NO20063326L - Kombinasjon av (a) N-{5-[4-(4-metyl-piperazinometyl)-benzoylamid]-2-metylfenyl}-4-(3-pyridyl)-2-pyrimidinamin og (b) minst en hypusineringsinhibitor og anvendelse derav - Google Patents

Kombinasjon av (a) N-{5-[4-(4-metyl-piperazinometyl)-benzoylamid]-2-metylfenyl}-4-(3-pyridyl)-2-pyrimidinamin og (b) minst en hypusineringsinhibitor og anvendelse derav

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Publication number
NO20063326L
NO20063326L NO20063326A NO20063326A NO20063326L NO 20063326 L NO20063326 L NO 20063326L NO 20063326 A NO20063326 A NO 20063326A NO 20063326 A NO20063326 A NO 20063326A NO 20063326 L NO20063326 L NO 20063326L
Authority
NO
Norway
Prior art keywords
combination
pyrimidinamine
methylphenyl
pyridyl
inhibitor
Prior art date
Application number
NO20063326A
Other languages
English (en)
Inventor
Tim H Bruemmendorf
Stefan Balabanov
Ulrike Hartmann
Winfried Kammer
Alfred Nordheim
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO20063326L publication Critical patent/NO20063326L/no

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Oppfinnelsen vedrører en fremgangsmåte for å behandle et vannblodig dyr, spesielt et menneske, som har en proliferativ sykdom som omfatter å administrere til dyret en kombinasjon som omfatter (a) N-{5-[4-(4-metylpiperazinometyl)-benzoylamido]-2-metylfenyl}-4-(3-pyridyl)-2-pyrimidinamin og (b) minst en hypusineringsinhibitor, en kombinasjon som innbefatter (a) og (b) som definert over og eventuelt minst en farmasøytisk akseptabel bærer for samtidig, separat eller sekvensiell bruk, i særdeleshet for forsinkelse av progresjon eller behandling av en proliferativ sykdom og endelig anvendelse av minst en hypusineringsinhibitor for fremstilling av et medikament for forsinkelse av progresjon eller behandling av leukemi, i særdeleshet Imatinib resistent leukemi.
NO20063326A 2003-12-19 2006-07-18 Kombinasjon av (a) N-{5-[4-(4-metyl-piperazinometyl)-benzoylamid]-2-metylfenyl}-4-(3-pyridyl)-2-pyrimidinamin og (b) minst en hypusineringsinhibitor og anvendelse derav NO20063326L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53156303P 2003-12-19 2003-12-19
PCT/EP2004/014439 WO2005058320A1 (en) 2003-12-19 2004-12-17 COMBINATION OF (a) N-{5-[4-(4-METHYL-PIPERAZINO-METHYL)-BENZOYLAMIDO]-2METHYLPHENYL}-4-(3-PYRIDYL)-2-PYRIMIDINE-AMINE AND (b) AT LEAST ONE HYPUSINATION INHIBITOR AND THE USE THEREOF

Publications (1)

Publication Number Publication Date
NO20063326L true NO20063326L (no) 2006-09-19

Family

ID=34700180

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20063326A NO20063326L (no) 2003-12-19 2006-07-18 Kombinasjon av (a) N-{5-[4-(4-metyl-piperazinometyl)-benzoylamid]-2-metylfenyl}-4-(3-pyridyl)-2-pyrimidinamin og (b) minst en hypusineringsinhibitor og anvendelse derav

Country Status (17)

Country Link
US (1) US20080139480A1 (no)
EP (1) EP1696917A1 (no)
JP (1) JP2007514699A (no)
KR (1) KR20060125810A (no)
CN (1) CN1889952A (no)
AU (2) AU2004298761A1 (no)
BR (1) BRPI0417759A (no)
CA (1) CA2547196A1 (no)
EC (1) ECSP066656A (no)
IL (1) IL176070A0 (no)
MA (1) MA28240A1 (no)
MX (1) MXPA06006925A (no)
NO (1) NO20063326L (no)
RU (1) RU2006125741A (no)
TN (1) TNSN06182A1 (no)
WO (1) WO2005058320A1 (no)
ZA (1) ZA200603904B (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2197440T3 (pl) 2007-08-31 2013-05-31 Janssen Pharmaceutica Nv Kombinacje imazalilu i hydroksypirydonów
WO2009036753A2 (de) * 2007-09-20 2009-03-26 Schebo Biotech Ag Neue pharmazeutika, verfahren zu ihrer herstellung und ihre verwendung in der medizinischen therapie
US8575187B2 (en) 2008-02-06 2013-11-05 Janssen Pharmaceutica, Nv Combinations of anilinopyrimidines and pyrion compounds
CA2711762C (en) 2008-02-06 2016-11-01 Jan Pieter Hendrik Bosselaers Combinations of phenylpyrroles and pyrion compounds
WO2010048712A1 (en) * 2008-10-31 2010-05-06 University Health Network Ciclopirox and cytarabine for the treatment of leukemic disorders
AU2011261501B2 (en) * 2010-06-01 2016-01-21 Biotheryx, Inc. Methods of treating hematologic malignancies using 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone
WO2011153197A1 (en) * 2010-06-01 2011-12-08 Biotheryx, Inc. Hydroxypyridone derivatives, pharmaceutical compositions thereof, and their therapeutic use for treating proliferative diseases
AU2011263720B2 (en) 2010-06-10 2013-11-07 Janssen Pharmaceutica Nv Combinations of pyrimethanil and monoterpenes
WO2012001028A1 (en) 2010-07-01 2012-01-05 Janssen Pharmaceutica Nv Antimicrobial combinations of pyrion compounds with polyethyleneimines
CN103191110A (zh) * 2013-03-28 2013-07-10 中国科学院昆明植物研究所 环吡酮及环吡酮胺在制备防治黑色素瘤的药物中的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0227593A1 (en) * 1985-11-25 1987-07-01 The Hospital For Sick Children Use of chelating agents
GB8528983D0 (en) * 1985-11-25 1986-01-02 Ciba Geigy Ag Use of chelating agents
MY129541A (en) * 1996-06-25 2007-04-30 Novartis Ag Substituded 3,5-diphenyl-1,2,4-triazoles and their use as pharmaceutical metal chelators
DK1379257T3 (da) * 2001-03-23 2009-12-14 Enzon Inc Anticancer-profarmakon anvendende substituerede aromatiske syrer
AU2003251875A1 (en) * 2002-07-15 2004-02-02 Combinatorx, Incorporated Combination therapy for the treatment of neoplasms

Also Published As

Publication number Publication date
AU2004298761A1 (en) 2005-06-30
JP2007514699A (ja) 2007-06-07
AU2009201694A1 (en) 2009-05-28
TNSN06182A1 (en) 2007-11-15
CA2547196A1 (en) 2005-06-30
US20080139480A1 (en) 2008-06-12
KR20060125810A (ko) 2006-12-06
MXPA06006925A (es) 2006-08-23
CN1889952A (zh) 2007-01-03
RU2006125741A (ru) 2008-01-27
ZA200603904B (en) 2007-09-26
WO2005058320A1 (en) 2005-06-30
IL176070A0 (en) 2006-10-05
MA28240A1 (fr) 2006-10-02
BRPI0417759A (pt) 2007-04-10
ECSP066656A (es) 2006-10-25
EP1696917A1 (en) 2006-09-06

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