NO20042731L - Fremgangsmater for rensing av levofloxacin - Google Patents

Fremgangsmater for rensing av levofloxacin

Info

Publication number: NO20042731L
Authority: NO; Norway
Prior art keywords: levofloxacin; purifying; methods; purified; antioxidant
Prior art date: 2001-11-29

Application number

NO20042731A

Other languages

English (en)

Norwegian (no)

Inventor

Valerie Niddam-Hildesheim

Neomi Gershon

Eduard Schwartz

Original Assignee

Teva Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-11-29

Filing date

2004-06-29

Publication date

2004-06-29

2002-10-03 Priority claimed from US10/263,192 external-priority patent/US7629458B2/en

2004-06-29 Application filed by Teva Pharma filed Critical Teva Pharma

2004-06-29 Publication of NO20042731L publication Critical patent/NO20042731L/no

Links

GSDSWSVVBLHKDQ-JTQLQIEISA-N Levofloxacin Chemical compound C([C@@H](N1C2=C(C(C(C(O)=O)=C1)=O)C=C1F)C)OC2=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-JTQLQIEISA-N 0.000 title abstract 4
229960003376 levofloxacin Drugs 0.000 title abstract 4
239000003963 antioxidant agent Substances 0.000 abstract 1
230000003078 antioxidant effect Effects 0.000 abstract 1
238000002425 crystallisation Methods 0.000 abstract 1
230000008025 crystallization Effects 0.000 abstract 1
239000002798 polar solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)

NO20042731A 2001-11-29 2004-06-29 Fremgangsmater for rensing av levofloxacin NO20042731L (no)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US33431601P	2001-11-29	2001-11-29
US35493902P	2002-02-11	2002-02-11
US26296502A	2002-10-03	2002-10-03
US10/263,192 US7629458B2 (en)	2001-10-03	2002-10-03	Preparation of levofloxacin and hemihydrate thereof
PCT/US2002/038182 WO2003045329A2 (en)	2001-11-29	2002-11-27	Methods for the purification of levofloxacin

Publications (1)

Publication Number	Publication Date
NO20042731L true NO20042731L (no)	2004-06-29

Family

ID=31892240

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20042731A NO20042731L (no)	2001-11-29	2004-06-29	Fremgangsmater for rensing av levofloxacin

Country Status (13)

Country	Link
EP (1)	EP1460997A4 (is)
JP (3)	JP2005527484A (is)
CN (1)	CN1596256A (is)
AU (1)	AU2002365416A1 (is)
CA (1)	CA2466860A1 (is)
HR (1)	HRP20040546A2 (is)
HU (1)	HUP0500285A3 (is)
IL (1)	IL162172A0 (is)
IS (1)	IS7288A (is)
MX (1)	MXPA04005196A (is)
NO (1)	NO20042731L (is)
PL (1)	PL374558A1 (is)
WO (1)	WO2003045329A2 (is)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7629458B2 (en)	2001-10-03	2009-12-08	Teva Pharmaceutical Industries Ltd.	Preparation of levofloxacin and hemihydrate thereof
US20060276463A1 (en) *	2002-12-16	2006-12-07	Sharma Tarun K	Pure levofloxacin hemihydrate and processes for preparation thereof
KR100704641B1 (ko) *	2004-07-21	2007-04-06	주식회사유한양행	고순도의 레보플록사신 제조방법
JP2006273718A (ja) *	2005-03-28	2006-10-12	Shiono Chemical Co Ltd	レボフロキサシン・１／２水和物の製法
CN1321121C (zh) *	2005-04-21	2007-06-13	浙江医药股份有限公司新昌制药厂	左氧氟沙星制备及后处理方法
US7964723B2 (en) *	2008-08-02	2011-06-21	Apeloa-Kangyu	And practical process for exclusively producing (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido-[1,2,3,de][1,4]benzoxazine-6-carboxylic acid hemihydrate
CN102070650B (zh) *	2011-01-28	2012-06-27	山东省药品检验所	左氧氟沙星-n-氧化物的制备方法
US20120251685A1 (en) *	2011-04-04	2012-10-04	Martek Biosciences Corporation	Oil-in-Water Emulsions Comprising a Polyunsaturated Fatty Acid and Methods of Making the Same
CN105823851A (zh) *	2015-12-15	2016-08-03	浙江海洋学院	一种检测海水中氧氟沙星对映体的方法
CN108218892A (zh) *	2018-03-16	2018-06-29	乐山职业技术学院	一种左氧氟沙星的纯化方法
CN112174981A (zh) *	2020-11-03	2021-01-05	深圳市祥根生物科技有限公司	一种左氧氟沙星脱氟杂质的制备方法
CN114507242B (zh) *	2022-01-26	2023-05-19	上虞京新药业有限公司	高光学纯度左氧氟沙星的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NO166131C (no) *	1985-06-20	1991-06-05	Daiichi Seiyaku Co	Analogifremgangsmaate for fremstilling av s(-)-pyridobenzoksazinforbindelser.
US5237060A (en) *	1985-12-10	1993-08-17	Bayer Aktiengesellschaft	Process of preparing enantiomerically pure 1,8-bridged 4-quinolone-3-carboxylic acids
TW208013B (is) *	1990-03-01	1993-06-21	Daiichi Co Ltd
JPH07501835A (ja) *	1992-10-07	1995-02-23	デリバドス・デル・エチロ・ソシエダッド・アノニマ	オフロキサジン，レボフロキサジン及び誘導体の合成に使用されるベンゾキサジンの製造法
KR0125115B1 (ko) *	1994-03-22	1997-12-05	김은영	(-)피페라진 벤즈옥사진 유도체의 제조방법
KR100309871B1 (ko) *	1999-02-24	2001-10-29	윤종용	(-)피리도벤즈옥사진 카르복실산 유도체의 제조방법
US7629458B2 (en) *	2001-10-03	2009-12-08	Teva Pharmaceutical Industries Ltd.	Preparation of levofloxacin and hemihydrate thereof

2002
- 2002-11-27 EP EP02791339A patent/EP1460997A4/en not_active Withdrawn
- 2002-11-27 PL PL02374558A patent/PL374558A1/xx not_active Application Discontinuation
- 2002-11-27 WO PCT/US2002/038182 patent/WO2003045329A2/en not_active Ceased
- 2002-11-27 JP JP2003546834A patent/JP2005527484A/ja active Pending
- 2002-11-27 MX MXPA04005196A patent/MXPA04005196A/es not_active Application Discontinuation
- 2002-11-27 AU AU2002365416A patent/AU2002365416A1/en not_active Abandoned
- 2002-11-27 CN CNA028236440A patent/CN1596256A/zh active Pending
- 2002-11-27 IL IL16217202A patent/IL162172A0/xx unknown
- 2002-11-27 HR HR20040546A patent/HRP20040546A2/hr not_active Application Discontinuation
- 2002-11-27 HU HU0500285A patent/HUP0500285A3/hu unknown
- 2002-11-27 CA CA002466860A patent/CA2466860A1/en not_active Abandoned
2004
- 2004-05-27 IS IS7288A patent/IS7288A/is unknown
- 2004-06-29 NO NO20042731A patent/NO20042731L/no not_active Application Discontinuation
2006
- 2006-05-01 JP JP2006127862A patent/JP2006219496A/ja not_active Withdrawn
2007
- 2007-08-22 JP JP2007216178A patent/JP2008007517A/ja active Pending

Also Published As

Publication number	Publication date
IS7288A (is)	2004-06-21
HUP0500285A3 (en)	2009-03-30
CA2466860A1 (en)	2003-06-05
IL162172A0 (en)	2005-11-20
MXPA04005196A (es)	2005-11-23
EP1460997A2 (en)	2004-09-29
JP2006219496A (ja)	2006-08-24
WO2003045329A2 (en)	2003-06-05
HUP0500285A2 (hu)	2005-06-28
HRP20040546A2 (en)	2004-10-31
JP2005527484A (ja)	2005-09-15
CN1596256A (zh)	2005-03-16
AU2002365416A1 (en)	2003-06-10
JP2008007517A (ja)	2008-01-17
EP1460997A4 (en)	2005-06-15
PL374558A1 (en)	2005-10-31
WO2003045329A3 (en)	2004-02-19

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Legal Events

Date	Code	Title	Description
2006-07-03	FC2A	Withdrawal, rejection or dismissal of laid open patent application