NO20063760L - Selektive ostrogenreseptormodulatorer for behandling av vasomotoriske symptomer - Google Patents
Selektive ostrogenreseptormodulatorer for behandling av vasomotoriske symptomerInfo
- Publication number
- NO20063760L NO20063760L NO20063760A NO20063760A NO20063760L NO 20063760 L NO20063760 L NO 20063760L NO 20063760 A NO20063760 A NO 20063760A NO 20063760 A NO20063760 A NO 20063760A NO 20063760 L NO20063760 L NO 20063760L
- Authority
- NO
- Norway
- Prior art keywords
- estrogen receptor
- selective estrogen
- treatment
- vasomotor symptoms
- receptor modulators
- Prior art date
Links
- 208000024891 symptom Diseases 0.000 title abstract 3
- 229940095743 selective estrogen receptor modulator Drugs 0.000 title abstract 2
- 239000000333 selective estrogen receptor modulator Substances 0.000 title abstract 2
- 230000001457 vasomotor Effects 0.000 title abstract 2
- 208000033830 Hot Flashes Diseases 0.000 abstract 1
- 206010060800 Hot flush Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000009245 menopause Effects 0.000 abstract 1
- 206010029410 night sweats Diseases 0.000 abstract 1
- 230000036565 night sweats Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Pyrane Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53844204P | 2004-01-22 | 2004-01-22 | |
| US53834204P | 2004-01-22 | 2004-01-22 | |
| PCT/US2005/000020 WO2005073204A1 (en) | 2004-01-22 | 2005-01-18 | Selective estrogen receptor modulators for the treatment of vasomotor symptoms |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20063760L true NO20063760L (no) | 2006-10-16 |
Family
ID=34830456
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20063760A NO20063760L (no) | 2004-01-22 | 2006-08-22 | Selektive ostrogenreseptormodulatorer for behandling av vasomotoriske symptomer |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US20090023917A1 (de) |
| EP (1) | EP1709021B1 (de) |
| JP (1) | JP4909086B2 (de) |
| KR (2) | KR100849559B1 (de) |
| CN (1) | CN102250042A (de) |
| AT (1) | ATE476428T1 (de) |
| AU (1) | AU2005207821B2 (de) |
| BR (1) | BRPI0506721A (de) |
| CA (1) | CA2551956C (de) |
| CR (1) | CR8517A (de) |
| DE (1) | DE602005022673D1 (de) |
| EA (2) | EA012262B1 (de) |
| EC (1) | ECSP066711A (de) |
| ES (1) | ES2347973T3 (de) |
| IL (1) | IL176738A0 (de) |
| MA (1) | MA28436B1 (de) |
| NO (1) | NO20063760L (de) |
| SG (1) | SG149867A1 (de) |
| UA (1) | UA85862C2 (de) |
| WO (1) | WO2005073204A1 (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008002490A2 (en) | 2006-06-23 | 2008-01-03 | Radius Health, Inc. | Treatment of vasomotor symptoms with selective estrogen receptor modulators |
| US9259426B2 (en) | 2006-07-20 | 2016-02-16 | Gilead Sciences, Inc. | 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections |
| US10144736B2 (en) * | 2006-07-20 | 2018-12-04 | Gilead Sciences, Inc. | Substituted pteridines useful for the treatment and prevention of viral infections |
| US20100087402A1 (en) * | 2008-09-29 | 2010-04-08 | Vivus, Inc. | Methods and compositions for the treatment of estrogen-dependent hyperproliferative uterine disorders |
