NO20043286L - Piperidinderivatforbindelser og legemidler inneholdende forbindelsene som den aktive bestanddel - Google Patents

Piperidinderivatforbindelser og legemidler inneholdende forbindelsene som den aktive bestanddel

Info

Publication number: NO20043286L
Authority: NO; Norway
Prior art keywords: compounds; gen; active ingredient; piperidine derivative; drugs containing
Prior art date: 2002-02-08

Application number

NO20043286A

Other languages

English (en)

Other versions

NO327417B1 (no

Inventor

Hiroshi Ochiai

Yoshitaka Nishita

Tazumi Ohtani

Masaya Hamano

Original Assignee

Ono Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-02-08

Filing date

2004-08-06

Publication date

2004-11-08

2004-08-06 Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co

2004-11-08 Publication of NO20043286L publication Critical patent/NO20043286L/no

2009-06-22 Publication of NO327417B1 publication Critical patent/NO327417B1/no

Links

-1 Piperidine derivative compounds Chemical class 0.000 title 1
239000004480 active ingredient Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
239000003814 drug Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1
GARSYZASUHNFPZ-UHFFFAOYSA-N 2-[4-cyano-4-[3-cyclopentyloxy-4-(difluoromethoxy)phenyl]piperidin-1-yl]acetic acid;hydrate Chemical compound O.C1CN(CC(=O)O)CCC1(C#N)C1=CC=C(OC(F)F)C(OC2CCCC2)=C1 GARSYZASUHNFPZ-UHFFFAOYSA-N 0.000 abstract 2
150000003053 piperidines Chemical class 0.000 abstract 2
MSYGAHOHLUJIKV-UHFFFAOYSA-N 3,5-dimethyl-1-(3-nitrophenyl)-1h-pyrazole-4-carboxylic acid ethyl ester Chemical compound CC1=C(C(=O)OCC)C(C)=NN1C1=CC=CC([N+]([O-])=O)=C1 MSYGAHOHLUJIKV-UHFFFAOYSA-N 0.000 abstract 1
JNRDVRQSUTYTJK-UHFFFAOYSA-N 4-[3-cyclopentyloxy-4-(difluoromethoxy)phenyl]piperidine-4-carbonitrile Chemical compound FC(F)OC1=CC=C(C2(CCNCC2)C#N)C=C1OC1CCCC1 JNRDVRQSUTYTJK-UHFFFAOYSA-N 0.000 abstract 1
208000030814 Eating disease Diseases 0.000 abstract 1
208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
102000011017 Type 4 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 abstract 1
108010037584 Type 4 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 abstract 1
229910052783 alkali metal Inorganic materials 0.000 abstract 1
150000001340 alkali metals Chemical class 0.000 abstract 1
229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
150000001342 alkaline earth metals Chemical class 0.000 abstract 1
230000001539 anorectic effect Effects 0.000 abstract 1
230000003266 anti-allergic effect Effects 0.000 abstract 1
230000002456 anti-arthritic effect Effects 0.000 abstract 1
230000001088 anti-asthma Effects 0.000 abstract 1
230000000844 anti-bacterial effect Effects 0.000 abstract 1
230000001430 anti-depressive effect Effects 0.000 abstract 1
230000003178 anti-diabetic effect Effects 0.000 abstract 1
230000036436 anti-hiv Effects 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
230000000648 anti-parkinson Effects 0.000 abstract 1
230000003356 anti-rheumatic effect Effects 0.000 abstract 1
230000000767 anti-ulcer Effects 0.000 abstract 1
239000000924 antiasthmatic agent Substances 0.000 abstract 1
239000000935 antidepressant agent Substances 0.000 abstract 1
229940005513 antidepressants Drugs 0.000 abstract 1
239000003472 antidiabetic agent Substances 0.000 abstract 1
239000000939 antiparkinson agent Substances 0.000 abstract 1
239000003435 antirheumatic agent Substances 0.000 abstract 1
238000003556 assay Methods 0.000 abstract 1
239000000824 cytostatic agent Substances 0.000 abstract 1
230000001085 cytostatic effect Effects 0.000 abstract 1
206010061428 decreased appetite Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000001553 hepatotropic effect Effects 0.000 abstract 1
230000001506 immunosuppresive effect Effects 0.000 abstract 1
230000010534 mechanism of action Effects 0.000 abstract 1
230000000324 neuroprotective effect Effects 0.000 abstract 1
230000001777 nootropic effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/04—Antibacterial agents
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- A61P31/12—Antivirals
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- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Orthopedic Medicine & Surgery (AREA)
Hematology (AREA)
Oncology (AREA)
Obesity (AREA)
Ophthalmology & Optometry (AREA)
Urology & Nephrology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Epidemiology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Dermatology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Emergency Medicine (AREA)

NO20043286A 2002-02-08 2004-08-06 Piperidinderivatforbindelser, fremstilling derav, og legemidler inneholdende derivatene som den aktive bestanddel NO327417B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2002031602		2002-02-08
PCT/JP2003/001318 WO2003066590A1 (en)	2002-02-08	2003-02-07	Piperidine derivative compounds and drugs containing the compounds as the active ingredient

Publications (2)

Publication Number	Publication Date
NO20043286L true NO20043286L (no)	2004-11-08
NO327417B1 NO327417B1 (no)	2009-06-22

Family

ID=27677940

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20043286A NO327417B1 (no)	2002-02-08	2004-08-06	Piperidinderivatforbindelser, fremstilling derav, og legemidler inneholdende derivatene som den aktive bestanddel

Country Status (19)

Country	Link
US (1)	US7425567B2 (no)
EP (1)	EP1481969B1 (no)
KR (1)	KR100960062B1 (no)
CN (1)	CN1323074C (no)
AT (1)	ATE496028T1 (no)
AU (1)	AU2003207178B2 (no)
BR (1)	BR0307490A (no)
CA (1)	CA2475498C (no)
DE (1)	DE60335788D1 (no)
ES (1)	ES2356306T3 (no)
IL (1)	IL163344A (no)
MX (1)	MXPA04007688A (no)
NO (1)	NO327417B1 (no)
NZ (1)	NZ534523A (no)
PL (1)	PL215006B1 (no)
RU (1)	RU2308450C2 (no)
TW (1)	TWI305530B (no)
WO (1)	WO2003066590A1 (no)
ZA (1)	ZA200406274B (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2005007161A1 (ja) *	2003-07-17	2005-01-27	Santen Pharmaceutical Co., Ltd.	ピペリジン誘導体を有効成分とする掻痒治療剤
US20090182035A1 (en) *	2007-04-11	2009-07-16	Alcon Research, Ltd.	Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
TW201038295A (en) *	2009-04-17	2010-11-01	Alcon Res Ltd	Aqueous ophthalmic compositions containing anionic therapeutic agents
RU2012117141A (ru) *	2009-10-01	2013-11-10	Алькон Рисерч, Лтд.	Композиции олопатадина и способы их применения
AR091507A1 (es)	2012-06-21	2015-02-11	Intra Cellular Therapies Inc	SALES DE (6aR,9aS)-5,6a,7,8,9,9a-HEXAHIDRO-5-METIL-3-(FENILAMINO)-2-((4-(6-FLUOROPIRIDIN-2-IL)FENIL)METIL)-CICLOPENT[4,5]IMIDAZO[1,2-a]PIRAZOLO[4,3-e]PIRIMIDIN-4(2H)-ONA
KR20160040522A (ko) *	2013-06-21	2016-04-14	인트라-셀룰라 써래피스, 인코퍼레이티드.	유리 염기 결정
CN115974956A (zh)	2016-08-23	2023-04-18	萨奇治疗股份有限公司	19-去甲c3,3-二取代的c21-n-吡唑基类固醇的晶体
US12435093B2 (en)	2020-05-06	2025-10-07	Intra-Cellular Therapies, Inc.	Free base crystals
CN121449548B (zh) *	2026-01-07	2026-04-07	成都施贝康生物医药科技有限公司	一种哌啶衍生物及其药物组合物、用途以及制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE8904298D0 (sv) *	1989-12-21	1989-12-21	Astra Ab	New compounds
US5602173A (en) *	1992-04-02	1997-02-11	Smithkline Beecham Corporation	Compounds useful for treating allergic and inflammatory diseases
US5459151A (en)	1993-04-30	1995-10-17	American Home Products Corporation	N-acyl substituted phenyl piperidines as bronchodilators and antiinflammatory agents
CZ301834B6 (cs) *	2000-08-11	2010-07-07	Ono Pharmaceutical Co., Ltd.	Piperidinové deriváty a cinidlo, které tyto deriváty obsahuje jako úcinnou prísadu

2003
- 2003-02-07 DE DE60335788T patent/DE60335788D1/de not_active Expired - Lifetime
- 2003-02-07 PL PL371729A patent/PL215006B1/pl unknown
- 2003-02-07 KR KR1020047012207A patent/KR100960062B1/ko not_active Expired - Fee Related
- 2003-02-07 CN CNB038075180A patent/CN1323074C/zh not_active Expired - Fee Related
- 2003-02-07 NZ NZ534523A patent/NZ534523A/en not_active IP Right Cessation
- 2003-02-07 ES ES03703257T patent/ES2356306T3/es not_active Expired - Lifetime
- 2003-02-07 WO PCT/JP2003/001318 patent/WO2003066590A1/ja not_active Ceased
- 2003-02-07 TW TW092102479A patent/TWI305530B/zh not_active IP Right Cessation
- 2003-02-07 AU AU2003207178A patent/AU2003207178B2/en not_active Ceased
- 2003-02-07 EP EP03703257A patent/EP1481969B1/en not_active Expired - Lifetime
- 2003-02-07 BR BR0307490-0A patent/BR0307490A/pt not_active IP Right Cessation
- 2003-02-07 RU RU2004126953/04A patent/RU2308450C2/ru not_active IP Right Cessation
- 2003-02-07 MX MXPA04007688A patent/MXPA04007688A/es active IP Right Grant
- 2003-02-07 CA CA2475498A patent/CA2475498C/en not_active Expired - Fee Related
- 2003-02-07 AT AT03703257T patent/ATE496028T1/de not_active IP Right Cessation
- 2003-02-07 US US10/504,028 patent/US7425567B2/en not_active Expired - Fee Related
2004
- 2004-08-04 IL IL163344A patent/IL163344A/en not_active IP Right Cessation
- 2004-08-05 ZA ZA2004/06274A patent/ZA200406274B/en unknown
- 2004-08-06 NO NO20043286A patent/NO327417B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
PL371729A1 (en)	2005-06-27
WO2003066590A1 (en)	2003-08-14
AU2003207178B2 (en)	2008-10-23
IL163344A (en)	2011-04-28
NZ534523A (en)	2006-10-27
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BR0307490A (pt)	2004-12-28
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Publication	Publication Date	Title
ATE223378T1 (de)	2002-09-15	Prolineamid-derivate
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CA2445145A1 (en)	2002-11-21	Carboxylic acid substituted oxazole derivatives for use as ppar-alpha and -gamma activators in the treatment of diabetes
EP1400529A4 (en)	2007-12-19	GLUCOPYRANOSYLOXYPYRAZOLE DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND MEDICINAL AND INTERMEDIARY USE THEREOF
FI962418A0 (fi)	1996-06-11	Syklisiä amidijohdannaisia neurokiniini A antagonisteina
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EP1481969A4 (en)	2006-01-11	Piperidin derivative compounds and medicines containing these compounds as an active ingredient
EA200100916A1 (ru)	2002-02-28	Лекарственное средство, содержащее производное сульфопиранозилацилглицерина
ATE284882T1 (de)	2005-01-15	Chromenylmethylpyrimidindiamine als antibakterielle wirkstoffe
EP1174421A4 (en)	2003-04-23	3-AMIDINOBENZENESULFONAMIDE DERIVATIVES, MEDICAL PREPARATIONS CONTAINING IT AND INTERMEDIATE PRODUCTS IN THEIR PRODUCTION
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WO2003018564A1 (en)	2003-03-06	Vascular wall-selective acat inhibitor
EP1464636A4 (en)	2006-01-11	NEW SUBSTANCE WITH ANTITUM EFFECT / INFLAMMATORY EFFECT
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DK1237866T3 (da)	2005-10-10	Amycomycin, en fremgangsmåde til dets fremstilling og dets anvendelse som et lægemiddel
AU2003236180A1 (en)	2003-10-13	Hydroxymorpholinone derivative and medicinal use thereof
NO20042881L (no)	2004-07-07	Substituerte cykloheksan-derivater