NO20064183L - Less immunogenic binding molecules - Google Patents
Less immunogenic binding moleculesInfo
- Publication number
- NO20064183L NO20064183L NO20064183A NO20064183A NO20064183L NO 20064183 L NO20064183 L NO 20064183L NO 20064183 A NO20064183 A NO 20064183A NO 20064183 A NO20064183 A NO 20064183A NO 20064183 L NO20064183 L NO 20064183L
- Authority
- NO
- Norway
- Prior art keywords
- amino acid
- binding molecules
- molecules
- nucleic acid
- acid sequence
- Prior art date
Links
- 230000027455 binding Effects 0.000 title abstract 4
- 230000002163 immunogen Effects 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 4
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 239000013598 vector Substances 0.000 abstract 2
- 239000012636 effector Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000009870 specific binding Effects 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Landscapes
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Sammendrag Den foreliggende oppfinnelsen tilveiebringer et spesifikt bindingsmolekyl, hvor nevnte molekyl omfatter eller består av minst to domener hvorved ett av nevnte minst to domener spesifikt binder til/interagerer med det humane CD3-komplekset og det nevnte domenet omfatter en aminosyresekvens av en antistoff derivert lett kjede, hvor nevnte aminosyresekvens er en spesielt identifisert aminosyresekvens som omfatter spesifikke aminosyresubstitusjoner, og et andre domene er eller inneholder minst ett ytterligere antigen-interagerende-sete og/eller minst ett ytterligere effektordomene. Oppfinnelsen tilveiebringer videre nukleinsyremolekyler som koder for de bispesifikke bindingsmolekylene av oppfinnelsen, vektorer som omfatter nevnte ukleinsyremolekyler og vertsceller transformert eller transfektert med nevnte vektorer. Videre angår oppfinnelsen en fremgangsmåte for produksjonen av bispesifikke bindingsmolekyler av oppfinnelsen og sammensetninger som omfatter de bispesifikke bindingsmolekylene av oppfinnelsen, nukleinsyremolekylene av oppfinnelsen eller vertscellene av oppfinnelsen.SUMMARY The present invention provides a specific binding molecule, wherein said molecule comprises or consists of at least two domains wherein one of said at least two domains specifically binds to / interacts with the human CD3 complex and said domain comprises an amino acid sequence of an antibody derived light chain , wherein said amino acid sequence is a specifically identified amino acid sequence comprising specific amino acid substitutions, and a second domain is or contains at least one additional antigen-interacting site and / or at least one additional effector domain. The invention further provides nucleic acid molecules encoding the bispecific binding molecules of the invention, vectors comprising said nucleic acid molecules and host cells transformed or transfected with said vectors. Furthermore, the invention relates to a process for the production of bispecific binding molecules of the invention and compositions comprising the bispecific binding molecules of the invention, the nucleic acid molecules of the invention or the host cells of the invention.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05715354A EP1716178B1 (en) | 2004-02-16 | 2005-02-16 | Less immunogenic binding molecules |
| PCT/EP2005/001573 WO2005077982A1 (en) | 2004-02-16 | 2005-02-16 | Less immunogenic binding molecules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20064183L true NO20064183L (en) | 2006-11-08 |
Family
ID=37564058
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20064183A NO20064183L (en) | 2005-02-16 | 2006-09-15 | Less immunogenic binding molecules |
Country Status (1)
| Country | Link |
|---|---|
| NO (1) | NO20064183L (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2370467B1 (en) * | 2008-10-01 | 2016-09-07 | Amgen Research (Munich) GmbH | Cross-species-specific pscaxcd3, cd19xcd3, c-metxcd3, endosialinxcd3, epcamxc d3, igf-1rxcd3 or fapalpha xcd3 bispecific single chain antibody |
| US11472886B2 (en) | 2008-10-01 | 2022-10-18 | Amgen Research (Munich) Gmbh | Cross-species-specific PSMAxCD3 bispecific single chain antibody |
-
2006
- 2006-09-15 NO NO20064183A patent/NO20064183L/en not_active Application Discontinuation
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2370467B1 (en) * | 2008-10-01 | 2016-09-07 | Amgen Research (Munich) GmbH | Cross-species-specific pscaxcd3, cd19xcd3, c-metxcd3, endosialinxcd3, epcamxc d3, igf-1rxcd3 or fapalpha xcd3 bispecific single chain antibody |
| US11472886B2 (en) | 2008-10-01 | 2022-10-18 | Amgen Research (Munich) Gmbh | Cross-species-specific PSMAxCD3 bispecific single chain antibody |
| US12281172B2 (en) | 2008-10-01 | 2025-04-22 | Amgen Research (Munich) Gmbh | Cross-species-specific PSMAxCD3 bispecific single chain antibody |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1716178T3 (en) | Less immunogenic binding molecules | |
| DK1752471T3 (en) | Synthetic immunoglogulin domains with binding properties that are modified in regions of the molecule that differ from the complementarity determining regions | |
| NO20091283L (en) | Human antibodies that bind CXCR4 and its applications | |
| CY1118303T1 (en) | SPECIFICATION FOR CROSS-CUTTING SINGLE SPECIAL SINGLE-SINGLE ANTIBODY PSMAXCD3 | |
| MX2009013328A (en) | Methods of modifying antibodies, and modified antibodies with improved functional properties. | |
| NZ717429A (en) | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly | |
| AR060583A1 (en) | ANTIBODY OF HUMANIZED C- KIT | |
| NO20092285L (en) | Human monoclonal antibodies to BTLA and methods of use | |
| NO20090406L (en) | Antigen-binding molecules that bind EGFR, vectors encoding these, and uses thereof | |
| DK1819830T3 (en) | Methods for antibody generation | |
| BRPI0812878C1 (en) | isolated antibody or functional part thereof, vector, method for producing an antibody or a functional part thereof, for producing an antibody-producing cell and for producing an antibody capable of specifically binding to rsv, composition, and use of an antibody or functional part of it or of a composition or vector | |
| EA200702402A1 (en) | AGENTS CONNECTING SCLEROSTINS | |
| HRP20080053A2 (en) | HUMAN MONOCLONAL ANTIBODIES TO LIGAND 1 FOR PROGRAMMED DEATH OF THE STATION (PD-L1) | |
| EA201490931A1 (en) | Binding Molecules for VSMA and CD3 | |
| TN2011000253A1 (en) | Process for the modulation of the antagonistic activity of a monoclonal antibody | |
| NO20071432L (en) | Method for concentration of antibodies or therapeutic products thereof. | |
| PL392809A1 (en) | Anti-CD40 monoclonal antibody and its antigen-binding portion, composition and use thereof, and cell line, nucleic acid molecule, host cell vector and method of production | |
| MY150246A (en) | Alpha 5 - beta 1 antibodies and their uses | |
| MX2009008608A (en) | Monoclonal anti-cxcl13 antibodies. | |
| MX2022010665A (en) | Antibodies binding il4r and uses thereof. | |
| NO20064866L (en) | IRTA-5 antibodies and their use | |
| NO20084672L (en) | Binds for C-reactive protein | |
| ATE523523T1 (en) | MONOCLONAL ANTI MINICHOMOSOME MAINTENANCE 2 PROTEIN ANTIBODIES AND METHOD FOR USE THEREOF IN DETECTING CERVICAL DISEASE | |
| DE602005027399D1 (en) | FOR HUMAN MATRIPTASE SPECIFIC TIE PROTEINS | |
| WO2012099949A3 (en) | Antibody purification via affinity chromatography |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |