NO20065321L - Fremgangsmate for fremstilling av clopidogrelhydrogensulfat polymorf for I - Google Patents

Fremgangsmate for fremstilling av clopidogrelhydrogensulfat polymorf for I

Info

Publication number
NO20065321L
NO20065321L NO20065321A NO20065321A NO20065321L NO 20065321 L NO20065321 L NO 20065321L NO 20065321 A NO20065321 A NO 20065321A NO 20065321 A NO20065321 A NO 20065321A NO 20065321 L NO20065321 L NO 20065321L
Authority
NO
Norway
Prior art keywords
preparation
hydrogen sulfate
clopidogrel hydrogen
sulfate polymorph
polymorph
Prior art date
Application number
NO20065321A
Other languages
English (en)
Other versions
NO339878B1 (no
Inventor
Haifang Mao
Hongguang Qian
Chen Chen
Original Assignee
Krka Tovarna Zdravil Dd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN 200410009028 external-priority patent/CN1690060A/zh
Priority claimed from SI200400122A external-priority patent/SI21749A/sl
Application filed by Krka Tovarna Zdravil Dd filed Critical Krka Tovarna Zdravil Dd
Publication of NO20065321L publication Critical patent/NO20065321L/no
Publication of NO339878B1 publication Critical patent/NO339878B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Det er beskrevet fremgangsmåter for fremstilling av klopridogrelhydrogensulfat av polymorf form I, disse omfatter anvendelse av spesifikke løsningsmidler og fremgangsmåtetrekk for å unngå dannelsen av uønskede biprodukter.
NO20065321A 2004-04-19 2006-11-20 Fremgangsmåte for fremstilling av clopidogrelhydrogensulfat polymorf form I NO339878B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN 200410009028 CN1690060A (zh) 2004-04-19 2004-04-19 一种制备i型硫酸氯吡格雷的方法
SI200400122A SI21749A (sl) 2004-04-21 2004-04-21 Postopek za pripravo polimorfne oblike I klopidogrel hidrogen sulfata
PCT/EP2005/004160 WO2005100364A1 (en) 2004-04-19 2005-04-19 Processes for the preparation of clopidogrel hydrogen sulfate polymorphic form i

Publications (2)

Publication Number Publication Date
NO20065321L true NO20065321L (no) 2007-01-09
NO339878B1 NO339878B1 (no) 2017-02-13

Family

ID=34965241

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20065321A NO339878B1 (no) 2004-04-19 2006-11-20 Fremgangsmåte for fremstilling av clopidogrelhydrogensulfat polymorf form I

Country Status (10)

Country Link
US (1) US7999106B2 (no)
EP (1) EP1740593B1 (no)
EA (1) EA010198B1 (no)
ES (1) ES2577303T3 (no)
HR (1) HRP20160757T1 (no)
HU (1) HUE029459T2 (no)
NO (1) NO339878B1 (no)
PL (1) PL1740593T3 (no)
SI (1) SI1740593T1 (no)
WO (1) WO2005100364A1 (no)

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US7772398B2 (en) * 2005-03-11 2010-08-10 Dr. Reddy's Laboratories, Inc. Process for making crystalline form I of clopidogrel hydrogen sulphate
US20090093635A1 (en) * 2006-03-09 2009-04-09 Sandor Garadnay PROCESS FOR MAKING POLYMORPH FROM I OF (S) - (+) -METHYL-ALPHA- (2-CHLOROPHENYL) -6, 7-DYHIDRO-THIENO- [3, 2-c] PYRIDINE-5 (4H) -ACETATE HYDROGEN SULFATE
EP1931682A2 (en) * 2006-08-03 2008-06-18 Teva Pharmaceutical Industries Ltd. Process for preparing clopidogrel bisulphate
WO2008032995A1 (en) * 2006-09-15 2008-03-20 Boryung Pharmaceutical Co., Ltd Clopidogrel(+)-camphorsulfonate salt, method of preparing the same and a pharmaceutical composition comprising the same
SI22383A (sl) * 2006-09-22 2008-04-30 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze klopidogrela in nove oblike njegovih farmacevtsko sprejemljivih soli
WO2008068569A2 (en) * 2006-12-01 2008-06-12 Wockhardt Research Centre Processes for the preparation of clopidogrel hydrochloride
WO2008093357A2 (en) * 2007-01-29 2008-08-07 Ipca Laboratories Limited Process for preparation of crystalline clopidogrel hydrogen sulphate form i
PL382055A1 (pl) * 2007-03-23 2008-09-29 Koźluk Tomasz Nobilus Ent Sposób wytwarzania formy krystalicznej 1 wodorosiarczanu klopidogrelu
EP2107061A1 (en) * 2008-04-02 2009-10-07 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of optically enriched clopidogrel
WO2011042804A2 (en) 2009-10-08 2011-04-14 Jubliant Life Sciences Limited An improved process for the preparation of clopidogrel hydrogen sulfate form i
WO2011051976A2 (en) * 2009-10-30 2011-05-05 Matrix Laboratories Ltd An improved process for the preparation of clopidogrel bisulfate form i
WO2011125069A1 (en) * 2010-03-22 2011-10-13 Rpg Life Sciences Limited A process for preparation of crystalline form i of clopidogrel bisulfate
CN103360406A (zh) * 2012-03-26 2013-10-23 黑龙江福和华星制药集团股份有限公司 一种制备i型硫酸氢氯吡格雷的方法
CN102924474B (zh) * 2012-11-08 2015-04-01 浙江海翔药业股份有限公司 一种氯吡格雷硫酸氢盐晶型ⅰ的制备方法
FI3587400T3 (fi) 2013-10-22 2024-06-20 Chiesi Farm Spa Menetelmä pde4:n estäjän valmistamiseksi
SG10202008673WA (en) 2015-03-06 2020-10-29 Beyondspring Pharmaceuticals Inc Method of treating cancer associated with a ras mutation
KR101710922B1 (ko) 2015-06-03 2017-02-28 경동제약 주식회사 클로피도그렐 황산염 결정형 i형의 제조방법
MX387591B (es) 2015-06-17 2025-03-18 Otsuka America Pharmaceutical Inc Compuestos cristalinos
US10155748B2 (en) 2015-07-13 2018-12-18 Beyondspring Pharmaceuticals, Inc. Plinabulin compositions
JP2019511565A (ja) 2016-02-08 2019-04-25 ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド ツカレゾールまたはそのアナログを含む組成物
AU2017278245B2 (en) 2016-06-06 2022-09-15 Beyondspring Pharmaceuticals, Inc. Composition and method for reducing neutropenia
EP3565812B1 (en) 2017-01-06 2023-12-27 Beyondspring Pharmaceuticals, Inc. Tubulin binding compounds and therapeutic use thereof
KR20240110997A (ko) 2017-02-01 2024-07-16 비욘드스프링 파마수티컬스, 인코포레이티드. 호중구감소증의 감소 방법
CA3053202C (en) 2017-02-16 2022-10-04 Sandoz Ag Crystalline forms of cabotegravir sodium
EP3743074A4 (en) 2018-01-24 2021-12-15 Beyondspring Pharmaceuticals Inc. COMPOSITION AND METHOD FOR REDUCING THROMBOCYTOPENIA BY THE ADMINISTRATION OF PLINABULINE
TW202028208A (zh) 2018-10-09 2020-08-01 瑞士商諾華公司 N-(4-氟-3-(6-(3-甲基吡啶-2-基)-[1,2,4]三唑并[1,5-a]嘧啶-2-基)苯基)-2,4-二甲基㗁唑-5-甲醯胺固體形式
WO2022216908A1 (en) 2021-04-09 2022-10-13 Beyondspring Pharmaceuticals, Inc. Therapeutic compositions and methods for treating tumors

