NO20042406L - Heterosykliske derivater av glysinamid og deres medisinske anvendelse - Google Patents
Heterosykliske derivater av glysinamid og deres medisinske anvendelseInfo
- Publication number
- NO20042406L NO20042406L NO20042406A NO20042406A NO20042406L NO 20042406 L NO20042406 L NO 20042406L NO 20042406 A NO20042406 A NO 20042406A NO 20042406 A NO20042406 A NO 20042406A NO 20042406 L NO20042406 L NO 20042406L
- Authority
- NO
- Norway
- Prior art keywords
- medical use
- heterocyclic derivatives
- glycine amide
- glycine
- amide
- Prior art date
Links
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 title 1
- 239000004471 Glycine Substances 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Quinoline Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0127141.0A GB0127141D0 (en) | 2001-11-10 | 2001-11-10 | Novel compounds |
| PCT/EP2002/012505 WO2003042179A1 (en) | 2001-11-10 | 2002-11-08 | Heterocyclic derivatives of glycinamide and their medical use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20042406L true NO20042406L (no) | 2004-06-09 |
Family
ID=9925627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20042406A NO20042406L (no) | 2001-11-10 | 2004-06-09 | Heterosykliske derivater av glysinamid og deres medisinske anvendelse |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20050043335A1 (no) |
| EP (1) | EP1442020A1 (no) |
| JP (1) | JP2005511622A (no) |
| KR (1) | KR20050044366A (no) |
| CN (1) | CN1289483C (no) |
| AU (1) | AU2002351921B2 (no) |
| BR (1) | BR0213994A (no) |
| CA (1) | CA2468497A1 (no) |
| CO (1) | CO5580825A2 (no) |
| GB (1) | GB0127141D0 (no) |
| HU (1) | HUP0402244A2 (no) |
| IL (1) | IL161854A0 (no) |
| MX (1) | MXPA04004372A (no) |
| NO (1) | NO20042406L (no) |
| NZ (1) | NZ532520A (no) |
| PL (1) | PL369521A1 (no) |
| RU (1) | RU2004117603A (no) |
| WO (1) | WO2003042179A1 (no) |
| ZA (1) | ZA200403186B (no) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1887000A4 (en) * | 2005-05-27 | 2011-09-07 | Shionogi & Co | ARYLACETATE DERIVATIVES WITH ISOXAZO EASY |
| US7705005B2 (en) | 2006-10-13 | 2010-04-27 | Glaxo Group Limited | Bicyclic heteroaromatic compounds |
| US9029383B2 (en) | 2007-05-11 | 2015-05-12 | The Trustees Of The University Of Pennsylvania | Methods of treatment of skin ulcers |
| US8962633B2 (en) | 2007-05-11 | 2015-02-24 | Thomas Jefferson University | Methods of treatment and prevention of metabolic bone diseases and disorders |
| BRPI0721697A2 (pt) | 2007-05-11 | 2014-08-05 | Univ Jefferson | " métodos para tratar e/ou prevenir uma doença ou distúrbio neurodegenerativo em um indivíduo, para tratar e/ou prevenir um indivíduo com ou em risco de demência vascular, para tratar e/ou prevenir uma doença ou distúrbio associado com uma barreira hematoencefálica anormal em um indivíduo, para diminuir o acúmulo beta amilóide no cérebro de um indivíduo, para tratar e/ou prevenir mal de alzheimer em um indivíduo e para prevenir ou reduzir o risco de desenvolver mal de alzhheimer, e, uso de um agente que inibe a expressão e/ou atividade da proteína lp-pla2." |
| US8637536B2 (en) | 2010-12-06 | 2014-01-28 | Glaxo Group Limited | Pyrimidinone compounds for use in the treatment of diseases or conditions mediated by Lp-PLA2 |
| EP2651403B1 (en) | 2010-12-17 | 2020-12-02 | Glaxo Group Limited | Use of lp-pla2 inhibitors in the treatment and prevention of eye diseases |
| US20140171431A1 (en) | 2011-06-27 | 2014-06-19 | Jianhua Shen | Azole heterocyclic compound, preparation method, pharmaceutical composition and use |
| US9273054B2 (en) | 2011-07-27 | 2016-03-01 | Glaxo Group Limited | Substituted pyrimido[1,6-a]pyrimidines as Lp-PLA2 inhibitors |
| EP2739627A4 (en) | 2011-07-27 | 2015-01-21 | Glaxo Group Ltd | 2,3-DIHYDROIMIDAZO- [1,2-C-] PYRIMIDIN-5 (1H) -ONE COMPOUNDS AS LP-PLA² INHIBITORS |
| US8946430B2 (en) | 2011-09-30 | 2015-02-03 | Bristol-Myers Squibb Company | Quinolinone carboxamide inhibitors of endothelial lipase |
| JP2016505053A (ja) | 2013-01-25 | 2016-02-18 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | Ｌｐ‐ＰＬＡ２の阻害剤としての二環式ピリミドン化合物 |
| CA2899124A1 (en) | 2013-01-25 | 2014-07-31 | Glaxosmithkline Intellectual Property Development Limited | Compounds |
| WO2014114694A1 (en) | 2013-01-25 | 2014-07-31 | Glaxosmithkline Intellectual Property Development Limited | 2,3-dihydroimidazol[1,2-c]pyrimidin-5(1h)-one based lipoprotein-associated phospholipase a2 (lp-pla2) inhibitors |
| WO2016012917A1 (en) | 2014-07-22 | 2016-01-28 | Glaxosmithkline Intellectual Property Development Limited | 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2 |
| WO2016012916A1 (en) | 2014-07-22 | 2016-01-28 | Glaxosmithkline Intellectual Property Development Limited | 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2 |
| CN114805389B (zh) | 2019-11-09 | 2023-08-29 | 上海赛默罗生物科技有限公司 | 三环二氢咪唑并嘧啶酮衍生物、其制备方法、药物组合物和用途 |
| CN115304620A (zh) | 2021-05-07 | 2022-11-08 | 上海赛默罗生物科技有限公司 | 嘧啶酮衍生物、其制备方法、药物组合物和用途 |
| JP2026516205A (ja) | 2023-04-18 | 2026-05-20 | サイニューロ セラピューティクス インコーポレイテッド | Ｌｐ－ｐｌａ２阻害剤と第２の薬剤の併用治療 |
| CN118221687B (zh) | 2023-07-17 | 2024-12-31 | 上海枢境生物科技有限公司 | 双环[5,6]咪唑嘧啶酮类衍生物、其制备方法和应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60139429D1 (de) * | 2000-02-16 | 2009-09-10 | Smithkline Beecham Plc | Pyrimidin-5-Onderivate als LDL-PLA2 Inhibitoren |
-
2001
- 2001-11-10 GB GBGB0127141.0A patent/GB0127141D0/en not_active Ceased
-
2002
- 2002-11-08 KR KR1020047006964A patent/KR20050044366A/ko not_active Withdrawn
- 2002-11-08 BR BR0213994-4A patent/BR0213994A/pt not_active IP Right Cessation
- 2002-11-08 IL IL16185402A patent/IL161854A0/xx unknown
- 2002-11-08 MX MXPA04004372A patent/MXPA04004372A/es unknown
- 2002-11-08 CA CA002468497A patent/CA2468497A1/en not_active Abandoned
- 2002-11-08 AU AU2002351921A patent/AU2002351921B2/en not_active Ceased
- 2002-11-08 US US10/494,509 patent/US20050043335A1/en not_active Abandoned
- 2002-11-08 NZ NZ532520A patent/NZ532520A/en unknown
- 2002-11-08 RU RU2004117603/04A patent/RU2004117603A/ru not_active Application Discontinuation
- 2002-11-08 CN CNB028259688A patent/CN1289483C/zh not_active Expired - Fee Related
- 2002-11-08 PL PL02369521A patent/PL369521A1/xx not_active Application Discontinuation
- 2002-11-08 JP JP2003544015A patent/JP2005511622A/ja active Pending
- 2002-11-08 WO PCT/EP2002/012505 patent/WO2003042179A1/en not_active Ceased
- 2002-11-08 EP EP02787607A patent/EP1442020A1/en not_active Withdrawn
- 2002-11-08 HU HU0402244A patent/HUP0402244A2/hu unknown
-
2004
- 2004-04-28 ZA ZA200403186A patent/ZA200403186B/en unknown
- 2004-05-07 CO CO04042442A patent/CO5580825A2/es not_active Application Discontinuation
- 2004-06-09 NO NO20042406A patent/NO20042406L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IL161854A0 (en) | 2005-11-20 |
| JP2005511622A (ja) | 2005-04-28 |
| US20050043335A1 (en) | 2005-02-24 |
| CA2468497A1 (en) | 2003-05-22 |
| KR20050044366A (ko) | 2005-05-12 |
| GB0127141D0 (en) | 2002-01-02 |
| NZ532520A (en) | 2006-12-22 |
| MXPA04004372A (es) | 2004-08-11 |
| WO2003042179A1 (en) | 2003-05-22 |
| CN1608053A (zh) | 2005-04-20 |
| HUP0402244A2 (hu) | 2005-02-28 |
| CO5580825A2 (es) | 2005-11-30 |
| ZA200403186B (en) | 2005-01-14 |
| RU2004117603A (ru) | 2005-04-20 |
| CN1289483C (zh) | 2006-12-13 |
| BR0213994A (pt) | 2004-08-31 |
| AU2002351921B2 (en) | 2007-01-25 |
| PL369521A1 (en) | 2005-04-18 |
| EP1442020A1 (en) | 2004-08-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |