NO20063556L - HIV gp41 HR2-avledede syntetiske peptider og deres anvendelse ved behandling av human mangel pa immunitet mot virus - Google Patents

HIV gp41 HR2-avledede syntetiske peptider og deres anvendelse ved behandling av human mangel pa immunitet mot virus

Info

Publication number
NO20063556L
NO20063556L NO20063556A NO20063556A NO20063556L NO 20063556 L NO20063556 L NO 20063556L NO 20063556 A NO20063556 A NO 20063556A NO 20063556 A NO20063556 A NO 20063556A NO 20063556 L NO20063556 L NO 20063556L
Authority
NO
Norway
Prior art keywords
hiv
synthetic peptides
amino acid
treating human
synthetic
Prior art date
Application number
NO20063556A
Other languages
English (en)
Inventor
Mary K Delmedico
John Dwyer
Original Assignee
Trimeris Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trimeris Inc filed Critical Trimeris Inc
Publication of NO20063556L publication Critical patent/NO20063556L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/24—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a MBP (maltose binding protein)-tag
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • AIDS & HIV (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Det tilveiebringes syntetiske peptider som er basert på en nativ sekvens av HIV gp41 HR2, bortsett fra det syntetiske peptid har et antall aminosyreerstatninger omfattende (a) en heliksfremmende aminosyre, eller (b) en kombinasjon av heliksfremmende aminosyrer, og ladede aminosyrer innført for å danne ionepar i det syntetiske peptid; der de syntetiske peptider viser en uventet, forbedret biologisk aktivitet sammenlignet med et peptid med en aminosyresekvens uten antallet aminosyresubstitusjoner. Det tilveiebringes videre polynukleotider som koder det syntetiske peptid, samt metoder for å anvende disse syntetiske peptider ved inhibering av, eller som preparater for å inhibere, transmisjon av HIV til en målcelle.
NO20063556A 2004-01-07 2006-08-04 HIV gp41 HR2-avledede syntetiske peptider og deres anvendelse ved behandling av human mangel pa immunitet mot virus NO20063556L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53481004P 2004-01-07 2004-01-07
PCT/US2004/042918 WO2005067960A1 (en) 2004-01-07 2004-12-21 HIV gp41 HR2-DERIVED SYNTHETIC PEPTIDES, AND THEIR USE IN THERAPY TO INHIBIT TRANSMISSION OF HUMAN IMMUNODEFICIENCY VIRUS

Publications (1)

Publication Number Publication Date
NO20063556L true NO20063556L (no) 2006-10-06

Family

ID=34794319

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20063556A NO20063556L (no) 2004-01-07 2006-08-04 HIV gp41 HR2-avledede syntetiske peptider og deres anvendelse ved behandling av human mangel pa immunitet mot virus

Country Status (12)

Country Link
US (1) US20060247416A1 (no)
EP (1) EP1708734A4 (no)
JP (1) JP2007517522A (no)
KR (1) KR20070006708A (no)
CN (1) CN1901931A (no)
AU (1) AU2004313242A1 (no)
BR (1) BRPI0418304A (no)
CA (1) CA2551082A1 (no)
IL (1) IL176721A0 (no)
NO (1) NO20063556L (no)
RU (1) RU2006128593A (no)
WO (1) WO2005067960A1 (no)

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US7456251B2 (en) 2006-02-02 2008-11-25 Trimeris, Inc. HIV fusion inhibitor peptides with improved biological properties
JP2008029239A (ja) * 2006-07-27 2008-02-14 Gekkeikan Sake Co Ltd Ｎ３６結合ペプチドの製造方法
TW200817438A (en) 2006-08-17 2008-04-16 Hoffmann La Roche A conjugate of an antibody against CCR5 and an antifusogenic peptide
AU2007286451A1 (en) 2006-08-17 2008-02-21 F. Hoffmann-La Roche Ag A conjugate of an antibody against CCR5 and an antifusogenic peptide
CL2008000707A1 (es) 2007-03-13 2008-09-22 Hoffmann La Roche Conjugado de polipeptidos antifusogenicos y polipeptidos derivados de la cabeza globular del factor del complemento c1q; composicion farmaceutica que lo comprende; su uso para tratar infecciones viricas; y metodo de produccion.
BRPI0809995A2 (pt) * 2007-04-03 2015-07-21 Trimeris Inc Composição, e, métodos para a liberação prolongada de um peptídeo em um paciente e para melhorar um sintoma associado com uma infecção por hiv
US20090022720A1 (en) 2007-07-20 2009-01-22 Stephan Fischer Conjugate of an antibody against CD4 and antifusogenic peptides
KR20100080812A (ko) * 2007-09-25 2010-07-12 트라이머리스, 인코퍼레이티드 치료용 항-ｈｉｖ 펩티드의 합성 방법
JP5788178B2 (ja) 2008-01-23 2015-09-30 ダナ ファーバー キャンサー インスティテュート インコーポレイテッド ウィルス感染症の治療のための組成物及び方法
WO2009155789A1 (zh) * 2008-06-25 2009-12-30 中国人民解放军军事医学科学院毒物药物研究所 抑制hiv感染的多肽及其衍生物
WO2010089129A1 (en) 2009-02-06 2010-08-12 Cormus Srl Inhibitors of viral fusion and uses thereof
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CA2761568C (en) * 2009-06-18 2020-10-13 Dana-Farber Cancer Institute, Inc. Structured viral peptide compositions and methods of use
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RU2013113723A (ru) 2010-09-14 2014-10-20 Ф.Хоффманн-Ля Рош Аг Гибридный полипептид с серпиновым "пальцем"
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Also Published As

Publication number Publication date
CN1901931A (zh) 2007-01-24
WO2005067960A1 (en) 2005-07-28
US20060247416A1 (en) 2006-11-02
JP2007517522A (ja) 2007-07-05
RU2006128593A (ru) 2008-02-20
EP1708734A4 (en) 2009-06-17
EP1708734A1 (en) 2006-10-11
BRPI0418304A (pt) 2007-05-02
CA2551082A1 (en) 2005-07-28
AU2004313242A1 (en) 2005-07-28
IL176721A0 (en) 2006-10-31
KR20070006708A (ko) 2007-01-11

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