NO20062923L - New benzofuran derivatives that can be used in the prevention or treatment of 5-HT6 receptor-related disorder - Google Patents

New benzofuran derivatives that can be used in the prevention or treatment of 5-HT6 receptor-related disorder

Info

Publication number
NO20062923L
NO20062923L NO20062923A NO20062923A NO20062923L NO 20062923 L NO20062923 L NO 20062923L NO 20062923 A NO20062923 A NO 20062923A NO 20062923 A NO20062923 A NO 20062923A NO 20062923 L NO20062923 L NO 20062923L
Authority
NO
Norway
Prior art keywords
receptor
prevention
treatment
related disorder
benzofuran derivatives
Prior art date
Application number
NO20062923A
Other languages
Norwegian (no)
Inventor
Gary Johansson
Bjorn M Nilsson
Peter Brandt
Original Assignee
Biovitrum Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0303480A external-priority patent/SE0303480D0/en
Application filed by Biovitrum Ab filed Critical Biovitrum Ab
Publication of NO20062923L publication Critical patent/NO20062923L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Foreliggende oppfinnelse vedrører forbindelser med formel (I); hvori P, R3, W1 og W2 er som beskrevet heri, for farmasøytiske sammensetninger som omfatter forbindelsene, fremgangsmåter for deres fremstilling, så vel som for anvendelsen av forbindelsene for fremstilling av et medikament mot 5-HT6 reseptorrelaterte forstyrrelser.The present invention relates to compounds of formula (I); wherein P, R3, W1 and W2 are as described herein, for pharmaceutical compositions comprising the compounds, processes for their preparation, as well as for the use of the compounds for the preparation of a drug for 5-HT6 receptor-related disorders.

NO20062923A 2003-12-19 2006-06-22 New benzofuran derivatives that can be used in the prevention or treatment of 5-HT6 receptor-related disorder NO20062923L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0303480A SE0303480D0 (en) 2003-12-19 2003-12-19 Benzofuranes
US54965204P 2004-03-03 2004-03-03
PCT/SE2004/001949 WO2005058858A1 (en) 2003-12-19 2004-12-20 Novel benzofuran derivatives, which can be used in prophylaxis or treatment of 5-ht6 receptor-related disorder

Publications (1)

Publication Number Publication Date
NO20062923L true NO20062923L (en) 2006-06-22

Family

ID=34703499

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20062923A NO20062923L (en) 2003-12-19 2006-06-22 New benzofuran derivatives that can be used in the prevention or treatment of 5-HT6 receptor-related disorder

Country Status (9)

Country Link
EP (1) EP1694663A1 (en)
KR (1) KR20060127886A (en)
AU (1) AU2004299438A1 (en)
BR (1) BRPI0417833A (en)
CA (1) CA2545506A1 (en)
EA (1) EA010298B1 (en)
IL (1) IL175960A0 (en)
NO (1) NO20062923L (en)
WO (1) WO2005058858A1 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7435837B2 (en) 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
WO2006062481A1 (en) * 2004-12-09 2006-06-15 Biovitrum Ab New benzofuran derivatives and their use in the treatment of obesity, type ii diabetes and cns disorders .
WO2007108744A2 (en) * 2006-03-17 2007-09-27 Astrazeneca Ab Novel quinazolines as 5-ht6 modulators
JP2010500300A (en) 2006-08-08 2010-01-07 サノフィ−アベンティス Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for their preparation, agents containing these compounds, and uses thereof
WO2008024724A1 (en) 2006-08-21 2008-02-28 Genentech, Inc. Aza-benzothiophenyl compounds and methods of use
HU230761B1 (en) * 2007-05-30 2018-03-28 Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság New benzofuran derivatives as selective inhibitors of 5-ht6 and process for their preparation
CA2727250A1 (en) 2008-07-01 2010-01-07 Genentech, Inc. Bicyclic heterocycles as mek kinase inhibitors
JP5615274B2 (en) 2008-07-01 2014-10-29 ジェネンテック， インコーポレイテッド Isoindolone derivatives as MEK kinase inhibitors and methods of use thereof
WO2010003624A2 (en) 2008-07-09 2010-01-14 Sanofi-Aventis Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
MX2011002884A (en) 2008-09-17 2011-04-21 Suven Life Sciences Ltd Aryl sulfonamide amine compounds and their use as 5-ht6 ligands.
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
SG178880A1 (en) 2009-08-26 2012-04-27 Sanofi Sa Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use
PE20121384A1 (en) * 2009-12-08 2012-10-13 Novartis Ag HETEROCYCLIC SULFONAMIDE DERIVATIVES
MX2012007253A (en) * 2009-12-22 2012-07-17 Cephalon Inc Tricyclic derivatives and their pharmaceutical use and compositions.
EP2683703B1 (en) 2011-03-08 2015-05-27 Sanofi Novel substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
EP2683698B1 (en) 2011-03-08 2017-10-04 Sanofi Benzyl-oxathiazine derivates substituted with adamantane or noradamantane, medicaments containing said compounds and use thereof
WO2012120054A1 (en) 2011-03-08 2012-09-13 Sanofi Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8846666B2 (en) 2011-03-08 2014-09-30 Sanofi Oxathiazine derivatives which are substituted with benzyl or heteromethylene groups, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
WO2012120056A1 (en) 2011-03-08 2012-09-13 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
EP2683704B1 (en) 2011-03-08 2014-12-17 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8809324B2 (en) 2011-03-08 2014-08-19 Sanofi Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
WO2012120055A1 (en) 2011-03-08 2012-09-13 Sanofi Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2766349B1 (en) 2011-03-08 2016-06-01 Sanofi Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DZ2376A1 (en) * 1996-12-19 2002-12-28 Smithkline Beecham Plc New sulfonamide derivatives process for their preparation and pharmaceutical compositions containing them.
GB9926302D0 (en) * 1999-11-05 2000-01-12 Smithkline Beecham Plc Novel compounds
RU2294932C2 (en) * 2001-06-07 2007-03-10 Ф.Хоффманн-Ля Рош Аг Indole derivatives showing affinity to 5-ht6 receptors
CN100457726C (en) * 2001-06-11 2009-02-04 比奥维特罗姆股份公开公司 Substituted sulfonamide compounds, process for their preparation and their use as medicaments for the treatment of CNS disorders, obesity and type II diabetes
US20040242589A1 (en) * 2001-08-07 2004-12-02 Bromidge Steven Mark 3-arylsulfonyl-7-piperzinyl-indoles-benzofurans and -benzothiophenes with 5-ht6 receptor affinity for treating cns disorders
CN1662521A (en) * 2002-06-20 2005-08-31 比奥维特罗姆股份公司 New Compounds May Be Used to Treat Obesity, Type 2 Diabetes and CNS Disorders

Also Published As

Publication number Publication date
KR20060127886A (en) 2006-12-13
AU2004299438A1 (en) 2005-06-30
EA010298B1 (en) 2008-08-29
WO2005058858A1 (en) 2005-06-30
EP1694663A1 (en) 2006-08-30
EA200601194A1 (en) 2006-10-27
BRPI0417833A (en) 2007-04-17
CA2545506A1 (en) 2005-06-30
IL175960A0 (en) 2006-10-05

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application