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني |
| AU2008258596B2 (en) | 2007-06-04 | 2013-02-14 | Egalet Ltd | Controlled release pharmaceutical compositions for prolonged effect |
| JP2011511782A (ja) | 2008-02-12 | 2011-04-14 | アボット・ラボラトリーズ | 長期放出性ヒドロコドンアセトアミノフェンならびにその関連方法および用途 |
| KR101094231B1 (ko) | 2008-02-18 | 2011-12-14 | 하나제약 주식회사 | 서방성 고형 제제 및 그의 제조방법 |
| NZ594207A (en) | 2009-02-06 | 2013-03-28 | Egalet Ltd | Immediate release composition resistant to abuse by intake of alcohol |
| WO2010149169A2 (en) | 2009-06-24 | 2010-12-29 | Egalet A/S | Controlled release formulations |
| RU2015138422A (ru) | 2009-07-22 | 2018-12-25 | Грюненталь Гмбх | Стабильная при окислении, прочная на излом лекарственная форма |
| NZ607392A (en) | 2010-09-02 | 2015-03-27 | Gruenenthal Chemie | Tamper resistant dosage form comprising inorganic salt |
| ES2616115T3 (es) * | 2011-06-30 | 2017-06-09 | Develco Pharma Schweiz Ag | Forma farmacéutica oral de liberación controlada que comprende oxicodona |
| PE20141638A1 (es) | 2011-07-29 | 2014-11-22 | Gruenenthal Chemie | Tableta a prueba de manipulacion que proporciona liberacion de farmaco inmediato |
| RS56527B1 (sr) | 2011-07-29 | 2018-02-28 | Gruenenthal Gmbh | Tableta za trenutno oslobađanje leka rezistentna na zloupotrebu |
| US9549899B2 (en) | 2012-07-06 | 2017-01-24 | Egalet Ltd. | Abuse deterrent pharmaceutical compositions for controlled release |
| CN102871982B (zh) * | 2012-10-16 | 2014-09-10 | 中国科学院上海药物研究所 | 一种药物渗透泵制剂 |
| US10624862B2 (en) | 2013-07-12 | 2020-04-21 | Grünenthal GmbH | Tamper-resistant dosage form containing ethylene-vinyl acetate polymer |
| AU2014306759B2 (en) | 2013-08-12 | 2018-04-26 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
| AU2014356581C1 (en) | 2013-11-26 | 2020-05-28 | Grunenthal Gmbh | Preparation of a powdery pharmaceutical composition by means of cryo-milling |
| US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| US10172797B2 (en) | 2013-12-17 | 2019-01-08 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| EP3169315B1 (en) | 2014-07-17 | 2020-06-24 | Pharmaceutical Manufacturing Research Services, Inc. | Immediate release abuse deterrent liquid fill dosage form |
| US20160106737A1 (en) | 2014-10-20 | 2016-04-21 | Pharmaceutical Manufacturing Research Services, Inc. | Extended Release Abuse Deterrent Liquid Fill Dosage Form |
| AU2016319203A1 (en) | 2015-09-10 | 2018-02-22 | Grünenthal GmbH | Protecting oral overdose with abuse deterrent immediate release formulations |
| KR102285510B1 (ko) * | 2019-10-29 | 2021-08-04 | 강동국 | 양액 농도조절용 캡슐 및 그 용도 |
| EP4245300B1 (en) * | 2022-01-31 | 2026-02-25 | Sumitomo Seika Chemicals Co., Ltd. | Controlled drug release preparation composition and controlled drug release preparation |
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-
2003
- 2003-05-28 RU RU2004134728/15A patent/RU2004134728A/ru not_active Application Discontinuation
- 2003-05-28 AU AU2003245345A patent/AU2003245345A1/en not_active Abandoned
- 2003-05-28 NZ NZ536693A patent/NZ536693A/en unknown
- 2003-05-28 IL IL16536103A patent/IL165361A0/xx unknown
- 2003-05-28 CA CA002487786A patent/CA2487786A1/en not_active Abandoned
- 2003-05-28 WO PCT/US2003/016747 patent/WO2003101384A2/en not_active Ceased
- 2003-05-28 PL PL03372797A patent/PL372797A1/xx not_active Application Discontinuation
- 2003-05-28 CN CNA038177668A patent/CN1671358A/zh active Pending
- 2003-05-28 JP JP2004508742A patent/JP2005528423A/ja not_active Withdrawn
- 2003-05-28 US US10/447,910 patent/US20030224051A1/en not_active Abandoned
- 2003-05-28 BR BR0304960-4A patent/BR0304960A/pt not_active IP Right Cessation
- 2003-05-28 EP EP03738984A patent/EP1513497A2/en not_active Ceased
- 2003-05-28 MX MXPA04012021A patent/MXPA04012021A/es not_active Application Discontinuation
- 2003-05-28 KR KR1020047019390A patent/KR20050034645A/ko not_active Withdrawn
- 2003-05-30 MY MYPI20032004 patent/MY151013A/en unknown
- 2003-05-30 TW TW092114712A patent/TW200406206A/zh unknown
- 2003-06-02 AR ARP030101964A patent/AR040245A1/es not_active Application Discontinuation
- 2003-06-02 UY UY27832A patent/UY27832A1/es not_active Application Discontinuation
-
2004
- 2004-01-30 NO NO20040421A patent/NO20040421L/no not_active Application Discontinuation
- 2004-11-30 EC EC2004005465A patent/ECSP045465A/es unknown
- 2004-12-23 ZA ZA200410398A patent/ZA200410398B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003101384A2 (en) | 2003-12-11 |
| ZA200410398B (en) | 2006-02-22 |
| WO2003101384A3 (en) | 2004-04-08 |
| JP2005528423A (ja) | 2005-09-22 |
| MY151013A (en) | 2014-03-31 |
| KR20050034645A (ko) | 2005-04-14 |
| CN1671358A (zh) | 2005-09-21 |
| TW200406206A (en) | 2004-05-01 |
| MXPA04012021A (es) | 2005-08-16 |
| AR040245A1 (es) | 2005-03-23 |
| AU2003245345A1 (en) | 2003-12-19 |
| NZ536693A (en) | 2007-01-26 |
| RU2004134728A (ru) | 2005-06-10 |
| PL372797A1 (en) | 2005-08-08 |
| CA2487786A1 (en) | 2003-12-11 |
| IL165361A0 (en) | 2006-01-15 |
| UY27832A1 (es) | 2003-09-30 |
| EP1513497A2 (en) | 2005-03-16 |
| US20030224051A1 (en) | 2003-12-04 |
| BR0304960A (pt) | 2005-01-04 |
| ECSP045465A (es) | 2005-01-28 |
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