NO20055849L - Nye polyetylenglykolmodifiserte forbindelser og anvendelse av slike - Google Patents
Nye polyetylenglykolmodifiserte forbindelser og anvendelse av slikeInfo
- Publication number
- NO20055849L NO20055849L NO20055849A NO20055849A NO20055849L NO 20055849 L NO20055849 L NO 20055849L NO 20055849 A NO20055849 A NO 20055849A NO 20055849 A NO20055849 A NO 20055849A NO 20055849 L NO20055849 L NO 20055849L
- Authority
- NO
- Norway
- Prior art keywords
- moiety
- peptide
- polyethylene glycol
- glycol modified
- modified compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47024603P | 2003-05-12 | 2003-05-12 | |
| PCT/US2004/014888 WO2004101600A2 (en) | 2003-05-12 | 2004-05-12 | Novel poly(ethylene glycol) modified compounds and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20055849L true NO20055849L (no) | 2006-02-13 |
Family
ID=33452386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20055849A NO20055849L (no) | 2003-05-12 | 2005-12-09 | Nye polyetylenglykolmodifiserte forbindelser og anvendelse av slike |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20050107297A1 (de) |
| EP (2) | EP2336162A1 (de) |
| JP (2) | JP2007530440A (de) |
| KR (1) | KR20060028675A (de) |
| CN (1) | CN1820024B (de) |
| AT (1) | ATE478093T1 (de) |
| AU (1) | AU2004238869B2 (de) |
| BR (1) | BRPI0411160A (de) |
| CA (1) | CA2525464A1 (de) |
| DE (1) | DE602004028725D1 (de) |
| EA (1) | EA010016B1 (de) |
| IS (1) | IS8169A (de) |
| MX (1) | MXPA05012315A (de) |
| NO (1) | NO20055849L (de) |
| NZ (1) | NZ544024A (de) |
| WO (1) | WO2004101600A2 (de) |
Families Citing this family (115)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA05012314A (es) * | 2003-05-12 | 2006-04-18 | Affymax Inc | Radical separador para peptido modificado con polietilenglicol. |
| PT1629007E (pt) * | 2003-05-12 | 2009-05-06 | Affymax Inc | Péptidos novos que se ligam ao receptor da eritropoietina |
| DK1625156T3 (da) | 2003-05-12 | 2013-01-07 | Affymax Inc | Peptider, der bindes til erythropoietinreceptoren |
| US7710923B2 (en) * | 2004-05-07 | 2010-05-04 | Interdigital Technology Corporation | System and method for implementing a media independent handover |
| US7589063B2 (en) | 2004-12-14 | 2009-09-15 | Aplagen Gmbh | Molecules which promote hematopoiesis |
| US7632921B2 (en) | 2004-11-12 | 2009-12-15 | Bayer Healthcare Llc | Site-directed modification of FVIII |
| US7824919B2 (en) * | 2005-03-04 | 2010-11-02 | Dr. Reddy's Laboratories Limited | Method for analyzing activated polyethylene glycol compounds |
| US7550433B2 (en) | 2005-06-03 | 2009-06-23 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
| JP2008546732A (ja) * | 2005-06-23 | 2008-12-25 | アプラゲン ゲーエムベーハー | 多価化合物 |
| CN101002945B (zh) * | 2006-01-20 | 2012-09-05 | 清华大学 | 一种用于肿瘤治疗的新型复合物 |
| RU2008137796A (ru) | 2006-02-23 | 2010-03-27 | Фибрекс Медикал Рисерч Энд Девелопмент Гмбх (At) | Пептиды и производные пептидов, а также содержащие их фармацевтические композиции |
| SG170086A1 (en) * | 2006-03-09 | 2011-04-29 | Aplagen Gmbh De | Modified molecules which promote hematopoiesis |
| EP3669894A3 (de) | 2006-06-30 | 2020-08-26 | Syntab Therapeutics GmbH | Neuartige multifunktionale verbindungen für pharmazeutische zwecke |
| EP2118127A4 (de) | 2007-01-31 | 2010-12-01 | Affymax Inc | Linker auf stickstoffbasis zur bindung modifizierender gruppen an polypeptide und andere makromoleküle |
| MX2009008104A (es) * | 2007-02-02 | 2009-08-07 | Amgen Inc | Hepcidina, antagonistas de hepcidina y metodos de uso. |
| US8420598B2 (en) * | 2007-04-20 | 2013-04-16 | B & L Delipharm Corp. | Mono modified exendin with polyethylene glycol or its derivatives and uses thereof |
| WO2009002947A2 (en) * | 2007-06-22 | 2008-12-31 | Affymax, Inc. | Compounds and peptides that bind the trail receptor |
| EP2018835B1 (de) | 2007-07-09 | 2014-03-05 | Augustinus Bader | Wirkstoff abgebendes Pflaster |
| WO2009043049A2 (en) * | 2007-09-27 | 2009-04-02 | Amgen Inc. | Pharmaceutical formulations |
| WO2009064838A1 (en) | 2007-11-15 | 2009-05-22 | Amgen, Inc. | Aqueous formulation of erythropoiesis stimulating protein stablised by antioxidants for parenteral administration |
| CN101456911A (zh) * | 2007-12-12 | 2009-06-17 | 江苏豪森药业股份有限公司 | 促红细胞生成素模拟肽衍生物及其可药用盐和其制备方法与用途 |
| CA2711826C (en) | 2008-01-25 | 2018-02-27 | Amgen Inc. | Ferroportin antibodies and methods of use |
| US9315577B2 (en) | 2008-05-01 | 2016-04-19 | Amgen Inc. | Anti-hepcidin antibodies and methods of use |
| US8088890B2 (en) | 2008-09-26 | 2012-01-03 | Fibrex Medical Research & Development Gmbh | Peptides and peptidomimetic compounds, the manufacturing thereof as well as their use for preparing a therapeutically and/or preventively active pharmaceutical composition |
| US8318167B2 (en) | 2008-11-13 | 2012-11-27 | The General Hospital Corporation | Methods and compositions for regulating iron homeostasis by modulation of BMP-6 |
| ES2534947T3 (es) | 2009-03-25 | 2015-04-30 | The Board Of Regents Of The University Of Texas System | Composiciones para la estimulación de resistencia inmunitaria innata de mamíferos a patógenos |
| MX344382B (es) | 2009-10-23 | 2016-12-14 | Amgen Inc * | Adaptador de vial y sistema. |
| HUE026173T2 (en) | 2010-06-07 | 2016-05-30 | Amgen Inc | pharmaceutical Pump |
| DK2590666T3 (en) | 2010-07-06 | 2017-07-17 | Augustinus Bader | TOPICAL APPLICATION OF ERYTHROPOIETIN FOR USE IN THE TREATMENT OF DAMAGE OF THE CORNS |
| AU2012236573B2 (en) | 2011-03-31 | 2016-06-02 | Amgen Inc. | Vial adapter and system |
| TR201905991T4 (tr) | 2011-04-20 | 2019-05-21 | Amgen Inc | Oto enjektör aparatı. |
| EP3045188B1 (de) | 2011-10-14 | 2020-12-23 | Amgen Inc. | Injektor und verfahren zur montage |
| EP2922590B1 (de) | 2012-11-21 | 2020-02-05 | Amgen Inc. | Arzneimittelabgabevorrichtung |
| KR102218494B1 (ko) | 2013-03-15 | 2021-02-19 | 인트린식 라이프사이언시스, 엘엘씨 | 항-헵시딘 항체 및 그의 용도 |
| TWI614041B (zh) | 2013-03-15 | 2018-02-11 | 安美基公司 | 用於注射器之匣盒 |
| US10092703B2 (en) | 2013-03-15 | 2018-10-09 | Amgen Inc. | Drug cassette, autoinjector, and autoinjector system |
| SG11201507417RA (en) | 2013-03-15 | 2015-10-29 | Amgen Inc | Body contour adaptable autoinjector device |
| EP2976117B1 (de) | 2013-03-22 | 2020-12-30 | Amgen Inc. | Injektor und verfahren zur montage |
| EP3957345B1 (de) | 2013-10-24 | 2025-12-10 | Amgen Inc. | Arzneimittelabgabesystem mit temperaturempfindlicher steuerung |
| CA2920894C (en) | 2013-10-24 | 2023-03-14 | Amgen Inc. | Injector and method of assembly |
| US10994112B2 (en) | 2014-02-05 | 2021-05-04 | Amgen Inc. | Drug delivery system with electromagnetic field generator |
| MX388536B (es) | 2014-05-07 | 2025-03-20 | Amgen Inc | Autoinyector con elementos reductores del shock. |
| CN106470717B (zh) | 2014-06-03 | 2020-09-11 | 安姆根有限公司 | 药物递送系统和使用方法 |
| WO2016044839A2 (en) | 2014-09-19 | 2016-03-24 | The Board Of Regents Of The University Of Texas System | Compositions and methods for treating viral infections through stimulated innate immunity in combination with antiviral compounds |
| AU2015321462B2 (en) | 2014-09-22 | 2020-04-30 | Intrinsic Lifesciences Llc | Humanized anti-hepcidin antibodies and uses thereof |
| AU2015332557B2 (en) | 2014-10-14 | 2020-05-14 | Amgen Inc. | Drug injection device with visual and audio indicators |
| ES2785311T3 (es) | 2014-12-19 | 2020-10-06 | Amgen Inc | Dispositivo de administración de fármacos con botón móvil o campo de interfaz de usuario |
| EP3848072A1 (de) | 2014-12-19 | 2021-07-14 | Amgen Inc. | Medikamentenabgabevorrichtung mit näherungssensor |
| CA3069716C (en) | 2015-02-17 | 2021-11-09 | Amgen Inc. | Drug delivery device with vacuum assisted securement and/or feedback |
| EP3261690B1 (de) | 2015-02-27 | 2021-12-15 | Amgen Inc. | Arzneimittelabgabevorrichtung mit nadelschutzmechanismus mit abstimmbarem widerstandsschwellwert gegenüber der bewegung des nadelschutzes |
| WO2017039786A1 (en) | 2015-09-02 | 2017-03-09 | Amgen Inc. | Syringe assembly adapter for a syringe |
| WO2017100501A1 (en) | 2015-12-09 | 2017-06-15 | Amgen Inc. | Auto-injector with signaling cap |
| US11154661B2 (en) | 2016-01-06 | 2021-10-26 | Amgen Inc. | Auto-injector with signaling electronics |
| WO2017160799A1 (en) | 2016-03-15 | 2017-09-21 | Amgen Inc. | Reducing probability of glass breakage in drug delivery devices |
| WO2017189089A1 (en) | 2016-04-29 | 2017-11-02 | Amgen Inc. | Drug delivery device with messaging label |
| US11389588B2 (en) | 2016-05-02 | 2022-07-19 | Amgen Inc. | Syringe adapter and guide for filling an on-body injector |
| AU2017263558B2 (en) | 2016-05-13 | 2022-12-22 | Amgen Inc. | Vial sleeve assembly |
| EP3458988B1 (de) | 2016-05-16 | 2023-10-18 | Amgen Inc. | Datenverschlüsselung in medizinischen vorrichtungen mit eingeschränkter rechenfähigkeit |
| GB201609083D0 (en) | 2016-05-24 | 2016-07-06 | Syntab Therapeutics Gmbh | Synthetic compound |
| WO2017209899A1 (en) | 2016-06-03 | 2017-12-07 | Amgen Inc. | Impact testing apparatuses and methods for drug delivery devices |
| WO2018004842A1 (en) | 2016-07-01 | 2018-01-04 | Amgen Inc. | Drug delivery device having minimized risk of component fracture upon impact events |
| GB201613166D0 (en) * | 2016-07-29 | 2016-09-14 | Vectura Ltd | Polymer |
| US20190328965A1 (en) | 2016-08-17 | 2019-10-31 | Amgen Inc. | Drug delivery device with placement detection |
| WO2018081234A1 (en) | 2016-10-25 | 2018-05-03 | Amgen Inc. | On-body injector |
| JP2020503976A (ja) | 2017-01-17 | 2020-02-06 | アムジエン・インコーポレーテツド | 注入デバイスならびに関連する使用および組立方法 |
| EP3582829A1 (de) | 2017-02-17 | 2019-12-25 | Amgen Inc. | Einführmechanismus für eine arzneimittelabgabevorrichtung |
| MX2019009625A (es) | 2017-02-17 | 2019-10-09 | Amgen Inc | Dispositivo de administracion de farmacos con trayectoria de flujo de fluido esteril y metodo relacionado de ensamblaje. |
| EP3592403B1 (de) | 2017-03-06 | 2025-08-20 | Amgen Inc. | Wirkstofffreisetzungsvorrichtung mit aktivierungsverhinderungsfunktion |
| CA3052482A1 (en) | 2017-03-07 | 2018-09-13 | Amgen Inc. | Needle insertion by overpressure |
| AU2018230486B2 (en) | 2017-03-09 | 2023-05-11 | Amgen Inc. | Insertion mechanism for drug delivery device |
| EP3570871B1 (de) | 2017-03-20 | 2020-11-18 | H. Hoffnabb-La Roche Ag | Verfahren für in-vitro-glyco-engineering eines erythropoiesestimulierenden proteins |
| CN118743804A (zh) | 2017-03-28 | 2024-10-08 | 美国安进公司 | 柱塞杆和注射器组件系统以及方法 |
| AU2018280054B2 (en) | 2017-06-08 | 2023-07-13 | Amgen Inc. | Syringe assembly for a drug delivery device and method of assembly |
| CA3066399A1 (en) | 2017-06-08 | 2018-12-13 | Amgen Inc. | Torque driven drug delivery device |
| AU2018288604B2 (en) | 2017-06-22 | 2023-12-21 | Amgen Inc. | Device activation impact/shock reduction |
| MA49461A (fr) | 2017-06-23 | 2020-04-29 | Amgen Inc | Dispositif électronique d'administration de médicament comprenant un bouchon activé par un ensemble commutateur |
| MA49562A (fr) | 2017-07-14 | 2020-05-20 | Amgen Inc | Système d'insertion-rétractation d'aiguille présentant un système à ressort en double torsion |
| US11672733B2 (en) | 2017-07-21 | 2023-06-13 | Amgen Inc. | Gas permeable sealing member for drug container and methods of assembly |
| US11484648B2 (en) | 2017-07-25 | 2022-11-01 | Amgen Inc. | Drug delivery device with container access system and related method of assembly |
| JP2020528296A (ja) | 2017-07-25 | 2020-09-24 | アムジエン・インコーポレーテツド | ギヤモジュールを有する薬物送達デバイス及び関連する組立方法 |
| WO2019032482A2 (en) | 2017-08-09 | 2019-02-14 | Amgen Inc. | HYDRAULIC-PNEUMATIC PRESSURE CHAMBER DELIVERY SYSTEM |
| WO2019036181A1 (en) | 2017-08-18 | 2019-02-21 | Amgen Inc. | BODY INJECTOR WITH STERILE ADHESIVE PATCH |
| US11103636B2 (en) | 2017-08-22 | 2021-08-31 | Amgen Inc. | Needle insertion mechanism for drug delivery device |
| ES2939292T3 (es) | 2017-10-04 | 2023-04-20 | Amgen Inc | Adaptador de flujo para dispositivo de administración de fármacos |
| EP4257164A3 (de) | 2017-10-06 | 2024-01-17 | Amgen Inc. | Arzneimittelabgabevorrichtung mit verriegelungsvorrichtung und zugehöriges montageverfahren |
| EP3694578B1 (de) | 2017-10-09 | 2025-09-24 | Amgen Inc. | Arzneimittelabgabevorrichtung mit antriebsanordnung sowie zugehöriges verfahren zur montage |
| MA50528A (fr) | 2017-11-03 | 2020-09-09 | Amgen Inc | Systèmes et approches pour stériliser un dispositif d'administration de médicament |
| US12053618B2 (en) | 2017-11-06 | 2024-08-06 | Amgen Inc. | Fill-finish assemblies and related methods |
| WO2019089178A1 (en) | 2017-11-06 | 2019-05-09 | Amgen Inc. | Drug delivery device with placement and flow sensing |
| IL319987A (en) | 2017-11-10 | 2025-06-01 | Amgen Inc | Plungers for drug delivery devices |
| JP7747438B2 (ja) | 2017-11-16 | 2025-10-01 | アムジエン・インコーポレーテツド | 失速及び終点検出を有するオートインジェクタ |
| SG11202003004RA (en) | 2017-11-16 | 2020-04-29 | Amgen Inc | Door latch mechanism for drug delivery device |
| US10835685B2 (en) | 2018-05-30 | 2020-11-17 | Amgen Inc. | Thermal spring release mechanism for a drug delivery device |
| US11083840B2 (en) | 2018-06-01 | 2021-08-10 | Amgen Inc. | Modular fluid path assemblies for drug delivery devices |
| US12042645B2 (en) | 2018-07-24 | 2024-07-23 | Amgen Inc. | Delivery devices for administering drugs |
| US12115360B2 (en) | 2018-07-24 | 2024-10-15 | Amgen Inc. | Hybrid drug delivery devices with grip portion |
| US12303677B2 (en) | 2018-07-24 | 2025-05-20 | Amgen Inc. | Hybrid drug delivery devices with optional grip portion and related method of preparation |
| MX2021000749A (es) | 2018-07-24 | 2021-03-29 | Amgen Inc | Dispositivos de suministro para administrar farmacos. |
| EP3829692A1 (de) | 2018-07-31 | 2021-06-09 | Amgen Inc. | Flüssigkeitsweganordnungen für wirkstofffreisetzungsvorrichtung |
| US20210346601A1 (en) | 2018-09-24 | 2021-11-11 | Amgen Inc. | Interventional dosing systems and methods |
| EP3856283A1 (de) | 2018-09-28 | 2021-08-04 | Amgen Inc. | Anordnung zur aktivierung des muskeldrahtvorschubs für eine medikamentenabgabevorrichtung |
| AU2019352616B2 (en) | 2018-10-02 | 2024-10-10 | Amgen Inc. | Injection systems for drug delivery with internal force transmission |
| US12151089B2 (en) | 2018-10-05 | 2024-11-26 | Amgen Inc. | Drug delivery device having dose indicator |
| SG11202103800RA (en) | 2018-10-15 | 2021-05-28 | Amgen Inc | Drug delivery device having damping mechanism |
| JP2022504805A (ja) | 2018-10-15 | 2022-01-13 | アムジエン・インコーポレーテツド | 薬物送達デバイスのプラットフォーム式組み立てプロセス |
| TWI831847B (zh) | 2018-11-01 | 2024-02-11 | 美商安進公司 | 部分針頭縮回之藥物遞送裝置及其操作方法 |
| US11213620B2 (en) | 2018-11-01 | 2022-01-04 | Amgen Inc. | Drug delivery devices with partial drug delivery member retraction |
| AU2019370159B2 (en) | 2018-11-01 | 2025-05-29 | Amgen Inc. | Drug delivery devices with partial drug delivery member retraction |
| JP7510952B2 (ja) | 2019-04-24 | 2024-07-04 | アムジエン・インコーポレーテツド | シリンジ滅菌確認アセンブリ及び方法 |
| JP7608439B2 (ja) | 2019-08-23 | 2025-01-06 | アムジエン・インコーポレーテツド | 構成可能な針シールド係合構成要素を備えた薬物送達デバイス及び関連方法 |
| WO2021188966A1 (en) * | 2020-03-19 | 2021-09-23 | Massachusetts Institute Of Technology | Sars-cov-2 spike protein binding peptides |
| CA3217207A1 (en) | 2021-05-21 | 2022-11-24 | Amgen Inc. | Method of optimizing a filling recipe for a drug container |
| EP4612312A1 (de) | 2022-11-02 | 2025-09-10 | F. Hoffmann-La Roche AG | Verfahren zur herstellung von glycoproteinzusammensetzungen |
| WO2025262329A1 (en) | 2024-06-21 | 2025-12-26 | Syntab Therapeutics Gmbh | Synthetic molecules comprising tlr2 ligands |
| WO2026030152A1 (en) | 2024-07-29 | 2026-02-05 | Amgen Inc. | System and method for assessing transferability of a fill recipe |
Family Cites Families (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US469993A (en) | 1892-03-01 | Bolt and nut fastening device | ||
| US479245A (en) | 1892-07-19 | Cartridge-reloader | ||
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| NZ210501A (en) * | 1983-12-13 | 1991-08-27 | Kirin Amgen Inc | Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence |
| KR850004274A (ko) * | 1983-12-13 | 1985-07-11 | 원본미기재 | 에리트로포이에틴의 제조방법 |
| US4677195A (en) * | 1985-01-11 | 1987-06-30 | Genetics Institute, Inc. | Method for the purification of erythropoietin and erythropoietin compositions |
| NL8720442A (nl) | 1986-08-18 | 1989-04-03 | Clinical Technologies Ass | Afgeefsystemen voor farmacologische agentia. |
| US5006333A (en) * | 1987-08-03 | 1991-04-09 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
| IE64284B1 (en) * | 1987-08-03 | 1995-07-26 | Ddi Pharmaceuticals | Conjugates of superoxide dismutase |
| US5080891A (en) * | 1987-08-03 | 1992-01-14 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
| US5114921A (en) * | 1988-05-27 | 1992-05-19 | The Children's Hospital Of Philadelphia | Amphiphilic peptides and use thereof |
| JP2989002B2 (ja) | 1988-12-22 | 1999-12-13 | キリン―アムジエン・インコーポレーテツド | 化学修飾顆粒球コロニー刺激因子 |
| WO1990008822A1 (en) * | 1989-02-03 | 1990-08-09 | Genetics Institute, Inc. | Erythropoietin receptor |
| US5324844A (en) | 1989-04-19 | 1994-06-28 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
| US5166322A (en) | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
| ES2085297T3 (es) * | 1989-05-27 | 1996-06-01 | Sumitomo Pharma | Procedimiento para preparar derivados de poli(etilenglicol) y proteina modificada. |
| US5286637A (en) * | 1989-08-07 | 1994-02-15 | Debiopharm, S.A. | Biologically active drug polymer derivatives and method for preparing same |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5292654A (en) * | 1990-12-13 | 1994-03-08 | Whitehead Institute For Biomedical Research | Mutant EPO receptor and uses therefor |
| AU643141B2 (en) | 1991-03-15 | 1993-11-04 | Amgen, Inc. | Pulmonary administration of granulocyte colony stimulating factor |
| DE69233069T2 (de) * | 1991-03-15 | 2003-11-27 | Amgen Inc., Thousand Oaks | Pegylation von polypeptiden |
| US5206219A (en) * | 1991-11-25 | 1993-04-27 | Applied Analytical Industries, Inc. | Oral compositions of proteinaceous medicaments |
| US5614184A (en) * | 1992-07-28 | 1997-03-25 | New England Deaconess Hospital | Recombinant human erythropoietin mutants and therapeutic methods employing them |
| US6153407A (en) * | 1992-07-28 | 2000-11-28 | Beth Israel Deaconess Medical Center | Erythropoietin DNA having modified 5' and 3' sequences and its use to prepare EPO therapeutics |
| US5919455A (en) * | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| CN1090684C (zh) | 1993-11-16 | 2002-09-11 | 帝国化学工业澳大利亚作业有限公司 | 带有锌或锌铝合金镀层的钢表面处理方法 |
| US5830851A (en) * | 1993-11-19 | 1998-11-03 | Affymax Technologies N.V. | Methods of administering peptides that bind to the erythropoietin receptor |
| US5773569A (en) | 1993-11-19 | 1998-06-30 | Affymax Technologies N.V. | Compounds and peptides that bind to the erythropoietin receptor |
| US5919758A (en) * | 1994-03-22 | 1999-07-06 | Beth Israel Deaconess Medical Center | Modified polypeptides with altered biological activity |
| US5747446A (en) * | 1994-03-22 | 1998-05-05 | Beth Israel Deaconess Medical Center | Modified polypeptides with increased biological activity |
| US5580853A (en) * | 1994-03-22 | 1996-12-03 | New England Deaconess Hospital | Modified polypeptides with increased biological activity |
| US5451569A (en) | 1994-04-19 | 1995-09-19 | Hong Kong University Of Science And Technology R & D Corporation Limited | Pulmonary drug delivery system |
| JP2763020B2 (ja) | 1995-04-27 | 1998-06-11 | 日本電気株式会社 | 半導体パッケージ及び半導体装置 |
| US5677280A (en) | 1995-06-07 | 1997-10-14 | Glaxo Group Limited | Peptides and compounds that bind to the IL-5 receptor |
| US5683983A (en) | 1995-06-07 | 1997-11-04 | Glaxo Group Limited | Peptides and compounds that bind to the IL-5 receptor |
| US5654276A (en) | 1995-06-07 | 1997-08-05 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-5 receptor |
| US5869451A (en) | 1995-06-07 | 1999-02-09 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
| US5668110A (en) | 1995-06-07 | 1997-09-16 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-5 receptor |
| US6251864B1 (en) * | 1995-06-07 | 2001-06-26 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
| EP0886648B8 (de) | 1995-06-07 | 2004-03-03 | Ortho Pharmaceutical Corporation | An den erythropoietin-rezeptor bindende zusammensetzungen und peptide |
| ES2303338T3 (es) | 1995-06-07 | 2008-08-01 | Glaxo Group Limited | Peptidos y compuestos que se unen a un receptor de trombopoyetina. |
| US5767078A (en) | 1995-06-07 | 1998-06-16 | Johnson; Dana L. | Agonist peptide dimers |
| US5672662A (en) | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
| SE9503380D0 (sv) * | 1995-09-29 | 1995-09-29 | Pharmacia Ab | Protein derivatives |
| US6346390B1 (en) | 1996-03-08 | 2002-02-12 | Receptron, Inc. | Receptor derived peptides involved in modulation of response to ligand binding |
| US6103879A (en) * | 1996-06-21 | 2000-08-15 | Axys Pharmaceuticals, Inc. | Bivalent molecules that form an activating complex with an erythropoietin receptor |
| AU3908597A (en) | 1996-08-02 | 1998-02-25 | Ortho-Mcneil Pharmaceutical, Inc. | Polypeptides having a single covalently bound n-terminal water-soluble polymer |
| US5932546A (en) | 1996-10-04 | 1999-08-03 | Glaxo Wellcome Inc. | Peptides and compounds that bind to the thrombopoietin receptor |
| US6221608B1 (en) * | 1997-01-22 | 2001-04-24 | Ortho Pharmaceutical Corporation | Methods for identifying erythropoietin receptor binding protein |
| CA2338665C (en) * | 1998-08-06 | 2011-01-18 | Mountain View Pharmaceuticals, Inc. | Peg-urate oxidase conjugates and use thereof |
| US6783965B1 (en) * | 2000-02-10 | 2004-08-31 | Mountain View Pharmaceuticals, Inc. | Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates |
| DE69936322T2 (de) * | 1998-08-28 | 2008-02-21 | Amylin Pharmaceuticals, Inc., San Diego | Polyamideketten von genauer Länge und deren Konjugate mit Proteinen |
| US6660843B1 (en) * | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| DK2319928T3 (da) * | 1998-10-23 | 2013-06-24 | Kirin Amgen Inc | Dimere trombopoietiske peptidomimetika, der binder til MPL-receptor og har trombopoietisk aktivitet |
| AU1732900A (en) * | 1998-11-17 | 2000-06-05 | Ligand Pharmaceuticals Incorporated | Methods of treating thrombocytopenia |
| CZ299516B6 (cs) * | 1999-07-02 | 2008-08-20 | F. Hoffmann-La Roche Ag | Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem |
| JO2291B1 (en) * | 1999-07-02 | 2005-09-12 | اف . هوفمان لاروش ايه جي | Erythropoietin derivatives |
| AUPQ873300A0 (en) * | 2000-07-12 | 2000-08-03 | Medvet Science Pty. Ltd. | A binding motif of a receptor (2) |
| DE60032783T2 (de) * | 1999-09-24 | 2007-12-06 | Smithkline Beecham Corp. | Thrombopoietinmimetika |
| DE60025241T2 (de) * | 1999-09-27 | 2007-01-11 | Chugai Seiyaku K.K. | HäMOPOIETINREZEPTOR-PROTEIN, NR12 |
| US6703480B1 (en) | 1999-11-24 | 2004-03-09 | Palani Balu | Peptide dimers as agonists of the erythropoientin (EPO) receptor, and associated methods of synthesis and use |
| US6858630B2 (en) * | 1999-12-06 | 2005-02-22 | Smithkline Beecham Corporation | Naphthimidazole derivatives and their use as thrombopoietin mimetics |
| JP2004512258A (ja) * | 2000-03-21 | 2004-04-22 | ウィスコンシン アルムニ リサーチ ファンデイション | 生物系における細胞応答の調節のための方法および試薬 |
| US6777387B2 (en) * | 2000-03-31 | 2004-08-17 | Enzon Pharmaceuticals, Inc. | Terminally-branched polymeric linkers containing extension moieties and polymeric conjugates containing the same |
| EP1149906A1 (de) * | 2000-04-25 | 2001-10-31 | Pliva, Farmaceutska, Industrija, Dionicko Drustvo | Thrombopoietin Rezeptormodulations Peptide |
| ATE291436T2 (de) * | 2000-05-15 | 2005-04-15 | Hoffmann La Roche | Flüssige arzneizubereitung enthaltend ein erythropoietin derivat |
| NZ522924A (en) * | 2000-05-26 | 2004-12-24 | Ortho Mcneil Pharm Inc | Neuroprotective peptides |
| CZ2003311A3 (cs) * | 2000-08-02 | 2004-04-14 | Ortho-Mcneil Pharmaceutical, Inc. | Protivirová a protinádorová terapie za použití erythropoetinu |
| AU2001273385B2 (en) * | 2000-09-08 | 2005-04-07 | Gryphon Therapeutics, Inc. | Polymer-modified synthetic proteins |
| MXPA03005406A (es) * | 2000-12-20 | 2003-09-25 | Hoffmann La Roche | Conjugados de eritropoyetina. |
| US6531121B2 (en) * | 2000-12-29 | 2003-03-11 | The Kenneth S. Warren Institute, Inc. | Protection and enhancement of erythropoietin-responsive cells, tissues and organs |
| US7767643B2 (en) * | 2000-12-29 | 2010-08-03 | The Kenneth S. Warren Institute, Inc. | Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs |
| CA2437989A1 (en) * | 2001-02-20 | 2002-08-29 | Enzon, Inc. | Terminally-branched polymeric linkers and polymeric conjugates containing the same |
| FR2823220B1 (fr) * | 2001-04-04 | 2003-12-12 | Genodyssee | Nouveaux polynucleotides et polypeptides de l'erythropoietine (epo) |
| US20020169128A1 (en) * | 2001-04-09 | 2002-11-14 | Geroge Sigounas | Erythropoietin ameliorates chemotherapy-induced toxicity in vivo |
| DE60229958D1 (de) * | 2001-06-28 | 2009-01-02 | Mountain View Pharmaceuticals | Polymerstabilisierte proteinasen |
| US20030078372A1 (en) * | 2001-09-19 | 2003-04-24 | Scinopharm Singapore | Process for synthesizing peptides by using a PEG polymer support |
