NO20062832L - Nye salicylanilider - Google Patents
Nye salicylaniliderInfo
- Publication number
- NO20062832L NO20062832L NO20062832A NO20062832A NO20062832L NO 20062832 L NO20062832 L NO 20062832L NO 20062832 A NO20062832 A NO 20062832A NO 20062832 A NO20062832 A NO 20062832A NO 20062832 L NO20062832 L NO 20062832L
- Authority
- NO
- Norway
- Prior art keywords
- new
- anilides
- new salicylic
- salicylic anilides
- salicylanilides
- Prior art date
Links
- WKEDVNSFRWHDNR-UHFFFAOYSA-N salicylanilide Chemical class OC1=CC=CC=C1C(=O)NC1=CC=CC=C1 WKEDVNSFRWHDNR-UHFFFAOYSA-N 0.000 title 1
- 206010033307 Overweight Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/64—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Gastroenterology & Hepatology (AREA)
- Child & Adolescent Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Color Printing (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200301738 | 2003-11-25 | ||
| US52637803P | 2003-12-01 | 2003-12-01 | |
| PCT/DK2004/000304 WO2005051894A1 (en) | 2003-11-25 | 2004-05-04 | Novel salicylic anilides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20062832L true NO20062832L (no) | 2006-06-16 |
Family
ID=34635235
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20062832A NO20062832L (no) | 2003-11-25 | 2006-06-16 | Nye salicylanilider |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7645791B2 (pt) |
| EP (1) | EP1689700A1 (pt) |
| JP (1) | JP2007513880A (pt) |
| KR (1) | KR20060101500A (pt) |
| AU (1) | AU2004293133A1 (pt) |
| BR (1) | BRPI0416933A (pt) |
| CA (1) | CA2545023A1 (pt) |
| IL (1) | IL175154A0 (pt) |
| NO (1) | NO20062832L (pt) |
| RU (1) | RU2006116421A (pt) |
| WO (1) | WO2005051894A1 (pt) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005105712A1 (en) * | 2004-05-05 | 2005-11-10 | Novo Nordisk A/S | Sulfonamide derivatives |
| US20080234381A1 (en) * | 2005-05-23 | 2008-09-25 | Novo Nordisk A/S | Novel Trifluoromethoxy-Substituted Aryl Anilides |
| JP2008545677A (ja) * | 2005-05-23 | 2008-12-18 | ノボ ノルディスク アクティーゼルスカブ | 新規なハロアルコキシ置換サリチル酸アニリド |
| AU2007284801A1 (en) * | 2006-08-08 | 2008-02-21 | The Regents Of The University Of Californina | Salicylanilides enhance oral delivery of therapeutic peptides |
| US7939690B2 (en) | 2006-11-15 | 2011-05-10 | High Point Pharmaceuticals, Llc | Haloalkylsulfone substituted compounds useful for treating obesity and diabetes |
| EP2097388B1 (en) | 2006-11-15 | 2011-09-07 | High Point Pharmaceuticals, LLC | Novel 2-(2-hydroxyphenyl)benzimidazoles useful for treating obesity and diabetes |
| US8022066B2 (en) | 2006-11-15 | 2011-09-20 | High Point Pharmaceuticals, Llc | 2-(2-hydroxyphenyl) benzothiadiazines useful for treating obesity and diabetes |
| WO2008059024A1 (en) * | 2006-11-15 | 2008-05-22 | High Point Pharmaceuticals, Llc | 2- ( 2 -hydroxyphenyl) -quinazolin-4-ones useful for treating obesity and diabetes |
| MA34373B1 (fr) | 2010-07-14 | 2013-07-03 | Novartis Ag | Composés hétérocycliques agonistes du récepteur ip |
| KR101665009B1 (ko) * | 2012-03-09 | 2016-10-11 | 한미사이언스 주식회사 | 비알콜성 지방간 질환의 예방 또는 치료용 약학적 조성물 |
| US9604981B2 (en) | 2013-02-13 | 2017-03-28 | Novartis Ag | IP receptor agonist heterocyclic compounds |
| EP4086242A1 (en) | 2017-01-06 | 2022-11-09 | Rivus Pharmaceuticals, Inc. | 5-[(2,4-dinitrophenoxy)methyl]-1-methyl-2-nitro-l h-imidazole and its pharmaceutical use |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE34102C (de) | TH. GARE in Stockpprt Cheshire, England | Neuerungen an Maschinen zum Zurechtschneiden, Poliren, Ausfertigen und Putzen von Stiefeln oder Schuhen | ||
| CH281901A (de) * | 1950-04-25 | 1952-03-31 | Hoffmann La Roche | Verfahren zur Herstellung eines neuen Tropasäureabkömmlings. |
| GB728098A (en) * | 1952-03-05 | 1955-04-13 | Geigy Ag J R | Improvements relating to salicylanilides and their use |
| GB1153994A (en) * | 1965-07-21 | 1969-06-04 | Aspro Nicholas Ltd | Hydroxyphenyl Anthranilic Acid Derivatives Capable of Absorbing 'Ultra-Violet Light and Compositions containing them |
| GB1493375A (en) * | 1974-09-20 | 1977-11-30 | Ici Ltd | Salicylanilide derivatives |
| US4673691A (en) | 1984-11-05 | 1987-06-16 | Nicholas Bachynsky | Human weight loss inducing method |
| JP2668231B2 (ja) | 1987-12-29 | 1997-10-27 | 大日精化工業株式会社 | 電子写真感光体 |
| US5965606A (en) * | 1995-12-29 | 1999-10-12 | Allergan Sales, Inc. | Methods of treatment with compounds having RAR.sub.α receptor specific or selective activity |
| US7635722B1 (en) | 1998-07-27 | 2009-12-22 | Saint Jude Pharmaceuticals, Inc. | Chemical induced intracellular hyperthermia |
| JP3937200B2 (ja) * | 1998-09-10 | 2007-06-27 | 三井化学株式会社 | 新規な遷移金属錯体、オレフィン重合用触媒およびオレフィンの重合方法 |
| WO2001007028A2 (en) * | 1999-07-23 | 2001-02-01 | Allergan Sales, Inc. | The use of retinoid receptor antagonists in the treatment of prostate carcinoma |
| WO2001044172A1 (en) | 1999-12-15 | 2001-06-21 | Axys Pharmaceuticals, Inc. | Salicylamides as serine protease and factor xa inhibitors |
| WO2001082924A1 (en) | 2000-05-02 | 2001-11-08 | Smithkline Beecham Corporation | Phosphate transport inhibitors |
| US6790569B2 (en) | 2000-06-13 | 2004-09-14 | Eastman Kodak Company | Color photothermographic elements comprising phenolic thermal solvents |
| JPWO2003103648A1 (ja) * | 2002-06-05 | 2005-10-06 | 株式会社医薬分子設計研究所 | 糖尿病治療薬 |
| CA2488974A1 (en) * | 2002-06-10 | 2003-12-18 | Institute Of Medicinal Molecular Design, Inc. | Medicament for treatment of cancer |
| AU2003275939A1 (en) * | 2002-11-08 | 2004-06-07 | Novo Nordisk A/S | Safe chemical uncouplers for the treatment of obesity |
-
2004
- 2004-05-04 RU RU2006116421/04A patent/RU2006116421A/ru not_active Application Discontinuation
- 2004-05-04 WO PCT/DK2004/000304 patent/WO2005051894A1/en not_active Ceased
- 2004-05-04 JP JP2006540164A patent/JP2007513880A/ja not_active Withdrawn
- 2004-05-04 EP EP04730961A patent/EP1689700A1/en not_active Withdrawn
- 2004-05-04 AU AU2004293133A patent/AU2004293133A1/en not_active Abandoned
- 2004-05-04 KR KR1020067010059A patent/KR20060101500A/ko not_active Ceased
- 2004-05-04 CA CA002545023A patent/CA2545023A1/en not_active Abandoned
- 2004-05-04 BR BRPI0416933-6A patent/BRPI0416933A/pt not_active IP Right Cessation
-
2006
- 2006-04-25 IL IL175154A patent/IL175154A0/en unknown
- 2006-06-16 NO NO20062832A patent/NO20062832L/no not_active Application Discontinuation
-
2008
- 2008-06-27 US US12/147,678 patent/US7645791B2/en not_active Expired - Fee Related
-
2009
- 2009-11-24 US US12/625,068 patent/US20100075932A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| IL175154A0 (en) | 2006-09-05 |
| AU2004293133A1 (en) | 2005-06-09 |
| BRPI0416933A (pt) | 2007-01-16 |
| KR20060101500A (ko) | 2006-09-25 |
| WO2005051894A1 (en) | 2005-06-09 |
| RU2006116421A (ru) | 2008-01-10 |
| US20100075932A1 (en) | 2010-03-25 |
| JP2007513880A (ja) | 2007-05-31 |
| US20090005434A1 (en) | 2009-01-01 |
| CA2545023A1 (en) | 2005-06-09 |
| US7645791B2 (en) | 2010-01-12 |
| EP1689700A1 (en) | 2006-08-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12019501611A1 (en) | Chemical compounds as inhibitors of interleukin-1 activity | |
| NO20081042L (no) | PPAR aktive forbindelser | |
| NO20071549L (no) | Nye benzofuserte heteroalrylsulfamidderivater, anvendelige som anti-krampemidler | |
| CL2007002384A1 (es) | Uso de compuestos derivados de 2,5-dihidroxibenceno para el tratamiento de la psoriasis. | |
| NO20091976L (no) | Nye forbindelser | |
| DK1594858T3 (da) | Nye benzoimidazol-derivater, der kan anvendes som antiproliferative midler | |
| MX2021003187A (es) | Inhibición de la peptidasa específica de ubiquitina 9x. | |
| DK1206474T3 (da) | Sulfonylphenylpyrazolforbindelser anvendelige som cox-2-inhibitorer | |
| IS7721A (is) | Píperidín-pýrídasón og þalasón sem PDE4 hemlar | |
| NO20062649L (no) | Biarylsulfonamider og metoder for anvendelse av disse | |
| IS6251A (is) | Not af mónóamín oxíðasa lötum fyrir framleiðslu ályfjum ætluðum til meðhöndlunar á offitu | |
| BR112015032736A2 (pt) | inibidores de bromodomínio cristalino | |
| EA201592212A8 (ru) | Кристаллические полиморфные формы свободного основания 2-гидрокси-6-((2-(1-изопропил-1н-пиразол-5-ил)пиридин-3-ил)метокси)бензальдегида | |
| TW200519089A (en) | Biaryl sulfonamides and methods for using same | |
| SE0203752D0 (sv) | New compounds | |
| BRPI0608886B8 (pt) | derivados de n-sulfonilpirróis e seus usos | |
| NO20083153L (no) | Kjemiske forbindelser | |
| BRPI0416268A (pt) | composições de delta-9-thc e métodos para o tratamento de sintomas associados à esclerose múltipla | |
| ECSP056229A (es) | Una composición farmacéutica que comprende formas polimórficas de 3-(4-amino-1-oxo-1.3 dyhidro-isoindol-2-il)-piperidina-2,6-diona para el tratamiento y manejo de cánceres | |
| TR200102969T2 (tr) | Siklik protein tirozin kinaz önleyicileri. | |
| DE602004017037D1 (de) | 2,3-dihydro-6-nitroimidazoä2,1-büoxazolverbindungen zur behandlung von tuberkulose | |
| ATE353217T1 (de) | 3-hydroxy-6-phenylphenanthridine als pde-4 inhibitoren | |
| NO20062832L (no) | Nye salicylanilider | |
| NO20071534L (no) | Behandling av inflammatoriske forstyrrelser og smerte | |
| NO20080462L (no) | Krystallformer av astaxantin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |