NO20050320L - Fremgangsmate for oppregulering av tumor antigen ekspresjon ved thymalfasin - Google Patents
Fremgangsmate for oppregulering av tumor antigen ekspresjon ved thymalfasinInfo
- Publication number
- NO20050320L NO20050320L NO20050320A NO20050320A NO20050320L NO 20050320 L NO20050320 L NO 20050320L NO 20050320 A NO20050320 A NO 20050320A NO 20050320 A NO20050320 A NO 20050320A NO 20050320 L NO20050320 L NO 20050320L
- Authority
- NO
- Norway
- Prior art keywords
- methods
- thymal
- phasin
- antigen expression
- expression
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 6
- 239000000427 antigen Substances 0.000 title abstract 2
- 102000036639 antigens Human genes 0.000 title abstract 2
- 108091007433 antigens Proteins 0.000 title abstract 2
- QYUPYXHDDLXBET-UHFFFAOYSA-N 5-methyl-2,4-dioxopyrimidine-1-carbaldehyde Chemical compound CC1=CN(C=O)C(=O)NC1=O QYUPYXHDDLXBET-UHFFFAOYSA-N 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 108010033574 phasin Proteins 0.000 title 1
- 210000004881 tumor cell Anatomy 0.000 abstract 4
- 210000004027 cell Anatomy 0.000 abstract 2
- 230000001024 immunotherapeutic effect Effects 0.000 abstract 2
- 238000001727 in vivo Methods 0.000 abstract 2
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 230000035945 sensitivity Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2292—Thymosin; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Den foreliggende oppfinnelsen frembringer en fremgangsmåte for oppregulering av tumorcelle antigenekspresjon, omfattende adminisfrering til cellene en mengde thymalfasin tilsfrekkehg til å øke ekspresjonen av TLP i forhold til ubehandlede tumorceller. Fremgangsmåter for forbedring av sensitiviteten til immunodiagnostiske eller immimoterapeutiske fremgangsmåter fremlegges også, omfattende forbehandling av måltumorceller ved adminisfrering til cellene av en mengde thymalfasin tilsfrekkehg til å øke ekspresjonen av TLP i forhold til ubehandlede tumorceller, fulgt av anvendelse av den immunodiagnostiske eller immimoterapeutiske metoden. Disse fremgangsmåtene kan anvendes både i in vivo og in vitro diagnostiske metoder, og i in vivo immimoterapeutiske metoder.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39196902P | 2002-06-28 | 2002-06-28 | |
| PCT/US2003/020829 WO2004003174A2 (en) | 2002-06-28 | 2003-06-30 | Method of up-regulating tumor antigen expression using thymalfasin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20050320L true NO20050320L (no) | 2005-01-20 |
Family
ID=30000788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20050320A NO20050320L (no) | 2002-06-28 | 2005-01-20 | Fremgangsmate for oppregulering av tumor antigen ekspresjon ved thymalfasin |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20060052297A1 (no) |
| EP (1) | EP1539211A4 (no) |
| JP (1) | JP2005537246A (no) |
| CN (1) | CN1665522A (no) |
| AU (1) | AU2003248792B2 (no) |
| BR (1) | BR0312270A (no) |
| CA (1) | CA2490868A1 (no) |
| EA (1) | EA006599B1 (no) |
| IL (1) | IL166004A0 (no) |
| MX (1) | MXPA05000078A (no) |
| NO (1) | NO20050320L (no) |
| NZ (1) | NZ537867A (no) |
| PL (1) | PL374537A1 (no) |
| WO (1) | WO2004003174A2 (no) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101072582B (zh) | 2004-12-06 | 2012-06-27 | 赛生制药有限公司 | 作为癌症疫苗佐剂的α胸腺肽 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3100974A1 (de) * | 1980-01-18 | 1982-01-21 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Thymosin(alpha)(pfeil abwaerts)1(pfeil abwaerts)-fragmente enthaltende arzneimittel mit immunregulierender wirkung, und thymosin(alpha)(pfeil abwaerts)1(pfeil abwaerts)-fragmente |
| US4517119A (en) * | 1983-04-04 | 1985-05-14 | Hoffmann-La Roche Inc. | Synthesis of thymosin α1 |
| US5273963A (en) * | 1991-03-29 | 1993-12-28 | The George Washington University | Compositions and methods for treating small cell and nonsmall cell lung cancers |
-
2003
- 2003-06-30 US US10/519,082 patent/US20060052297A1/en not_active Abandoned
- 2003-06-30 PL PL03374537A patent/PL374537A1/xx not_active Application Discontinuation
- 2003-06-30 EA EA200500071A patent/EA006599B1/ru not_active IP Right Cessation
- 2003-06-30 WO PCT/US2003/020829 patent/WO2004003174A2/en not_active Ceased
- 2003-06-30 JP JP2004518207A patent/JP2005537246A/ja not_active Withdrawn
- 2003-06-30 NZ NZ537867A patent/NZ537867A/en unknown
- 2003-06-30 CA CA002490868A patent/CA2490868A1/en not_active Abandoned
- 2003-06-30 MX MXPA05000078A patent/MXPA05000078A/es not_active Application Discontinuation
- 2003-06-30 AU AU2003248792A patent/AU2003248792B2/en not_active Ceased
- 2003-06-30 BR BR0312270-0A patent/BR0312270A/pt not_active IP Right Cessation
- 2003-06-30 EP EP03762310A patent/EP1539211A4/en not_active Withdrawn
- 2003-06-30 CN CN038153963A patent/CN1665522A/zh active Pending
-
2004
- 2004-12-26 IL IL16600404A patent/IL166004A0/xx unknown
-
2005
- 2005-01-20 NO NO20050320A patent/NO20050320L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EA006599B1 (ru) | 2006-02-24 |
| WO2004003174A3 (en) | 2004-05-06 |
| EP1539211A4 (en) | 2007-05-23 |
| NZ537867A (en) | 2007-04-27 |
| MXPA05000078A (es) | 2005-04-11 |
| AU2003248792B2 (en) | 2007-06-21 |
| PL374537A1 (en) | 2005-10-31 |
| CA2490868A1 (en) | 2004-01-08 |
| BR0312270A (pt) | 2005-04-26 |
| IL166004A0 (en) | 2006-01-15 |
| CN1665522A (zh) | 2005-09-07 |
| AU2003248792C1 (en) | 2004-01-19 |
| US20060052297A1 (en) | 2006-03-09 |
| WO2004003174A2 (en) | 2004-01-08 |
| AU2003248792A1 (en) | 2004-01-19 |
| EP1539211A2 (en) | 2005-06-15 |
| JP2005537246A (ja) | 2005-12-08 |
| EA200500071A1 (ru) | 2005-08-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |