NO20063407L - Benzenforbindelser disubstituert med cykliske grupper i 1- og 2-posisjoner - Google Patents

Benzenforbindelser disubstituert med cykliske grupper i 1- og 2-posisjoner

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Publication number
NO20063407L
NO20063407L NO20063407A NO20063407A NO20063407L NO 20063407 L NO20063407 L NO 20063407L NO 20063407 A NO20063407 A NO 20063407A NO 20063407 A NO20063407 A NO 20063407A NO 20063407 L NO20063407 L NO 20063407L
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Norway
Prior art keywords
alkyl
positions
hydrogen
optionally substituted
cyclic groups
Prior art date
Application number
NO20063407A
Other languages
English (en)
Other versions
NO336948B1 (no
Inventor
Tetsuya Kawahara
Makoto Kotake
Naoki Yoneda
Shinsuke Hirota
Masayoshi Ohkuro
Original Assignee
Eisai Co Ltd
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Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of NO20063407L publication Critical patent/NO20063407L/no
Publication of NO336948B1 publication Critical patent/NO336948B1/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P37/02—Immunomodulators
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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
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Abstract

Forbindelser representert ved den generelle formel (1) eller (100), har utmerkede inhiberende aktiviteter mot celleadhesjon og celleinfiltrasjon og er anvendbare som terapeutiske eller forebyggende midler for forskjellige inflammatoriske og auto-immune sykdommer forårsaket av adhesjon og infiltrasjon av hvite blodceller, f.eks. inflammatoriske tarmsykdommer (særlig ulcerøs kolitt eller Crohns sykdom), irritabel tarm-syndrom, revmatisk artritt, psoriasis, multippel sklerose, astma og atopisk dermatitt. hvori RIO er eventuelt substituert cykloalkyl, eller lignende; R20, R21, R22 og R23 er hver hydrogen, alkyl, alkoksy, eller lignende; R30, R3 1 og R32 er hver hydrogen, alkyl, okso eller lignende; og R40 er eventuelt substituert alkyl eller lignende.
NO20063407A 2003-12-26 2006-07-24 1,2-di(cyclisk)substituerte benzenforbindelser, medikament omfattende slike forbindelser, slike forbindelser for bruk som medikament og slike forbindelser for anvendelse i terapi for behandling av sykdom NO336948B1 (no)

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PCT/JP2004/019795 WO2005063705A1 (ja) 2003-12-26 2004-12-24 1,2-ジ（環式基）置換ベンゼン化合物

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KR100782966B1 (ko) 2007-12-07
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IL176160A0 (en) 2006-10-05
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BRPI0418152A (pt) 2007-04-27
CA2545999A1 (en) 2005-07-14
US7425554B2 (en) 2008-09-16
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AU2004309280A1 (en) 2005-07-14
AU2004309280B2 (en) 2007-10-04
WO2005063705A1 (ja) 2005-07-14
EP1698620A1 (en) 2006-09-06
EP1698620A4 (en) 2008-11-05
RU2340602C2 (ru) 2008-12-10
KR20070026348A (ko) 2007-03-08
NO336948B1 (no) 2015-11-30
BRPI0418152B8 (pt) 2021-05-25
CA2545999C (en) 2010-01-05

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