NO20063231L - Pyrido[2,3-D]pyrimidin-2,4-diaminer som PDE 2 inhibitorer - Google Patents

Pyrido[2,3-D]pyrimidin-2,4-diaminer som PDE 2 inhibitorer

Info

Publication number
NO20063231L
NO20063231L NO20063231A NO20063231A NO20063231L NO 20063231 L NO20063231 L NO 20063231L NO 20063231 A NO20063231 A NO 20063231A NO 20063231 A NO20063231 A NO 20063231A NO 20063231 L NO20063231 L NO 20063231L
Authority
NO
Norway
Prior art keywords
pde
pyrido
diamines
pyrimidine
inhibitors
Prior art date
Application number
NO20063231A
Other languages
English (en)
Inventor
Andrew Ian Morrell
David Duane Thompson
Robert James Chambers
Thomas Arthur Beyer
Kelvin Lam
Mel Li
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of NO20063231L publication Critical patent/NO20063231L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Det er beskrevet forbindelser av formel (I), promedikamenter derav og farmasøytisk akseptable salter av forbindelsene eller promedikamentene, hvor n, X og Y er som definert heri, farmasøytiske preparater derav, kombinasjoner derav og anvendelse derav.
NO20063231A 2003-12-16 2006-07-11 Pyrido[2,3-D]pyrimidin-2,4-diaminer som PDE 2 inhibitorer NO20063231L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52999403P 2003-12-16 2003-12-16
PCT/IB2004/004013 WO2005061497A1 (en) 2003-12-16 2004-12-06 Pyrido[2,3-d]pyrimidine-2,4-diamines as pde 2 inhibitors

Publications (1)

Publication Number Publication Date
NO20063231L true NO20063231L (no) 2006-07-11

Family

ID=34710150

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20063231A NO20063231L (no) 2003-12-16 2006-07-11 Pyrido[2,3-D]pyrimidin-2,4-diaminer som PDE 2 inhibitorer

Country Status (39)

Country Link
US (1) US20070135457A1 (no)
EP (1) EP1697356B1 (no)
JP (1) JP4073944B2 (no)
KR (1) KR100816179B1 (no)
CN (1) CN100439366C (no)
AP (1) AP2006003632A0 (no)
AR (1) AR046766A1 (no)
AT (1) ATE387446T1 (no)
AU (1) AU2004303609A1 (no)
BR (1) BRPI0417663A (no)
CA (1) CA2549510A1 (no)
CL (1) CL2008001920A1 (no)
DE (1) DE602004012154T2 (no)
DK (1) DK1697356T3 (no)
EA (1) EA010424B1 (no)
EC (1) ECSP066643A (no)
ES (1) ES2299888T3 (no)
GE (1) GEP20094720B (no)
GT (1) GT200400268A (no)
HN (1) HN2004000538A (no)
HR (1) HRP20080142T3 (no)
IL (1) IL175813A0 (no)
IS (1) IS8474A (no)
MA (1) MA28270A1 (no)
MX (1) MXPA06006777A (no)
NL (1) NL1027787C2 (no)
NO (1) NO20063231L (no)
PE (1) PE20050681A1 (no)
PL (1) PL1697356T3 (no)
PT (1) PT1697356E (no)
RS (1) RS50575B (no)
SI (1) SI1697356T1 (no)
SV (1) SV2005001979A (no)
TN (1) TNSN06186A1 (no)
TW (1) TWI291961B (no)
UA (1) UA83091C2 (no)
UY (1) UY28671A1 (no)
WO (1) WO2005061497A1 (no)
ZA (1) ZA200604970B (no)

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EP1960372B1 (en) * 2005-12-15 2015-12-09 Rigel Pharmaceuticals, Inc. Kinase inhibitors and their uses
CN101573127B (zh) * 2006-09-21 2013-04-10 大黑俊树 硬组织再生促进剂
WO2009116577A1 (ja) * 2008-03-18 2009-09-24 日産化学工業株式会社 １－（置換フェニル）－１－置換シリルエーテル、アルコールまたはケトンの製造方法および中間体
WO2010062366A1 (en) * 2008-10-31 2010-06-03 Arginetix, Inc. Compositions and methods of treating endothelial disorders
WO2011011312A1 (en) 2009-07-22 2011-01-27 Merck Sharp & Dohme Corp. Quinolinone pde2 inhibitors
US8440710B2 (en) 2009-10-15 2013-05-14 Hoffmann-La Roche Inc. HSL inhibitors useful in the treatment of diabetes
US9540379B2 (en) 2011-01-31 2017-01-10 Boehringer Ingelheim International Gmbh (1,2,4)triazolo[4,3-A]quinoxaline derivatives as inhibitors of phosphodiesterases
JP2014511894A (ja) 2011-04-20 2014-05-19 グラクソ グループ リミテッド 抗結核化合物としてのテトラヒドロピラゾロ［１，５‐ａ］ピリミジン
EA029892B1 (ru) 2012-04-25 2018-05-31 Такеда Фармасьютикал Компани Лимитед Азотсодержащее гетероциклическое соединение
JP6205356B2 (ja) 2012-07-13 2017-09-27 武田薬品工業株式会社 複素環化合物
US20140045856A1 (en) 2012-07-31 2014-02-13 Boehringer Ingelheim International Gmbh 4-Methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes
EP2975031A4 (en) 2013-03-14 2017-04-19 Takeda Pharmaceutical Company Limited Heterocyclic compound
JP6411342B2 (ja) 2013-07-03 2018-10-24 武田薬品工業株式会社 アミド化合物
EP3018126A4 (en) 2013-07-03 2016-12-07 Takeda Pharmaceuticals Co HETEROCYCLIC CONNECTION
JPWO2015012328A1 (ja) * 2013-07-24 2017-03-02 武田薬品工業株式会社 複素環化合物
WO2015096651A1 (en) 2013-12-23 2015-07-02 Merck Sharp & Dohme Corp. Pyrimidone carboxamide compounds as pde2 inhibitors
JP6696904B2 (ja) 2014-01-08 2020-05-20 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 製剤および医薬組成物
MX380860B (es) * 2014-08-01 2025-03-12 Firmenich & Cie Dispersion solida de compuestos con sabor de amida.
WO2016090382A1 (en) 2014-12-06 2016-06-09 Intra-Cellular Therapies, Inc. Organic compounds
BR112017012007B1 (pt) 2014-12-06 2022-11-01 Intra-Cellular Therapies, Inc Compostos orgânicos inibitórios de pde2, composições farmacêuticas compreendendo os ditos compostos e uso dos mesmos no tratamento de um distúrbio mediado por pde2
WO2016145614A1 (en) 2015-03-17 2016-09-22 Merck Sharp & Dohme Corp. Triazolyl pyrimidinone compounds as pde2 inhibitors
EP3285581B1 (en) 2015-03-26 2021-08-11 Merck Sharp & Dohme Corp. Pyrazolyl pyrimidinone compounds as pde2 inhibitors
EP3291817B1 (en) 2015-05-05 2019-10-02 Merck Sharp & Dohme Corp. Heteroaryl-pyrimidinone compounds as pde2 inhibitors
WO2016183741A1 (en) 2015-05-15 2016-11-24 Merck Sharp & Dohme Corp. Pyrimidinone amide compounds as pde2 inhibitors
WO2016191935A1 (en) 2015-05-29 2016-12-08 Merck Sharp & Dohme Corp. 6-alkyl dihydropyrazolopyrimidinone compounds as pde2 inhibitors
WO2016192083A1 (en) 2015-06-04 2016-12-08 Merck Sharp & Dohme Corp. Dihydropyrazolopyrimidinone compounds as pde2 inhibitors
US10647727B2 (en) 2015-06-25 2020-05-12 Merck Sharp & Dohme Corp. Substituted pyrazolo/imidazolo bicyclic compounds as PDE2 inhibitors
WO2017000277A1 (en) * 2015-07-01 2017-01-05 Merck Sharp & Dohme Corp. Substituted triazolo bicycliccompounds as pde2 inhibitors
WO2017000276A1 (en) 2015-07-01 2017-01-05 Merck Sharp & Dohme Corp. Bicyclic heterocyclic compounds as pde2 inhibitors
EP3156405A1 (en) 2015-10-13 2017-04-19 Boehringer Ingelheim International GmbH Spirocyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxamide
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Also Published As

Publication number Publication date
MXPA06006777A (es) 2006-08-23
SV2005001979A (es) 2005-12-13
TNSN06186A1 (fr) 2007-11-15
GEP20094720B (en) 2009-06-25
EP1697356B1 (en) 2008-02-27
EP1697356A1 (en) 2006-09-06
GT200400268A (es) 2005-09-20
SI1697356T1 (sl) 2008-06-30
ZA200604970B (en) 2007-11-28
HRP20080142T3 (en) 2008-06-30
IS8474A (is) 2006-05-18
ATE387446T1 (de) 2008-03-15
WO2005061497A1 (en) 2005-07-07
KR20060105776A (ko) 2006-10-11
HN2004000538A (es) 2008-02-21
RS50575B (sr) 2010-05-07
JP4073944B2 (ja) 2008-04-09
DE602004012154T2 (de) 2009-03-12
UA83091C2 (en) 2008-06-10
NL1027787A1 (nl) 2005-06-21
BRPI0417663A (pt) 2007-04-03
AU2004303609A1 (en) 2005-07-07
CL2008001920A1 (es) 2008-10-17
DE602004012154D1 (de) 2008-04-10
CA2549510A1 (en) 2005-07-07
CN1894245A (zh) 2007-01-10
TW200522952A (en) 2005-07-16
UY28671A1 (es) 2005-07-29
DK1697356T3 (da) 2009-01-12
ES2299888T3 (es) 2008-06-01
CN100439366C (zh) 2008-12-03
PT1697356E (pt) 2008-05-05
EA010424B1 (ru) 2008-08-29
PL1697356T3 (pl) 2008-07-31
EA200600973A1 (ru) 2006-10-27
JP2007513996A (ja) 2007-05-31
US20070135457A1 (en) 2007-06-14
KR100816179B1 (ko) 2008-03-28
IL175813A0 (en) 2006-10-05
NL1027787C2 (nl) 2006-03-09
PE20050681A1 (es) 2005-10-04
AP2006003632A0 (en) 2006-06-30
MA28270A1 (fr) 2006-11-01
AR046766A1 (es) 2005-12-21
TWI291961B (en) 2008-01-01
ECSP066643A (es) 2006-10-25

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