NO20064151L - Nye forbindelser - Google Patents

Nye forbindelser

Info

Publication number
NO20064151L
NO20064151L NO20064151A NO20064151A NO20064151L NO 20064151 L NO20064151 L NO 20064151L NO 20064151 A NO20064151 A NO 20064151A NO 20064151 A NO20064151 A NO 20064151A NO 20064151 L NO20064151 L NO 20064151L
Authority
NO
Norway
Prior art keywords
treatment
active compounds
derivatives
alkyl
new connections
Prior art date
Application number
NO20064151A
Other languages
English (en)
Other versions
NO337281B1 (no
Inventor
Ivan Leo Pinto
Shahzad Sharooq
Neville Hubert Nicholson
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0403282A external-priority patent/GB0403282D0/en
Priority claimed from GB0423562A external-priority patent/GB0423562D0/en
Priority claimed from GB0428375A external-priority patent/GB0428375D0/en
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of NO20064151L publication Critical patent/NO20064151L/no
Publication of NO337281B1 publication Critical patent/NO337281B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Foreliggende oppfinnelse tilveiebringer farmasøytisk aktive forbindelser som er xantinderivater, fremgangsmåter for fremstilling av nevnte derivater, farmasøytiske formuleringer som inneholder de aktive forbindelsene og anvendelse av forbindelsene ved behandling, særlig ved behandling av sykdommer hvor underaktivering av HM74A reseptoren bidrar til sykdommen eller hvor aktivering av reseptoren vil være fordelaktig, som har formel (II); hvori R' er valgt fra: hydrogen og C_alkyl som eventuelt kan være substituert med en eller flere grupper valgt fra CN og CF, Rer valgt fra: C-io usubstituert alkyl, Calkyl substituert med en eller flere grupper valgt fra fluor og CN, Calkenyl, uforgrenet Calkenyl og C^ alkyl substituert med cykloalkyl og Rer valgt fra halogen og CN.
NO20064151A 2004-02-14 2006-09-13 Nye forbindelser, anvendelse derav for fremstilling av et medikament, farmasøytisk formulering og kombinasjon NO337281B1 (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0403282A GB0403282D0 (en) 2004-02-14 2004-02-14 Chemical compounds
GB0423562A GB0423562D0 (en) 2004-10-22 2004-10-22 Novel compounds
GB0428375A GB0428375D0 (en) 2004-12-24 2004-12-24 Novel compounds
PCT/EP2005/001449 WO2005077950A2 (en) 2004-02-14 2005-02-10 Medicaments with hm74a receptor activity

Publications (2)

Publication Number Publication Date
NO20064151L true NO20064151L (no) 2006-11-06
NO337281B1 NO337281B1 (no) 2016-02-29

Family

ID=34864831

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20064151A NO337281B1 (no) 2004-02-14 2006-09-13 Nye forbindelser, anvendelse derav for fremstilling av et medikament, farmasøytisk formulering og kombinasjon

Country Status (25)

Country Link
US (5) US7713982B2 (no)
EP (1) EP1781657B1 (no)
JP (2) JP5001012B2 (no)
KR (1) KR101100601B1 (no)
CN (2) CN101103030B (no)
AR (1) AR047669A1 (no)
AU (1) AU2005212816C1 (no)
BR (1) BRPI0507604A (no)
CA (1) CA2556073C (no)
CY (1) CY1114022T1 (no)
DK (1) DK1781657T3 (no)
ES (1) ES2406732T3 (no)
HR (1) HRP20130406T1 (no)
IL (1) IL177051A (no)
MA (1) MA28357A1 (no)
MY (1) MY148937A (no)
NO (1) NO337281B1 (no)
NZ (1) NZ548496A (no)
PE (1) PE20060317A1 (no)
PL (1) PL1781657T3 (no)
PT (1) PT1781657E (no)
SG (1) SG157242A1 (no)
SI (1) SI1781657T1 (no)
TW (1) TWI350289B (no)
WO (1) WO2005077950A2 (no)

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CN104892610B (zh) * 2015-05-27 2016-08-24 福建师范大学 一种8-酯基咖啡因衍生物的制备方法
CN105622610A (zh) * 2016-03-28 2016-06-01 浙江诚意药业股份有限公司 一种黄嘌呤化合物的制备方法
EP3490579B1 (en) 2016-07-27 2025-09-10 Hartis-Pharma SA Therapeutic combinations to treat red blood cell disorders
CN106632061B (zh) * 2016-11-23 2020-07-24 上海皓元医药股份有限公司 一种1-(4-苯基-1-烷基-1h-咪唑-2-基)乙酮及其衍生物的合成方法
TW201837026A (zh) 2017-01-10 2018-10-16 德商拜耳廠股份有限公司 作為除害劑之雜環衍生物（二）
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Also Published As

Publication number Publication date
PE20060317A1 (es) 2006-06-22
MA28357A1 (fr) 2006-12-01
AR047669A1 (es) 2006-02-01
AU2005212816B2 (en) 2009-07-23
WO2005077950A3 (en) 2007-04-19
HK1104530A1 (en) 2008-01-18
JP2007522176A (ja) 2007-08-09
JP5001012B2 (ja) 2012-08-15
US20150080418A1 (en) 2015-03-19
CA2556073C (en) 2012-01-10
CN101863888B (zh) 2012-07-18
BRPI0507604A (pt) 2007-07-03
US8268839B2 (en) 2012-09-18
PT1781657E (pt) 2013-05-23
JP2008120831A (ja) 2008-05-29
US20100160354A1 (en) 2010-06-24
CN101103030B (zh) 2010-10-13
MY148937A (en) 2013-06-14
CN101863888A (zh) 2010-10-20
IL177051A0 (en) 2006-12-10
SI1781657T1 (sl) 2013-07-31
US20070135456A1 (en) 2007-06-14
KR101100601B1 (ko) 2011-12-29
AU2005212816A1 (en) 2005-08-25
AU2005212816C1 (en) 2010-03-04
PL1781657T3 (pl) 2013-08-30
DK1781657T3 (da) 2013-06-10
US8394808B2 (en) 2013-03-12
NZ548496A (en) 2010-02-26
TW200536537A (en) 2005-11-16
SG157242A1 (en) 2009-12-29
ES2406732T3 (es) 2013-06-07
CA2556073A1 (en) 2005-08-25
TWI350289B (en) 2011-10-11
US20100010021A1 (en) 2010-01-14
HRP20130406T1 (hr) 2013-06-30
IL177051A (en) 2013-01-31
CN101103030A (zh) 2008-01-09
EP1781657A2 (en) 2007-05-09
CY1114022T1 (el) 2016-07-27
US20130150383A1 (en) 2013-06-13
WO2005077950A2 (en) 2005-08-25
NO337281B1 (no) 2016-02-29
KR20060126772A (ko) 2006-12-08
EP1781657B1 (en) 2013-03-27
JP5020848B2 (ja) 2012-09-05
US7713982B2 (en) 2010-05-11

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