NO20061646L - Plasminogen activators that have reduced light binding capacity - Google Patents

Plasminogen activators that have reduced light binding capacity

Info

Publication number
NO20061646L
NO20061646L NO20061646A NO20061646A NO20061646L NO 20061646 L NO20061646 L NO 20061646L NO 20061646 A NO20061646 A NO 20061646A NO 20061646 A NO20061646 A NO 20061646A NO 20061646 L NO20061646 L NO 20061646L
Authority
NO
Norway
Prior art keywords
binding capacity
plasminogen activators
reduced light
light binding
plasminogen
Prior art date
Application number
NO20061646A
Other languages
Norwegian (no)
Inventor
Wolfgang Sohngen
Oliver Kops
Vincent Ellis
Original Assignee
Paion Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paion Deutschland Gmbh filed Critical Paion Deutschland Gmbh
Publication of NO20061646L publication Critical patent/NO20061646L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Oppfinnelsen vedrører anvendelsen av plasminogenaktivatorer som har redusert lysin- bindingskapasitet i behandlingen av ttombotiske forstyrrelser.The invention relates to the use of plasminogen activators which have reduced lysine binding capacity in the treatment of thrombotic disorders.

NO20061646A 2003-09-12 2006-04-11 Plasminogen activators that have reduced light binding capacity NO20061646L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10342518A DE10342518A1 (en) 2003-09-12 2003-09-12 Plasminogen activators with reduced lysine binding capacity
PCT/EP2004/010220 WO2005026341A2 (en) 2003-09-12 2004-09-13 Plasminogen activators having reduced lysine binding capacity

Publications (1)

Publication Number Publication Date
NO20061646L true NO20061646L (en) 2006-04-11

Family

ID=34305758

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20061646A NO20061646L (en) 2003-09-12 2006-04-11 Plasminogen activators that have reduced light binding capacity

Country Status (14)

Country Link
EP (2) EP1664293A2 (en)
JP (1) JP2007505079A (en)
CN (1) CN1849394A (en)
AU (1) AU2004272731A1 (en)
BR (1) BRPI0413718A (en)
CA (1) CA2537696A1 (en)
DE (1) DE10342518A1 (en)
EA (2) EA011156B1 (en)
IL (1) IL173953A0 (en)
MX (1) MXPA06002756A (en)
NO (1) NO20061646L (en)
NZ (1) NZ545825A (en)
WO (1) WO2005026341A2 (en)
ZA (1) ZA200602716B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8430749B2 (en) 2001-08-10 2013-04-30 Igt Dynamic casino tracking and optimization
US7946917B2 (en) 2001-08-10 2011-05-24 Igt Flexible loyalty points programs
DE10153601A1 (en) 2001-11-02 2003-05-22 Paion Gmbh DSPA for the treatment of stroke
DE10342518A1 (en) 2003-09-12 2005-05-12 Paion Gmbh Plasminogen activators with reduced lysine binding capacity
IL190184A0 (en) * 2008-03-16 2009-02-11 Hadasit Med Res Service tPA MUTANT IN THE TREATMENT OF ACUTE BRAIN INJURY AND NEURODEGENERATIVE DISORDERS

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4766075A (en) 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
US5094953A (en) * 1988-03-21 1992-03-10 Genentech, Inc. Human tissue plasminogen activator variants
DK176140B1 (en) * 1988-07-20 2006-09-25 Schering Ag Patentabteilung Bat salivary plasminogen activators
DE3825253A1 (en) * 1988-07-25 1990-02-01 Boehringer Mannheim Gmbh T-PA DERIVATIVE AND ITS PRODUCTION
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US6008019A (en) 1989-02-13 1999-12-28 Schering Aktiengesellschaft Plasminogen activator from saliva of the vampire bat
EP0383417B1 (en) 1989-02-13 1995-12-27 Schering Aktiengesellschaft Vampire bat salivary Plasminogen activator vPA-alpha 1
DE69215537T2 (en) * 1991-12-16 1997-04-30 Genentech, Inc., South San Francisco, Calif. t-PA SUBSTITUTION VARIANTS WITH IMPROVED FIBRINE SPECIFICITY
DE4423574A1 (en) * 1994-07-05 1996-01-11 Boehringer Mannheim Gmbh Non-glycosylated plasminogen activator derivatives and their use when there is an increased risk of bleeding
DE10153601A1 (en) * 2001-11-02 2003-05-22 Paion Gmbh DSPA for the treatment of stroke
BRPI0409865A (en) * 2003-05-02 2006-05-16 Paion Deutschland Gmbh intravenous injection of non-neurotoxic plasminogen activators for stroke attack treatment
DE10342518A1 (en) 2003-09-12 2005-05-12 Paion Gmbh Plasminogen activators with reduced lysine binding capacity

Also Published As

Publication number Publication date
EA200600573A1 (en) 2006-08-25
WO2005026341A3 (en) 2005-09-01
EA011156B1 (en) 2009-02-27
EP2368984A1 (en) 2011-09-28
ZA200602716B (en) 2007-07-25
EP1664293A2 (en) 2006-06-07
IL173953A0 (en) 2006-07-05
DE10342518A1 (en) 2005-05-12
NZ545825A (en) 2009-08-28
BRPI0413718A (en) 2006-10-17
MXPA06002756A (en) 2007-08-24
CA2537696A1 (en) 2005-03-24
CN1849394A (en) 2006-10-18
JP2007505079A (en) 2007-03-08
AU2004272731A1 (en) 2005-03-24
WO2005026341A2 (en) 2005-03-24
EA200801861A1 (en) 2010-06-30

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application