NO20061268L - Acyloksyalcylkarbamat prodrugs fremgangsmate for syntese og anvendelse - Google Patents

Acyloksyalcylkarbamat prodrugs fremgangsmate for syntese og anvendelse

Info

Publication number
NO20061268L
NO20061268L NO20061268A NO20061268A NO20061268L NO 20061268 L NO20061268 L NO 20061268L NO 20061268 A NO20061268 A NO 20061268A NO 20061268 A NO20061268 A NO 20061268A NO 20061268 L NO20061268 L NO 20061268L
Authority
NO
Norway
Prior art keywords
acyloxyalkylcarbamate
synthesis
group
rrepresents
chlorophenyl
Prior art date
Application number
NO20061268A
Other languages
English (en)
Other versions
NO335606B1 (no
Inventor
Mark A Gallop
Fenmei Yao
Maria J Ludwikow
Thu Phan
Ge Peng
Original Assignee
Xenoport Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2004/027330 external-priority patent/WO2005019163A2/en
Application filed by Xenoport Inc filed Critical Xenoport Inc
Publication of NO20061268L publication Critical patent/NO20061268L/no
Publication of NO335606B1 publication Critical patent/NO335606B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Det er beskrevet generelt acyloksyalkyl karbamat prodrug av (±)-4-amino-3-(4-klorfenyl)butansyre og analoger derav, farmasøytiske sammensetninger derav, fremgangsmåter for fremstilling av prodrug av (±)-4-amino-3-(4-klorfenyl)butansyre og analoger derav, fremgangsmåter for anvendelse av prodrug av (±)-4-amino-3-(4-klorfenyl)butansyre og analoger derav, og farmasøytiske sammensetninger derav for behandling eller hindring av vanlige sykdommer og/eller forstyrrelser slike som spastisitet og/eller syre refluks sykdom. I tillegg er det beskrevet acyloksyalkyl karbamat prodrug av (±)-4-amino-3-(4-klorfenyl)butansyre og analoger derav som er egnet for oral administrasjon og egnede vedvarende frigivelses orale doseringsformer derav.
NO20061268A 2003-08-20 2006-03-20 Acyloksyalkyl karbamatforbindelser, anvendelse derav, samt mellomprodukter for fremstilling av disse NO335606B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49693803P 2003-08-20 2003-08-20
US60663704P 2004-08-13 2004-08-13
PCT/US2004/027330 WO2005019163A2 (en) 2003-08-20 2004-08-20 Acyloxyalkyl carbamate prodrugs, methods of synthesis and use

Publications (2)

Publication Number Publication Date
NO20061268L true NO20061268L (no) 2006-05-22
NO335606B1 NO335606B1 (no) 2015-01-12

Family

ID=36762986

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20061268A NO335606B1 (no) 2003-08-20 2006-03-20 Acyloksyalkyl karbamatforbindelser, anvendelse derav, samt mellomprodukter for fremstilling av disse

Country Status (13)

Country Link
EP (1) EP1660440B1 (no)
JP (3) JP5148874B2 (no)
CN (2) CN101914040A (no)
AT (1) ATE546427T1 (no)
CA (1) CA2536257C (no)
CY (1) CY1112827T1 (no)
ES (1) ES2382000T3 (no)
IL (1) IL173826A (no)
NO (1) NO335606B1 (no)
NZ (1) NZ545719A (no)
PL (1) PL1660440T3 (no)
RU (2) RU2423347C2 (no)
SG (1) SG145759A1 (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1660440B1 (en) * 2003-08-20 2012-02-22 XenoPort, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
EP2250143B1 (en) * 2008-01-25 2016-04-20 XenoPort, Inc. Method for the enzymatic kinetic resolution of acyloxyalkyl thiocarbonates used for the synthesis of acyloxyalkyl carbamates
WO2019037791A1 (zh) * 2017-08-25 2019-02-28 广州市恒诺康医药科技有限公司 一种长效雷沙吉兰前药及其制备方法和用途
CN107805202A (zh) * 2017-12-01 2018-03-16 内蒙古圣氏化学股份有限公司 一种氯甲基异丙基碳酸酯连续化反应装置及方法
WO2024046279A1 (zh) * 2022-08-29 2024-03-07 广州市恒诺康医药科技有限公司 一种mao-b抑制剂前药的多晶型及其制备方法和用途
CN116870899B (zh) * 2023-06-08 2025-06-20 桂林理工大学 一种基于锰化合物的具有类漆酶活性的纳米酶合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0130119B1 (en) * 1983-06-23 1988-11-09 Merck & Co. Inc. (acyloxyalkoxy) carbonyl derivatives as bioreversible prodrug moieties for primary and secondary amine functions in drugs, their preparation and pharmaceutical compositions containing said derivatives
SE9603408D0 (sv) * 1996-09-18 1996-09-18 Astra Ab Medical use
GB2365425A (en) * 2000-08-01 2002-02-20 Parke Davis & Co Ltd Alkyl amino acid derivatives useful as pharmaceutical agents
MXPA03011566A (es) * 2001-06-11 2004-10-28 Xenoport Inc Formas de dosificacion de profarmacos de analogos de gaba administrados oralmente que tienen toxicidad reducida.
EP1660440B1 (en) * 2003-08-20 2012-02-22 XenoPort, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use

Also Published As

Publication number Publication date
JP2007521318A (ja) 2007-08-02
JP2011256182A (ja) 2011-12-22
PL1660440T3 (pl) 2012-07-31
ATE546427T1 (de) 2012-03-15
RU2423347C2 (ru) 2011-07-10
EP1660440A2 (en) 2006-05-31
IL173826A0 (en) 2006-07-05
HK1090912A1 (en) 2007-01-05
SG145759A1 (en) 2008-09-29
CA2536257A1 (en) 2005-03-03
EP1660440B1 (en) 2012-02-22
CA2536257C (en) 2012-01-03
NO335606B1 (no) 2015-01-12
JP2013006842A (ja) 2013-01-10
NZ545719A (en) 2010-03-26
CY1112827T1 (el) 2016-02-10
CN1860101A (zh) 2006-11-08
ES2382000T3 (es) 2012-06-04
RU2006108541A (ru) 2007-09-27
IL173826A (en) 2014-07-31
RU2010147826A (ru) 2012-05-27
JP5148874B2 (ja) 2013-02-20
CN101914040A (zh) 2010-12-15
CN1860101B (zh) 2010-10-27

Similar Documents

Publication Publication Date Title
CY1112827T1 (el) Προφαρμακα καρβαμιδικου ακυλοξυαλκυλεστερα, μεθοδοι συνθεσης και χρηση
EA200802223A1 (ru) 1,5-дифенилпиразолы ii в качестве ингибиторов hsp90
NO20060416L (no) Ny anvendelse I
CY1118672T1 (el) Συνθεσεις ταπενταδολης
NO20060847L (no) Substituert 2-aminotetralin til behandling av depresjon
MX2009008439A (es) Nuevos inhibidores de la replicacion del virus de hepatitis c.
NO20083005L (no) Anvendelse av benzofuserte heterocykliske sulfamidderivater for behandling av smerte
EA201001669A1 (ru) Замещенные пиримидин-5-карбоксамиды 281
NO20062513L (no) Sammensetninger og doseringsformer for forsterket absorpsjon av metformin
SE0301888D0 (sv) New use VII
SE0301886D0 (sv) New use V
WO2009026176A3 (en) Antiinfective flavononol compounds and methods of use thereof
CY1109519T1 (el) Κεκορεσμενες και ακορεστες 3-πυριδυλο-βενζοκυκλοαλκυλομεθυλαμινες για τη θεραπεια πονων, καταθλιψεων και καταστασεων φοβου
WO2009015485A8 (en) Cyclic inhibitors of carnitine palmitoyltransferase and treating cancer
NO20081804L (no) Pyrazolforbindelser egnet til behandling av inflammasjon
EP4327886A3 (en) Pyrimido- pyridazinone compounds and use thereof
EA201000362A1 (ru) Производные 1,3-дигидроизоиндола
EA201100872A1 (ru) Производные хиназолинамида
SE0401969D0 (sv) Piperidine derivatives
NZ585338A (en) Insulin-regulated aminopeptidase (irap) inhibitors and uses thereof
NO20062453L (no) Tiozolidinoner, fremstilling og anvendelse derav som legemidler
NO20092018L (no) Fremgangsmater for a behandle depresjon
WO2009063897A1 (ja) 皮膚の乾癬予防または改善剤
DE602005018390D1 (de) Verwendung von thiazolidinon-derivaten zur behandlung von festen tumoren
EA200600502A1 (ru) Способ асимметрической гидрогенизации бета-аминокетонов

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees