|
MY164523A
(en)
|
2000-05-23 |
2017-12-29 |
Univ Degli Studi Cagliari |
Methods and compositions for treating hepatitis c virus
|
|
NZ537662A
(en)
|
2002-06-28 |
2007-10-26 |
Idenix Cayman Ltd |
2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
|
|
PL374781A1
(en)
|
2002-06-28 |
2005-10-31 |
Idenix (Cayman) Limited |
2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
|
|
HUE033832T2
(en)
|
2002-11-15 |
2018-01-29 |
Idenix Pharmaceuticals Llc |
2'-methyl nucleosides in combination with interferon and Flaviviridae mutation
|
|
RU2005121904A
(ru)
|
2002-12-12 |
2006-01-20 |
Айденикс (Кайман) Лимитед (Ky) |
Способ получения 2`-разветвленных нуклеозидов
|
|
EP2345657A1
(en)
|
2003-05-30 |
2011-07-20 |
Pharmasset, Inc. |
Modified fluorinated nucleoside analogues
|
|
CN1863813B
(zh)
*
|
2003-08-27 |
2011-03-30 |
生物区科学管理控股有限公司 |
作为治疗剂的三环核苷或核苷酸
|
|
AU2005254057B2
(en)
|
2004-06-15 |
2011-02-17 |
Isis Pharmaceuticals, Inc. |
C-purine nucleoside analogs as inhibitors of RNA-dependent RNA viral polymerase
|
|
CN101023094B
(zh)
|
2004-07-21 |
2011-05-18 |
法莫赛特股份有限公司 |
烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
|
|
AU2005285045B2
(en)
|
2004-09-14 |
2011-10-13 |
Gilead Sciences, Inc. |
Preparation of 2'fluoro-2'- alkyl- substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives
|
|
WO2006121468A1
(en)
|
2004-11-22 |
2006-11-16 |
Genelabs Technologies, Inc. |
5-nitro-nucleoside compounds for treating viral infections
|
|
HRP20070436A2
(hr)
|
2005-02-28 |
2008-02-29 |
Genelabs Technologies |
Triciklički nukleozidni predlijekovi za liječenjevirusnih infekcija
|
|
MY150667A
(en)
|
2005-12-09 |
2014-02-28 |
Gilead Pharmasset Llc |
Antiviral nucleosides
|
|
US7659274B2
(en)
*
|
2006-01-25 |
2010-02-09 |
Osi Pharmaceuticals, Inc. |
Unsaturated mTOR inhibitors
|
|
US7666851B1
(en)
*
|
2006-05-18 |
2010-02-23 |
Steven Albert Benner |
Three ring fused analogs of isoguanosine
|
|
WO2008005542A2
(en)
*
|
2006-07-07 |
2008-01-10 |
Gilead Sciences, Inc., |
Antiviral phosphinate compounds
|
|
BRPI0717176A2
(pt)
*
|
2006-09-19 |
2013-10-15 |
Daiichi Sankyo Co Ltd |
Composto, inibidores de hsp90, da atividade de atpase de hsp90 e da ligação de hsp90 a atp, medicamento, agente anticâncer, composição farmacêutica, método para tratar câncer, e, uso do composto
|
|
US8912321B2
(en)
*
|
2006-10-10 |
2014-12-16 |
Gilead Pharmasset Llc |
Preparation of nucleosides ribofuranosyl pyrimidines
|
|
US20080261913A1
(en)
|
2006-12-28 |
2008-10-23 |
Idenix Pharmaceuticals, Inc. |
Compounds and pharmaceutical compositions for the treatment of liver disorders
|
|
US7964580B2
(en)
|
2007-03-30 |
2011-06-21 |
Pharmasset, Inc. |
Nucleoside phosphoramidate prodrugs
|
|
CA2685520A1
(en)
*
|
2007-05-10 |
2008-11-20 |
Biocryst Pharmaceuticals, Inc. |
Tetrahydrofuro [3 4-d] dioxolane compounds for use in the treatment of viral infections and cancer
|
|
US20090048189A1
(en)
*
|
2007-08-15 |
2009-02-19 |
Genelabs Technologies, Inc. |
Tricyclic-nucleoside compounds for treating viral infections
|
|
WO2009029729A1
(en)
*
|
2007-08-31 |
2009-03-05 |
Genelabs Technologies, Inc. |
Amino tricyclic-nucleoside compounds, compositions, and methods of use
|
|
GB0718575D0
(en)
|
2007-09-24 |
2007-10-31 |
Angeletti P Ist Richerche Bio |
Nucleoside derivatives as inhibitors of viral polymerases
|
|
US20090318380A1
(en)
|
2007-11-20 |
2009-12-24 |
Pharmasset, Inc. |
2',4'-substituted nucleosides as antiviral agents
|
|
EP2234977A4
(en)
|
2007-12-19 |
2011-04-13 |
Boehringer Ingelheim Int |
VIRAL POLYMERASE INHIBITORS
|
|
CN101977923B
(zh)
*
|
2008-01-18 |
2014-10-08 |
捷克有机化学和生物化学研究院 |
抑制细胞生长的7-脱氮嘌呤核苷
|
|
TW200942243A
(en)
|
2008-03-05 |
2009-10-16 |
Biocryst Pharm Inc |
Antiviral therapeutic agents
|
|
US8697357B2
(en)
|
2008-03-12 |
2014-04-15 |
Japan Advanced Institute Of Science And Technology |
Method for detection of methylcytosine using photoresponsive probe
|
|
US8227431B2
(en)
|
2008-03-17 |
2012-07-24 |
Hetero Drugs Limited |
Nucleoside derivatives
|
|
ES2398684T3
(es)
|
2008-04-23 |
2013-03-21 |
Gilead Sciences, Inc. |
Análogos de carbanucleósido para el tratamiento antiviral
|
|
US8173621B2
(en)
|
2008-06-11 |
2012-05-08 |
Gilead Pharmasset Llc |
Nucleoside cyclicphosphates
|
|
WO2010015637A1
(en)
*
|
2008-08-06 |
2010-02-11 |
Novartis Ag |
New antiviral modified nucleosides
|
|
RU2572826C2
(ru)
|
2008-12-02 |
2016-01-20 |
Чиралджен, Лтд. |
Способ синтеза модифицированных по атому фосфора нуклеиновых кислот
|
|
WO2010068708A2
(en)
|
2008-12-09 |
2010-06-17 |
Rfs Pharma, Llc |
3'-azido purine nucleotide prodrugs for treatment of viral infections
|
|
PT2376088T
(pt)
|
2008-12-23 |
2017-05-02 |
Gilead Pharmasset Llc |
Fosforamidatos de nucleósidos de 2-amino-purina 6-osubstituída
|
|
KR20110098849A
(ko)
|
2008-12-23 |
2011-09-01 |
파마셋 인코포레이티드 |
뉴클레오시드 유사체
|
|
SG194404A1
(en)
|
2008-12-23 |
2013-11-29 |
Gilead Pharmasset Llc |
Synthesis of purine nucleosides
|
|
CN102271699A
(zh)
|
2009-01-07 |
2011-12-07 |
西尼克斯公司 |
用于治疗hcv和hiv感染的环孢菌素衍生物
|
|
JP2012517443A
(ja)
|
2009-02-06 |
2012-08-02 |
アールエフエス ファーマ,エルエルシー |
癌及びウイルス感染の治療のためのプリンヌクレオシド一リン酸プロドラッグ
|
|
CN102333781B
(zh)
|
2009-02-25 |
2014-06-11 |
第一三共株式会社 |
三环吡唑并嘧啶衍生物
|
|
AU2010226466A1
(en)
|
2009-03-20 |
2011-10-20 |
Alios Biopharma, Inc. |
Substituted nucleoside and nucleotide analogs
|
|
TW201102390A
(en)
|
2009-03-31 |
2011-01-16 |
Arqule Inc |
Substituted pyrazolo-pyrimidine compounds
|
|
WO2010132538A1
(en)
|
2009-05-12 |
2010-11-18 |
Schering Corporation |
Fused tricyclic aryl compounds useful for the treatment of viral diseases
|
|
TWI598358B
(zh)
|
2009-05-20 |
2017-09-11 |
基利法瑪席特有限責任公司 |
核苷磷醯胺
|
|
US8618076B2
(en)
|
2009-05-20 |
2013-12-31 |
Gilead Pharmasset Llc |
Nucleoside phosphoramidates
|
|
CA2763140A1
(en)
|
2009-05-29 |
2010-12-02 |
Schering Corporation |
Antiviral compounds composed of three linked aryl moieties to treat diseases such as hepatitis c
|
|
US8772505B2
(en)
|
2009-05-29 |
2014-07-08 |
Merck Sharp & Dohme Corp. |
Antiviral compounds composed of three aligned aryl moieties to treat diseases such as hepatitis C
|
|
CA2767253A1
(en)
|
2009-07-06 |
2011-01-13 |
Ontorii, Inc. |
Novel nucleic acid prodrugs and methods of use thereof
|
|
TWI483950B
(zh)
|
2009-09-21 |
2015-05-11 |
Gilead Sciences Inc |
用於製備1’-取代碳核苷類似物之方法及中間物
|
|
US20130156731A1
(en)
*
|
2009-12-22 |
2013-06-20 |
Kevin X. Chen |
Fused tricyclic compounds and methods of use thereof for the treatment of viral diseas
|
|
EA201290882A1
(ru)
*
|
2010-03-09 |
2013-04-30 |
Мерк Шарп Энд Домэ Корп. |
Конденсированные трициклические силильные соединения и способы их применения для лечения вирусных заболеваний
|
|
PT2609923T
(pt)
|
2010-03-31 |
2017-08-30 |
Gilead Pharmasset Llc |
Processo para a cristalização de 2-(((s)- (perfluorofenoxi)(fenoxi)fosforil)amino)propanoato de (s)-isopropilo
|
|
UY33312A
(es)
|
2010-03-31 |
2011-10-31 |
Pharmasset Inc |
Fosforamidato de nucleosido de purina
|
|
PL3290428T3
(pl)
|
2010-03-31 |
2022-02-07 |
Gilead Pharmasset Llc |
Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu
|
|
KR101995598B1
(ko)
|
2010-07-19 |
2019-07-02 |
길리애드 사이언시즈, 인코포레이티드 |
부분입체 이성질성으로 순수한 포스포라미데이트 전구약물의 제조 방법
|
|
BR122020020745B8
(pt)
|
2010-07-22 |
2023-10-31 |
Gilead Sciences Inc |
Composto antiviral para o tratamento de infecções por paramyxoviridae e composição farmacêutica que o compreende
|
|
EP2610259A4
(en)
|
2010-08-23 |
2014-01-08 |
Daiichi Sankyo Co Ltd |
FREE CRYSTAL OF A TRICYCLIC PYRAZOLOPYRIMIDINE DERIVATIVE
|
|
TW201213333A
(en)
|
2010-08-23 |
2012-04-01 |
Daiichi Sankyo Co Ltd |
Crystal forms of tricyclic pyrazolopyrimidine derivative
|
|
BR112013005872A2
(pt)
|
2010-09-22 |
2019-09-24 |
Alios Biopharma Inc |
compostos, composição farmacêutica e respectivos usos
|
|
EP2619215B1
(en)
|
2010-09-22 |
2018-09-05 |
Alios Biopharma, Inc. |
Azido nucleosides and nucleotide analogs
|
|
JP5868324B2
(ja)
|
2010-09-24 |
2016-02-24 |
株式会社Wave Life Sciences Japan |
不斉補助基
|
|
AU2011336632B2
(en)
|
2010-11-30 |
2015-09-03 |
Gilead Pharmasset Llc |
Compounds
|
|
EP2691409B1
(en)
|
2011-03-31 |
2018-02-21 |
Idenix Pharmaceuticals LLC. |
Compounds and pharmaceutical compositions for the treatment of viral infections
|
|
AU2012284265B2
(en)
|
2011-07-19 |
2017-08-17 |
Wave Life Sciences Ltd. |
Methods for the synthesis of functionalized nucleic acids
|
|
TW201329096A
(zh)
|
2011-09-12 |
2013-07-16 |
Idenix Pharmaceuticals Inc |
經取代羰氧基甲基磷酸醯胺化合物及用於治療病毒感染之藥學組成物
|
|
PL2709613T5
(pl)
|
2011-09-16 |
2020-12-14 |
Gilead Pharmasset Llc |
Metody leczenia hcv
|
|
US8889159B2
(en)
|
2011-11-29 |
2014-11-18 |
Gilead Pharmasset Llc |
Compositions and methods for treating hepatitis C virus
|
|
UA117095C2
(uk)
|
2011-12-22 |
2018-06-25 |
Аліос Біофарма, Інк. |
Нуклеозидна сполука або її фармацевтично прийнятна сіль
|
|
EP2794630A4
(en)
|
2011-12-22 |
2015-04-01 |
Alios Biopharma Inc |
SUBSTITUTED PHOSPHORTHIOAT NUCLEOTIDE ANALOGUE
|
|
EP2639238A1
(en)
*
|
2012-03-15 |
2013-09-18 |
Universität Bern |
Tricyclic nucleosides and oligomeric compounds prepared therefrom
|
|
USRE48171E1
(en)
|
2012-03-21 |
2020-08-25 |
Janssen Biopharma, Inc. |
Substituted nucleosides, nucleotides and analogs thereof
|
|
US9441007B2
(en)
|
2012-03-21 |
2016-09-13 |
Alios Biopharma, Inc. |
Substituted nucleosides, nucleotides and analogs thereof
|
|
WO2013142124A1
(en)
|
2012-03-21 |
2013-09-26 |
Vertex Pharmaceuticals Incorporated |
Solid forms of a thiophosphoramidate nucleotide prodrug
|
|
US9012427B2
(en)
|
2012-03-22 |
2015-04-21 |
Alios Biopharma, Inc. |
Pharmaceutical combinations comprising a thionucleotide analog
|
|
SG11201407336PA
(en)
|
2012-05-25 |
2015-03-30 |
Janssen Sciences Ireland Uc |
Uracyl spirooxetane nucleosides
|
|
SG11201500239VA
(en)
|
2012-07-13 |
2015-03-30 |
Wave Life Sciences Japan |
Asymmetric auxiliary group
|
|
GEP201706757B
(en)
|
2012-12-21 |
2017-10-25 |
Alios Biopharma Inc |
Substituted nucleosides, nucleotides and analogs thereof
|
|
PT2950786T
(pt)
|
2013-01-31 |
2020-03-03 |
Gilead Pharmasset Llc |
Formulação de combinação de dois compostos antivirais
|
|
EA201690473A1
(ru)
|
2013-08-27 |
2017-03-31 |
ГАЙЛИД ФАРМАССЕТ ЭлЭлСи |
Комбинированный состав двух противовирусных соединений
|
|
EP3055319A4
(en)
|
2013-10-11 |
2018-01-10 |
Alios Biopharma, Inc. |
Substituted nucleosides, nucleotides and analogs thereof
|
|
JP6115897B2
(ja)
*
|
2013-12-09 |
2017-04-19 |
国立大学法人 鹿児島大学 |
抗b型肝炎ウイルス薬
|
|
ES2917473T3
(es)
|
2014-01-16 |
2022-07-08 |
Wave Life Sciences Ltd |
Diseño quiral
|
|
TWI767201B
(zh)
|
2014-10-29 |
2022-06-11 |
美商基利科學股份有限公司 |
絲狀病毒科病毒感染之治療
|
|
CA3182565A1
(en)
|
2015-03-06 |
2016-09-15 |
Atea Pharmaceuticals, Inc. |
.beta.-d-2'-deoxy-2'-.alpha.-fluoro-2'-.beta.-c-substituted-2-modified-n6-substituted purine nucleotides for hcv treatment
|
|
US10703756B2
(en)
|
2015-05-01 |
2020-07-07 |
Pfizer Inc. |
Pyrrolo[2,3-D]pyrimidinyl, pyrrolo[2,3-B]pyrazinyl, pyrrolo[2,3-B]pyridinyl acrylamides and epoxides thereof
|
|
SI3349758T1
(sl)
|
2015-09-16 |
2022-08-31 |
Gilead Sciences, Inc. |
Postopki za zdravljenje okužb z virusom arenaviridae
|
|
CN107286212B
(zh)
*
|
2016-04-11 |
2020-07-07 |
天方药业有限公司 |
一种高纯度去羟肌苷杂质的制备方法
|
|
CA3029170C
(en)
*
|
2016-06-29 |
2021-02-16 |
Ustav Organicke Chemie A Biochemie Av Cr, V.V.I. |
Substituted thienopyrrolopyrimidine ribonucleosides for therapeutic use
|
|
US10202412B2
(en)
|
2016-07-08 |
2019-02-12 |
Atea Pharmaceuticals, Inc. |
β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N6-substituted-6-aminopurinenucleotides for the treatment of paramyxovirus and orthomyxovirus infections
|
|
US10711029B2
(en)
|
2016-07-14 |
2020-07-14 |
Atea Pharmaceuticals, Inc. |
Beta-d-2′-deoxy-2′-alpha-fluoro-2′-beta-c-substituted-4′fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection
|
|
CZ307334B6
(cs)
*
|
2016-08-02 |
2018-06-13 |
Ústav organické chemie a biochemie AV ČR, v.v.i. |
Substituované heteropentadieno-pyrrolopyrimidinové ribonukleosidy pro terapeutické použití
|
|
DK3512863T3
(da)
|
2016-09-07 |
2022-03-07 |
Atea Pharmaceuticals Inc |
2¿-substituerede-N6-substituerede purinnukleotider til behandling af RNA-virus
|
|
WO2018089786A1
(en)
*
|
2016-11-11 |
2018-05-17 |
Millennium Pharmaceuticals, Inc. |
Atg7 inhibitors and the uses thereof
|
|
CN115477679A
(zh)
|
2017-02-01 |
2022-12-16 |
阿堤亚制药公司 |
用于治疗丙型肝炎病毒的核苷酸半硫酸盐
|
|
US10682368B2
(en)
|
2017-03-14 |
2020-06-16 |
Gilead Sciences, Inc. |
Methods of treating feline coronavirus infections
|
|
AU2018262501B2
(en)
|
2017-05-01 |
2020-12-10 |
Gilead Sciences, Inc. |
Crystalline forms of (S) 2 ethylbutyl 2 (((S) (((2R,3S,4R,5R) 5 (4 aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2 yl)methoxy)(phenoxy) phosphoryl)amino)propanoate
|
|
WO2019014247A1
(en)
|
2017-07-11 |
2019-01-17 |
Gilead Sciences, Inc. |
COMPOSITIONS COMPRISING POLYMERASE RNA INHIBITOR AND CYCLODEXTRIN FOR THE TREATMENT OF VIRAL INFECTIONS
|
|
EP3773753A4
(en)
|
2018-04-10 |
2021-12-22 |
ATEA Pharmaceuticals, Inc. |
TREATMENT OF PATIENTS INFECTED WITH THE HEPATITIS C VIRUS WITH CIRRHOSIS
|
|
AU2020256166A1
(en)
|
2019-04-02 |
2021-10-14 |
Aligos Therapeutics, Inc. |
Compounds targeting PRMT5
|
|
CA3164134A1
(en)
|
2019-12-06 |
2021-06-10 |
Vertex Pharmaceuticals Incorporated |
Substituted tetrahydrofurans as modulators of sodium channels
|
|
US11660307B2
(en)
|
2020-01-27 |
2023-05-30 |
Gilead Sciences, Inc. |
Methods for treating SARS CoV-2 infections
|
|
TWI794742B
(zh)
|
2020-02-18 |
2023-03-01 |
美商基利科學股份有限公司 |
抗病毒化合物
|
|
TWI775313B
(zh)
|
2020-02-18 |
2022-08-21 |
美商基利科學股份有限公司 |
抗病毒化合物
|
|
AU2021224588B2
(en)
|
2020-02-18 |
2024-07-18 |
Gilead Sciences, Inc. |
Antiviral compounds
|
|
US10874687B1
(en)
|
2020-02-27 |
2020-12-29 |
Atea Pharmaceuticals, Inc. |
Highly active compounds against COVID-19
|
|
JP7554841B2
(ja)
|
2020-03-12 |
2024-09-20 |
ギリアード サイエンシーズ, インコーポレイテッド |
1’-シアノヌクレオシドを調製する方法
|
|
WO2021207049A1
(en)
|
2020-04-06 |
2021-10-14 |
Gilead Sciences, Inc. |
Inhalation formulations of 1'-cyano substituted carbanucleoside analogs
|
|
CA3179226A1
(en)
|
2020-05-29 |
2021-12-02 |
Tomas Cihlar |
Remdesivir treatment methods
|
|
AU2021296841B2
(en)
|
2020-06-24 |
2025-01-23 |
Gilead Sciences, Inc. |
1'-cyano nucleoside analogs and uses thereof
|
|
SI4204421T1
(sl)
|
2020-08-27 |
2024-07-31 |
Gilead Sciences, Inc., |
Spojine in postopki za zdravljenje virusnih okužb
|
|
EP4323362B1
(en)
|
2021-04-16 |
2025-05-07 |
Gilead Sciences, Inc. |
Methods of preparing carbanucleosides using amides
|
|
SI4347031T1
(sl)
|
2021-06-04 |
2026-01-30 |
Vertex Pharmaceuticals Incorporated |
N-(hidroksialkil (hetero)aril) tetrahidrofuran karboksamidi kot modulatorji natrijevih kanalčkov
|
|
KR102639275B1
(ko)
*
|
2021-06-08 |
2024-02-21 |
퓨쳐메디신 주식회사 |
다중 표적 인산화효소 저해 활성을 갖는 뉴클레오사이드 유도체 및 이를 포함하는 암의 예방 및 치료용 약학적 조성물
|
|
KR20240022574A
(ko)
|
2021-06-17 |
2024-02-20 |
아테아 파마슈티컬즈, 인크. |
유리한 항-hcv 조합 요법
|
|
AU2022328698B2
(en)
|
2021-08-18 |
2025-02-20 |
Gilead Sciences, Inc. |
Phospholipid compounds and methods of making and using the same
|
|
CN114213490B
(zh)
*
|
2021-12-31 |
2024-04-02 |
中南民族大学 |
一类三环核苷酸类似物及其合成方法和应用
|
|
CN114213491B
(zh)
*
|
2021-12-31 |
2024-04-02 |
中南民族大学 |
一类内源性核苷M1dG及其衍生物的合成方法及其应用
|
|
IL315102A
(en)
|
2022-03-02 |
2024-10-01 |
Gilead Sciences Inc |
COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS
|
|
US12357577B1
(en)
|
2024-02-02 |
2025-07-15 |
Gilead Sciences, Inc. |
Pharmaceutical formulations and uses thereof
|