NO20052100L - Raloksifensalt I - Google Patents
Raloksifensalt IInfo
- Publication number
- NO20052100L NO20052100L NO20052100A NO20052100A NO20052100L NO 20052100 L NO20052100 L NO 20052100L NO 20052100 A NO20052100 A NO 20052100A NO 20052100 A NO20052100 A NO 20052100A NO 20052100 L NO20052100 L NO 20052100L
- Authority
- NO
- Norway
- Prior art keywords
- raloxifene
- solvates
- addition salts
- acid addition
- sulphuric acid
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 4
- GZUITABIAKMVPG-UHFFFAOYSA-N raloxifene Chemical compound C1=CC(O)=CC=C1C1=C(C(=O)C=2C=CC(OCCN3CCCCC3)=CC=2)C2=CC=C(O)C=C2S1 GZUITABIAKMVPG-UHFFFAOYSA-N 0.000 abstract 4
- 239000012453 solvate Substances 0.000 abstract 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 3
- 229960004622 raloxifene Drugs 0.000 abstract 3
- 239000001117 sulphuric acid Substances 0.000 abstract 3
- 235000011149 sulphuric acid Nutrition 0.000 abstract 3
- 238000002360 preparation method Methods 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000008355 cartilage degradation Effects 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 210000004051 gastric juice Anatomy 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229960002119 raloxifene hydrochloride Drugs 0.000 abstract 1
- BKXVVCILCIUCLG-UHFFFAOYSA-N raloxifene hydrochloride Chemical compound [H+].[Cl-].C1=CC(O)=CC=C1C1=C(C(=O)C=2C=CC(OCCN3CCCCC3)=CC=2)C2=CC=C(O)C=C2S1 BKXVVCILCIUCLG-UHFFFAOYSA-N 0.000 abstract 1
- 210000002784 stomach Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200201450 | 2002-09-30 | ||
| PCT/DK2003/000645 WO2004029046A2 (en) | 2002-09-30 | 2003-09-30 | Novel raloxifene acid addition salts and/or solvates thereof, improved method for purification of said raloxifene acid addition salts and/or solvates thereof and pharmaceutical compositions comprising these |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20052100D0 NO20052100D0 (no) | 2005-04-29 |
| NO20052100L true NO20052100L (no) | 2005-06-29 |
Family
ID=32039058
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20052100A NO20052100L (no) | 2002-09-30 | 2005-04-29 | Raloksifensalt I |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7964734B2 (de) |
| EP (4) | EP1832583A1 (de) |
| AT (1) | ATE541840T1 (de) |
| AU (1) | AU2003266940B2 (de) |
| CA (1) | CA2499819A1 (de) |
| NO (1) | NO20052100L (de) |
| WO (1) | WO2004029046A2 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1832583A1 (de) | 2002-09-30 | 2007-09-12 | A/S GEA Farmaceutisk Fabrik | Neue Schwefelsäureadditionssalze aus Raloxifen und/oder Solvate daraus sowie pharmazeutische Zusammensetzungen damit |
| SG182849A1 (en) | 2003-04-25 | 2012-08-30 | Gilead Sciences Inc | Antiviral phosphonate analogs |
| PT2258376T (pt) | 2004-07-27 | 2019-05-31 | Gilead Sciences Inc | Análogos fosfonatados de compostos inibidores do vih |
| JP5508003B2 (ja) | 2006-06-30 | 2014-05-28 | アイスイティカ ピーティーワイ リミテッド | ナノ粒子状の形態における生物学的に活性な化合物の調製のための方法 |
| GB2456096B (en) * | 2006-10-17 | 2011-08-17 | Cipla Ltd | Crystalline form of benzothiophene compound and process for preparation thereof |
| JP4825697B2 (ja) | 2007-01-25 | 2011-11-30 | 株式会社ミツトヨ | デジタル式変位測定器 |
| BRPI0915878A2 (pt) | 2008-07-08 | 2015-11-03 | Gilead Sciences Inc | sais ou hidratos de compostos inibidores de hiv, seu uso e composição farmacêutica que os compreende |
| NZ710384A (en) | 2009-04-24 | 2017-03-31 | Iceutica Pty Ltd | A novel formulation of indomethacin |
| CA2759109A1 (en) | 2009-04-24 | 2010-10-28 | Iceutica Pty Ltd | A solid dosage form of ciprofloxacin having small particle size and improved powder handling characteristics |
| WO2011099942A1 (en) | 2010-02-09 | 2011-08-18 | Silverstone Pharma | New addition salts of raloxifene, process for the preparation thereof and use thereof in therapy |
| IN2013MU00665A (de) | 2013-03-05 | 2015-07-03 | Cipla Ltd | |
| US9526734B2 (en) | 2014-06-09 | 2016-12-27 | Iceutica Pty Ltd. | Formulation of meloxicam |
| PT3661937T (pt) | 2017-08-01 | 2021-09-24 | Gilead Sciences Inc | Formas cristalinas de ((s)-((((2r,5r)-5-(6-amino-9h-purin-9-il)-4-fluoro-2,5-dihidrofurano-2-il)oxi)metil)(fenoxi)fosforil)-l-alaninato de etil (gs-9131) para tratamento de infeções virais |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
| GB2097788B (en) * | 1981-04-03 | 1985-04-24 | Lilly Co Eli | Benzothiophene compounds and process for preparing them |
| IL65378A (en) | 1981-04-03 | 1986-02-28 | Lilly Co Eli | Process for preparing 3-(4-aminoethoxybenzoyl)benzo-(b)thiophenes |
| US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
| IL65379A0 (en) | 1981-04-03 | 1982-05-31 | Lilly Co Eli | Process for preparing acylated benzothiophenes |
| TW366342B (en) | 1992-07-28 | 1999-08-11 | Lilly Co Eli | The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss |
| US5418252A (en) * | 1993-10-15 | 1995-05-23 | Eli Lilly And Company | Method for inhibiting cartilage degradation |
| US5478847A (en) | 1994-03-02 | 1995-12-26 | Eli Lilly And Company | Methods of use for inhibiting bone loss and lowering serum cholesterol |
| IL112746A (en) | 1994-03-02 | 1999-12-31 | Lilly Co Eli | Orally administrable pharmaceutical formulation comprising raloxifene hydrochoride |
| CA2145614A1 (en) | 1994-03-31 | 1995-10-01 | Jeffrey A. Dodge | Intermediates and processes for preparing benzothiophene compounds |
| US5420349A (en) | 1994-06-10 | 1995-05-30 | Eli Lilly And Company | 2-amino-3-aroyl-benzo[β]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-]benzo[4-(2-aminoethoxy)-benzoyl[β]thiophenes |
| US5523416A (en) | 1994-07-22 | 1996-06-04 | Eli Lilly And Company | Process for preparing 3-(4-aminoethoxy-benzoyl) benzo (B)-thiophenes |
| US5731436A (en) | 1994-08-31 | 1998-03-24 | Eli Lilly And Company | Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents |
| US5631369A (en) | 1994-08-31 | 1997-05-20 | Eli Lilly And Company | Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents |
| CO4410191A1 (es) | 1994-09-19 | 1997-01-09 | Lilly Co Eli | SINTESIS DE 3-[4-(2-AMINOETOXI)BENZOIL]-2-ARIL-6- HIDROXIBENZO [b] TIOFENOS |
| TR199801495T2 (xx) | 1995-06-07 | 1998-09-21 | Eli Lilly And Company | Vinil s�lfoksitler ve sentezlenmeleri i�in bir i�lem. |
| CZ387997A3 (cs) | 1995-06-07 | 1998-09-16 | Eli Lilly And Company | Způsob syntézy derivátů kyseliny vinylsulfenové |
| US5606076A (en) | 1995-06-07 | 1997-02-25 | Eli Lilly And Company | Process for the synthesis of benzo[b]thiophenes |
| US5569772A (en) | 1995-06-07 | 1996-10-29 | Eli Lilly And Company | Process for the synthesis of benzo[b]thiophenes |
| US5606075A (en) | 1995-06-07 | 1997-02-25 | Eli Lilly And Company | Process for the synthesis of benzo[b]thiophenes |
| PT791591E (pt) | 1996-02-22 | 2001-12-28 | Lilly Co Eli | Benzotiofenos, formulacoes que os contem e metodos |
| AU5258696A (en) | 1996-03-19 | 1997-10-10 | Eli Lilly And Company | Synthesis of 3-{4-(2-aminoethoxy)-benzoyl}-2-aryl-6-hydroxy-benzo{b}thiop henes |
| JP2000507268A (ja) * | 1996-03-26 | 2000-06-13 | イーライ・リリー・アンド・カンパニー | ベンゾチオフェン類、それを含む製剤、および方法 |
| JP2002514174A (ja) | 1996-08-28 | 2002-05-14 | イーライ・リリー・アンド・カンパニー | 非晶質ベンゾチオフェン類、製造方法および使用方法 |
| CA2265950A1 (en) | 1996-09-25 | 1998-04-02 | Merck Sharp & Dohme Limited | Spiro-azacyclic derivatives and their use as therapeutic agents |
| ZA9710262B (en) | 1996-11-19 | 1999-05-13 | Lilly Co Eli | Process for the synthesis of benzothiophenes |
| CN1254280A (zh) | 1997-04-30 | 2000-05-24 | 伊莱利利公司 | 用于制备取代的苯并[b]噻吩的区域选择性烷基化方法 |
| CA2231013A1 (en) * | 1997-04-30 | 1998-10-30 | Eli Lilly And Company | Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceuticals |
| CN1252717A (zh) | 1997-04-30 | 2000-05-10 | 伊莱利利公司 | 制备苯并[b]噻吩的中间体和方法 |
| JP2001522372A (ja) | 1997-04-30 | 2001-11-13 | イーライ・リリー・アンド・カンパニー | ベンゾチオフェンの製造方法 |
| CA2236254A1 (en) * | 1997-04-30 | 1998-10-30 | David Warren Hoard | Process for preparing benzo¬b|thiophenes |
| CA2287922A1 (en) | 1997-04-30 | 1998-11-05 | Eli Lilly And Company | Intermediates and processes for preparing benzo[b]thiophenes |
| WO2000004880A1 (en) | 1998-07-23 | 2000-02-03 | Novo Nordisk A/S | A wet granulation method for preparing a stable pharmaceutical formulation |
| FI982733L (fi) * | 1998-12-17 | 2000-06-18 | Orion Yhtymae Oyj | Trifenyylietyleeniantiestrogeenien liukoisia koostumuksia |
| US6294192B1 (en) | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
| WO2001023369A2 (en) | 1999-09-27 | 2001-04-05 | Eli Lilly And Company | Process for preparing benzoic acids |
| AU2002230409A1 (en) | 2000-11-27 | 2002-06-03 | Eli Lilly And Company | Process for preparing 3-aryl-benzo(b)thiophenes |
| AU2002228593A8 (en) | 2000-11-27 | 2008-06-12 | Lilly Co Eli | Process for preparing alpha-(3-arylthio)-acetophenones |
| EP1832583A1 (de) | 2002-09-30 | 2007-09-12 | A/S GEA Farmaceutisk Fabrik | Neue Schwefelsäureadditionssalze aus Raloxifen und/oder Solvate daraus sowie pharmazeutische Zusammensetzungen damit |
| ITMI20031333A1 (it) | 2003-06-30 | 2005-01-01 | Erregierre Spa | Processo di preparazione di raloxifene cloridrato. |
-
2003
- 2003-09-30 EP EP07108498A patent/EP1832583A1/de not_active Withdrawn
- 2003-09-30 EP EP03747847A patent/EP1546138B1/de not_active Expired - Lifetime
- 2003-09-30 EP EP07108497A patent/EP1826205A1/de not_active Withdrawn
- 2003-09-30 AT AT03747847T patent/ATE541840T1/de active
- 2003-09-30 WO PCT/DK2003/000645 patent/WO2004029046A2/en not_active Ceased
- 2003-09-30 US US10/528,691 patent/US7964734B2/en not_active Expired - Fee Related
- 2003-09-30 EP EP07108496A patent/EP1832582A1/de not_active Withdrawn
- 2003-09-30 AU AU2003266940A patent/AU2003266940B2/en not_active Ceased
- 2003-09-30 CA CA002499819A patent/CA2499819A1/en not_active Abandoned
-
2005
- 2005-04-29 NO NO20052100A patent/NO20052100L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1832583A1 (de) | 2007-09-12 |
| EP1826205A1 (de) | 2007-08-29 |
| WO2004029046A2 (en) | 2004-04-08 |
| EP1546138B1 (de) | 2012-01-18 |
| AU2003266940C1 (en) | 2004-04-19 |
| WO2004029046A3 (en) | 2004-10-14 |
| US20060154966A1 (en) | 2006-07-13 |
| US7964734B2 (en) | 2011-06-21 |
| AU2003266940A1 (en) | 2004-04-19 |
| AU2003266940B9 (en) | 2004-04-19 |
| NO20052100D0 (no) | 2005-04-29 |
| EP1832582A1 (de) | 2007-09-12 |
| AU2003266940B2 (en) | 2007-02-08 |
| CA2499819A1 (en) | 2004-04-08 |
| EP1546138A2 (de) | 2005-06-29 |
| ATE541840T1 (de) | 2012-02-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |