NO20043661L - Bipolar trans-carotenoid salts and their applications - Google Patents

Bipolar trans-carotenoid salts and their applications

Info

Publication number
NO20043661L
NO20043661L NO20043661A NO20043661A NO20043661L NO 20043661 L NO20043661 L NO 20043661L NO 20043661 A NO20043661 A NO 20043661A NO 20043661 A NO20043661 A NO 20043661A NO 20043661 L NO20043661 L NO 20043661L
Authority
NO
Norway
Prior art keywords
applications
bipolar trans
carotenoid salts
trans
processes
Prior art date
Application number
NO20043661A
Other languages
Norwegian (no)
Inventor
John L Gainer
Raymond C Grabiak
Original Assignee
Diffusion Pharmaceuticals Llc
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Publication date
Application filed by Diffusion Pharmaceuticals Llc filed Critical Diffusion Pharmaceuticals Llc
Publication of NO20043661L publication Critical patent/NO20043661L/en

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    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/602—Dicarboxylic acid esters having at least two carbon-to-carbon double bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/06—Potassium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P3/00—Drugs for disorders of the metabolism
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/12—Antihypertensives
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C305/00—Esters of sulfuric acids
    • C07C305/02—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C305/14—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being acyclic and unsaturated
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
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    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
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    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/04—Sodium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/113—Esters of phosphoric acids with unsaturated acyclic alcohols

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Public Health (AREA)
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  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
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  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Reproductive Health (AREA)
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  • Toxicology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Oppfinnelsen angår trans-karotenoidsalt forbindelser, fremgangsmåter for fremstilling av dem, fremgangsmåter for oppløsning av dem og anvendelser derav. Forbindelsene er nyttige i forbedring av diffusivitet til oksygen mellom røde blodceller og kroppsvev i pattedyr, inkludert mennesket.The invention relates to trans-carotenoid salt compounds, processes for their preparation, processes for their dissolution and uses thereof. The compounds are useful in improving the diffusivity of oxygen between red blood cells and body tissues in mammals, including humans.

NO20043661A 2002-02-25 2004-09-01 Bipolar trans-carotenoid salts and their applications NO20043661L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35871802P 2002-02-25 2002-02-25
PCT/US2003/005521 WO2003072734A2 (en) 2002-02-25 2003-02-25 Bipolar trans carotenoid salts and their uses

Publications (1)

Publication Number Publication Date
NO20043661L true NO20043661L (en) 2004-09-01

Family

ID=27765977

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20043661A NO20043661L (en) 2002-02-25 2004-09-01 Bipolar trans-carotenoid salts and their applications

Country Status (19)