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Publication number Priority date Publication date Assignee Title
FR2623810B2 (fr) 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
FR2779726B1 (fr) 1998-06-15 2001-05-18 Sanofi Sa Forme polymorphe de l'hydrogenosulfate de clopidogrel
WO2002018357A1 (en) 2000-08-29 2002-03-07 Rpg Life Sciences Limited A ONE-POT PROCESS FOR THE PREPARATION OF PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS OF 4, 5, 6, 7 - TETRAHYDROTHIENO (3,2-c) PYRIDINE DERIVATIVES HAVING ANTITHROMBOTIC ACTIVITY
GB0125708D0 (en) 2001-10-26 2001-12-19 Generics Uk Ltd Novel compounds and processes
CA2470479A1 (en) 2001-12-18 2003-06-26 Teva Pharmaceutical Industries Ltd. Polymorphs of clopidogrel hydrogensulfate
CA2495437A1 (en) 2002-08-27 2004-03-11 Yamanouchi Pharmaceutical Co., Ltd. Novel crystal
CZ297472B6 (cs) * 2002-08-27 2006-12-13 Zentiva, A.S. Zpusob výroby clopidogrelu hydrogensulfátu krystalické formy I
WO2004048385A2 (en) * 2002-11-28 2004-06-10 Instytut Farmaceutyczny A process for the preparation of crystalline form 1 or clopidogrel hydrogen sulfate
AU2003238664A1 (en) 2003-03-12 2004-09-30 Cadila Healthcare Limited Polymorphs and amorphous form of (s) - (+) -clopidogrel bisulfate
DE602004026059D1 (de) 2003-07-02 2010-04-29 Egis Gyogyszergyar Nyilvanosan Prozess zur herstellung eines kristallinen polymorphs eines die plättchen aggregation hemmenden arzneistoffs
BR0318449A (pt) 2003-08-04 2006-08-01 Wockhardt Ltd processo para fabricação de (+)-(s)-clopidogrel bissulfato forma-i
DE10337773A1 (de) * 2003-08-13 2005-03-24 Krka Tovarna Zdravil, D.D. Kristallisation von festen Formen von Clopidogrel-Additionssalzen
EP1723141A4 (en) * 2004-03-05 2007-10-10 Ipca Lab Ltd MOST TECHNICAL PROCESS FOR THE PREPARATION OF CLOPIDOGRAPHYDROGENSULFATE

Also Published As

Publication number Publication date
EP1740593B1 (en) 2016-04-06
WO2005100364A1 (en) 2005-10-27
PL1740593T3 (pl) 2016-09-30
NO339878B1 (no) 2017-02-13
US20090234123A1 (en) 2009-09-17
EA010198B1 (ru) 2008-06-30
SI1740593T1 (sl) 2016-08-31
HRP20160757T1 (hr) 2016-08-12
US7999106B2 (en) 2011-08-16
EA200601822A1 (ru) 2007-02-27
HUE029459T2 (en) 2017-02-28
EP1740593A1 (en) 2007-01-10
ES2577303T3 (es) 2016-07-14

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