NO20045276L - Heteroarylforbindelser som inhiberer leukocyttadhesjon formidlet ved alfa-4-integriner - Google Patents

Heteroarylforbindelser som inhiberer leukocyttadhesjon formidlet ved alfa-4-integriner

Info

Publication number
NO20045276L
NO20045276L NO20045276A NO20045276A NO20045276L NO 20045276 L NO20045276 L NO 20045276L NO 20045276 A NO20045276 A NO 20045276A NO 20045276 A NO20045276 A NO 20045276A NO 20045276 L NO20045276 L NO 20045276L
Authority
NO
Norway
Prior art keywords
sub
alpha
integrins
compounds
leukocyte adhesion
Prior art date
Application number
NO20045276A
Other languages
English (en)
Inventor
Eugene D Thorsett
Michael A Pleiss
Christopher M Semko
Andrei W Konradi
Ying-Zi Xu
Frank Stappenbeck
Brian P Stupi
Jenifer Smith
Original Assignee
Elan Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc filed Critical Elan Pharm Inc
Publication of NO20045276L publication Critical patent/NO20045276L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Det er beskrevet forbindelser som binder 4 integriner, hvor 4 integrinet fortrirmsvis er VLA-4. Visse av disse forbindelsene inhiberer også leukocyttadhesjon og, spesielt, leukocyttadhesjon formidlet ved 4 integriner, hvor 4 integrinet fortrirmsvis er VLA-4. Slike forbindelser er nyttige for behandlingen av inflammatoriske lidelser i en pattedyrpasient, feks mennesket, så som astma, Alzheimers sykdom, aterosklerose, AIDS demens, diabetes, inflammatorisk tarmsykdom, reumatoid artritt, vevsttansplantasjon, tumor metastase og myokardial ischemi. Forbindelsene kan også administteres for behandling av inflammatorisk hjemesykdom, så som multippel sklerose.
NO20045276A 2002-05-24 2004-12-01 Heteroarylforbindelser som inhiberer leukocyttadhesjon formidlet ved alfa-4-integriner NO20045276L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38324402P 2002-05-24 2002-05-24
PCT/US2003/017150 WO2003099231A2 (en) 2002-05-24 2003-05-27 Heteroaryl compounds which inhibit leukocyte adhesion mediated by alpha-4 integrins

Publications (1)

Publication Number Publication Date
NO20045276L true NO20045276L (no) 2004-12-01

Family

ID=29584533

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20045276A NO20045276L (no) 2002-05-24 2004-12-01 Heteroarylforbindelser som inhiberer leukocyttadhesjon formidlet ved alfa-4-integriner

Country Status (17)

Country Link
US (2) US7335663B2 (no)
EP (1) EP1507533B1 (no)
JP (1) JP4413135B2 (no)
CN (1) CN1311829C (no)
AT (1) ATE464298T1 (no)
AU (1) AU2003237302B8 (no)
BR (1) BR0309619A (no)
CA (1) CA2480756A1 (no)
DE (1) DE60332109D1 (no)
EA (1) EA008180B1 (no)
IL (1) IL164323A (no)
MX (1) MXPA04011657A (no)
NO (1) NO20045276L (no)
NZ (1) NZ535723A (no)
TW (1) TW200307671A (no)
WO (1) WO2003099231A2 (no)
ZA (1) ZA200407944B (no)

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Also Published As

Publication number Publication date
US7008949B2 (en) 2006-03-07
TW200307671A (en) 2003-12-16
IL164323A (en) 2010-02-17
EA008180B1 (ru) 2007-04-27
AU2003237302B8 (en) 2008-04-03
JP4413135B2 (ja) 2010-02-10
AU2003237302A1 (en) 2003-12-12
BR0309619A (pt) 2005-06-28
JP2005529155A (ja) 2005-09-29
DE60332109D1 (de) 2010-05-27
CN1311829C (zh) 2007-04-25
AU2003237302B2 (en) 2008-03-06
WO2003099231A2 (en) 2003-12-04
EA200401561A1 (ru) 2005-06-30
NZ535723A (en) 2005-08-26
EP1507533A4 (en) 2007-05-23
IL164323A0 (en) 2005-12-18
CA2480756A1 (en) 2003-12-04
US20050130999A1 (en) 2005-06-16
CN1652789A (zh) 2005-08-10
US20040142954A1 (en) 2004-07-22
EP1507533B1 (en) 2010-04-14
US7335663B2 (en) 2008-02-26
ZA200407944B (en) 2006-07-26
EP1507533A2 (en) 2005-02-23
ATE464298T1 (de) 2010-04-15
WO2003099231A3 (en) 2004-01-22
MXPA04011657A (es) 2005-08-18

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