Country Link
US (4) US7351844B2 (en)
EP (1) EP1487774B1 (en)
JP (4) JP2005518453A (en)
KR (1) KR101020115B1 (en)
CN (1) CN1671643B (en)
AU (1) AU2003215396B2 (en)
BR (1) BR0307935A (en)
CA (1) CA2477245A1 (en)
CZ (1) CZ2004904A3 (en)
EA (1) EA200401111A1 (en)
HU (1) HUP0500134A3 (en)
IL (1) IL163685A0 (en)
MX (1) MXPA04008253A (en)
NO (1) NO20043661L (en)
NZ (2) NZ564486A (en)
PL (1) PL373780A1 (en)
UA (1) UA83341C2 (en)
WO (1) WO2003072734A2 (en)
ZA (1) ZA200406673B (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA200401111A1 (en) 2002-02-25 2005-02-24 Диффьюжн Фармасьютикалз Ллс TRANS-CAROTINOID BIPOLAR SALTS AND THEIR APPLICATION
US7759506B2 (en) 2002-02-25 2010-07-20 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
AU2011265546B2 (en) * 2003-08-25 2016-05-12 Diffusion Pharmaceuticals Llc Bipolar Trans Carotenoid Salts and Their Uses
KR101017668B1 (en) * 2003-08-25 2011-02-25 디퓨젼 파마슈티컬즈 엘엘씨 Bipolar Trans Carotenoid Salts and Their Uses
UA95903C2 (en) * 2005-02-24 2011-09-26 Дифьюжен Фармасьютикалз Ллк Trans carotenoids, their synthesis, formulation and uses
WO2006112283A1 (en) * 2005-04-13 2006-10-26 Riken Vitamin Co., Ltd. Anti-fatigue agent
EP1965807A4 (en) * 2005-11-23 2010-10-27 Epix Delaware Inc S1p receptor modulating compounds and use thereof
US20070288322A1 (en) * 2006-05-23 2007-12-13 Toshiba Tec Kabushiki Kaisha Portable terminal and its programs, settlement apparatus, and merchandising information providing apparatus
CN101687757A (en) 2007-04-13 2010-03-31 扩散药品有限公司 Use of bipolar trans carotenoids as a pretreatment and in the treatment of peripheral vascular disease
WO2008155338A2 (en) * 2007-06-19 2008-12-24 Novartis Ag Organic compounds
JP2011502125A (en) 2007-10-31 2011-01-20 ディフュージョン・ファーマシューティカルズ・エルエルシー A new class of treatments that promote small molecule diffusion
CN101157645B (en) * 2007-11-27 2010-06-02 江南大学 A kind of synthetic method of crocetin
KR101875843B1 (en) 2009-06-22 2018-07-06 디퓨젼 파마슈티컬즈 엘엘씨 Diffusion enhancing compounds and their use alone or with thrombolytics
JP2010090151A (en) * 2009-12-09 2010-04-22 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salt and its use
KR101891357B1 (en) 2010-06-02 2018-08-24 디퓨젼 파마슈티컬즈 엘엘씨 Oral formulations of bipolar trans carotenoids
CN101967087A (en) * 2010-09-21 2011-02-09 上海大学 Method for preparing (E)-4.4-dimethoxy-2-propylene aldehyde
CN103172504B (en) * 2011-12-26 2014-10-08 南京工业大学 Synthesis method of 2, 7-dimethyl-2, 4, 6-octatriene-1, 8-dialdehyde
US11185523B2 (en) 2016-03-24 2021-11-30 Diffusion Pharmaceuticals Llc Use of bipolar trans carotenoids with chemotherapy and radiotherapy for treatment of cancer
CA3098868A1 (en) 2018-05-03 2019-11-07 L.E.A.F. Holdings Group Llc Carotenoid compositions and uses thereof
WO2021207650A1 (en) * 2020-04-09 2021-10-14 L.E.A.F. Holdings Group Llc Trans-crocetin compositions and treatment regimens
EP4132482A4 (en) * 2020-04-09 2024-05-08 L.E.A.F Holdings Group LLC TRANS-CROCETINE COMPOSITIONS AND TREATMENT REGIMENS
US20240316000A1 (en) * 2021-06-29 2024-09-26 Diffusion Pharmaceuticals Llc Methods of treatment
EP4426282A4 (en) * 2021-11-03 2025-12-10 Diffusion Pharmaceuticals Llc CRYSTALLINE FORMS OF A DIFFUSION-ENHANCING COMPOUND
CN114534729B (en) * 2022-03-07 2024-05-03 万华化学集团股份有限公司 Catalyst, preparation method thereof and application of catalyst in preparation of beta-carotene by electrochemical method

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2948748A (en) * 1960-08-09 Esters thereof
US2175843A (en) * 1936-06-26 1939-10-10 Winthrop Chem Co Inc Polyene carboxylic acids and esters and manufacture thereof
CH468330A (en) 1966-01-28 1969-02-15 Hoffmann La Roche Process for the production of isoprenoid compounds
US3489806A (en) 1967-01-19 1970-01-13 Hoffmann La Roche Isoprenoid compounds and a process for producing the same
CH522572A (en) * 1969-10-31 1972-06-30 Hoffmann La Roche Polyenic derivs prepn
US3853993A (en) * 1973-05-01 1974-12-10 Univ Virginia Process for increasing oxygen diffusivity and method for treating atherosclerosis
US3788468A (en) * 1973-05-01 1974-01-29 Univ Virginia Process for increasing oxygen diffusivity
US3853933A (en) * 1974-01-14 1974-12-10 Gen Electric Continuous process for producing polysiloxane oils utilizing a carbon black catalyst
DE2505869C3 (en) * 1975-02-12 1978-05-18 Basf Ag, 6700 Ludwigshafen Process for the preparation of symmetrical carotenoids
US3965261A (en) * 1975-04-29 1976-06-22 University Of Virginia Method for treating papillomas
US3975519A (en) * 1975-06-09 1976-08-17 University Of Virginia Method for increasing the oxygen partial pressure in the bloodstream of mammals
US4070460A (en) * 1975-11-10 1978-01-24 University Of Virginia Patents Foundation Method for treating cerebral edema
US4009270A (en) * 1975-11-21 1977-02-22 The University Of Virginia Method for treating spinal cord injury
US4038144A (en) * 1976-04-19 1977-07-26 The University Of Virginia Method of increasing fermentation yields
US4046880A (en) * 1976-04-20 1977-09-06 The University Of Virginia Method of treating hypertension
US4068144A (en) * 1976-09-20 1978-01-10 Recognition Equipment Incorporated Liquid jet modulator with piezoelectric hemispheral transducer
US4099270A (en) * 1977-02-16 1978-07-11 Jabour Richard J Slip-on rubber gloves
US4216211A (en) * 1977-10-31 1980-08-05 The Procter & Gamble Company Therapeutic composition
US4176179A (en) * 1978-04-17 1979-11-27 The University Of Virginia Alumni Patents Foundation Method for treating arthritis
US4699664A (en) 1985-05-01 1987-10-13 Nestec S.A. Stabilized natural pigment complexes
US5032613A (en) * 1986-02-12 1991-07-16 W. Keith R. Watson Method and composition for treating arthritis
JPH0661211B2 (en) * 1986-08-29 1994-08-17 花王株式会社 Bread modifier, bread dough, and method for manufacturing bread
US5811119A (en) 1987-05-19 1998-09-22 Board Of Regents, The University Of Texas Formulation and use of carotenoids in treatment of cancer
US5472946A (en) 1988-04-08 1995-12-05 Peck; James V. Transdermal penetration enhancers
FR2647343B1 (en) 1989-05-24 1994-05-06 Rhone Poulenc Sante NOVEL POROUS PHARMACEUTICAL FORM AND ITS PREPARATION
IT1233303B (en) 1989-06-07 1992-03-26 Azionaria Costruzioni Acma Spa EQUIPMENT FOR CONVEYING PRODUCTS
US5053240A (en) 1989-10-24 1991-10-01 Kalamazoo Holdings, Inc. Norbixin adducts with water-soluble or water-dispersible proteins or branched-chain or cyclic polysaccharides
US5175843A (en) * 1989-10-30 1992-12-29 General Electric Company Computer-aided design method for restructuring computational networks to minimize shimming delays
JPH04264020A (en) 1991-02-18 1992-09-18 Yamanouchi Pharmaceut Co Ltd Lyophilized stable medicinal preparation
US5107030A (en) * 1991-03-04 1992-04-21 Loyola University Of Chicago Method of making 2,7-dimethyl-2,4,6-octatrienedial and derivatives thereof
JP3176716B2 (en) 1991-06-21 2001-06-18 武田薬品工業株式会社 Poorly water-soluble drug composition having improved solubility
JP2977961B2 (en) * 1991-07-26 1999-11-15 株式会社資生堂 Cosmetics
JPH06248193A (en) 1993-02-25 1994-09-06 Ensuiko Sugar Refining Co Ltd Crocetin-containing pigment
IL110139A0 (en) 1993-06-28 1994-10-07 Howard Foundation Pharmaceutically-active antioxidants
JPH0723736A (en) 1993-06-30 1995-01-27 Taishiyoo Technos:Kk Method for solubilizing carotenoid coloring matter
JP2704356B2 (en) 1994-02-08 1998-01-26 正和薬品株式会社 Brain function improver
JPH07291854A (en) 1994-04-26 1995-11-07 Tanabe Seiyaku Co Ltd Pharmaceutical formulations with improved solubility
GB2290964A (en) 1994-07-08 1996-01-17 Arto Olavi Urtti Transdermal drug delivery system
US6060511A (en) 1995-10-05 2000-05-09 Gainer; John L. Trans-sodium crocetinate, methods of making and methods of use thereof
US6090771A (en) * 1996-10-24 2000-07-18 Reckitt Benckiser Inc. Low residue aqueous hard surface cleaning and disinfecting compositions
RU2107496C1 (en) 1997-02-10 1998-03-27 Российская медицинская академия последипломного образования Министерства здравоохранения РФ Method to treat diabetic angiopathy
US6391336B1 (en) 1997-09-22 2002-05-21 Royer Biomedical, Inc. Inorganic-polymer complexes for the controlled release of compounds including medicinals
US6150561A (en) * 1997-10-03 2000-11-21 Roche Vitamins Inc. Method of making carotenoids
JPH11209642A (en) 1998-01-27 1999-08-03 Taito Kk Annatto color preparation and its production
MA25590A1 (en) 1998-09-14 2002-12-31 Inhale Therapeutic Syst ACTIVE AGENT FOR DRY POWDER DELIVERY
BE1012495A3 (en) * 1999-03-02 2000-11-07 Messadek Jallal Glycine betaine-for its use antithrombotic.
CA2355814C (en) 2000-09-14 2010-06-29 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Pharmaceutical composition for ophthalmic use
EA200401111A1 (en) * 2002-02-25 2005-02-24 Диффьюжн Фармасьютикалз Ллс TRANS-CAROTINOID BIPOLAR SALTS AND THEIR APPLICATION
US7759506B2 (en) 2002-02-25 2010-07-20 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
US20030180282A1 (en) 2002-03-25 2003-09-25 Victor Serebruany Method of treatment of thrombotic events
RU2226096C1 (en) 2002-07-01 2004-03-27 Санкт-Петербургский государственный научно-исследовательский институт скорой помощи им. И.И.Джанелидзе Method for treating hypoxia consequences in patients in critical state
EP2392562B1 (en) * 2002-07-29 2018-03-07 Cardax Pharma, Inc. Structural carotenoid analogs for the inhibition and amelioration of disease
DE10254809A1 (en) 2002-11-22 2004-06-03 Basf Ag Process for the production of carotenoids
WO2004049095A2 (en) 2002-11-25 2004-06-10 Jallal Messadek Betaine and salicylic acid compositions
US20040109920A1 (en) 2002-12-04 2004-06-10 Bioactives Llc Coated carotenoid cyclodextrin complexes
KR101017668B1 (en) * 2003-08-25 2011-02-25 디퓨젼 파마슈티컬즈 엘엘씨 Bipolar Trans Carotenoid Salts and Their Uses
RU2265434C2 (en) 2003-09-30 2005-12-10 Государственное учреждение Научно-исследовательский Институт Общей реаниматологии Российской Академии Медицинских Наук (ГУ НИИ ОР РАМН) Method for treating acute respiratory distress-syndrome
RU2256446C1 (en) 2003-10-22 2005-07-20 Государственное учреждение Межотраслевой научно-технический комплекс "Микрохирургия глаза" им. акад. С.Н. Федорова Method for preventing metastases after having surgically removed intraocular neoplasms
US7446101B1 (en) 2003-12-12 2008-11-04 Bioactives, Llc Bioavailable carotenoid-cyclodextrin formulations for soft-gels and other encapsulation systems
RU2007101074A (en) 2004-06-14 2008-07-20 Зозер Б. САЛАМА (DE) PHARMACEUTICAL ANTICANCER COMPOSITION PROLINE OR ITS DERIVATIVES AND ANTITUM ANTIBODY
JP4514114B2 (en) 2004-06-18 2010-07-28 ヤマハ発動機株式会社 Coil movable linear motor and single axis robot
EP2444071A1 (en) 2004-09-27 2012-04-25 Sigmoid Pharma Limited Minicapsule formulations
US20060111580A1 (en) 2004-10-01 2006-05-25 Lockwood Samuel F Methods for the synthesis of chiral dihydroxy ketone intermediates useful for the chiral synthesis of carotenoids
WO2006091924A2 (en) 2005-02-24 2006-08-31 Regents Of The University Of Minnesota Producing carotenoids
UA95903C2 (en) 2005-02-24 2011-09-26 Дифьюжен Фармасьютикалз Ллк Trans carotenoids, their synthesis, formulation and uses
EP1861109A2 (en) 2005-03-09 2007-12-05 Cardax Pharmaceuticals, Inc. Carotenoids, carotenoid analogs, or carotenoid derivatives for the treatment of proliferative disorders
CA2620943A1 (en) 2005-09-02 2007-03-08 Iomai Corporation Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs and uses thereof
ITMI20052486A1 (en) 2005-12-23 2007-06-24 Italiana Sint Spa INTERMEDIATE SYNTHESIS PROCEDURE FOR THE PREPARATION OF ASTAXANTIN
WO2007109824A1 (en) 2006-03-24 2007-10-04 Ian Simon Tracton Stable packaged dosage form and process therefor
CN101687757A (en) 2007-04-13 2010-03-31 扩散药品有限公司 Use of bipolar trans carotenoids as a pretreatment and in the treatment of peripheral vascular disease
JP2011502125A (en) 2007-10-31 2011-01-20 ディフュージョン・ファーマシューティカルズ・エルエルシー A new class of treatments that promote small molecule diffusion

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