NO20062053L - Transdermalt, farmasoytisk preparat - Google Patents

Transdermalt, farmasoytisk preparat

Info

Publication number: NO20062053L
Authority: NO; Norway
Prior art keywords: transdermal; complex; liquid crystal; propylene glycol; acid salt
Prior art date: 2003-10-09

Application number

NO20062053A

Other languages

English (en)

Norwegian (no)

Inventor

Janos Illes

Erzsebet Francsicsne Czinege

Istvan Eros

Ildiko Pannonhalminee Csoka

Erzsebet Soosne Csanyi

Attila Bodis

Emoke Kissne Csikos

Original Assignee

Richter Gedeon Vegyeszet

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-10-09

Filing date

2006-05-08

Publication date

2006-05-08

2006-05-08 Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet

2006-05-08 Publication of NO20062053L publication Critical patent/NO20062053L/no

Links

239000000825 pharmaceutical preparation Substances 0.000 title abstract 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 6
KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical class CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract 2
HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 abstract 2
229920003171 Poly (ethylene oxide) Polymers 0.000 abstract 2
PHYFQTYBJUILEZ-UHFFFAOYSA-N Trioleoylglycerol Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCCCCCCCC)COC(=O)CCCCCCCC=CCCCCCCCC PHYFQTYBJUILEZ-UHFFFAOYSA-N 0.000 abstract 2
239000004973 liquid crystal related substance Substances 0.000 abstract 2
-1 polyoxyethylene Polymers 0.000 abstract 2
PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 abstract 2
229940117972 triolein Drugs 0.000 abstract 2
RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 abstract 1
239000002537 cosmetic Substances 0.000 abstract 1
229940011871 estrogen Drugs 0.000 abstract 1
239000000262 estrogen Substances 0.000 abstract 1
230000035876 healing Effects 0.000 abstract 1
238000002657 hormone replacement therapy Methods 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
239000000583 progesterone congener Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases or cochleates; Sponge phases
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/06—Anabolic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/34—Gestagens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Physical Education & Sports Medicine (AREA)
Endocrinology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Heart & Thoracic Surgery (AREA)
Dermatology (AREA)
Diabetes (AREA)
Dispersion Chemistry (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Communicable Diseases (AREA)
Urology & Nephrology (AREA)
Oncology (AREA)
Reproductive Health (AREA)
Otolaryngology (AREA)
Gynecology & Obstetrics (AREA)
Tropical Medicine & Parasitology (AREA)
Vascular Medicine (AREA)
Anesthesiology (AREA)

NO20062053A 2003-10-09 2006-05-08 Transdermalt, farmasoytisk preparat NO20062053L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU0303313A HUP0303313A2 (hu)	2003-10-09	2003-10-09	Transzdermális gyógyszerkészítmények
PCT/HU2004/000092 WO2005032514A1 (en)	2003-10-09	2004-10-06	Transdermal pharmaceutical composition

Publications (1)

Publication Number	Publication Date
NO20062053L true NO20062053L (no)	2006-05-08

Family

ID=90001702

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20062053A NO20062053L (no)	2003-10-09	2006-05-08	Transdermalt, farmasoytisk preparat

Country Status (13)

Country	Link
US (1)	US7728042B2 (pl)
EP (1)	EP1673063B1 (pl)
JP (1)	JP4884223B2 (pl)
AT (1)	ATE383849T1 (pl)
DE (1)	DE602004011374T2 (pl)
DK (1)	DK1673063T3 (pl)
EA (1)	EA009900B1 (pl)
ES (1)	ES2300820T3 (pl)
HU (1)	HUP0303313A2 (pl)
NO (1)	NO20062053L (pl)
PL (1)	PL1673063T3 (pl)
RS (2)	RS20060249A (pl)
WO (1)	WO2005032514A1 (pl)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20050238672A1 (en) *	2004-04-27	2005-10-27	Nimni Marcel E	Antifungal drug delivery
CA2607777A1 (en) *	2005-04-28	2006-11-09	Japan Science And Technology Agency	Transdermal absorption enhancer
FR2900575B1 (fr) *	2006-05-05	2008-10-17	Anteis Sa	Gel biocompatible a liberation controlee, son procede de preparation et son utilisation
HUP0700828A2 (en) *	2007-12-20	2010-01-28	Richter Gedeon Nyrt	Transdermal pharmaceutical compositions containing tolperisone alone and in combination
ES2326721B1 (es) *	2008-01-04	2010-07-16	Endor Nanotechnologies, S.L.	Conjugado de acido hialuronico para el tratamiento cosmetico y procedimiento de preparacion.
WO2010069519A1 (en) *	2008-12-18	2010-06-24	Merz Pharma Gmbh & Co. Kgaa	Topical compositions comprising at least one active ingredient poorly soluble in water and biopolymers such as hyaluronic acid with a pka-value between 5-7
US20110033515A1 (en) *	2009-08-04	2011-02-10	Rst Implanted Cell Technology	Tissue contacting material
ES2574210T3 (es) *	2010-03-02	2016-06-15	Fervent Pharmaceuticals, Llc	Métodos y composiciones para tratar o prevenir los síntomas de las variaciones hormonales
US8461102B2 (en)	2010-03-02	2013-06-11	George E. Royster, JR.	Methods and compositions for treating and preventing symptoms of hormonal variations
JP2013537552A (ja)	2010-08-18	2013-10-03	デルマーファーマスーティカルズ	ジアンヒドロガラクチトール及びジアセチルジアンヒドロガラクチトール等の置換ヘキシトールを含む準最適に投与された化合物の治療的有効性を改良するための組成物及び方法
US9114258B2 (en)	2011-01-04	2015-08-25	Kato Medical Systems Llc	Electrokinetic nerve stimulator
EP2758043A4 (en)	2011-08-17	2016-02-24	Dennis M Brown	COMPOSITIONS AND METHODS FOR INCREASING THE THERAPEUTIC UTILITY OF SUBOPTIMALLY APPLIED CHEMICAL COMPOUNDS INCLUDING SUBSTITUTED HEXITOLS SUCH AS DIBROMODULCITOL
RS62297B1 (sr)	2011-11-23	2021-09-30	Therapeuticsmd Inc	Prirodne kombinovane hormonske supstitucione formulacije i terapije
US9301920B2 (en)	2012-06-18	2016-04-05	Therapeuticsmd, Inc.	Natural combination hormone replacement formulations and therapies
MX385227B (es)	2012-01-20	2025-03-14	Del Mar Pharmaceuticals	Uso de hexitoles sustituidos que incluyen dianhidrogalactitol y análogos para tratar enfermedad neoplásica y células madre de cáncer que incluyen glioblastoma multiforme y meduloblastoma.
WO2013169600A1 (en)	2012-05-09	2013-11-14	Delmar Pharmaceuticals	Veterinary use of dianhydrogalactitol, diacetyldianhydrogalactitol, and dibromodulcitol to treat malignancies
US10806697B2 (en)	2012-12-21	2020-10-20	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US20130338122A1 (en)	2012-06-18	2013-12-19	Therapeuticsmd, Inc.	Transdermal hormone replacement therapies
US10806740B2 (en)	2012-06-18	2020-10-20	Therapeuticsmd, Inc.	Natural combination hormone replacement formulations and therapies
US20150196640A1 (en)	2012-06-18	2015-07-16	Therapeuticsmd, Inc.	Progesterone formulations having a desirable pk profile
SG10201610869TA (en)	2012-06-26	2017-02-27	Del Mar Pharmaceuticals	Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalacti
CN104736176B (zh) *	2012-08-24	2017-10-13	英特格拉斯疗法有限公司	用于增强治疗剂透皮递送的化学组合物和方法
US11266661B2 (en)	2012-12-21	2022-03-08	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en)	2012-12-21	2020-01-21	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en)	2012-12-21	2022-02-15	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en)	2012-12-21	2015-11-10	Therapeuticsmd, Inc.	Soluble estradiol capsule for vaginal insertion
US10568891B2 (en)	2012-12-21	2020-02-25	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en)	2012-12-21	2019-11-12	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
HU230989B1 (hu) *	2013-01-17	2019-08-28	Gd Photonics Kft.	Készítmény az UVB-fényterápia hatékonyságának fokozására, eljárás annak előállítására és alkalmazása
EP2983674A4 (en)	2013-04-08	2017-05-10	Dennis M. Brown	Therapeutic benefit of suboptimally administered chemical compounds
JP6125547B2 (ja) *	2013-04-24	2017-05-10	あすか製薬株式会社	無定形レボノルゲストレル、固体分散体及びそれらの製造方法
CA2928568A1 (en)	2013-07-26	2015-01-29	Update Pharma Inc.	Combinatorial methods to improve the therapeutic benefit of bisantrene
JP6783224B2 (ja)	2014-04-04	2020-11-11	デルマーファーマシューティカルズ	肺の非小細胞癌腫及び卵巣癌を処置するためのジアンヒドロガラクチトール及びその類縁体又は誘導体の使用
RU2016143081A (ru)	2014-05-22	2018-06-26	Терапьютиксмд, Инк.	Натуральные комбинированные гормонозаместительные составы и терапии
EP3174542A4 (en)	2014-07-29	2018-01-03	TherapeuticsMD, Inc.	Transdermal cream
CN104725370B (zh) *	2015-03-19	2017-03-01	天津大学	一种长春西汀管状晶体及制备方法
US10328087B2 (en)	2015-07-23	2019-06-25	Therapeuticsmd, Inc.	Formulations for solubilizing hormones
US9931349B2 (en)	2016-04-01	2018-04-03	Therapeuticsmd, Inc.	Steroid hormone pharmaceutical composition
US10286077B2 (en)	2016-04-01	2019-05-14	Therapeuticsmd, Inc.	Steroid hormone compositions in medium chain oils
CN109091451B (zh) *	2018-09-10	2021-08-13	武汉百纳礼康生物制药有限公司	亲水性药物的油相液晶凝胶前体制剂及其制备方法
RU2712918C1 (ru) *	2019-08-01	2020-02-03	Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации	Способ предотвращения острой боли при выполнении химического плевродеза после радикальных торакопластических операций онкологического характера
CN112426403B (zh) *	2020-12-09	2021-09-17	南京天纵易康生物科技股份有限公司	一种口腔溃疡凝胶及其制备方法和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4968539A (en) *	1987-12-01	1990-11-06	Lion Corporation	Liquid crystal membrane
US6458774B1 (en) *	1989-02-24	2002-10-01	Richter Gedeon Vegyeszeti Gyar Rt.	Compositions containing hyaluronic acid associates and a process for preparing same
CA1340994C (en) *	1989-09-21	2000-05-16	Rudolf Edgar Dr. Falk	Treatment of conditions and disease
IT1248666B (it) *	1990-05-30	1995-01-26	Fidia Spa	Gel in forma di film autosupportanti altamente idrati, processo per laloro preparazione e impiego nella terapia di lesioni e/o patologie cutanee
HU209605B (en) *	1991-04-15	1994-09-28	Chinoin Gyogyszer Es Vegyeszet	Process for production of wather-free transdermal preparation
TW218849B (pl) *	1991-05-17	1994-01-11	Bristol Myers Squibb Co
US5326566A (en) *	1991-05-17	1994-07-05	Bristol-Myers Squibb Company	Use of dibutyl adipate and isopropyl myristate in topical and transdermal products
US5616568A (en) *	1993-11-30	1997-04-01	The Research Foundation Of State University Of New York	Functionalized derivatives of hyaluronic acid
RU2276998C2 (ru) *	2001-05-01	2006-05-27	Институт Нефтехимического Синтеза Имени А.В. Топчиева Российской Академии Наук	Гидрогелевые композиции
EP1390041B1 (en) *	2001-05-23	2009-11-25	Pantarhei Bioscience B.V.	Drug delivery system comprising a tetrahydroxylated estrogen for use in hormonal contraception
JP2003063996A (ja) *	2001-08-23	2003-03-05	禎秀 ▲廣▼▲崎▼	皮膚外用剤
US6960563B2 (en) *	2001-08-31	2005-11-01	Morton Grove Pharmaceuticals, Inc.	Spontaneous emulsions containing cyclosporine

2003
- 2003-10-09 HU HU0303313A patent/HUP0303313A2/hu unknown
2004
- 2004-10-06 PL PL04769091T patent/PL1673063T3/pl unknown
- 2004-10-06 DK DK04769091T patent/DK1673063T3/da active
- 2004-10-06 DE DE602004011374T patent/DE602004011374T2/de not_active Expired - Lifetime
- 2004-10-06 EP EP04769091A patent/EP1673063B1/en not_active Expired - Lifetime
- 2004-10-06 US US10/575,145 patent/US7728042B2/en not_active Expired - Fee Related
- 2004-10-06 RS YUP-2006/0249A patent/RS20060249A/sr unknown
- 2004-10-06 ES ES04769091T patent/ES2300820T3/es not_active Expired - Lifetime
- 2004-10-06 AT AT04769091T patent/ATE383849T1/de active
- 2004-10-06 RS RS20060249A patent/RS51764B/sr unknown
- 2004-10-06 JP JP2006530614A patent/JP4884223B2/ja not_active Expired - Fee Related
- 2004-10-06 WO PCT/HU2004/000092 patent/WO2005032514A1/en not_active Ceased
- 2004-10-06 EA EA200600750A patent/EA009900B1/ru not_active IP Right Cessation
2006
- 2006-05-08 NO NO20062053A patent/NO20062053L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
ES2300820T3 (es)	2008-06-16
JP4884223B2 (ja)	2012-02-29
DE602004011374D1 (de)	2008-03-06
PL1673063T3 (pl)	2008-06-30
EP1673063B1 (en)	2008-01-16
DE602004011374T2 (de)	2009-01-08
EA200600750A1 (ru)	2006-08-25
HUP0303313D0 (en)	2003-12-29
RS20060249A (sr)	2008-06-05
EA009900B1 (ru)	2008-04-28
ATE383849T1 (de)	2008-02-15
JP2007508287A (ja)	2007-04-05
US7728042B2 (en)	2010-06-01
RS51764B (sr)	2011-12-31
DK1673063T3 (da)	2008-05-19
US20070264345A1 (en)	2007-11-15
HUP0303313A2 (hu)	2005-07-28
EP1673063A1 (en)	2006-06-28
WO2005032514A1 (en)	2005-04-14

Legal Events

Date	Code	Title	Description
2014-05-26	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
EA200600750A1 (ru)	2006-08-25	Трансдермальная фармацевтическая композиция
PT1183029E (pt)	2005-09-30	Preparado farmaceutico contendo contendo o principio activo diamorfina e sua utilizacao num processo para o tratamento da dependencia de opiaceos
NO963447L (no)	1996-08-19	Transdermale, terapeutiske systemer som inneholder seksualsteroider
GB2303629B (en)	1998-09-02	Hydroxamic acids and their use as metalloproteinase inhibitors
ATE455547T1 (de)	2010-02-15	Pharmazeutische verwendungen von kondensierten 1, 2,4-triazolen
MY145590A (en)	2012-02-29	Phenylacetamides and their use as glucokinase modulators
SE0100901D0 (sv)	2001-03-15	New composition
DE60043305D1 (de)	2009-12-24	Pharmazeutische zubereitungen zur behandlung von insulinresitenz
BR0316402A (pt)	2006-02-21	vesìcula fusogênica, métodos para preparar uma vesìcula fusogênica encapsulante, e para encapsular pelo menos uma substáncia terapêutica ou imunologicamente ativa em uma vesìcula fusogênica, uso de uma vesìcula fusogênica, e, formulação farmacêutica
EE03292B1 (et)	2000-10-16	Prootonpumba inhibiitorit sisaldav paljuosaline ravimpreparaat ja selle valmistamise protsess
AU2001246484A1 (en)	2001-11-29	Anti-infective active substance combinations and the use thereof for the topical treatment of fungus diseases of toe and finger nails
AU2002214389A1 (en)	2002-04-22	Pharmaceutical composition containing honey for the treatment of wounds
DK1280558T3 (da)	2005-12-27	Halvfast indgivelsesvehikel og farmaceutiske sammensætninger
WO2002074290B1 (en)	2004-03-25	Dermatological preparations containing a nsaid
BRPI0620431A8 (pt)	2018-01-09	uso de um poliuretano formador de película, preparação farmacêutica líquida, aplicador e emplastro contendo a referida preparação farmacêutica
AU2003296692A1 (en)	2005-01-21	Lipidic protein-transfer systems and cosmetic/dermatological use thereof
DE60331574D1 (de)	2010-04-15	Verfahren zur behandlung von erkrankungen mit mangel an thiolhaltiger verbindung
WO2001045650A3 (de)	2001-12-27	Kosmetische verwendung von rückständen aus der weinherstellung
WO2002051379A3 (en)	2003-03-13	Thixotropic nasal spray
NO995838L (no)	2000-01-31	Nye heteroetynylenforbindelser og farmasoeytiske og kosmetiske preparater inneholdende de samme
AU2001267561A1 (en)	2002-01-08	Combination preparations of 3-n-formylhydroxylaminopropyl phosphonic acid derivatives or 3-n-acetylhydroxylaminopropyl phosphonic acid derivatives combined withspecific pharmaceutical active agents
BR0014751A (pt)	2002-07-02	Composto, estereoisÈmero ou mistura de estereoisÈmeros, composição farmacêutica, método de tratamento de um paciente em necessidade de tratamento antimicrobiano, e, uso de um composto
WO2004052331A3 (fr)	2004-08-12	Utilisation d'un extrait de miellat de coton comme ingredient acitif
WO2001041771A3 (de)	2001-12-27	Acetylsalicylsäure enthaltendes transdermales system zur behandlung von migräne
IT1291307B1 (it)	1999-01-07	Composizione farmaceutica atta al trattamento delle patologie neurodegenerative