| AU2009296974B2 (en) * | 2008-09-29 | 2013-06-27 | Eli Lilly And Company | Selective estrogen repector modulator for the treatment of osteoarthritis |
| US20100317635A1 (en) * | 2009-06-16 | 2010-12-16 | Endorecherche, Inc. | Treatment of hot flushes, vasomotor symptoms, and night sweats with sex steroid precursors in combination with selective estrogen receptor modulators |
| SI2568806T1 (sl) | 2010-05-12 | 2016-09-30 | Radius Health, Inc. | Režimi zdravljenja |
| US9133182B2 (en) | 2010-09-28 | 2015-09-15 | Radius Health, Inc. | Selective androgen receptor modulators |
| FR3014437B1 (fr) * | 2013-12-05 | 2016-12-23 | Servier Lab | Nouveau procede de synthese de l'agomelatine |
| FR3014434B1 (fr) * | 2013-12-05 | 2015-12-25 | Servier Lab | Nouveau procede de synthese du 7-methoxy-naphtalene-1-carbaldehyde et application a la synthese de l'agomelatine |
| US9421264B2 (en) | 2014-03-28 | 2016-08-23 | Duke University | Method of treating cancer using selective estrogen receptor modulators |
| EP4035664A3 (de) | 2014-03-28 | 2022-11-30 | Duke University | Behandlung von krebs unter verwendung von selektiven östrogenrezeptormodulatoren |
| PL3097102T3 (pl) | 2015-03-04 | 2018-04-30 | Gilead Sciences Inc | Związki 4,6-diamino-pirydo[3,2-d]pirymidyny modulujące działanie receptora toll-podobnego |
| RU2769527C2 (ru) | 2016-06-22 | 2022-04-01 | Эллипсес Фарма Лтд | Способы лечения ar+ рака молочной железы |
| KR102268448B1 (ko) | 2016-09-02 | 2021-06-22 | 길리애드 사이언시즈, 인코포레이티드 | 톨 유사 수용체 조정제 화합물 |
| ES2826748T3 (es) | 2016-09-02 | 2021-05-19 | Gilead Sciences Inc | Derivados de 4,6-diamino-pirido[3,2-d]pirimidina como moduladores de receptores de tipo Toll |
| DK3565542T3 (da) | 2017-01-05 | 2024-07-01 | Radius Pharmaceuticals Inc | Polymorphic forms of rad1901-2hcl |
| CN108675999B (zh) * | 2018-05-09 | 2021-03-16 | 浙江农林大学暨阳学院 | 一种醋酸铜催化制备8-(9-亚砜基-10-二氢菲)喹啉类化合物的方法 |
| KR102792490B1 (ko) | 2018-07-04 | 2025-04-04 | 래디어스 파마슈티컬스, 인코포레이티드 | Rad1901-2hcl의 다형 형태 |
| TWI702219B (zh) | 2018-07-12 | 2020-08-21 | 美商美國禮來大藥廠 | 選擇性雌激素受體降解劑 |
| CN112424205B (zh) | 2018-07-12 | 2023-10-31 | 伊莱利利公司 | 选择性的雌激素受体降解剂 |
| MX2021009569A (es) | 2019-02-12 | 2021-09-08 | Radius Pharmaceuticals Inc | Procesos y compuestos. |
| TW202210480A (zh) | 2019-04-17 | 2022-03-16 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TWI751517B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TWI879779B (zh) | 2019-06-28 | 2025-04-11 | 美商基利科學股份有限公司 | 類鐸受體調節劑化合物的製備方法 |
| TWI894443B (zh) | 2021-03-16 | 2025-08-21 | 美商美國禮來大藥廠 | 選擇性雌激素受體降解劑 |
| US11926634B2 (en) | 2022-02-01 | 2024-03-12 | Eli Lilly And Company | Processes for the preparation of selective estrogen receptor degraders |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5998401A (en) * | 1995-02-28 | 1999-12-07 | Eli Lilly And Company | Naphthyl compounds, intermediates, compositions, and methods |
| US5726186A (en) * | 1995-09-08 | 1998-03-10 | Eli Lilly And Company | Pentacyclic compounds, intermediates, processes, compositions, and methods |
| CA2213810C (en) * | 1996-08-29 | 2006-06-06 | Lewis Dale Pennington | Benzo¬b|thiophene compounds, intermediates, processes, compositions and methods |
| ID19392A (id) * | 1996-08-29 | 1998-07-09 | Lilly Co Eli | Senyawa naftil dan bahan pertengahan serta komposisi dan metode penggunaan |
| US5916916A (en) * | 1996-10-10 | 1999-06-29 | Eli Lilly And Company | 1-aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods |
| CA2217810A1 (en) * | 1996-10-10 | 1998-04-10 | Eli Lilly And Company | 2-aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods |
| AU8683398A (en) * | 1997-08-07 | 1999-03-01 | Eli Lilly And Company | 1-{4-(substituted alkoxy)benzyl}naphthalene compounds having estrogen inhibitoryactivity |
| ATE433322T1 (de) * | 2002-07-22 | 2009-06-15 | Lilly Co Eli | Selektive östrogenrezeptor modulatoren, die eine phenylsulfonyl-gruppe enthalten |
-
2005
- 2005-01-18 AT AT05704874T patent/ATE476428T1/de not_active IP Right Cessation
- 2005-01-18 CN CN2011101337521A patent/CN102250042A/zh active Pending
- 2005-01-18 UA UAA200607867A patent/UA85862C2/uk unknown
- 2005-01-18 KR KR1020067014630A patent/KR100849559B1/ko not_active Expired - Fee Related
- 2005-01-18 BR BRPI0506721-9A patent/BRPI0506721A/pt not_active IP Right Cessation
- 2005-01-18 SG SG200900414-4A patent/SG149867A1/en unknown
- 2005-01-18 US US10/597,241 patent/US20090023917A1/en not_active Abandoned
- 2005-01-18 AU AU2005207821A patent/AU2005207821B2/en not_active Ceased
- 2005-01-18 CA CA2551956A patent/CA2551956C/en not_active Expired - Fee Related
- 2005-01-18 EA EA200601353A patent/EA012262B1/ru not_active IP Right Cessation
- 2005-01-18 KR KR1020087003065A patent/KR101008804B1/ko not_active Expired - Fee Related
- 2005-01-18 WO PCT/US2005/000020 patent/WO2005073204A1/en not_active Ceased
- 2005-01-18 EP EP05704874A patent/EP1709021B1/de not_active Expired - Lifetime
- 2005-01-18 DE DE602005022673T patent/DE602005022673D1/de not_active Expired - Lifetime
- 2005-01-18 ES ES05704874T patent/ES2347973T3/es not_active Expired - Lifetime
- 2005-01-18 JP JP2006551097A patent/JP4909086B2/ja not_active Expired - Fee Related
- 2005-01-18 EA EA200900586A patent/EA016613B1/ru not_active IP Right Cessation
-
2006
- 2006-07-06 IL IL176738A patent/IL176738A0/en unknown
- 2006-07-19 EC EC2006006711A patent/ECSP066711A/es unknown
- 2006-07-19 CR CR8517A patent/CR8517A/es unknown
- 2006-08-18 MA MA29277A patent/MA28436B1/fr unknown
- 2006-08-22 NO NO20063760A patent/NO20063760L/no not_active Application Discontinuation
-
2011
- 2011-06-23 US US13/167,343 patent/US8217032B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005207821B2 (en) | 2011-02-10 |
| EP1709021B1 (de) | 2010-08-04 |
| US20110281847A1 (en) | 2011-11-17 |
| US20090023917A1 (en) | 2009-01-22 |
| US8217032B2 (en) | 2012-07-10 |
| JP2007519721A (ja) | 2007-07-19 |
| UA85862C2 (uk) | 2009-03-10 |
| SG149867A1 (en) | 2009-02-27 |
| IL176738A0 (en) | 2006-10-31 |
| EA012262B1 (ru) | 2009-08-28 |
| EA200900586A1 (ru) | 2009-08-28 |
| KR101008804B1 (ko) | 2011-01-14 |
| CR8517A (es) | 2006-12-01 |
| ES2347973T3 (es) | 2010-11-26 |
| AU2005207821A1 (en) | 2005-08-11 |
| EA016613B1 (ru) | 2012-06-29 |
| DE602005022673D1 (de) | 2010-09-16 |
| EP1709021A1 (de) | 2006-10-11 |
| CN102250042A (zh) | 2011-11-23 |
| JP4909086B2 (ja) | 2012-04-04 |
| ECSP066711A (es) | 2006-10-31 |
| BRPI0506721A (pt) | 2007-05-02 |
| CA2551956A1 (en) | 2005-08-11 |
| ATE476428T1 (de) | 2010-08-15 |
| KR20060129277A (ko) | 2006-12-15 |
| KR100849559B1 (ko) | 2008-07-31 |
| WO2005073204A1 (en) | 2005-08-11 |
| EA200601353A1 (ru) | 2007-02-27 |
| KR20080016755A (ko) | 2008-02-21 |
| MA28436B1 (fr) | 2007-02-01 |
| CA2551956C (en) | 2013-05-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20063760L (no) | Selektive ostrogenreseptormodulatorer for behandling av vasomotoriske symptomer | |
| SG155188A1 (en) | Pyrrole derivatives as pharmaceutical agents | |
| EA200900202A1 (ru) | Селективные модуляторы андрогенного рецептора, их аналоги и производные и их использование | |
| NO20081975L (no) | Diarylamin-inneholdende forbindelser og sammensetninger, og deres anvendelse som modulatorer av C-kit-reseptorer | |
| ATE530524T1 (de) | Substituierte sulfonamid-derivate | |
| TW200745124A (en) | Azepinoindole derivatives as pharmaceutical agents | |
| NO20084792L (no) | Substituerte imidazol-4-karboksamider som kolecystokinin-1-reseptormodulatorer | |
| NO20090295L (no) | Substituerte heteroarylderivater | |
| MX2010006206A (es) | Derivados de oxindol substituidos por 5-halogeno y el uso de los mismos para el tratamiento de enfermedades dependientes de la vasopresina. | |
| EA201190138A1 (ru) | Производные фуропиримидиндиона в качестве модуляторов trpa1 | |
| WO2008002490A3 (en) | Treatment of vasomotor symptoms with selective estrogen receptor modulators | |
| EA201001329A1 (ru) | Соединения и композиции в качестве модуляторов активности gpr119 | |
| MY149855A (en) | Benzimidazole derivatives and their use for modulating the gaba? receptor complex | |
| MY149459A (en) | Novel 2-substituted benzimidazoles as selective androgen receptor modulator (sarms) | |
| EA201001332A1 (ru) | Соединения и композиции в качестве модуляторов активности gpr119 | |
| EA201001330A1 (ru) | Соединения и композиции в качестве модуляторов активности gpr119 | |
| EA201170043A1 (ru) | Комбинация пилокарпина и метимазола для лечения заболевания шарко-мари-тута и связанных с ним нарушений | |
| DE602007007594D1 (de) | Substituierte imidazol-4-carboxamide als cholecystokinin-1-rezeptor-modulatoren | |
| EP2010178A4 (de) | Substituierte imidazol-4-carboxamide als cholecystokinin-1-rezeptor-modulatoren | |
| NO20064325L (no) | Heteroarylaminopyrazolderivativer nyttige for behandling av diabetes | |
| MY157425A (en) | Substituted oxindole derivatives and the use thereof for the treatment of vasopressin-dependent illnesses | |
| ATE473741T1 (de) | Neue imidazolopyrazolderivate als selektive androgen-rezeptor-modulatoren | |
| WO2009071691A3 (de) | Oxindol-derivate und ihre verwendung als medikament | |
| EA201000732A1 (ru) | Производные s-алкилизотиурония для лечения нарушений, обусловленных гиперсократимостью матки | |
| WO2008128155A3 (en) | SIRTUIN BASED METHODS AND COMPOSITIONS FOR TREATING β- CATENIN-RELATED CONDITIONS |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |