NO20056060L - Polyetylenoksidbaserte filmer og legemiddelleveringssystemer fremstilt fra disse - Google Patents

Polyetylenoksidbaserte filmer og legemiddelleveringssystemer fremstilt fra disse

Info

Publication number
NO20056060L
NO20056060L NO20056060A NO20056060A NO20056060L NO 20056060 L NO20056060 L NO 20056060L NO 20056060 A NO20056060 A NO 20056060A NO 20056060 A NO20056060 A NO 20056060A NO 20056060 L NO20056060 L NO 20056060L
Authority
NO
Norway
Prior art keywords
polyethylene oxide
films
drug delivery
delivery systems
oxide based
Prior art date
Application number
NO20056060A
Other languages
English (en)
Inventor
Robert K Yang
Richard C Fuisz
Gary L Myers
Joseph M Fuisz
Original Assignee
Monosolrx Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monosolrx Llc filed Critical Monosolrx Llc
Publication of NO20056060L publication Critical patent/NO20056060L/no

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J5/00Manufacture of articles or shaped materials containing macromolecular substances
    • C08J5/18Manufacture of films or sheets
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02Polyalkylene oxides
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2371/00Characterised by the use of polyethers obtained by reactions forming an ether link in the main chain; Derivatives of such polymers
    • C08J2371/02Polyalkylene oxides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Manufacturing & Machinery (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Materials Engineering (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

Oppfinnelsen vedrører de filmprodukter og fremgangsmåter for disses preparering som demonstrerer en ikke-selvaggregerende ensartet heterogenitet. Helst desintegreres filmene i vann og de kan dannes ved en kontrollert tørkeprosess, eller annen prosess som opprettholder filmens påkrevde ensartethet. Filmene inneholder en polymerkomponent, som inkluderer polyetylenoksid valgfritt blandet med hydrofile celluloseholdige polymerer. Helst inneholder filmene også et farmasøytisk og/eller kosmetisk aktivt agens med ikke mer enn et 10% avvik av det aktive farmasøytiske agens og/eller kosmetiske aktive agens pr. enhet areal av filmen.
NO20056060A 2003-05-28 2005-12-20 Polyetylenoksidbaserte filmer og legemiddelleveringssystemer fremstilt fra disse NO20056060L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47390203P 2003-05-28 2003-05-28
PCT/US2004/017076 WO2006031209A1 (en) 2003-05-28 2004-05-28 Polyethylene oxide-based films and drug delivery systems made therefrom

Publications (1)

Publication Number Publication Date
NO20056060L true NO20056060L (no) 2006-02-07

Family

ID=35811416

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20056060A NO20056060L (no) 2003-05-28 2005-12-20 Polyetylenoksidbaserte filmer og legemiddelleveringssystemer fremstilt fra disse

Country Status (8)

Country Link
EP (3) EP2716284A3 (no)
JP (1) JP4795962B2 (no)
CN (2) CN102670568A (no)
AU (2) AU2004319243B2 (no)
BR (1) BRPI0410956A (no)
CA (1) CA2544776C (no)
NO (1) NO20056060L (no)
WO (1) WO2006031209A1 (no)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040234602A1 (en) 2001-09-21 2004-11-25 Gina Fischer Polymer release system
EP1429744A1 (en) 2001-09-21 2004-06-23 Egalet A/S Morphine polymer release system
US11207805B2 (en) 2001-10-12 2021-12-28 Aquestive Therapeutics, Inc. Process for manufacturing a resulting pharmaceutical film
US20080050422A1 (en) * 2001-10-12 2008-02-28 Monosolrx, Llc. Method of administering a film product containing a drug
US20110033542A1 (en) 2009-08-07 2011-02-10 Monosol Rx, Llc Sublingual and buccal film compositions
US8900497B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for making a film having a substantially uniform distribution of components
US20070281003A1 (en) 2001-10-12 2007-12-06 Fuisz Richard C Polymer-Based Films and Drug Delivery Systems Made Therefrom
US7357891B2 (en) 2001-10-12 2008-04-15 Monosol Rx, Llc Process for making an ingestible film
US20190328679A1 (en) 2001-10-12 2019-10-31 Aquestive Therapeutics, Inc. Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US8765167B2 (en) 2001-10-12 2014-07-01 Monosol Rx, Llc Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US8900498B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for manufacturing a resulting multi-layer pharmaceutical film
US10285910B2 (en) 2001-10-12 2019-05-14 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions
US8603514B2 (en) 2002-04-11 2013-12-10 Monosol Rx, Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
WO2004084868A1 (en) 2003-03-26 2004-10-07 Egalet A/S Morphine controlled release system
CA2581851C (en) * 2004-09-30 2016-11-01 Monosolrx Llc Multi-layer films having uniform content
WO2008028047A2 (en) * 2006-08-30 2008-03-06 Lab International Srl Bioadhesive film drug delivery system
WO2008036299A2 (en) * 2006-09-20 2008-03-27 Monosol Rx Llc Edible water-soluble film containing a foam reducing flavoring agent
CA2664986C (en) 2006-10-02 2015-09-22 Labtec Gesellschaft Fuer Technologische Forschung Und Entwicklung Mbh Non-mucoadhesive film dosage forms
JP2010515761A (ja) * 2007-01-12 2010-05-13 モノソル アールエックス リミテッド ライアビリティ カンパニー 高用量フィルム組成物およびその製法
US20080292683A1 (en) * 2007-05-24 2008-11-27 Monosolrx, Llc. Film shreds and delivery system incorporating same
EP2155167A2 (en) 2007-06-04 2010-02-24 Egalet A/S Controlled release pharmaceutical compositions for prolonged effect
US8298583B2 (en) 2007-10-19 2012-10-30 Monosol Rx, Llc Film delivery system for tetrahydrolipstatin
US20110305768A1 (en) * 2008-07-01 2011-12-15 The Johns Hopkins University Quick-dissolving oral thin film for targeted delivery of therapeutic agents
WO2010086989A1 (ja) 2009-01-29 2010-08-05 日東電工株式会社 口腔内フィルム状基剤及び製剤
NZ594207A (en) 2009-02-06 2013-03-28 Egalet Ltd Immediate release composition resistant to abuse by intake of alcohol
ES2699077T3 (es) 2009-06-12 2019-02-07 Sunovion Pharmaceuticals Inc Apomorfina sublingual
NZ597283A (en) 2009-06-24 2013-07-26 Egalet Ltd Controlled release formulations
DK2493457T3 (en) 2009-10-30 2017-10-02 Ix Biopharma Ltd QUICK-SOLVING SOLID DOSAGE FORM
US12186426B2 (en) 2009-10-30 2025-01-07 Ix Biopharma Ltd. Solid dosage form
JP5588688B2 (ja) 2010-01-28 2014-09-10 日東電工株式会社 フィルム状製剤
US8577488B2 (en) * 2010-02-11 2013-11-05 Monosol Rx, Llc Method and system for optimizing film production and minimizing film scrap
US20110236666A1 (en) * 2010-03-26 2011-09-29 Hall Mark J Melt-extruded film
JP5800527B2 (ja) * 2010-03-30 2015-10-28 日東電工株式会社 安定化医薬組成物、安定化医薬組成物溶液製剤、フィルム状製剤及びフィルム状製剤の製造方法
JP5751868B2 (ja) 2010-03-30 2015-07-22 日東電工株式会社 フィルム状製剤及びその製造方法
US9149959B2 (en) 2010-10-22 2015-10-06 Monosol Rx, Llc Manufacturing of small film strips
US20120107402A1 (en) * 2010-10-29 2012-05-03 Monosol Rx, Llc Process for analyzing and establishing dosage size in an ingestible film
PT2651357T (pt) 2010-12-16 2020-06-17 Sunovion Pharmaceuticals Inc Películas sublinguais
JP5841433B2 (ja) 2012-01-11 2016-01-13 日東電工株式会社 口腔内フィルム状基剤及び製剤
BR112015000150A2 (pt) 2012-07-06 2017-06-27 Egalet Ltd composições farmacêuticas dissuasoras de abuso de liberação controlada
US20140323505A1 (en) * 2013-04-25 2014-10-30 Rinsenergy LLC Oral rinse composition and method to deliver energy supplements
US10226450B2 (en) 2014-09-25 2019-03-12 Shilpa Medicare Limited Pharmaceutical film composition
US20160220480A1 (en) * 2015-02-03 2016-08-04 Intelgenx Corp. Oral dosage film exhibiting enhanced mucosal penetration
EP3072502B1 (en) * 2015-03-25 2020-07-08 Universitätsmedizin der Johannes Gutenberg-Universität Mainz Rheological blood replacement solution and uses thereof
EP4578461A3 (en) 2015-04-21 2025-09-03 Sumitomo Pharma America, Inc. Methods of treating parkinsons disease by administration of apomorphine to an oral mucosa
WO2017192921A1 (en) 2016-05-05 2017-11-09 Monosol Rx, Llc Enhanced delivery epinephrine compositions
US12433850B2 (en) 2016-05-05 2025-10-07 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine and prodrug compositions
US12427121B2 (en) 2016-05-05 2025-09-30 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine compositions
US11273131B2 (en) 2016-05-05 2022-03-15 Aquestive Therapeutics, Inc. Pharmaceutical compositions with enhanced permeation
US11013249B2 (en) * 2016-05-13 2021-05-25 University Of Guelph Compositions for controlled release of volatile compounds
IL267689B2 (en) 2016-12-31 2025-05-01 Bioxcel Therapeutics Inc Use of sublingual dexmedetomidine for the treatment of agitation
CN110167642B (zh) * 2017-01-09 2022-06-07 宝洁公司 具有可溶性膜的阻隔贴片和改善皮肤外观的方法
DE102017103346A1 (de) * 2017-02-17 2018-08-23 Lts Lohmann Therapie-Systeme Ag Strukturierte orodispergierbare Filme
CN110505871B (zh) * 2017-03-13 2023-08-15 纳米及先进材料研发院有限公司 用于药物吸收的高负载快速崩解膜
DE102017112527B4 (de) * 2017-06-07 2019-01-03 Lts Lohmann Therapie-Systeme Ag Schnell zerfallende Schaumwafer mit hohem Flächengewicht
CN107325332B (zh) * 2017-07-07 2018-10-26 许辉良 速溶羟丙基甲基纤维素及其制备方法
BR112020026672A2 (pt) 2018-06-27 2021-03-30 Bioxcel Therapeutics, Inc. Formulações de filme contendo dexmedetomidina e métodos para produzi-las
CN109382996B (zh) * 2018-12-05 2024-04-30 无锡会通轻质材料股份有限公司 一种中空epp珠粒挤出机构
AR118828A1 (es) * 2019-05-02 2021-11-03 Tearclear Corp Extracción de conservante de colirios
BR112022000992A2 (pt) 2019-07-19 2022-06-14 Arx Llc Regimes de tratamento de dexmedetomidina não sedantes
CN111238199B (zh) * 2020-01-16 2024-08-02 肇庆方兴包装材料有限公司 一种解决薄膜之间粘连的生产工艺
EP3895691A1 (en) * 2020-04-15 2021-10-20 LTS Lohmann Therapie-Systeme AG Ulipristal acetate otf
EP3895692A1 (en) * 2020-04-15 2021-10-20 LTS Lohmann Therapie-Systeme AG Oral thin film with smooth fused film
CN111592670A (zh) * 2020-06-24 2020-08-28 上海应用技术大学 γ-聚谷氨酸分子印迹聚合物膜的制备方法
CN116457022A (zh) * 2020-09-08 2023-07-18 索恩健康科技公司 可溶解基质
CN112472593B (zh) * 2020-11-24 2022-06-10 牡丹江医学院 一种加入甜味剂掩盖苦味的口腔溃疡药膜加工设备
DE102021100779A1 (de) * 2021-01-15 2022-07-21 Lts Lohmann Therapie-Systeme Ag. Mehrschichtiger oraler dünnfilm
US12465564B2 (en) 2021-10-25 2025-11-11 Aquestive Therapeutics, Inc. Oral and nasal compositions and methods of treatment
CN114410044A (zh) * 2022-01-28 2022-04-29 孙琇芳 一种水溶型真空包装保鲜膜及其使用方法
CN114230840A (zh) * 2022-01-28 2022-03-25 孙琇芳 一种水溶可控型聚乙烯醇薄膜
CN114848612B (zh) * 2022-04-28 2026-02-03 青岛博益特生物材料股份有限公司 一种覆膜片状材料生产线
CN115048367B (zh) * 2022-06-02 2025-08-05 度小满科技(北京)有限公司 目标集合的确定方法、装置、终端及存储介质
CN115414876A (zh) * 2022-09-07 2022-12-02 天津科技大学 一种纤维素纳米纤丝凝胶的平板微波浓缩装置、方法和应用
CN116294531A (zh) * 2023-01-05 2023-06-23 安徽腾远化工科技有限公司 一种氨基模塑料高效烘干设备
US11806334B1 (en) 2023-01-12 2023-11-07 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens
CN116589019B (zh) * 2023-05-26 2023-10-27 深圳市一号芯环保科技有限公司 一种长效缓释型杀菌及抗氧化功能滤芯材料及制备方法
CN118183062A (zh) * 2023-12-31 2024-06-14 江阴市江泰高分子新材料有限公司 一种易撕保护膜及其生产工艺
CN118384560B (zh) * 2024-06-26 2024-08-23 广东蜀丰科技有限公司 一种泡沫分散均匀的消泡分散机

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136145A (en) 1974-07-05 1979-01-23 Schering Aktiengesellschaft Medicament carriers in the form of film having active substance incorporated therein
US4631837A (en) 1985-05-31 1986-12-30 Magoon Richard E Method and apparatus for drying fruit pulp and the like
ES2019275B3 (es) 1985-10-09 1991-06-16 Desitin Arzneimittel Gmbh Metodo para la produccion de una forma de administracion y de dosificacion para farmacos reactivos u otros principios activos.
US4764378A (en) * 1986-02-10 1988-08-16 Zetachron, Inc. Buccal drug dosage form
US4713243A (en) * 1986-06-16 1987-12-15 Johnson & Johnson Products, Inc. Bioadhesive extruded film for intra-oral drug delivery and process
DE3630603A1 (de) * 1986-09-09 1988-03-10 Desitin Arzneimittel Gmbh Darreichungs- und dosierungsform fuer arzneimittelwirkstoffe, reagentien oder dergleichen sowie verfahren zu deren herstellung
DE4018247A1 (de) 1990-06-07 1991-12-12 Lohmann Therapie Syst Lts Herstellungsverfahren fuer schnellzerfallende folienfoermige darreichungsformen
IT1249315B (it) * 1991-05-23 1995-02-22 Euroresearch Srl Lamina di collageno non poroso per uso terapeutico, metodo ed apparecchiature per ottenerlo
US5393528A (en) * 1992-05-07 1995-02-28 Staab; Robert J. Dissolvable device for contraception or delivery of medication
AU679937B2 (en) * 1992-11-18 1997-07-17 Johnson & Johnson Consumer Products, Inc. Extrudable compositions for topical or transdermal drug delivery
US20010006677A1 (en) * 1996-10-29 2001-07-05 Mcginity James W. Effervescence polymeric film drug delivery system
DE19646392A1 (de) 1996-11-11 1998-05-14 Lohmann Therapie Syst Lts Zubereitung zur Anwendung in der Mundhöhle mit einer an der Schleimhaut haftklebenden, Pharmazeutika oder Kosmetika zur dosierten Abgabe enthaltenden Schicht
US6153210A (en) * 1997-08-14 2000-11-28 Periodontix, Inc. Use of locally delivered metal ions for treatment of periodontal disease
US6072100A (en) * 1998-01-28 2000-06-06 Johnson & Johnson Consumer Products, Inc. Extrudable compositions for topical or transdermal drug delivery
US6281337B1 (en) 1998-11-12 2001-08-28 Schering Corporation Methods for conversion of protein isoforms
DE19960154A1 (de) * 1999-12-14 2001-07-12 Lohmann Therapie Syst Lts Flache Arzneizubereitung zur transmucosalen Verabreichung von Oxycodon oder einem vergleichbaren Wirkstoff in der Mundhöhle, für die Anwendung in der Schmerztherapie und Suchttherapie
AU7251200A (en) * 1999-12-23 2001-06-28 Johnson & Johnson Consumer Companies, Inc. Method of preparing a water soluble film
US7067116B1 (en) * 2000-03-23 2006-06-27 Warner-Lambert Company Llc Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1
US6375981B1 (en) * 2000-06-01 2002-04-23 A. E. Staley Manufacturing Co. Modified starch as a replacement for gelatin in soft gel films and capsules
US20030118653A1 (en) * 2001-07-06 2003-06-26 Lavipharm Laboratories Inc. Quick dissolving oral mucosal drug delivery device with moisture barrier coating
AU2002348432B2 (en) * 2001-10-12 2007-08-09 Aquestive Therapeutics, Inc. Thin film with non-self-aggregating uniform heterogeneity, process for their production and drug delivery systems made thereform
ATE536868T1 (de) * 2001-10-12 2011-12-15 Monosolrx Llc Einheitliche filme als schnell auflösende verabreichungsformen enthaltend geschmacksmaskiereden stoff
ATE553746T1 (de) * 2003-01-30 2012-05-15 Monosolrx Llc Verfahren zur herstellung eines dünnen films, thermolabile wirkstoffe enthaltend

Also Published As

Publication number Publication date
CN102670568A (zh) 2012-09-19
CA2544776A1 (en) 2006-03-23
JP4795962B2 (ja) 2011-10-19
EP1663178A1 (en) 2006-06-07
AU2004319243B2 (en) 2010-06-03
CN1812773B (zh) 2012-06-27
WO2006031209A1 (en) 2006-03-23
CN1812773A (zh) 2006-08-02
EP3210601A1 (en) 2017-08-30
AU2004319243A8 (en) 2008-08-07
EP2716284A2 (en) 2014-04-09
AU2010214780A1 (en) 2010-09-23
EP2716284A3 (en) 2014-11-05
JP2007500252A (ja) 2007-01-11
BRPI0410956A (pt) 2006-07-04
AU2004319243A1 (en) 2006-01-12
CA2544776C (en) 2014-04-15

Similar Documents

Publication Publication Date Title
NO20056060L (no) Polyetylenoksidbaserte filmer og legemiddelleveringssystemer fremstilt fra disse
WO2008100375A3 (en) Polymer-based films and drug delivery systems made therefrom
Fan et al. Thermosensitive hydrogels and advances in their application in disease therapy
Shi et al. Three‐dimensional printing alginate/gelatin scaffolds as dermal substitutes for skin tissue engineering
Hiemstra et al. Rapidly in situ-forming degradable hydrogels from dextran thiols through Michael addition
Hsu et al. Multimonth controlled small molecule release from biodegradable thin films
Li et al. Polymer nanocoating of amorphous drugs for improving stability, dissolution, powder flow, and tabletability: the case of chitosan-coated indomethacin
Maver et al. Polysaccharide thin solid films for analgesic drug delivery and growth of human skin cells
Layek A comprehensive review of xanthan gum-based oral drug delivery systems
Liaqat et al. pH-sensitive hydrogels fabricated with hyaluronic acid as a polymer for site-specific delivery of mesalamine
EP3096745B1 (en) Transdermal delivery system comprising donepezil or its salt
ATE515949T1 (de) Süssware
Ahmad et al. Enhancement of oral insulin bioavailability: in vitro and in vivo assessment of nanoporous stimuli-responsive hydrogel microparticles
Marzi et al. Hydrogels as promising therapeutic strategy for the treatment of skin cancer
Shibata et al. Thermoresponsive gelation of amphiphilic random copolymer micelles in water
Ramburrun et al. Design and characterization of neurodurable gellan-xanthan pH-responsive hydrogels for controlled drug delivery
CN109475573A (zh) 响应性弹性聚合物及其制备和使用方法
Censi et al. Photopolymerized thermosensitive poly (HPMAlactate)-PEG-based hydrogels: effect of network design on mechanical properties, degradation, and release behavior
Cisneros et al. Long‐Term Controlled Release of Simvastatin from Photoprinted Triple‐Networked Hydrogels Composed of Modified Chitosan and PLA–PEG Micelles
Maksym‐Bębenek et al. Study on Self‐Assembled Well‐Defined PEG Graft Copolymers as Efficient Drug‐Loaded Nanoparticles for Anti‐Inflammatory Therapy
Gunbas et al. Semi-IPN chitosan/PEG microspheres and films for biomedical applications: characterization and sustained release optimization
Ning et al. On-demand prolongation of peripheral nerve blockade through bupivacaine-loaded hydrogels with suitable residence periods
WO2019055996A8 (en) Polymer nanodiscs for biotechnology and medical applications
Cui et al. Light‐Operated Transient Unilateral Adhesive Hydrogel for Comprehensive Prevention of Postoperative Adhesions
Fan et al. Robust Controlled Degradation of Enzyme Loaded PCL‐Based Fibrous Scaffolds Toward Scarless Skin Tissue Regeneration

Legal Events

Date Code Title Description
CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: AQUESTIVE THERAPEUTICS INC., US

FC2A Withdrawal, rejection or dismissal of laid open patent application