| US6784154B2 (en) * | 2001-11-01 | 2004-08-31 | University Of Utah Research Foundation | Method of use of erythropoietin to treat ischemic acute renal failure |
| UA78726C2 (en) * | 2001-11-01 | 2007-04-25 | Sciclone Pharmaceuticals Inc | Pharmaceutical composition of thymosin alpha 1 conjugated with polyethylene glycol, method for production, and method for treatment |
| US8129330B2 (en) * | 2002-09-30 | 2012-03-06 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
| RS20050502A (sr) * | 2002-12-26 | 2007-08-03 | Mountain View Pharmaceuticals Inc., | Polimerni konjugati interferona- beta sa povećanom biološkom aktivnošću |
| PL396711A1 (pl) * | 2002-12-26 | 2011-12-19 | Mountain View Pharmaceuticals, Inc. | Koniugaty polimerów z cytokinami, chemokinami, czynnikami wzrostu, hormonami polipeptydowymi i ich antagonistami, kompozycja farmaceutyczna i sposób zapobiegania, diagnozowania lub leczenia |
| MXPA05012314A (es) * | 2003-05-12 | 2006-04-18 | Affymax Inc | Radical separador para peptido modificado con polietilenglicol. |
| PT1629007E (pt) * | 2003-05-12 | 2009-05-06 | Affymax Inc | Péptidos novos que se ligam ao receptor da eritropoietina |
| DK1625156T3 (da) * | 2003-05-12 | 2013-01-07 | Affymax Inc | Peptider, der bindes til erythropoietinreceptoren |
-
2004
- 2004-05-12 CA CA002525464A patent/CA2525464A1/en not_active Abandoned
- 2004-05-12 EP EP10173110A patent/EP2336162A1/de not_active Withdrawn
- 2004-05-12 EP EP04760997A patent/EP1626983B8/de not_active Expired - Lifetime
- 2004-05-12 AU AU2004238869A patent/AU2004238869B2/en not_active Ceased
- 2004-05-12 MX MXPA05012315A patent/MXPA05012315A/es active IP Right Grant
- 2004-05-12 US US10/844,933 patent/US20050107297A1/en not_active Abandoned
- 2004-05-12 AT AT04760997T patent/ATE478093T1/de not_active IP Right Cessation
- 2004-05-12 JP JP2006532999A patent/JP2007530440A/ja active Pending
- 2004-05-12 CN CN2004800187578A patent/CN1820024B/zh not_active Expired - Fee Related
- 2004-05-12 DE DE602004028725T patent/DE602004028725D1/de not_active Expired - Lifetime
- 2004-05-12 NZ NZ544024A patent/NZ544024A/en not_active IP Right Cessation
- 2004-05-12 WO PCT/US2004/014888 patent/WO2004101600A2/en not_active Ceased
- 2004-05-12 BR BRPI0411160-5A patent/BRPI0411160A/pt not_active IP Right Cessation
- 2004-05-12 KR KR1020057021600A patent/KR20060028675A/ko not_active Ceased
- 2004-05-12 EA EA200501799A patent/EA010016B1/ru not_active IP Right Cessation
-
2005
- 2005-12-02 IS IS8169A patent/IS8169A/is unknown
- 2005-12-09 NO NO20055849A patent/NO20055849L/no not_active Application Discontinuation
-
2012
- 2012-04-13 JP JP2012092128A patent/JP2012158598A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2525464A1 (en) | 2004-11-25 |
| DE602004028725D1 (de) | 2010-09-30 |
| BRPI0411160A (pt) | 2006-07-11 |
| EP2336162A1 (de) | 2011-06-22 |
| NZ544024A (en) | 2009-06-26 |
| EA010016B1 (ru) | 2008-06-30 |
| AU2004238869A1 (en) | 2004-11-25 |
| MXPA05012315A (es) | 2006-04-18 |
| JP2007530440A (ja) | 2007-11-01 |
| JP2012158598A (ja) | 2012-08-23 |
| ATE478093T1 (de) | 2010-09-15 |
| AU2004238869B2 (en) | 2009-06-25 |
| EP1626983B1 (de) | 2010-08-18 |
| EP1626983B8 (de) | 2010-12-22 |
| EP1626983A2 (de) | 2006-02-22 |
| EA200501799A1 (ru) | 2006-08-25 |
| CN1820024B (zh) | 2011-06-22 |
| US20050107297A1 (en) | 2005-05-19 |
| IS8169A (is) | 2005-12-02 |
| WO2004101600A3 (en) | 2006-02-16 |
| WO2004101600A2 (en) | 2004-11-25 |
| CN1820024A (zh) | 2006-08-16 |
| KR20060028675A (ko) | 2006-03-31 |
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